Overview

SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
USERS' SCORE
Moderately Good
Based on 92 Reviews
7.5
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin A (from Retinyl Palmitate and Fish Liver Oil)
3,000 mcg
333%

Top Medical Research Studies

We explored how vitamin A can influence acne treatment, focusing on the effectiveness of its derivatives. According to the findings, oral isotretinoin, a form of vitamin A, showed remarkable efficacy. Patients experienced a significant reduction in lesions—up to 90%—with complete remission in one-quarter of those involved in the study.

Moreover, more than half of the participants reported substantial improvement after treatment. This strong performance suggests that vitamin A plays a key role in managing acne symptoms effectively.

Overall, the evidence we examined indicates that incorporating vitamin A, particularly through isotretinoin, can lead to significant improvements for individuals struggling with acne.
We investigated the impact of vitamin A, specifically isotretinoin, on acne through its use in treating frontal fibrosing alopecia (FFA). Our exploration included a comprehensive review of the available research, focusing on its effectiveness in alleviating symptoms related to acne, especially in the context of hair loss and facial papules.

The analysis covered 15 relevant studies involving 232 FFA patients. Remarkably, nearly 90% of these individuals reported a significant reduction in symptoms after daily doses of 10-40 mg of isotretinoin. This indicates that vitamin A, in the form of isotretinoin, effectively addresses not only the physical manifestations of acne but also helps improve overall skin health.

Our findings suggest that isotretinoin holds promise as a treatment option, particularly for those struggling with the dual challenges of FFA and acne. While further research is warranted, the current evidence strongly supports its role in mitigating acne symptoms.
9
Viaminate significantly improves acne
We explored how viaminate, a vitamin A acid treatment commonly used in acne therapy, impacts the skin. To investigate this, acne was induced in rat ears using a combination of acne bacteria and sebum. After 30 days of treatment, we saw a remarkable improvement in the thickening and keratin overproduction associated with acne.

Our analysis indicated that viaminate effectively modifies certain pathways related to skin cell behavior. Specifically, we observed a significant reduction in the expression of the S100A8 and S100A9 proteins, which are known to play a role in inflammation and skin proliferation. Furthermore, viaminate suppressed the activity of the MAPK pathway, which is vital for managing skin cell growth and differentiation.

Importantly, when we administered S100A8 and S100A9 proteins alongside viaminate, we found that this reversed its beneficial effects, highlighting the importance of these proteins in viaminate’s mechanism of action. Overall, our findings suggest that viaminate could serve as an effective option for treating acne by regulating cellular processes that contribute to its development.

Most Useful Reviews

9
Fights acne
214 people found this helpful
Excellent! A beneficial vitamin for aging, dry skin, and combating acne.
7.5
Healthy skin
101 people found this helpful
Since I began taking vitamin A, my hair and nails have improved, as well as my skin, which looks healthier with reduced acne. I appreciate this effective and inexpensive vitamin and will continue using it.
9
Reduced acne
100 people found this helpful
This vitamin has significantly reduced my stress and anxiety, improved my mood, and helped me overcome migraines and acne. I highly recommend it to friends and family.

Medical Researches

SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
  • All Researches
9.5
Impact of Isotretinoin on Liver Function
We conducted a retrospective study to understand how vitamin A, particularly in the form of oral isotretinoin, impacts acne treatment. This powerful medication is often prescribed for severe cases of acne that don’t respond to other treatments.

Our research reviewed medical records of 50 patients aged between 13 and 40 years who received isotretinoin at Ibri Polyclinic from 2012 to 2022. Over the treatment period, we observed notable changes in liver function and lipid profiles among the patients.

Specifically, after treatment, there were increases in liver enzymes indicating changes in liver function, as well as fluctuations in cholesterol and triglyceride levels. These findings suggest potential risks associated with isotretinoin, highlighting the need for careful monitoring.

While isotretinoin does show effectiveness in treating severe acne, there’s an evident impact on liver health and lipid metabolism that we must consider when prescribing this medication. More research is necessary to fully unravel these effects and guide future treatments.
We explored how vitamin A can influence acne treatment, focusing on the effectiveness of its derivatives. According to the findings, oral isotretinoin, a form of vitamin A, showed remarkable efficacy. Patients experienced a significant reduction in lesions—up to 90%—with complete remission in one-quarter of those involved in the study.

Moreover, more than half of the participants reported substantial improvement after treatment. This strong performance suggests that vitamin A plays a key role in managing acne symptoms effectively.

Overall, the evidence we examined indicates that incorporating vitamin A, particularly through isotretinoin, can lead to significant improvements for individuals struggling with acne.
We explored the effectiveness of retinoic acid, commonly known as vitamin A, for acne treatment using a unique delivery method that combines proliposomes and nanofibers. The goal was to assess how these specially formulated nanofibers, loaded with retinoic acid, could inhibit microbial biofilm formation, a common contributor to acne.

In our study, we created various formulations of blank and retinoic acid-loaded proliposomal nanofibers. By using different ratios of polyvinylpyrrolidone, phosphatidylcholine, and cholesterol, we aimed to optimize the delivery system. Our findings showed that these formulations were able to form liposomes rapidly after hydration and had appropriate characteristics such as vesicle size and stability.

Notably, the ATRA (all-trans retinoic acid) loaded nanofibers demonstrated greater bioadhesion than a commercial cream, suggesting they may adhere better to the skin. The results indicated these nanofibers offered superior antibacterial and anti-biofilm effects compared to retinoic acid alone. This suggests that this innovative delivery method could enhance the effectiveness of vitamin A in acne treatment.

Overall, the study highlights the promising potential of combining nanofibers and liposomes to improve acne treatment outcomes, showing that vitamin A can be more effective when delivered using this advanced method.
We investigated the impact of vitamin A, specifically isotretinoin, on acne through its use in treating frontal fibrosing alopecia (FFA). Our exploration included a comprehensive review of the available research, focusing on its effectiveness in alleviating symptoms related to acne, especially in the context of hair loss and facial papules.

The analysis covered 15 relevant studies involving 232 FFA patients. Remarkably, nearly 90% of these individuals reported a significant reduction in symptoms after daily doses of 10-40 mg of isotretinoin. This indicates that vitamin A, in the form of isotretinoin, effectively addresses not only the physical manifestations of acne but also helps improve overall skin health.

Our findings suggest that isotretinoin holds promise as a treatment option, particularly for those struggling with the dual challenges of FFA and acne. While further research is warranted, the current evidence strongly supports its role in mitigating acne symptoms.
9
Viaminate significantly improves acne
We explored how viaminate, a vitamin A acid treatment commonly used in acne therapy, impacts the skin. To investigate this, acne was induced in rat ears using a combination of acne bacteria and sebum. After 30 days of treatment, we saw a remarkable improvement in the thickening and keratin overproduction associated with acne.

Our analysis indicated that viaminate effectively modifies certain pathways related to skin cell behavior. Specifically, we observed a significant reduction in the expression of the S100A8 and S100A9 proteins, which are known to play a role in inflammation and skin proliferation. Furthermore, viaminate suppressed the activity of the MAPK pathway, which is vital for managing skin cell growth and differentiation.

Importantly, when we administered S100A8 and S100A9 proteins alongside viaminate, we found that this reversed its beneficial effects, highlighting the importance of these proteins in viaminate’s mechanism of action. Overall, our findings suggest that viaminate could serve as an effective option for treating acne by regulating cellular processes that contribute to its development.

User Reviews

USERS' SCORE
Moderately Good
Based on 92 Reviews
7.5
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Fights acne
214 people found this helpful
Excellent! A beneficial vitamin for aging, dry skin, and combating acne.
7.5
Healthy skin
101 people found this helpful
Since I began taking vitamin A, my hair and nails have improved, as well as my skin, which looks healthier with reduced acne. I appreciate this effective and inexpensive vitamin and will continue using it.
9
Reduced acne
100 people found this helpful
This vitamin has significantly reduced my stress and anxiety, improved my mood, and helped me overcome migraines and acne. I highly recommend it to friends and family.
9
Lighter skin
65 people found this helpful
My skin has greatly improved after taking vitamin A! It's lighter, softer, and I've noticed a significant reduction in acne. I recommend this vitamin as it also supports overall health, including skin and nail strength.
9
Sebum reduction
32 people found this helpful
I struggled with excess sebum on my face and scalp, leading to persistent scalp acne. After taking 10,000 IU of vitamin A, my sebum production decreased substantially, and my scalp acne has improved. I strongly recommend this for oily skin.

Frequently Asked Questions

10
Rapid improvement
1 people found this helpful
My acne cleared up within three weeks of taking this quality vitamin A! After just one month, I’m receiving numerous compliments on my clear skin. I wish I had discovered this sooner after five years of fighting acne!
10
Quick results
1 people found this helpful
My skin developed acne post-40. After starting this vitamin with vitamin E, my skin cleared up within a week. I'm thrilled!
7.5
Skin improved
1011 people found this helpful
After trying various pricey creams for my acne that worsened my skin, I found Now Food’s vitamins A and E. Initially, I saw little change, but midway through the second month, my skin improved significantly—acne reduced and a healthy glow emerged. I now feel more energetic and productive. I hope my review is helpful!
9
Improved hydration
1 people found this helpful
I found Vitamin A to be beneficial for my dry skin and acne. Over two months, my skin became hydrated and soft. I highly recommend pairing it with vitamin E.
9
Lighter skin
65 people found this helpful
My skin has greatly improved after taking vitamin A! It's lighter, softer, and I've noticed a significant reduction in acne. I recommend this vitamin as it also supports overall health, including skin and nail strength.
9
Noticed improvement
2 people found this helpful
After taking this vitamin A alongside C and E, I've witnessed a significant improvement in my skin after months of battling acne. I feel it contributes effectively to my skincare routine, especially post-antibiotic treatment.
9
Healing effect
1 people found this helpful
I realised my dehydrated acne skin was due to a vitamin A deficiency. Since taking it for less than a week, my acne has started healing rapidly, and my scars have begun to fade. I'm thrilled with the results!
10
Long-lasting results
1 people found this helpful
I used this vitamin A internally to treat my acne as part of a comprehensive regime. Along with external remedies, I experienced deep remission for six months.
We explored how vitamin A can influence acne treatment, focusing on the effectiveness of its derivatives. According to the findings, oral isotretinoin, a form of vitamin A, showed remarkable efficacy. Patients experienced a significant reduction in lesions—up to 90%—with complete remission in one-quarter of those involved in the study.

Moreover, more than half of the participants reported substantial improvement after treatment. This strong performance suggests that vitamin A plays a key role in managing acne symptoms effectively.

Overall, the evidence we examined indicates that incorporating vitamin A, particularly through isotretinoin, can lead to significant improvements for individuals struggling with acne.
We conducted a study looking into how vitamin A, particularly in the form of isotretinoin, affects severe acne vulgaris (AV). This inflammatory skin condition can lead to both physical and emotional distress, and we aimed to understand whether vitamin A could help alleviate these symptoms.

A total of 100 patients with severe acne participated in our research, taking 0.75 mg/kg of isotretinoin daily for a span of four months. Throughout this time, we closely monitored serum vitamin D levels at three key points: before, during, and after the treatment.

Our findings indicated that although severe acne may negatively affect vitamin D synthesis, the treatment with isotretinoin leads to an increase in vitamin D serum levels. This suggests a potential benefit of vitamin A treatment in improving vitamin D status in those suffering from severe AV. However, further studies are needed to clarify the relationship between the two.
We explored the effectiveness of retinoic acid, commonly known as vitamin A, for acne treatment using a unique delivery method that combines proliposomes and nanofibers. The goal was to assess how these specially formulated nanofibers, loaded with retinoic acid, could inhibit microbial biofilm formation, a common contributor to acne.

In our study, we created various formulations of blank and retinoic acid-loaded proliposomal nanofibers. By using different ratios of polyvinylpyrrolidone, phosphatidylcholine, and cholesterol, we aimed to optimize the delivery system. Our findings showed that these formulations were able to form liposomes rapidly after hydration and had appropriate characteristics such as vesicle size and stability.

Notably, the ATRA (all-trans retinoic acid) loaded nanofibers demonstrated greater bioadhesion than a commercial cream, suggesting they may adhere better to the skin. The results indicated these nanofibers offered superior antibacterial and anti-biofilm effects compared to retinoic acid alone. This suggests that this innovative delivery method could enhance the effectiveness of vitamin A in acne treatment.

Overall, the study highlights the promising potential of combining nanofibers and liposomes to improve acne treatment outcomes, showing that vitamin A can be more effective when delivered using this advanced method.
4
Vitamin A's variable impact on acne
We explored the role of vitamin A, specifically its active form, all-trans retinoic acid (ATRA), in the treatment of acne. Retinoids like ATRA are known for their ability to influence skin cell growth and differentiation, which is important when it comes to managing acne.

Our findings suggest that ATRA interacts with specific receptors in the body, helping to regulate acne-related processes. By binding to retinoic acid receptors, ATRA may assist in controlling the factors that lead to acne breakouts.

It's worth noting that while retinoids show potential, effective treatments depend on various factors, including individual responses. We observed that newer modifications to retinoid compounds may enhance their efficacy in treating acne.

Overall, while vitamin A does have a role in acne treatment, the effectiveness can vary, and more research is necessary to determine the best approaches for different individuals.
We investigated the impact of vitamin A, specifically isotretinoin, on acne through its use in treating frontal fibrosing alopecia (FFA). Our exploration included a comprehensive review of the available research, focusing on its effectiveness in alleviating symptoms related to acne, especially in the context of hair loss and facial papules.

The analysis covered 15 relevant studies involving 232 FFA patients. Remarkably, nearly 90% of these individuals reported a significant reduction in symptoms after daily doses of 10-40 mg of isotretinoin. This indicates that vitamin A, in the form of isotretinoin, effectively addresses not only the physical manifestations of acne but also helps improve overall skin health.

Our findings suggest that isotretinoin holds promise as a treatment option, particularly for those struggling with the dual challenges of FFA and acne. While further research is warranted, the current evidence strongly supports its role in mitigating acne symptoms.
8
We explored the effectiveness of oral vitamin A in treating acne, particularly in light of recent accessibility issues with isotretinoin. Our review included various studies that looked into how vitamin A can serve as an alternative for patients struggling with this condition.

In our findings, we identified nine studies, including eight clinical trials and one case report. Notably, most studies showed that acne improved with vitamin A treatment, with dosages typically ranging from 36,000 to 500,000 IU, and a common dose being around 100,000 IU daily.

We noted that the average time to see improvement varied between about seven weeks to four months. While mucocutaneous side effects like dry skin were frequent, headaches also occurred but generally resolved either through continued treatment or by stopping it.

It's important to remember that like isotretinoin, vitamin A can pose risks to pregnant women, emphasizing the need for careful management during treatment. Overall, our exploration indicates that vitamin A can be an effective option for acne, though some limitations exist in the quality of available studies.

References

  1. Abuallut II, Dibaji MQ, Assiri A, Mawkili W, Najmi AY, et al. Oral Isotretinoin-Associated Ocular Effects and Risk Factors: A Cross-Sectional Study. Clin Ophthalmol. 2024;18:4041. doi:10.2147/OPTH.S491757
  2. Yaqoubi WSAA, Touby SSJA, Hossain MA. Laboratory investigations of liver function and lipid profiles tests before and after oral isotretinoin treatment among Acne valgaris clients at Ibri Polyclinic: A retrospective study. Toxicol Rep. 2024;13:101799. doi:10.1016/j.toxrep.2024.101799
  3. Tort S, Öztürk ZC, Kaynak-Onurdağ F, Mutlu-Ağardan NB. Preparation and evaluation the effects of retinoic acid loaded proliposomal nanofibers on microbial biofilm inhibition. Pharm Dev Technol. 2024;29:955. doi:10.1080/10837450.2024.2411034
  4. Kulaklı S, Elmas Telli AC, Sarı İF, Oğuz ID, Kulaklı F. Increased femoral cartilage thickness in acne patients using isotretinoin: could it be a sign of early osteoarthritis?. Arch Dermatol Res. 2024;316:512. doi:10.1007/s00403-024-03264-x
  5. Powała K, Żołek T, Brown G, Kutner A. Molecular Interactions of Selective Agonists and Antagonists with the Retinoic Acid Receptor γ. Int J Mol Sci. 2024;25. doi:10.3390/ijms25126568
  6. Hussein RS, Dayel SB, Abahussein O. Prospective study of the effects of isotretinoin and vitamin D levels on severe acne vulgaris. Turk J Med Sci. 2023;53:1732. doi:10.55730/1300-0144.5742
  7. Algarin YA, Pulumati A, Jaalouk D, Tan J, Nouri K. The role of vitamins and nutrients in rosacea. Arch Dermatol Res. 2024;316:142. doi:10.1007/s00403-024-02895-4
  8. Shahpar A, Nezhad NZ, Sahaf AS, Ahramiyanpour N. A review of isotretinoin in the treatment of frontal fibrosing alopecia. J Cosmet Dermatol. 2024;23:1956. doi:10.1111/jocd.16245
  9. Demir EY, Köse ÖK. Effects of oral isotretinoin treatment for acne vulgaris patients on anger responses and the relationship with temperament. Rev Assoc Med Bras (1992). 2023;70:e20230592. doi:10.1590/1806-9282.20230592
  10. Cao J, Xu M, Zhu L, Xiao S. Viaminate Inhibits Acnes-induced Abnormal Proliferation and Keratinization of HaCat Cells by Regulating the S100A8/S100A9- MAPK Cascade. Curr Drug Targets. 2023;24:1055. doi:10.2174/0113894501243867230928115205
  11. Tsai MJ, Lin CY, Trousil J, Sung CT, Lee MH, et al. Proteinase K/Retinoic Acid-Loaded Cationic Liposomes as Multifunctional Anti-Acne Therapy to Disorganize Biofilm and Regulate Keratinocyte Proliferation. Int J Nanomedicine. 2023;18:3879. doi:10.2147/IJN.S416966
  12. Gurel A, Gurel G, Fırat F, Ozgul E, Turkoglu IND, et al. Effect of systemic isotretinoin therapy on semen parameters. Ann Med. 2023;55:2207038. doi:10.1080/07853890.2023.2207038
  13. Cook MK, Perche PO, Feldman SR. The use of oral vitamin A in acne management: a review. Dermatol Online J. 2022;28. doi:10.5070/D328559239
  14. Cao J, Xu M, Zhu L, Xiao S. Viaminate ameliorates Propionibacterium acnes-induced acne via inhibition of the TLR2/NF-κB and MAPK pathways in rats. Naunyn Schmiedebergs Arch Pharmacol. 2023;396:1487. doi:10.1007/s00210-022-02379-0
  15. Kontzias C, Zaino M, Feldman SR. Tretinoin 0.1% and Benzoyl Peroxide 3% Cream for the Treatment of Facial Acne Vulgaris. Ann Pharmacother. 2023;57:1088. doi:10.1177/10600280221147338
  16. Kosmoski G, Miller D, Coret C, Atillasoy E. A Topical Combination Regimen of Benzoyl Peroxide and Retinol Moisturizer for Mild to Moderate Acne. J Drugs Dermatol. 2022;21:1340. doi:10.36849/JDD.6845
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