SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.7
USERS' SCORE
Good
Based on 33 Reviews
8.7
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin A (from Retinyl Palmitate and Fish Liver Oil)
3,000 mcg
333%
Top Medical Research Studies
9
Vitamin A deficiency worsens lupus nephritis
Hypovitaminosis A Drives the Progression of Tubulointerstitial Lupus Nephritis through Potentiating Predisease Cellular Autoreactivity.
Study findings are highly relevant
We examined the impact of vitamin A deficiency (VAD) on the progression of lupus nephritis in a mouse model. By inducing VAD during pregnancy or after weaning, we discovered that both methods significantly worsened the condition, leading to higher mortality rates.
Interestingly, restoring vitamin A levels after weaning reduced mortality. This suggests that VAD accelerates lupus nephritis through increased immune cell activation and autoantibody production. However, effects were less pronounced when VAD was introduced post-weaning. Overall, the study highlights the potential dangers of vitamin A deficiency in autoimmune diseases.
Interestingly, restoring vitamin A levels after weaning reduced mortality. This suggests that VAD accelerates lupus nephritis through increased immune cell activation and autoantibody production. However, effects were less pronounced when VAD was introduced post-weaning. Overall, the study highlights the potential dangers of vitamin A deficiency in autoimmune diseases.
Read More
8
Dietary retinol may lower RA risk
Association between dietary retinol intake and rheumatoid arthritis based on NHANES database.
High relevance due to findings.
We analyzed data from five cycles of the National Health and Nutrition Examination Survey (NHANES), focusing on how dietary retinol (a form of vitamin A) intake relates to rheumatoid arthritis (RA).
Our findings indicated that higher dietary retinol intake, especially in women, was linked to a reduced risk of developing RA. Specifically, women who consumed more than 354.86 mcg of retinol saw the most significant benefits.
This suggests that adjusting our diets to include more vitamin A could offer a protective effect against this autoimmune disorder.
Our findings indicated that higher dietary retinol intake, especially in women, was linked to a reduced risk of developing RA. Specifically, women who consumed more than 354.86 mcg of retinol saw the most significant benefits.
This suggests that adjusting our diets to include more vitamin A could offer a protective effect against this autoimmune disorder.
Read More
8
Vitamin A vaccine alters Th17 cells
Repeated immunization with ATRA-containing liposomal adjuvant transdifferentiates Th17 cells to a Tr1-like phenotype.
High relevance to autoimmune therapy
We investigated whether a therapeutic vaccine could target harmful Th17 cells in autoimmune diseases using vitamin A ingredients. By using all-trans retinoic acid (ATRA) in liposomal formulations, we found that it specifically inhibited Th17 cells related to a particular autoantigen, sparing unrelated ones.
This process not only reduced disease severity in a mouse model of multiple sclerosis, but also encouraged Th17 cells to adopt a more regulatory and tolerant role. Overall, our findings suggest that ATRA-containing vaccines might effectively alter the behavior of Th17 cells in autoimmune conditions.
This process not only reduced disease severity in a mouse model of multiple sclerosis, but also encouraged Th17 cells to adopt a more regulatory and tolerant role. Overall, our findings suggest that ATRA-containing vaccines might effectively alter the behavior of Th17 cells in autoimmune conditions.
Read More
Most Useful Reviews
9.5
Seizures alleviated
I took vitamins daily and noticed significant improvement after three days, achieving mostly normal mouth movement. After a week and a half, the seizures disappeared—though results can vary for others. I now take these vitamins in courses at the start of cold weather and in spring, and the issue with seizures no longer bothers me. I highly recommend purchasing these vitamins if prescribed by a doctor; you certainly won't regret it.
Read More
9.5
Skin condition improved
I took this drug primarily as a co-factor of vitamin E. Alongside Mason Natural Vitamin E, this dietary supplement restored my extremely dry skin to a normal condition quite quickly! I took both in tandem during the autumn-winter period when the heating in our house dries the air, causing my skin to crack and peel. After a month, everything improved, and I continue taking them. I plan to order vitamins A and E from these brands again in the autumn due to their good formulation, volume, and value for money.
Read More
9.5
Skin condition resolved
For years, I struggled with problematic skin since my teens. After trying various treatments, I ordered vitamin A to specifically address my skin issues. A month later, my skin feels smoother, the pores have tightened, and overall, I was pleasantly surprised. I did not experience any side effects and plan to continue using it.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.7
- All Researches
9
Vitamin A enhances rheumatoid arthritis treatment
Exploring the supplementary potential of all-trans retinoic acid with methotrexate in rheumatoid arthritis: modulation of synovial cell apoptosis and autophagy.
High relevance for arthritis treatment
We examined how well all-trans retinoic acid (ATRA) works alongside methotrexate (MTX) in treating rheumatoid arthritis. Our research focused on its ability to reduce the growth of synovial cells while promoting their death, which is essential in managing this condition.
While MTX alone didn't significantly affect cell viability or apoptosis, the addition of ATRA showed impressive results. It not only inhibited cell growth but also triggered both apoptosis and autophagy via the ROS-JNK pathway. In tests with rats, this combination therapy notably improved results compared to MTX alone.
ATRA may be a valuable supplementary treatment for rheumatoid arthritis, especially since MTX alone has limited effectiveness on these specific cellular processes.
While MTX alone didn't significantly affect cell viability or apoptosis, the addition of ATRA showed impressive results. It not only inhibited cell growth but also triggered both apoptosis and autophagy via the ROS-JNK pathway. In tests with rats, this combination therapy notably improved results compared to MTX alone.
ATRA may be a valuable supplementary treatment for rheumatoid arthritis, especially since MTX alone has limited effectiveness on these specific cellular processes.
Read More
9
ATRA microparticles improve arthritis treatment
Immunomodulatory Microparticles Epigenetically Modulate T Cells and Systemically Ameliorate Autoimmune Arthritis.
Significant potential therapeutic relevance
We explored an innovative treatment for autoimmune arthritis using microparticles that release all-trans retinoic acid (ATRA), a form of vitamin A. This method aims to enhance immune responses in a targeted way, improving T cells that help reduce inflammation.
Our findings show that these microparticles, when injected into the joints of mice, decreased symptoms of the disease without completely suppressing the immune response. The approach appears promising for enhancing treatment in patients who don’t respond well to traditional therapies like DMARDs.
Our findings show that these microparticles, when injected into the joints of mice, decreased symptoms of the disease without completely suppressing the immune response. The approach appears promising for enhancing treatment in patients who don’t respond well to traditional therapies like DMARDs.
Read More
9
Vitamin A deficiency worsens lupus nephritis
Hypovitaminosis A Drives the Progression of Tubulointerstitial Lupus Nephritis through Potentiating Predisease Cellular Autoreactivity.
Study findings are highly relevant
We examined the impact of vitamin A deficiency (VAD) on the progression of lupus nephritis in a mouse model. By inducing VAD during pregnancy or after weaning, we discovered that both methods significantly worsened the condition, leading to higher mortality rates.
Interestingly, restoring vitamin A levels after weaning reduced mortality. This suggests that VAD accelerates lupus nephritis through increased immune cell activation and autoantibody production. However, effects were less pronounced when VAD was introduced post-weaning. Overall, the study highlights the potential dangers of vitamin A deficiency in autoimmune diseases.
Interestingly, restoring vitamin A levels after weaning reduced mortality. This suggests that VAD accelerates lupus nephritis through increased immune cell activation and autoantibody production. However, effects were less pronounced when VAD was introduced post-weaning. Overall, the study highlights the potential dangers of vitamin A deficiency in autoimmune diseases.
Read More
9
Targeted therapy reduces RA symptoms
Engineered Platelet Microparticle-Membrane Camouflaged Nanoparticles for Targeting the Golgi Apparatus of Synovial Fibroblasts to Attenuate Rheumatoid Arthritis.
High relevance for arthritis treatment
We investigated a cutting-edge method using engineered nanoparticles to deliver all-trans retinoic acid (ATRA) directly to synovial fibroblasts in rheumatoid arthritis (RA). This approach utilizes a unique Golgi-targeting system to ensure effective treatment.
Our findings demonstrated that ATRA-loaded nanoparticles significantly disrupted pathogenic protein production in RA cells, leading to less inflammation and reduced joint damage in animal models. Overall, this targeted delivery method shows promise in effectively managing RA while being mindful of safety, as it caused minimal toxicity to major organs.
Our findings demonstrated that ATRA-loaded nanoparticles significantly disrupted pathogenic protein production in RA cells, leading to less inflammation and reduced joint damage in animal models. Overall, this targeted delivery method shows promise in effectively managing RA while being mindful of safety, as it caused minimal toxicity to major organs.
Read More
8
Dietary retinol may lower RA risk
Association between dietary retinol intake and rheumatoid arthritis based on NHANES database.
High relevance due to findings.
We analyzed data from five cycles of the National Health and Nutrition Examination Survey (NHANES), focusing on how dietary retinol (a form of vitamin A) intake relates to rheumatoid arthritis (RA).
Our findings indicated that higher dietary retinol intake, especially in women, was linked to a reduced risk of developing RA. Specifically, women who consumed more than 354.86 mcg of retinol saw the most significant benefits.
This suggests that adjusting our diets to include more vitamin A could offer a protective effect against this autoimmune disorder.
Our findings indicated that higher dietary retinol intake, especially in women, was linked to a reduced risk of developing RA. Specifically, women who consumed more than 354.86 mcg of retinol saw the most significant benefits.
This suggests that adjusting our diets to include more vitamin A could offer a protective effect against this autoimmune disorder.
Read More
User Reviews
USERS' SCORE
Good
Based on 33 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Seizures alleviated
I took vitamins daily and noticed significant improvement after three days, achieving mostly normal mouth movement. After a week and a half, the seizures disappeared—though results can vary for others. I now take these vitamins in courses at the start of cold weather and in spring, and the issue with seizures no longer bothers me. I highly recommend purchasing these vitamins if prescribed by a doctor; you certainly won't regret it.
Read More
9.5
Skin condition improved
I took this drug primarily as a co-factor of vitamin E. Alongside Mason Natural Vitamin E, this dietary supplement restored my extremely dry skin to a normal condition quite quickly! I took both in tandem during the autumn-winter period when the heating in our house dries the air, causing my skin to crack and peel. After a month, everything improved, and I continue taking them. I plan to order vitamins A and E from these brands again in the autumn due to their good formulation, volume, and value for money.
Read More
9.5
Skin condition resolved
For years, I struggled with problematic skin since my teens. After trying various treatments, I ordered vitamin A to specifically address my skin issues. A month later, my skin feels smoother, the pores have tightened, and overall, I was pleasantly surprised. I did not experience any side effects and plan to continue using it.
Read More
9
Acne reduced
After struggling with severe acne, I discovered that retinol (Vitamin A) could help. Once I started this supplement, I noticed a significant reduction in breakouts, although some pigment spots remain. I wholeheartedly recommend it as it has really worked for me!
9
Rapid healing effects
I took this alongside vitamin E during my rubella period to reduce peeling from the rash, and it helped. Although the formulation isn't the most natural, I noticed improvements within five days, quicker than the usual Aevit from the chemist. My grandmother also took it a couple of times yearly, but now I'm searching for a more natural alternative.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
