Last update
4/3/2026
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.7
USERS' SCORE
Good
Based on 8 Reviews
8.3
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin A (from Retinyl Palmitate and Fish Liver Oil)
3,000 mcg
333%
Top Medical Research Studies
9
Vitamin A deficiency worsens lupus nephritis
We examined the impact of vitamin A deficiency (VAD) on the progression of lupus nephritis in a mouse model. By inducing VAD during pregnancy or after weaning, we discovered that both methods significantly worsened the condition, leading to higher mortality rates.
Interestingly, restoring vitamin A levels after weaning reduced mortality. This suggests that VAD accelerates lupus nephritis through increased immune cell activation and autoantibody production. However, effects were less pronounced when VAD was introduced post-weaning. Overall, the study highlights the potential dangers of vitamin A deficiency in autoimmune diseases.
Interestingly, restoring vitamin A levels after weaning reduced mortality. This suggests that VAD accelerates lupus nephritis through increased immune cell activation and autoantibody production. However, effects were less pronounced when VAD was introduced post-weaning. Overall, the study highlights the potential dangers of vitamin A deficiency in autoimmune diseases.
Read More
8
We analyzed data from five cycles of the National Health and Nutrition Examination Survey (NHANES), focusing on how dietary retinol (a form of vitamin A) intake relates to rheumatoid arthritis (RA).
Our findings indicated that higher dietary retinol intake, especially in women, was linked to a reduced risk of developing RA. Specifically, women who consumed more than 354.86 mcg of retinol saw the most significant benefits.
This suggests that adjusting our diets to include more vitamin A could offer a protective effect against this autoimmune disorder.
Our findings indicated that higher dietary retinol intake, especially in women, was linked to a reduced risk of developing RA. Specifically, women who consumed more than 354.86 mcg of retinol saw the most significant benefits.
This suggests that adjusting our diets to include more vitamin A could offer a protective effect against this autoimmune disorder.
Read More
8
We investigated whether a therapeutic vaccine could target harmful Th17 cells in autoimmune diseases using vitamin A ingredients. By using all-trans retinoic acid (ATRA) in liposomal formulations, we found that it specifically inhibited Th17 cells related to a particular autoantigen, sparing unrelated ones.
This process not only reduced disease severity in a mouse model of multiple sclerosis, but also encouraged Th17 cells to adopt a more regulatory and tolerant role. Overall, our findings suggest that ATRA-containing vaccines might effectively alter the behavior of Th17 cells in autoimmune conditions.
This process not only reduced disease severity in a mouse model of multiple sclerosis, but also encouraged Th17 cells to adopt a more regulatory and tolerant role. Overall, our findings suggest that ATRA-containing vaccines might effectively alter the behavior of Th17 cells in autoimmune conditions.
Read More
Most Useful Reviews
9
Skin condition improved
7 people found this helpful
I took this drug primarily as a co-factor of vitamin E. Alongside Mason Natural Vitamin E, this dietary supplement restored my extremely dry skin to a normal condition quite quickly! I took both in tandem during the autumn-winter period when the heating in our house dries the air, causing my skin to crack and peel. After a month, everything improved, and I continue taking them. I plan to order vitamins A and E from these brands again in the autumn due to their good formulation, volume, and value for money.
Read More
9
Skin problems resolved
2 people found this helpful
I ordered it for my little sister, who had dry, cracked skin. She now says it has cleared up. It's important to remember that this is a fat-soluble vitamin that can accumulate in the body, so moderation is essential; no overdosing is key. I also combined it with omega-3.
Read More
9
Effective for sebum control
1 people found this helpful
I started taking vitamin A in hopes of controlling excessive sebum production, and it was effective. I noticed a difference by the third week. I appreciate that they are small and easy to swallow. I will definitely order more!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.7
- All Researches
9
Vitamin A enhances rheumatoid arthritis treatment
We examined how well all-trans retinoic acid (ATRA) works alongside methotrexate (MTX) in treating rheumatoid arthritis. Our research focused on its ability to reduce the growth of synovial cells while promoting their death, which is essential in managing this condition.
While MTX alone didn't significantly affect cell viability or apoptosis, the addition of ATRA showed impressive results. It not only inhibited cell growth but also triggered both apoptosis and autophagy via the ROS-JNK pathway. In tests with rats, this combination therapy notably improved results compared to MTX alone.
ATRA may be a valuable supplementary treatment for rheumatoid arthritis, especially since MTX alone has limited effectiveness on these specific cellular processes.
While MTX alone didn't significantly affect cell viability or apoptosis, the addition of ATRA showed impressive results. It not only inhibited cell growth but also triggered both apoptosis and autophagy via the ROS-JNK pathway. In tests with rats, this combination therapy notably improved results compared to MTX alone.
ATRA may be a valuable supplementary treatment for rheumatoid arthritis, especially since MTX alone has limited effectiveness on these specific cellular processes.
Read More
9
We explored an innovative treatment for autoimmune arthritis using microparticles that release all-trans retinoic acid (ATRA), a form of vitamin A. This method aims to enhance immune responses in a targeted way, improving T cells that help reduce inflammation.
Our findings show that these microparticles, when injected into the joints of mice, decreased symptoms of the disease without completely suppressing the immune response. The approach appears promising for enhancing treatment in patients who don’t respond well to traditional therapies like DMARDs.
Our findings show that these microparticles, when injected into the joints of mice, decreased symptoms of the disease without completely suppressing the immune response. The approach appears promising for enhancing treatment in patients who don’t respond well to traditional therapies like DMARDs.
Read More
9
Vitamin A deficiency worsens lupus nephritis
We examined the impact of vitamin A deficiency (VAD) on the progression of lupus nephritis in a mouse model. By inducing VAD during pregnancy or after weaning, we discovered that both methods significantly worsened the condition, leading to higher mortality rates.
Interestingly, restoring vitamin A levels after weaning reduced mortality. This suggests that VAD accelerates lupus nephritis through increased immune cell activation and autoantibody production. However, effects were less pronounced when VAD was introduced post-weaning. Overall, the study highlights the potential dangers of vitamin A deficiency in autoimmune diseases.
Interestingly, restoring vitamin A levels after weaning reduced mortality. This suggests that VAD accelerates lupus nephritis through increased immune cell activation and autoantibody production. However, effects were less pronounced when VAD was introduced post-weaning. Overall, the study highlights the potential dangers of vitamin A deficiency in autoimmune diseases.
Read More
9
We investigated a cutting-edge method using engineered nanoparticles to deliver all-trans retinoic acid (ATRA) directly to synovial fibroblasts in rheumatoid arthritis (RA). This approach utilizes a unique Golgi-targeting system to ensure effective treatment.
Our findings demonstrated that ATRA-loaded nanoparticles significantly disrupted pathogenic protein production in RA cells, leading to less inflammation and reduced joint damage in animal models. Overall, this targeted delivery method shows promise in effectively managing RA while being mindful of safety, as it caused minimal toxicity to major organs.
Our findings demonstrated that ATRA-loaded nanoparticles significantly disrupted pathogenic protein production in RA cells, leading to less inflammation and reduced joint damage in animal models. Overall, this targeted delivery method shows promise in effectively managing RA while being mindful of safety, as it caused minimal toxicity to major organs.
Read More
8
We analyzed data from five cycles of the National Health and Nutrition Examination Survey (NHANES), focusing on how dietary retinol (a form of vitamin A) intake relates to rheumatoid arthritis (RA).
Our findings indicated that higher dietary retinol intake, especially in women, was linked to a reduced risk of developing RA. Specifically, women who consumed more than 354.86 mcg of retinol saw the most significant benefits.
This suggests that adjusting our diets to include more vitamin A could offer a protective effect against this autoimmune disorder.
Our findings indicated that higher dietary retinol intake, especially in women, was linked to a reduced risk of developing RA. Specifically, women who consumed more than 354.86 mcg of retinol saw the most significant benefits.
This suggests that adjusting our diets to include more vitamin A could offer a protective effect against this autoimmune disorder.
Read More
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Skin condition improved
7 people found this helpful
I took this drug primarily as a co-factor of vitamin E. Alongside Mason Natural Vitamin E, this dietary supplement restored my extremely dry skin to a normal condition quite quickly! I took both in tandem during the autumn-winter period when the heating in our house dries the air, causing my skin to crack and peel. After a month, everything improved, and I continue taking them. I plan to order vitamins A and E from these brands again in the autumn due to their good formulation, volume, and value for money.
Read More
9
Skin problems resolved
2 people found this helpful
I ordered it for my little sister, who had dry, cracked skin. She now says it has cleared up. It's important to remember that this is a fat-soluble vitamin that can accumulate in the body, so moderation is essential; no overdosing is key. I also combined it with omega-3.
Read More
9
Effective for sebum control
1 people found this helpful
I started taking vitamin A in hopes of controlling excessive sebum production, and it was effective. I noticed a difference by the third week. I appreciate that they are small and easy to swallow. I will definitely order more!
Read More
9
Effective treatment
I like it. It’s an effective medication that has done its job well. I will definitely order more.
Read More
7.5
Skin condition improved
143 people found this helpful
I have suffered from atopic dermatitis and eczema since childhood. After switching from pharmacy vitamins to those from iHerb, my skin condition improved significantly. I take capsules for a month, followed by a month off to prevent vitamin A overdosing. I recommend checking your vitamin A levels with a test to adjust dosage accurately. If you're pregnant, avoid vitamin A due to teratogenic risks. If my experience has helped, please give it a thumbs up!
Read More
Frequently Asked Questions
9
Skin condition improved
7 people found this helpful
I took this drug primarily as a co-factor of vitamin E. Alongside Mason Natural Vitamin E, this dietary supplement restored my extremely dry skin to a normal condition quite quickly! I took both in tandem during the autumn-winter period when the heating in our house dries the air, causing my skin to crack and peel. After a month, everything improved, and I continue taking them. I plan to order vitamins A and E from these brands again in the autumn due to their good formulation, volume, and value for money.
9
Skin problems resolved
2 people found this helpful
I ordered it for my little sister, who had dry, cracked skin. She now says it has cleared up. It's important to remember that this is a fat-soluble vitamin that can accumulate in the body, so moderation is essential; no overdosing is key. I also combined it with omega-3.
7.5
Skin condition improved
143 people found this helpful
I have suffered from atopic dermatitis and eczema since childhood. After switching from pharmacy vitamins to those from iHerb, my skin condition improved significantly. I take capsules for a month, followed by a month off to prevent vitamin A overdosing. I recommend checking your vitamin A levels with a test to adjust dosage accurately. If you're pregnant, avoid vitamin A due to teratogenic risks. If my experience has helped, please give it a thumbs up!
References
- Cao TT, Ma JL, Zhang Y, Peng JW, Lin H. Efficacy of formic acid in combination with cDMARDs in rheumatoid arthritis. Eur Rev Med Pharmacol Sci. 2024;28:4366. 10.26355/eurrev_202410_36831
- Ni Y, Cao Y, Qiu Y, Li Y. Association between dietary retinol intake and rheumatoid arthritis based on NHANES database. BMC Public Health. 2024;24:2167. 10.1186/s12889-024-19620-5
- Zhang Y, Shi J, Xie Y, Shao H, Ning Y, et al. Exploring the supplementary potential of all-trans retinoic acid with methotrexate in rheumatoid arthritis: modulation of synovial cell apoptosis and autophagy. Clin Exp Rheumatol. 2024;42:1387. 10.55563/clinexprheumatol/3pd9rp
- Banaeeyeh S, Afkhami-Goli A, Moosavi Z, Razavi BM, Hosseinzadeh H. Anti-inflammatory, antioxidant and anti-mitophagy effects of trans sodium crocetinate on experimental autoimmune encephalomyelitis in BALB/C57 mice. Metab Brain Dis. 2024;39:783. 10.1007/s11011-024-01349-0
- Asgari F, Nikzamir A, Baghaei K, Salami S, Masotti A, et al. Immunomodulatory and Anti-Inflammatory Effects of Vitamin A and Tryptophan on Monocyte-Derived Dendritic Cells Stimulated with Gliadin in Celiac Disease Patients. Inflammation. 2024;47:1706. 10.1007/s10753-024-02004-7
- Wørzner K, Zimmermann J, Buhl R, Desoi A, Christensen D, et al. Repeated immunization with ATRA-containing liposomal adjuvant transdifferentiates Th17 cells to a Tr1-like phenotype. J Autoimmun. 2024;144:103174. 10.1016/j.jaut.2024.103174
- Nehzat N, Browne RW, Ghazal D, Tamaño-Blanco M, Jakimovski D, et al. Exploratory 5-year follow-up study of retinol, tocopherols, and carotenoids in multiple sclerosis. Mult Scler Relat Disord. 2024;81:105143. 10.1016/j.msard.2023.105143
- Uozumi T, Serizawa N, Hagino T, Morita T, Mizuno M, et al. Dietary habits in Japanese patients with bullous pemphigoid: low intake of retinol. Eur J Dermatol. 2023;33:394. 10.1684/ejd.2023.4527
- Mohammadi-Kordkhayli M, Sahraian MA, Ghorbani S, Mansouri F, Talebi F, et al. Vitamins A and D Enhance the Expression of Ror-γ-Targeting miRNAs in a Mouse Model of Multiple Sclerosis. Mol Neurobiol. 2023;60:5853. 10.1007/s12035-023-03427-3
- Yang J, Zhao L, Wang W, Wu Y. All-trans retinoic acid added to treatment of primary immune thrombocytopenia: a systematic review and meta-analysis. Ann Hematol. 2023;102:1695. 10.1007/s00277-023-05263-w
- Moura RP, Carvalho ED, Martins C, des Rieux A, Pêgo AP, et al. Functionalized retinoic acid lipid nanocapsules promotes a two-front attack on inflammation and lack of demyelination on neurodegenerative disorders. J Control Release. 2023;358:43. 10.1016/j.jconrel.2023.04.034
- McBride DA, Kerr MD, Johnson WT, Nguyen A, Zoccheddu M, et al. Immunomodulatory Microparticles Epigenetically Modulate T Cells and Systemically Ameliorate Autoimmune Arthritis. Adv Sci (Weinh). 2023;10:e2202720. 10.1002/advs.202202720
- Sun R, Yang M, Lin C, Wu Y, Sun J, et al. A clinical study of topical treatment for thyroid-associated ophthalmopathy with dry eye syndrome. BMC Ophthalmol. 2023;23:72. 10.1186/s12886-023-02805-8
- Abdelhamid L, Alajoleen R, Kingsmore KM, Cabana-Puig X, Lu R, et al. Hypovitaminosis A Drives the Progression of Tubulointerstitial Lupus Nephritis through Potentiating Predisease Cellular Autoreactivity. Immunohorizons. 2023;7:17. 10.4049/immunohorizons.2200015
- Nasl-Khameneh AM, Mirshafiey A, Moghadasi AN, Yekaninejad MS, Parastouei K, et al. The immunomodulatory effects of all-trans retinoic acid and docosahexaenoic acid combination treatment on the expression of IL-2, IL-4, T-bet, and GATA3 genes in PBMCs of multiple sclerosis patients. Neurol Res. 2023;45:510. 10.1080/01616412.2022.2162222
- Deng C, Zhao X, Chen Y, Ai K, Zhang Y, et al. Engineered Platelet Microparticle-Membrane Camouflaged Nanoparticles for Targeting the Golgi Apparatus of Synovial Fibroblasts to Attenuate Rheumatoid Arthritis. ACS Nano. 2022;16:18430. 10.1021/acsnano.2c06584
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