Topical Tretinoin enhances wart treatmentThe efficacy and safety of topical Tretinoin combined with superficial X-ray therapy (SXRT) in treating periungual warts.
We explored the combined effect of topical Tretinoin, a vitamin A derivative, with Superficial X-ray therapy (SXRT) in treating periungual warts (PWs). In this study, we observed 65 PWs, divided into two groups. One group received only SXRT, while the other group received SXRT along with Tretinoin cream from the very beginning.
Our findings indicated that the combination treatment with Tretinoin significantly enhanced the clearance rate of the warts compared to SXRT alone. Specifically, 92.7% of the PWs in the combined treatment group cleared completely within the study period, compared to just 75% in the SXRT group. Additionally, the time it took for the warts to heal was shorter with the combined treatment—16 days compared to 19.9 days for SXRT alone.
We also found that there were no severe side effects, and the minor effects reported were manageable. This suggests that using topical Tretinoin with SXRT is not only effective but also safe, making it an appealing option for those seeking a non-invasive treatment for PWs.
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RBP links to wart resistanceMeasuring the serum level of retinol-binding protein can enhance the treatment of recalcitrant warts.
We conducted a case-control study to investigate the link between retinol-binding protein (RBP) levels and resistant warts, which are warts that don’t respond to conventional treatments. Our research included 30 patients with such warts and 30 matched healthy controls, allowing us to measure serum levels of RBP through a method called ELISA.
From our findings, we observed a significant difference in serum RBP levels between the two groups, suggesting a connection between low RBP and the development of stubborn warts. RBP plays a crucial role in the metabolism of vitamin A, and a deficiency may hinder the body’s ability to fight off the viral factors involved in wart formation.
Despite the results indicating low serum RBP levels in patients with resistant warts, the study did not establish a direct treatment effect of vitamin A on warts. While low RBP levels might highlight a possible pathway in wart persistence, further research is needed to confirm if increasing vitamin A could effectively treat these stubborn skin issues.
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