Last update
5/7/2025

Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.6
USERS' SCORE
Good
Based on 3 Reviews
8.3
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin A (from Retinyl Palmitate and Fish Liver Oil)
3,000 mcg
333%

Top Medical Research Studies

9
Vitamin A shows limited wart benefits
We explored the impact of the oral aromatic retinoid, Ro 10-9359, on common warts caused by human papilloma virus (HPV) 2 in a patient with chronic lymphatic leukemia.

The treatment led to rapid improvement, with no detectable viral particles or DNA during the therapy. However, the treatment had to stop due to the patient's development of a liposarcoma, leading to a relapse of the warts.

Notably, the same HPV-2 subtype was present before and after the treatment, suggesting limited long-term effectiveness.
7
Mixed outcomes for wart treatment
We explored the effectiveness of a retinoic acid derivative, Ro 10-9359, for treating warts, particularly in patients who struggled to walk due to extensive verrucae plantares. While two patients experienced significant recovery, a larger group of 12 with verrucae vulgares showed disappointing results. We gradually increased the dosage to over 1.5 mg/kg, monitoring for side effects, which were notable but manageable. Overall, Ro 10-9359 may be beneficial for stubborn plantar warts, especially when standard treatments fail, but the results vary significantly among patients.
4
Limited efficacy of vitamin A
We examined how effective a topical ointment containing 2% vitamin A acid is for treating plantar warts in a group of 50 patients. Over a treatment period of 2 to 10 weeks, only 17 patients showed signs of being cured.

This indicates that while there may be some benefit to using vitamin A for warts, the results are not overwhelmingly positive.

Most Useful Reviews

9
Wart disappeared
The wart on my neck has vanished. I had several small warts there, which my doctor identified as a senile wart. Since I began taking vitamin A, it has significantly improved.
8.5
Works effectively
I am using it for healing warts on my hands. It seems to be effective!
6
Reduced size
I feel that the warts that are small and easily drinkable have decreased in size.

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.6
  • All Researches
9.5
Topical vitamin A shows promise
We explored the use of topical vitamin A in treating stubborn common warts. In a case study, a healthy 30-year-old woman with a long history of persistent warts tried multiple treatments without success.

After applying natural vitamin A from fish liver oil daily, most warts cleared up in about 70 days, while a larger wart took up to six months to resolve.

While this case suggests potential benefits, further controlled studies are needed to better understand vitamin A’s effectiveness against common warts and other related skin issues.
9
Topical Tretinoin enhances wart treatment
We explored the combined effect of topical Tretinoin, a vitamin A derivative, with Superficial X-ray therapy (SXRT) in treating periungual warts (PWs). In this study, we observed 65 PWs, divided into two groups. One group received only SXRT, while the other group received SXRT along with Tretinoin cream from the very beginning.

Our findings indicated that the combination treatment with Tretinoin significantly enhanced the clearance rate of the warts compared to SXRT alone. Specifically, 92.7% of the PWs in the combined treatment group cleared completely within the study period, compared to just 75% in the SXRT group. Additionally, the time it took for the warts to heal was shorter with the combined treatment—16 days compared to 19.9 days for SXRT alone.

We also found that there were no severe side effects, and the minor effects reported were manageable. This suggests that using topical Tretinoin with SXRT is not only effective but also safe, making it an appealing option for those seeking a non-invasive treatment for PWs.
9
Vitamin A shows limited wart benefits
We explored the impact of the oral aromatic retinoid, Ro 10-9359, on common warts caused by human papilloma virus (HPV) 2 in a patient with chronic lymphatic leukemia.

The treatment led to rapid improvement, with no detectable viral particles or DNA during the therapy. However, the treatment had to stop due to the patient's development of a liposarcoma, leading to a relapse of the warts.

Notably, the same HPV-2 subtype was present before and after the treatment, suggesting limited long-term effectiveness.
We conducted a case-control study to investigate the link between retinol-binding protein (RBP) levels and resistant warts, which are warts that don’t respond to conventional treatments. Our research included 30 patients with such warts and 30 matched healthy controls, allowing us to measure serum levels of RBP through a method called ELISA.

From our findings, we observed a significant difference in serum RBP levels between the two groups, suggesting a connection between low RBP and the development of stubborn warts. RBP plays a crucial role in the metabolism of vitamin A, and a deficiency may hinder the body’s ability to fight off the viral factors involved in wart formation.

Despite the results indicating low serum RBP levels in patients with resistant warts, the study did not establish a direct treatment effect of vitamin A on warts. While low RBP levels might highlight a possible pathway in wart persistence, further research is needed to confirm if increasing vitamin A could effectively treat these stubborn skin issues.
7
Mixed outcomes for wart treatment
We explored the effectiveness of a retinoic acid derivative, Ro 10-9359, for treating warts, particularly in patients who struggled to walk due to extensive verrucae plantares. While two patients experienced significant recovery, a larger group of 12 with verrucae vulgares showed disappointing results. We gradually increased the dosage to over 1.5 mg/kg, monitoring for side effects, which were notable but manageable. Overall, Ro 10-9359 may be beneficial for stubborn plantar warts, especially when standard treatments fail, but the results vary significantly among patients.

User Reviews

USERS' SCORE
Good
Based on 3 Reviews
8.3
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Wart disappeared
The wart on my neck has vanished. I had several small warts there, which my doctor identified as a senile wart. Since I began taking vitamin A, it has significantly improved.
8.5
Works effectively
I am using it for healing warts on my hands. It seems to be effective!
6
Reduced size
I feel that the warts that are small and easily drinkable have decreased in size.

Frequently Asked Questions

9
Wart disappeared
The wart on my neck has vanished. I had several small warts there, which my doctor identified as a senile wart. Since I began taking vitamin A, it has significantly improved.
6
Reduced size
I feel that the warts that are small and easily drinkable have decreased in size.
8.5
Works effectively
I am using it for healing warts on my hands. It seems to be effective!
9
Topical Tretinoin enhances wart treatment
We explored the combined effect of topical Tretinoin, a vitamin A derivative, with Superficial X-ray therapy (SXRT) in treating periungual warts (PWs). In this study, we observed 65 PWs, divided into two groups. One group received only SXRT, while the other group received SXRT along with Tretinoin cream from the very beginning.

Our findings indicated that the combination treatment with Tretinoin significantly enhanced the clearance rate of the warts compared to SXRT alone. Specifically, 92.7% of the PWs in the combined treatment group cleared completely within the study period, compared to just 75% in the SXRT group. Additionally, the time it took for the warts to heal was shorter with the combined treatment—16 days compared to 19.9 days for SXRT alone.

We also found that there were no severe side effects, and the minor effects reported were manageable. This suggests that using topical Tretinoin with SXRT is not only effective but also safe, making it an appealing option for those seeking a non-invasive treatment for PWs.
4
Limited efficacy of vitamin A
We examined how effective a topical ointment containing 2% vitamin A acid is for treating plantar warts in a group of 50 patients. Over a treatment period of 2 to 10 weeks, only 17 patients showed signs of being cured.

This indicates that while there may be some benefit to using vitamin A for warts, the results are not overwhelmingly positive.
9
Vitamin A shows limited wart benefits
We explored the impact of the oral aromatic retinoid, Ro 10-9359, on common warts caused by human papilloma virus (HPV) 2 in a patient with chronic lymphatic leukemia.

The treatment led to rapid improvement, with no detectable viral particles or DNA during the therapy. However, the treatment had to stop due to the patient's development of a liposarcoma, leading to a relapse of the warts.

Notably, the same HPV-2 subtype was present before and after the treatment, suggesting limited long-term effectiveness.

References

  1. Xu J, Zhang D, Feng L, Liu Y, Diao Q. The efficacy and safety of topical Tretinoin combined with superficial X-ray therapy (SXRT) in treating periungual warts. Dermatol Ther. 2022;35:e15295. 10.1111/dth.15295
  2. Khalid HN, Abd El Gayed EM, Dawoud RA, Bazid HAS. Measuring the serum level of retinol-binding protein can enhance the treatment of recalcitrant warts. J Cosmet Dermatol. 2021;20:1031. 10.1111/jocd.13683
  3. Gaston A, Garry RF. Topical vitamin A treatment of recalcitrant common warts. Virol J. 2012;9:21. 10.1186/1743-422X-9-21
  4. Gross G, Pfister H, Hagedorn M, Stahn R. Effect of oral aromatic retinoid (Ro 10-9359) on human papilloma virus-2-induced common warts. Dermatologica. 1983;166:48.
  5. Rüst O, Rufli T, Forrer J. [First experience with retinoid acid derivative Ro 10-9359 in the treatment of viral epithelioma]. Schweiz Med Wochenschr. 1979;109:1914.
  6. de Bersaques J. Vitamin A acid in the topic treament of plantar warts. Dermatologica. 1975;150:369.
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