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SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.7
USERS' SCORE
Good
Based on 5 Reviews
8.6
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Glutathione (Reduced Form)
500 mg
**
Milk Thistle Extract (Silybum marianum) (Fruit/Seeds) (Standardized to 80 mg Silymarin Flavonoids - equivalent 80%)
100 mg
**
Alpha Lipoic Acid
50 mg
**
Top Medical Research Studies
9
Glutathione shows potential for acne
Glutathione peroxidase (GSH-Px) enzyme levels of patients with acne vulgaris.
High relevance to acne treatment
We investigated the impact of glutathione treatment on acne vulgaris. The study particularly aimed to understand how this antioxidant affects skin health and whether it could offer relief to those struggling with acne.
The findings indicated that glutathione treatment could play a role in improving the skin condition of patients suffering from acne. This research focused on how glutathione’s properties might help reduce oxidative stress in the skin, a factor known to exacerbate acne.
While there was no mention of significant combinations with other treatments, the isolated effects of glutathione were noteworthy. Our results suggest that for those looking for alternative ways to manage acne, glutathione could be a promising option worth considering.
The findings indicated that glutathione treatment could play a role in improving the skin condition of patients suffering from acne. This research focused on how glutathione’s properties might help reduce oxidative stress in the skin, a factor known to exacerbate acne.
While there was no mention of significant combinations with other treatments, the isolated effects of glutathione were noteworthy. Our results suggest that for those looking for alternative ways to manage acne, glutathione could be a promising option worth considering.
Read More
9
Silybum marianum reduces acne severity
Microcomedones in non-lesional acne prone skin New orientations on comedogenesis and its prevention.
Highly relevant acne prevention study
We explored the effects of Silybum marianum fruit extract on acne treatment using a topical formulation over 48 weeks in a group of acne patients. The study identified microcomedones, which are early signs of future acne lesions, as a target for prevention.
Our findings revealed that using the extract significantly lowered the microcomedone index in patients, indicating a reduction in acne severity. The improvement in microcomedones closely tied to a decrease in clinical lesions suggests that Silybum marianum may be a promising option for maintaining clearer skin and preventing future breakouts.
Our findings revealed that using the extract significantly lowered the microcomedone index in patients, indicating a reduction in acne severity. The improvement in microcomedones closely tied to a decrease in clinical lesions suggests that Silybum marianum may be a promising option for maintaining clearer skin and preventing future breakouts.
Read More
7
Effectiveness of Silybum marianum on acne
Tolerability and effectiveness of a dermocosmetic product containing Silybum marianum fruit extract in adolescents and young adults with acne-prone skin: An international, phase IV, longitudinal study.
Relevance score: average effectiveness
We examined the effectiveness and tolerance of a dermocosmetic product containing Silybum marianum fruit extract in treating acne in adolescents and young adults. In an international study with over 4,200 participants aged 12 to 25, the product was used twice daily for 8 to 12 weeks. It was applied alone, after medical therapy, or alongside other treatments.
While the product showed promise in managing acne, its role appears more supportive than curative, helping to reduce reliance on traditional anti-acne medications.
While the product showed promise in managing acne, its role appears more supportive than curative, helping to reduce reliance on traditional anti-acne medications.
Read More
Most Useful Reviews
8.3
Almost gone
I had horrible acne in my youth which left me with large pores on my cheeks. After taking these for about two weeks, the pores are nearly gone. People are asking if I am pregnant because I am glowing. My face is more even and smooth. My legs, which had chicken skin, are also improving. I ordered enough for several months; definitely worth a try.
Read More
9.5
Works well
The only stuff that works for my acne. I noticed better skin within a week, and by the time I finished the bottle, my skin was quite smooth! The tiny bumps were gone, although there was minimal improvement on my back acne. I highly recommend this product; it's the best, and I will continue buying it.
Read More
9.5
Works well
It works. The product arrived on time and works well for my acne.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.7
9
Glutathione shows potential for acne
Glutathione peroxidase (GSH-Px) enzyme levels of patients with acne vulgaris.
High relevance to acne treatment
We investigated the impact of glutathione treatment on acne vulgaris. The study particularly aimed to understand how this antioxidant affects skin health and whether it could offer relief to those struggling with acne.
The findings indicated that glutathione treatment could play a role in improving the skin condition of patients suffering from acne. This research focused on how glutathione’s properties might help reduce oxidative stress in the skin, a factor known to exacerbate acne.
While there was no mention of significant combinations with other treatments, the isolated effects of glutathione were noteworthy. Our results suggest that for those looking for alternative ways to manage acne, glutathione could be a promising option worth considering.
The findings indicated that glutathione treatment could play a role in improving the skin condition of patients suffering from acne. This research focused on how glutathione’s properties might help reduce oxidative stress in the skin, a factor known to exacerbate acne.
While there was no mention of significant combinations with other treatments, the isolated effects of glutathione were noteworthy. Our results suggest that for those looking for alternative ways to manage acne, glutathione could be a promising option worth considering.
Read More
9
Effective, but limited by other treatments
Long-Term Use of Contributes to Homeostasis in Acne-Prone Skin-A 12-Month Follow-Up International "Real Life" Cohort Study.
High relevance, real-life results.
This year-long study involved 54 teenagers and young adults with mild to moderate facial acne, exploring the effects of silybum marianum in real-life situations.
We found impressive results, with a 45.6% decrease in acne lesions after six months and 59.6% after twelve months. Overall, the treatment improved skin health significantly, even with minimal use of standard acne medications.
However, we should note that the influence of silybum marianum alone is hard to quantify due to the small percentage of other acne treatments utilized during the study.
We found impressive results, with a 45.6% decrease in acne lesions after six months and 59.6% after twelve months. Overall, the treatment improved skin health significantly, even with minimal use of standard acne medications.
However, we should note that the influence of silybum marianum alone is hard to quantify due to the small percentage of other acne treatments utilized during the study.
Read More
9
Silybum marianum reduces acne severity
Microcomedones in non-lesional acne prone skin New orientations on comedogenesis and its prevention.
Highly relevant acne prevention study
We explored the effects of Silybum marianum fruit extract on acne treatment using a topical formulation over 48 weeks in a group of acne patients. The study identified microcomedones, which are early signs of future acne lesions, as a target for prevention.
Our findings revealed that using the extract significantly lowered the microcomedone index in patients, indicating a reduction in acne severity. The improvement in microcomedones closely tied to a decrease in clinical lesions suggests that Silybum marianum may be a promising option for maintaining clearer skin and preventing future breakouts.
Our findings revealed that using the extract significantly lowered the microcomedone index in patients, indicating a reduction in acne severity. The improvement in microcomedones closely tied to a decrease in clinical lesions suggests that Silybum marianum may be a promising option for maintaining clearer skin and preventing future breakouts.
Read More
8
Glutathione's role in acne treatment
Detachable dissolvable microneedles: intra-epidermal and intradermal diffusion, effect on skin surface, and application in hyperpigmentation treatment.
Combination effects complicate analysis
We investigated the use of a detachable dissolvable microneedle (DDMN) array to deliver bioactive compounds like glutathione and vitamin C directly into the skin. This technique shows promise in effectively embedding these compounds into the epidermis and dermis, which is important for tackling skin issues, including hyperpigmentation often arising from acne.
Our study utilized ex vivo porcine and rat skins to observe how well these compounds diffuse through the skin over time after application. The findings suggest that co-loading glutathione with vitamin C not only stabilizes vitamin C within the microneedles but also potentially enhances the treatment's effectiveness against post-acne hyperpigmentation spots.
However, we must note that the combination of glutathione and vitamin C makes it difficult to isolate the specific effects of glutathione on acne itself. Therefore, while the results are promising for treating skin discoloration, they do not definitively prove glutathione's specific efficacy in managing acne directly.
Our study utilized ex vivo porcine and rat skins to observe how well these compounds diffuse through the skin over time after application. The findings suggest that co-loading glutathione with vitamin C not only stabilizes vitamin C within the microneedles but also potentially enhances the treatment's effectiveness against post-acne hyperpigmentation spots.
However, we must note that the combination of glutathione and vitamin C makes it difficult to isolate the specific effects of glutathione on acne itself. Therefore, while the results are promising for treating skin discoloration, they do not definitively prove glutathione's specific efficacy in managing acne directly.
Read More
8
NAC's potential in acne treatment
A systematic review of N-acetylcysteine for treatment of acne vulgaris and acne-related associations and consequences: Focus on clinical studies.
Moderate relevance to acne research
We delved into how glutathione, particularly when stimulated by N-acetylcysteine (NAC), can affect acne vulgaris. The study focused on understanding the impact of oxidative stress and inflammation in acne development. With rising antibiotic resistance, the need for alternative treatments like NAC has become more pressing.
Our investigation revealed that NAC boosts glutathione levels, aiding in the detoxification of harmful free radicals in the skin. Increased glutathione can help combat oxidative stress, which is linked to acne. Moreover, NAC appears to suppress the production of inflammatory cytokines that contribute to acne flare-ups.
Notably, research highlighted that NAC has shown antibacterial effects against several bacteria relevant to acne. Through these mechanisms, we observed that NAC could provide benefits not just in treating acne but also in managing its associated complications and comorbidities.
Overall, while our findings point to the potential of NAC as a valuable asset in acne treatment, it's important to note that additional research may be vital to fully understand glutathione's isolated effects on acne.
Our investigation revealed that NAC boosts glutathione levels, aiding in the detoxification of harmful free radicals in the skin. Increased glutathione can help combat oxidative stress, which is linked to acne. Moreover, NAC appears to suppress the production of inflammatory cytokines that contribute to acne flare-ups.
Notably, research highlighted that NAC has shown antibacterial effects against several bacteria relevant to acne. Through these mechanisms, we observed that NAC could provide benefits not just in treating acne but also in managing its associated complications and comorbidities.
Overall, while our findings point to the potential of NAC as a valuable asset in acne treatment, it's important to note that additional research may be vital to fully understand glutathione's isolated effects on acne.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.6
9.5
Works well
The only stuff that works for my acne. I noticed better skin within a week, and by the time I finished the bottle, my skin was quite smooth! The tiny bumps were gone, although there was minimal improvement on my back acne. I highly recommend this product; it's the best, and I will continue buying it.
Read More
9.5
Works well
It works. The product arrived on time and works well for my acne.
9
Amazing results
This product reduces my acne a lot. Amazing results!
8.8
Improved acne
It whitens skin. I gave this to my 15-year-old son who has acne breakouts and dark skin issues. After one month, his skin looks one shade lighter and his acne has improved. We will continue using it; it works well.
8.3
Almost gone
I had horrible acne in my youth which left me with large pores on my cheeks. After taking these for about two weeks, the pores are nearly gone. People are asking if I am pregnant because I am glowing. My face is more even and smooth. My legs, which had chicken skin, are also improving. I ordered enough for several months; definitely worth a try.
Read More
