Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8
USERS' SCORE
Good
Based on 5 Reviews
8.2
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Glutathione (Reduced Form)
500 mg
**
Milk Thistle Extract (Silybum marianum) (Fruit/Seeds) (Standardized to 80 mg Silymarin Flavonoids - equivalent 80%)
100 mg
**
Alpha Lipoic Acid
50 mg
**
Top Medical Research Studies
9
ALA mitigates chemotherapy-related cognitive decline
We investigated the effects of alpha-lipoic acid (ALA) in protecting against cognitive impairments caused by the chemotherapy drug doxoruibicin (DOX). In a study involving Sprague-Dawley rats, we treated them with ALA for four weeks while administering DOX to evaluate memory function through specific tasks.
Our findings indicated that ALA not only improved memory performance but also reduced oxidative stress and inflammation in the brain. This suggests that ALA may offer significant neuroprotective benefits in the context of chemotherapy-induced cognitive issues, primarily through its antioxidant properties.
Our findings indicated that ALA not only improved memory performance but also reduced oxidative stress and inflammation in the brain. This suggests that ALA may offer significant neuroprotective benefits in the context of chemotherapy-induced cognitive issues, primarily through its antioxidant properties.
Read More
8
We explored the protective effects of alpha-lipoic acid against the hearing damage caused by cisplatin, a common chemotherapy agent. By systematically reviewing 13 studies, we found that alpha-lipoic acid may lessen the harmful impacts on auditory cells linked to cisplatin treatment.
The results showed improved cell viability and healthier biochemical and histological changes in the inner ear when alpha-lipoic acid was administered alongside cisplatin. This suggests that alpha-lipoic acid could be a valuable co-treatment in mitigating chemotherapy's adverse effects on hearing.
The results showed improved cell viability and healthier biochemical and histological changes in the inner ear when alpha-lipoic acid was administered alongside cisplatin. This suggests that alpha-lipoic acid could be a valuable co-treatment in mitigating chemotherapy's adverse effects on hearing.
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8
ALA shows potential for chemotherapy support
This randomized double-blind study explored the impact of alpha-lipoic acid (ALA) on women with breast cancer receiving chemotherapy. We divided 64 patients into two groups—one receiving ALA alongside standard treatments and the other receiving a placebo.
After several assessments, we found that ALA might help reduce neurotoxicity from paclitaxel and cardiotoxicity from doxorubicin. These results suggest that ALA could be a helpful addition to chemotherapy for improving patients' quality of life during treatment.
After several assessments, we found that ALA might help reduce neurotoxicity from paclitaxel and cardiotoxicity from doxorubicin. These results suggest that ALA could be a helpful addition to chemotherapy for improving patients' quality of life during treatment.
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Most Useful Reviews
10
Excellent chemotherapy support
Excellent support for chemotherapy!
Read More
9.5
Powerful antioxidant support
This is one of the most effective antioxidants used in chemotherapy rehabilitation. I take one tablet daily, and the capsules are convenient.
Read More
6.3
Detox after chemotherapy
This is a potent antioxidant naturally occurring in fruits and vegetables, as well as produced by the body. Being a cancer patient, I utilise this product following my chemotherapy and radiation treatments to aid recovery and detoxification.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8
- All Researches
9.5
We explored a new treatment combining iron and lipoic acid to enhance cancer therapy through ferroptosis, a process that can kill tumor cells. The study developed innovative nanoparticle aggregates (Fe@cLANAs) that release iron and support a cycle to boost the effectiveness of the treatment.
In tests, these aggregates showed significant anti-tumor activity, with a tumor inhibitory rate of 97.4% using just 1.53 mg/kg of iron. This is notably lower than the typical dosages required, suggesting a promising new path for effective cancer treatments.
In tests, these aggregates showed significant anti-tumor activity, with a tumor inhibitory rate of 97.4% using just 1.53 mg/kg of iron. This is notably lower than the typical dosages required, suggesting a promising new path for effective cancer treatments.
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9
Celastrol-Doxorubicin combination improves efficacy
This study focused on addressing multidrug resistance in chemotherapy by developing a nanodrug that combines doxorubicin (DOX) with a celastrol derivative.
We found that the nanoparticles effectively released both drugs in tumor conditions, enhancing treatment efficacy.
In tests against certain cancer cell lines, this innovative approach demonstrated a significant reduction in the drug's effectiveness threshold, which suggests that these nanoparticles could make chemotherapy more effective against resistant cancers.
We found that the nanoparticles effectively released both drugs in tumor conditions, enhancing treatment efficacy.
In tests against certain cancer cell lines, this innovative approach demonstrated a significant reduction in the drug's effectiveness threshold, which suggests that these nanoparticles could make chemotherapy more effective against resistant cancers.
Read More
9
ALA mitigates chemotherapy-related cognitive decline
We investigated the effects of alpha-lipoic acid (ALA) in protecting against cognitive impairments caused by the chemotherapy drug doxoruibicin (DOX). In a study involving Sprague-Dawley rats, we treated them with ALA for four weeks while administering DOX to evaluate memory function through specific tasks.
Our findings indicated that ALA not only improved memory performance but also reduced oxidative stress and inflammation in the brain. This suggests that ALA may offer significant neuroprotective benefits in the context of chemotherapy-induced cognitive issues, primarily through its antioxidant properties.
Our findings indicated that ALA not only improved memory performance but also reduced oxidative stress and inflammation in the brain. This suggests that ALA may offer significant neuroprotective benefits in the context of chemotherapy-induced cognitive issues, primarily through its antioxidant properties.
Read More
9
Alpha-lipoic acid reduces chemotherapy pain
We tested how well alpha-lipoic acid and ipidacrine hydrochloride work together to prevent nerve pain caused by paclitaxel chemotherapy in breast cancer patients.
In our study with 32 patients, those taking the medication combo showed a meaningful decrease in nerve pain severity compared to those who didn't.
The results indicated that after three and six cycles of chemotherapy, symptoms were significantly milder in the treated group, helping to improve their overall quality of life.
In our study with 32 patients, those taking the medication combo showed a meaningful decrease in nerve pain severity compared to those who didn't.
The results indicated that after three and six cycles of chemotherapy, symptoms were significantly milder in the treated group, helping to improve their overall quality of life.
Read More
8
Alpha lipoic acid aids mucosal healing
We explored the impact of alpha lipoic acid (LA) in a unique gel-forming oil aimed at treating oral mucositis, a painful side effect of chemotherapy.
Our findings showed that this LA-loaded gel can effectively adhere to the oral mucosa and promote healing by reducing oxidative stress from treatment.
In animal tests, the gel significantly improved wound healing and decreased inflammation, suggesting it could be a promising option for those suffering from oral mucositis.
However, further studies are needed to solidify these promising results.
Our findings showed that this LA-loaded gel can effectively adhere to the oral mucosa and promote healing by reducing oxidative stress from treatment.
In animal tests, the gel significantly improved wound healing and decreased inflammation, suggesting it could be a promising option for those suffering from oral mucositis.
However, further studies are needed to solidify these promising results.
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User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
10
Excellent chemotherapy support
Excellent support for chemotherapy!
Read More
9.5
Powerful antioxidant support
This is one of the most effective antioxidants used in chemotherapy rehabilitation. I take one tablet daily, and the capsules are convenient.
Read More
6.3
Detox after chemotherapy
This is a potent antioxidant naturally occurring in fruits and vegetables, as well as produced by the body. Being a cancer patient, I utilise this product following my chemotherapy and radiation treatments to aid recovery and detoxification.
Read More
6.8
Reduced neuropathy symptoms
The doctor recommended this to alleviate neuropathy symptoms post-chemotherapy, combined with vitamin B. I noticed a slight improvement, though it hasn't completely resolved. I plan to continue after the break and am hopeful for better results.
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6
No significant effect noted
Five stars for the cast! Glutathione was prescribed by my oncologist, and we sourced an analogue from IHerb. This medication, which contains alpha-lipoic acid, is hoped to be effective against neuropathic pain during chemotherapy. After a month of use, no significant effect was noticed from the capsules, despite improved liver tests after intramuscular administration. We're currently attempting to increase the dosage. The capsules are large but easy to swallow.
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Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Hiratsuka T, Kono Y, Tomimatsu C, Ohyama T, Aiba T, et al. Effects of scalp lotion containing alpha lipoic acid derivatives for chemotherapy-induced alopecia in patients with gastrointestinal cancer: A prospective cohort study. J Oncol Pharm Pract. 2025. doi:10.1177/10781552251330283
- Torres MJ, Ríos JC, Valle A, Indo S, Gv KB, et al. Alpha-Lipoic Acid-Mediated Inhibition of LTB Synthesis Suppresses Epithelial-Mesenchymal Transition, Modulating Functional and Tumorigenic Capacities in Non-Small Cell Lung Cancer A549 Cells. Curr Ther Res Clin Exp. 2025;102:100765. doi:10.1016/j.curtheres.2024.100765
- Zhang Y, Jiang Z, Lu K, Ding B, Wang J, et al. In situ gel-forming oil solubilizing α-lipoic acid as a physical shielding alleviated chemotherapy-induced oral mucositis via inhibiting oxidative stress. Int J Pharm. 2024;665:124714. doi:10.1016/j.ijpharm.2024.124714
- Su J, Chen X, Ye F, Liu C, Liang J, et al. Celastrol Derivative/DOX Co-Assembled Nanodrug for Enhanced Antitumor Therapy. Curr Drug Deliv. 2024. doi:10.2174/0115672018298512240819101159
- Çoban HŞ, Çil N, Önder E, Abban Mete G. Anti-cancer effects of alpha lipoic acid, cisplatin and paclitaxel combination in the OVCAR-3 ovarian adenocarcinoma cell line. Mol Biol Rep. 2024;51:485. doi:10.1007/s11033-024-09422-8
- Wang W, Zhang D, Sun L, Zhang Z, Zhang Y, et al. Alpha-lipoic acid supplementation reverses the declining quality of oocytes exposed to cyclophosphamide. Food Chem Toxicol. 2023;181:114090. doi:10.1016/j.fct.2023.114090
- Lateef Al-Awsi GR, Arshed U, Arif A, Ramírez-Coronel AA, Alhassan MS, et al. The Chemoprotective Potentials of Alpha-lipoic Acid against Cisplatin-induced Ototoxicity: A Systematic Review. Curr Med Chem. 2024;31:3588. doi:10.2174/0929867330666230509162513
- Lal R, Dharavath RN, Chopra K. Alpha-Lipoic Acid Ameliorates Doxorubicin-Induced Cognitive Impairments by Modulating Neuroinflammation and Oxidative Stress via NRF-2/HO-1 Signaling Pathway in the Rat Hippocampus. Neurochem Res. 2023;48:2476. doi:10.1007/s11064-023-03914-y
- Tan J, Zhou X, Zhang S. Iron-doped cross-linked lipoic acid nano-aggregates for ferroptosis-mediated cancer treatment. Acta Biomater. 2023;159:289. doi:10.1016/j.actbio.2023.01.029
- Aiba T, Kono Y, Etoh T, Kawano Y, Oshima Y, et al. Efficacy of cooling therapy and α-lipoic acid derivative against chemotherapy-induced alopecia in an animal model. Cancer Sci. 2023;114:1007. doi:10.1111/cas.15639
- Gong F, Jin J, Li H, Mao H. Alpha-Lipoic Acid Protects Against Doxorubicin-Induced Cardiotoxicity by Regulating Pyruvate Dehydrogenase Kinase 4. Cardiovasc Toxicol. 2022;22:879. doi:10.1007/s12012-022-09766-2
- Werida RH, Elshafiey RA, Ghoneim A, Elzawawy S, Mostafa TM. Role of alpha-lipoic acid in counteracting paclitaxel- and doxorubicin-induced toxicities: a randomized controlled trial in breast cancer patients. Support Care Cancer. 2022;30:7281. doi:10.1007/s00520-022-07124-0
- Holotiuk IS, Kryzhanivska AY, Holotiuk SI, Maliborska SV, Holotiuk VV. EVALUATION OF THE EFFICIENCY OF ALPHA-LIPOIC ACID AND IPIDACRINE HYDROCHLORIDE FOR THE PREVENTION OF PACLITAXEL-INDUCED PERIPHERAL NEUROPATHY ACCORDING TO THE TOTAL NEUROPATHY SCORE. Exp Oncol. 2022;44:75.
- Nakatomi C, Hitomi S, Yamaguchi K, Hsu CC, Seta Y, et al. Cisplatin induces TRPA1-mediated mechanical allodynia in the oral mucosa. Arch Oral Biol. 2022;133:105317. doi:10.1016/j.archoralbio.2021.105317
- Abdelrahman KA, Ibrahim AS, Osman AM, Aly MG, Ali AS, et al. Alpha lipoic acid with pulsed radiofrequency in treatment of chronic lumbosacral radicular pain: A prospective, randomized study. Medicine (Baltimore). 2021;100:e26344. doi:10.1097/MD.0000000000026344
- Agnes JP, Santos VWD, das Neves RN, Gonçalves RM, Delgobo M, et al. Antioxidants Improve Oxaliplatin-Induced Peripheral Neuropathy in Tumor-Bearing Mice Model: Role of Spinal Cord Oxidative Stress and Inflammation. J Pain. 2021;22:996. doi:10.1016/j.jpain.2021.03.142
