Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.1
USERS' SCORE
Good
Based on 4 Reviews
8.4
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Glutathione (Reduced Form)
500 mg
**
Milk Thistle Extract (Silybum marianum) (Fruit/Seeds) (Standardized to 80 mg Silymarin Flavonoids - equivalent 80%)
100 mg
**
Alpha Lipoic Acid
50 mg
**
Top Medical Research Studies
9
Silibinin reduces depression in mice
We investigated the impact of silibinin, a natural compound from Silybum marianum, on depression and anxiety in mice with Parkinson's disease. Through various behavioral tests, we found that silibinin significantly reduced depressive and anxious behaviors caused by MPTP, a chemical used to induce these symptoms.
Additionally, silibinin helped repair neuronal damage in the hippocampus and restored levels of important mood-regulating neurotransmitters. It also reduced markers of neuroinflammation linked to depression, suggesting silibinin may hold promise as a treatment for these conditions in Parkinson's.
Additionally, silibinin helped repair neuronal damage in the hippocampus and restored levels of important mood-regulating neurotransmitters. It also reduced markers of neuroinflammation linked to depression, suggesting silibinin may hold promise as a treatment for these conditions in Parkinson's.
Read More
9
We explored the impact of silymarin, a compound from the Silybum marianum plant, on depression-like behaviors in mice exposed to chronic stress over four weeks. By administering different doses of silymarin alongside fluoxetine, we observed behavioral and biochemical changes in the mice. The results showed that silymarin reversed several negative effects caused by stress, including decreased serotonin and dopamine levels, and improved neurobiological markers like BDNF. This suggests that silymarin could play a beneficial role in alleviating depression by enhancing critical neurochemical pathways.
Read More
9
We investigated whether silymarin, derived from milk thistle, has antidepressant-like effects in male mice. Administered in varying doses before tests, silymarin significantly reduced immobility times, indicating potential antidepressant activity.
Notably, the study found that nitric oxide may play a role in this effect, as inhibiting nitric oxide synthesis reversed silymarin’s impact. However, it’s important to note that this study only involved animal models, and results may not directly translate to humans.
Notably, the study found that nitric oxide may play a role in this effect, as inhibiting nitric oxide synthesis reversed silymarin’s impact. However, it’s important to note that this study only involved animal models, and results may not directly translate to humans.
Read More
Most Useful Reviews
9
Essential support
2 people found this helpful
Glutathione, a combination of cysteine, glycine, and glutamine, is effective when taken on an empty stomach, especially after covid or during episodes of spring blues and depression. It really supported me, and by the third day, I felt an extraordinary surge of energy throughout my body!
Read More
9
Notable mental clarity
I gave my teenage daughter this drink, one at a time over an extended period. The results are genuinely remarkable! Substantial corrections have been made regarding her intense fears, attention issues, memory, and depression, leading to enhanced cognitive functions. Now Foods supplies effective and affordable products, and I recommend it to anyone needing brain function improvement. Best of luck to you all!
Read More
7.5
Improved well-being
An irreplaceable remedy in our first aid kit. We started taking it as a family upon a homeopathic doctor’s recommendation. I was initially concerned about my liver and my state of depression and fatigue. However, after a week, I noticed a remarkable improvement in my overall well-being, a surge in strength, and clearer skin. Additionally, glutathione effectively removes toxins from the body.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.1
- All Researches
9
Silibinin reduces depression in mice
We investigated the impact of silibinin, a natural compound from Silybum marianum, on depression and anxiety in mice with Parkinson's disease. Through various behavioral tests, we found that silibinin significantly reduced depressive and anxious behaviors caused by MPTP, a chemical used to induce these symptoms.
Additionally, silibinin helped repair neuronal damage in the hippocampus and restored levels of important mood-regulating neurotransmitters. It also reduced markers of neuroinflammation linked to depression, suggesting silibinin may hold promise as a treatment for these conditions in Parkinson's.
Additionally, silibinin helped repair neuronal damage in the hippocampus and restored levels of important mood-regulating neurotransmitters. It also reduced markers of neuroinflammation linked to depression, suggesting silibinin may hold promise as a treatment for these conditions in Parkinson's.
Read More
9
We explored the impact of silymarin, a compound from the Silybum marianum plant, on depression-like behaviors in mice exposed to chronic stress over four weeks. By administering different doses of silymarin alongside fluoxetine, we observed behavioral and biochemical changes in the mice. The results showed that silymarin reversed several negative effects caused by stress, including decreased serotonin and dopamine levels, and improved neurobiological markers like BDNF. This suggests that silymarin could play a beneficial role in alleviating depression by enhancing critical neurochemical pathways.
Read More
9
We investigated whether silymarin, derived from milk thistle, has antidepressant-like effects in male mice. Administered in varying doses before tests, silymarin significantly reduced immobility times, indicating potential antidepressant activity.
Notably, the study found that nitric oxide may play a role in this effect, as inhibiting nitric oxide synthesis reversed silymarin’s impact. However, it’s important to note that this study only involved animal models, and results may not directly translate to humans.
Notably, the study found that nitric oxide may play a role in this effect, as inhibiting nitric oxide synthesis reversed silymarin’s impact. However, it’s important to note that this study only involved animal models, and results may not directly translate to humans.
Read More
8
We explored the potential antidepressant effects of silibinin, a compound from Silybum marianum, by looking into how it impacts brain health in depression. Supporting our study, we found that silibinin improved behaviors in mice showing depressive symptoms.
Our findings connected its positive effects to increased growth of neural stem cells and better signaling in the BDNF/TrkB pathway, which is crucial for brain function. These results suggest that silibinin could be a valuable supplement for enhancing neurogenesis in those struggling with depression.
Our findings connected its positive effects to increased growth of neural stem cells and better signaling in the BDNF/TrkB pathway, which is crucial for brain function. These results suggest that silibinin could be a valuable supplement for enhancing neurogenesis in those struggling with depression.
Read More
8
Silibinin shows potential in depression
We investigated whether silibinin, a compound extracted from milk thistle, could alleviate anxiety and depression-like behaviors in rats exposed to amyloid β. Our findings showed that silibinin significantly reduced these negative behaviors as indicated by multiple tests.
Additionally, it helped protect against cellular damage in the hippocampus, revealing its potential to enhance important neurological pathways. While promising, these results are based on animal studies, highlighting the need for further research to determine silibinin's effectiveness in humans.
Additionally, it helped protect against cellular damage in the hippocampus, revealing its potential to enhance important neurological pathways. While promising, these results are based on animal studies, highlighting the need for further research to determine silibinin's effectiveness in humans.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Essential support
2 people found this helpful
Glutathione, a combination of cysteine, glycine, and glutamine, is effective when taken on an empty stomach, especially after covid or during episodes of spring blues and depression. It really supported me, and by the third day, I felt an extraordinary surge of energy throughout my body!
Read More
9
Notable mental clarity
I gave my teenage daughter this drink, one at a time over an extended period. The results are genuinely remarkable! Substantial corrections have been made regarding her intense fears, attention issues, memory, and depression, leading to enhanced cognitive functions. Now Foods supplies effective and affordable products, and I recommend it to anyone needing brain function improvement. Best of luck to you all!
Read More
7.5
Improved well-being
An irreplaceable remedy in our first aid kit. We started taking it as a family upon a homeopathic doctor’s recommendation. I was initially concerned about my liver and my state of depression and fatigue. However, after a week, I noticed a remarkable improvement in my overall well-being, a surge in strength, and clearer skin. Additionally, glutathione effectively removes toxins from the body.
Read More
6
Minimal effect observed
I purchased this with hope for its effect on my mental depression. It seems to have some effect, albeit minimal.
Read More
Frequently Asked Questions
9
Essential support
2 people found this helpful
Glutathione, a combination of cysteine, glycine, and glutamine, is effective when taken on an empty stomach, especially after covid or during episodes of spring blues and depression. It really supported me, and by the third day, I felt an extraordinary surge of energy throughout my body!
7.5
Improved well-being
An irreplaceable remedy in our first aid kit. We started taking it as a family upon a homeopathic doctor’s recommendation. I was initially concerned about my liver and my state of depression and fatigue. However, after a week, I noticed a remarkable improvement in my overall well-being, a surge in strength, and clearer skin. Additionally, glutathione effectively removes toxins from the body.
6
Minimal effect observed
I purchased this with hope for its effect on my mental depression. It seems to have some effect, albeit minimal.
9
Notable mental clarity
I gave my teenage daughter this drink, one at a time over an extended period. The results are genuinely remarkable! Substantial corrections have been made regarding her intense fears, attention issues, memory, and depression, leading to enhanced cognitive functions. Now Foods supplies effective and affordable products, and I recommend it to anyone needing brain function improvement. Best of luck to you all!
9
Silibinin reduces depression in mice
We investigated the impact of silibinin, a natural compound from Silybum marianum, on depression and anxiety in mice with Parkinson's disease. Through various behavioral tests, we found that silibinin significantly reduced depressive and anxious behaviors caused by MPTP, a chemical used to induce these symptoms.
Additionally, silibinin helped repair neuronal damage in the hippocampus and restored levels of important mood-regulating neurotransmitters. It also reduced markers of neuroinflammation linked to depression, suggesting silibinin may hold promise as a treatment for these conditions in Parkinson's.
Additionally, silibinin helped repair neuronal damage in the hippocampus and restored levels of important mood-regulating neurotransmitters. It also reduced markers of neuroinflammation linked to depression, suggesting silibinin may hold promise as a treatment for these conditions in Parkinson's.
9
We explored the impact of silymarin, a compound from the Silybum marianum plant, on depression-like behaviors in mice exposed to chronic stress over four weeks. By administering different doses of silymarin alongside fluoxetine, we observed behavioral and biochemical changes in the mice. The results showed that silymarin reversed several negative effects caused by stress, including decreased serotonin and dopamine levels, and improved neurobiological markers like BDNF. This suggests that silymarin could play a beneficial role in alleviating depression by enhancing critical neurochemical pathways.
8
Silymarin shows antidepressant potential
We observed the effects of silymarin, derived from the milk thistle plant, on rats displaying depression-like symptoms through the olfactory bulbectomized (OBX) technique. When administered at doses of 100mg/kg and 200mg/kg, silymarin significantly decreased signs of depression, such as immobility time, while boosting levels of important neurotransmitters like serotonin and dopamine. This study highlights how silymarin positively impacts brain signaling and reduces inflammation, suggesting its potential as a natural treatment for depression.
References
- Turlier V, Froliger M, Ribet V, Mengeaud V, Reygagne P. A Well-Tolerated Hair Serum Containing New Natural Active Ingredients Reduced Hair Loss and Improved Quality of Life in Women With Chronic Telogen Effluvium: A 16-Week Controlled Study. J Cosmet Dermatol. 2024;23 Suppl 5:12. doi:10.1111/jocd.16656
- Liu P, Chen W, Kang Y, Wang C, Wang X, et al. Silibinin ameliorates STING-mediated neuroinflammation via downregulation of ferroptotic damage in a sporadic Alzheimer's disease model. Arch Biochem Biophys. 2023;744:109691. doi:10.1016/j.abb.2023.109691
- Liu X, Chen W, Wang C, Liu W, Hayashi T, et al. Silibinin ameliorates depression/anxiety-like behaviors of Parkinson's disease mouse model and is associated with attenuated STING-IRF3-IFN-β pathway activation and neuroinflammation. Physiol Behav. 2021;241:113593. doi:10.1016/j.physbeh.2021.113593
- Li YJ, Li YJ, Yang LD, Zhang K, Zheng KY, et al. Silibinin exerts antidepressant effects by improving neurogenesis through BDNF/TrkB pathway. Behav Brain Res. 2018;348:184. doi:10.1016/j.bbr.2018.04.025
- Thakare VN, Patil RR, Oswal RJ, Dhakane VD, Aswar MK, et al. Therapeutic potential of silymarin in chronic unpredictable mild stress induced depressive-like behavior in mice. J Psychopharmacol. 2018;32:223. doi:10.1177/0269881117742666
- Song X, Liu B, Cui L, Zhou B, Liu W, et al. Silibinin ameliorates anxiety/depression-like behaviors in amyloid β-treated rats by upregulating BDNF/TrkB pathway and attenuating autophagy in hippocampus. Physiol Behav. 2017;179:487. doi:10.1016/j.physbeh.2017.07.023
- Thakare VN, Aswar MK, Kulkarni YP, Patil RR, Patel BM. Silymarin ameliorates experimentally induced depressive like behavior in rats: Involvement of hippocampal BDNF signaling, inflammatory cytokines and oxidative stress response. Physiol Behav. 2017;179:401. doi:10.1016/j.physbeh.2017.07.010
- Khoshnoodi M, Fakhraei N, Dehpour AR. Possible involvement of nitric oxide in antidepressant-like effect of silymarin in male mice. Pharm Biol. 2015;53:739. doi:10.3109/13880209.2014.942787
