Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.3
USERS' SCORE
Good
Based on 2 Reviews
8.3
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Glutathione (Reduced Form)
500 mg
**
Milk Thistle Extract (Silybum marianum) (Fruit/Seeds) (Standardized to 80 mg Silymarin Flavonoids - equivalent 80%)
100 mg
**
Alpha Lipoic Acid
50 mg
**
Top Medical Research Studies
7
We explored the effects of alpha-lipoic acid (ALA) on hypothyroidism, particularly focusing on oxidative stress in the body. In a controlled experiment, rats were given propylthiouracil (PTU) to induce hypothyroidism, followed by treatment with ALA and thyroxine (T4) to assess the outcomes over a 10-week period.
Our findings revealed increased oxidative stress markers, particularly in the brain, in hypothyroid rats. ALA treatment alone significantly reduced these markers, suggesting it can help counteract oxidative damage linked to hypothyroidism. Moreover, ALA also improved conditions arising from T4 therapy.
Overall, our study indicates that ALA may offer a valuable approach to manage oxidative stress in thyroid dysfunctions, both on its own and when combined with traditional hormone replacement therapies.
Our findings revealed increased oxidative stress markers, particularly in the brain, in hypothyroid rats. ALA treatment alone significantly reduced these markers, suggesting it can help counteract oxidative damage linked to hypothyroidism. Moreover, ALA also improved conditions arising from T4 therapy.
Overall, our study indicates that ALA may offer a valuable approach to manage oxidative stress in thyroid dysfunctions, both on its own and when combined with traditional hormone replacement therapies.
Read More
9
Alpha lipoic acid aids testicular health
We investigated the effects of alpha-lipoic acid (ALA) on the testes of adult albino rats suffering from hypothyroidism induced by carbimazole. To conduct our research, we divided the rats into four groups: a control group, one receiving ALA, one exposed to carbimazole, and another that received both carbimazole and ALA over a period of 30 days.
Our findings showcased that hypothyroidism had a negative impact on the rats' reproductive health, significantly decreasing testicular weight, sperm count, and motility alongside deteriorating testicular structure. The study highlighted that ALA, known for its antioxidant properties, helped enhance the health of the testes. After ALA supplementation, improvements were noted in the tubular diameter and germinal epithelium thickness in the testes, although interstitial space saw no significant changes.
Furthermore, ALA seemed to counterbalance the negative alterations in hormone levels associated with hypothyroidism. We observed an increase in testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) after ALA treatment, indicating a rebound in steroidogenesis and reproductive function. These results suggest that ALA could play a beneficial role in improving the testicular health of rats with hypothyroidism.
Our findings showcased that hypothyroidism had a negative impact on the rats' reproductive health, significantly decreasing testicular weight, sperm count, and motility alongside deteriorating testicular structure. The study highlighted that ALA, known for its antioxidant properties, helped enhance the health of the testes. After ALA supplementation, improvements were noted in the tubular diameter and germinal epithelium thickness in the testes, although interstitial space saw no significant changes.
Furthermore, ALA seemed to counterbalance the negative alterations in hormone levels associated with hypothyroidism. We observed an increase in testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) after ALA treatment, indicating a rebound in steroidogenesis and reproductive function. These results suggest that ALA could play a beneficial role in improving the testicular health of rats with hypothyroidism.
Read More
4
We explored the interactions between thyroid hormones and energy regulation through AMP-activated protein kinase (AMPK) in broiler chicks. To do this, we created hyperthyroid and hypothyroid states by supplementing their diets with triiodothyronine (T) and methimazole (MMI) for a week.
During this study, we observed how the hypothalamic AMPK pathways responded to these hormonal changes, especially when we introduced α-lipoic acid, a known AMPK suppressor. Interestingly, both hyperthyroid and hypothyroid conditions resulted in reduced feed intake and body weight.
In hyperthyroid conditions, we noted an increase in the expression of the AMPKα1 subunit, while in hypothyroid conditions, although levels of active phosphorylated AMPK decreased, the gene expression of AMPKα1 and α2 subunits rose. This suggests that α-lipoic acid's impact on AMPK may be intertwined with other factors, making it difficult to isolate its effects specifically in hypothyroidism.
Overall, our findings highlight that changes in hypothalamic AMPK and other related genes play a role in how thyroid hormones affect appetite, showing varied responses based on whether the state is hyperthyroid or hypothyroid.
During this study, we observed how the hypothalamic AMPK pathways responded to these hormonal changes, especially when we introduced α-lipoic acid, a known AMPK suppressor. Interestingly, both hyperthyroid and hypothyroid conditions resulted in reduced feed intake and body weight.
In hyperthyroid conditions, we noted an increase in the expression of the AMPKα1 subunit, while in hypothyroid conditions, although levels of active phosphorylated AMPK decreased, the gene expression of AMPKα1 and α2 subunits rose. This suggests that α-lipoic acid's impact on AMPK may be intertwined with other factors, making it difficult to isolate its effects specifically in hypothyroidism.
Overall, our findings highlight that changes in hypothalamic AMPK and other related genes play a role in how thyroid hormones affect appetite, showing varied responses based on whether the state is hyperthyroid or hypothyroid.
Read More
Most Useful Reviews
8
Reduction in indicators
I like it. This isn't my first time taking glutathione. I have hypothyroidism, and it effectively reduces my indicators.
Read More
6
Clearer skin
As someone with hypothyroidism, I often tire easily, so I purchased glutathione based on good reviews. Surprisingly, I haven't felt fatigued, and I believe my skin has become clearer. I intend to keep purchasing it.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.3
- All Researches
9
α-Lipoic acid mitigates oxidative damage
We evaluated how α-lipoic acid might help with oxidative stress in the epididymis caused by maternal hypothyroidism during a study involving rats. Pregnant rats were divided into two groups: those that were not exposed to an antithyroid drug called carbimazole and those that were. After the pups were born, we examined the male offspring about 100 days later.
Our results showed that the rats exposed to carbimazole had increased lipid peroxidation and elevated levels of harmful oxidative stress markers in their epididymis. These rats also had lower levels of important antioxidant enzymes and an increase in sperm DNA damage. Furthermore, we noted structural changes in the epididymis, which is crucial for sperm maturation.
However, when we supplemented the affected rats with α-lipoic acid during their developmental phase, many of these negative effects were significantly reduced. This treatment helped restore normal epididymal function, likely due to α-lipoic acid's powerful antioxidant properties and its influence on hormone regulation.
Thus, our findings highlight the potential of α-lipoic acid as a beneficial treatment in mitigating the oxidative damage associated with maternal hypothyroidism in offspring.
Our results showed that the rats exposed to carbimazole had increased lipid peroxidation and elevated levels of harmful oxidative stress markers in their epididymis. These rats also had lower levels of important antioxidant enzymes and an increase in sperm DNA damage. Furthermore, we noted structural changes in the epididymis, which is crucial for sperm maturation.
However, when we supplemented the affected rats with α-lipoic acid during their developmental phase, many of these negative effects were significantly reduced. This treatment helped restore normal epididymal function, likely due to α-lipoic acid's powerful antioxidant properties and its influence on hormone regulation.
Thus, our findings highlight the potential of α-lipoic acid as a beneficial treatment in mitigating the oxidative damage associated with maternal hypothyroidism in offspring.
Read More
9
Alpha lipoic acid aids testicular health
We investigated the effects of alpha-lipoic acid (ALA) on the testes of adult albino rats suffering from hypothyroidism induced by carbimazole. To conduct our research, we divided the rats into four groups: a control group, one receiving ALA, one exposed to carbimazole, and another that received both carbimazole and ALA over a period of 30 days.
Our findings showcased that hypothyroidism had a negative impact on the rats' reproductive health, significantly decreasing testicular weight, sperm count, and motility alongside deteriorating testicular structure. The study highlighted that ALA, known for its antioxidant properties, helped enhance the health of the testes. After ALA supplementation, improvements were noted in the tubular diameter and germinal epithelium thickness in the testes, although interstitial space saw no significant changes.
Furthermore, ALA seemed to counterbalance the negative alterations in hormone levels associated with hypothyroidism. We observed an increase in testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) after ALA treatment, indicating a rebound in steroidogenesis and reproductive function. These results suggest that ALA could play a beneficial role in improving the testicular health of rats with hypothyroidism.
Our findings showcased that hypothyroidism had a negative impact on the rats' reproductive health, significantly decreasing testicular weight, sperm count, and motility alongside deteriorating testicular structure. The study highlighted that ALA, known for its antioxidant properties, helped enhance the health of the testes. After ALA supplementation, improvements were noted in the tubular diameter and germinal epithelium thickness in the testes, although interstitial space saw no significant changes.
Furthermore, ALA seemed to counterbalance the negative alterations in hormone levels associated with hypothyroidism. We observed an increase in testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) after ALA treatment, indicating a rebound in steroidogenesis and reproductive function. These results suggest that ALA could play a beneficial role in improving the testicular health of rats with hypothyroidism.
Read More
9
We investigated how alpha-lipoic acid (ALA) can influence neurogenesis affected by hypothyroidism. In our study, developmental hypothyroidism was induced in young male rats using a substance called 6-propyl-2-thiouracil (PTU). After weaning, we then provided these rats with different diets, including one containing ALA.
Our findings revealed that ALA played a beneficial role in restoring various types of neurons that had been disrupted due to hypothyroidism. Specifically, ALA helped recover both the postmitotic granule cells and the inhibitory interneurons, helping to rebalance the brain's neural networks. Additionally, we saw ALA's potential to influence genes critical for improving signaling pathways in the brain.
Overall, the introduction of ALA after weaning appeared effective in mitigating some of the adverse effects of developmental hypothyroidism. It offered promise for supporting neurogenesis and addressing oxidative stress that had been exacerbated by thyroid deficiencies.
Our findings revealed that ALA played a beneficial role in restoring various types of neurons that had been disrupted due to hypothyroidism. Specifically, ALA helped recover both the postmitotic granule cells and the inhibitory interneurons, helping to rebalance the brain's neural networks. Additionally, we saw ALA's potential to influence genes critical for improving signaling pathways in the brain.
Overall, the introduction of ALA after weaning appeared effective in mitigating some of the adverse effects of developmental hypothyroidism. It offered promise for supporting neurogenesis and addressing oxidative stress that had been exacerbated by thyroid deficiencies.
Read More
8
ALA shows potential neuroprotective effects
We set out to investigate the effects of alpha-lipoic acid (ALA) on the challenges posed by hypothyroidism. To do this, we observed a group of rats divided into different categories: a control group, a group experiencing hypothyroidism due to propylthiouracil, and those treated with ALA, metformin, or a combination of both.
Our findings revealed that rats suffering from hypothyroidism showed notable declines in memory and motor functions. This was confirmed through various behavioral tests indicating impaired recognition and reduced activity. We found significant changes in important neurochemical markers, such as increased lipid peroxidation and decreased levels of serotonin and dopamine in the rats' brains.
Fortunately, treatment with ALA and/or metformin led to improvements in both memory and movement. The treatments also worked to mitigate some of the biochemical changes associated with hypothyroidism, such as reducing harmful substances and restoring essential neurotransmitters and enzyme activities.
Overall, our research indicates a promising neuroprotective effect of ALA when it comes to combating the negative effects of hypothyroidism in rats. This offers potential avenues for further exploration in treatments for thyroid-related cognitive and motor issues.
Our findings revealed that rats suffering from hypothyroidism showed notable declines in memory and motor functions. This was confirmed through various behavioral tests indicating impaired recognition and reduced activity. We found significant changes in important neurochemical markers, such as increased lipid peroxidation and decreased levels of serotonin and dopamine in the rats' brains.
Fortunately, treatment with ALA and/or metformin led to improvements in both memory and movement. The treatments also worked to mitigate some of the biochemical changes associated with hypothyroidism, such as reducing harmful substances and restoring essential neurotransmitters and enzyme activities.
Overall, our research indicates a promising neuroprotective effect of ALA when it comes to combating the negative effects of hypothyroidism in rats. This offers potential avenues for further exploration in treatments for thyroid-related cognitive and motor issues.
Read More
7
We conducted a study to explore how alpha lipoic acid (ALA) can influence hypothyroidism and its associated complications. By using a group of male rats, we compared those with hypothyroidism, induced by a substance called propylthiouracil (PTU), to those treated with ALA and metformin, a commonly used diabetes medication.
Our findings revealed that hypothyroidism led to significant changes in various health markers, including noticeable decreases in thyroid hormone levels (T4 and T3) and increases in thyroid-stimulating hormone (TSH). This condition was also linked to a decline in body weight gain and adverse effects on cardiac, renal, and liver functions, manifesting as elevated enzyme levels and waste products in the blood.
When we treated the hypothyroid rats with ALA, they experienced an improvement in T3 and TSH levels. While it didn't restore all hormone levels to normal, ALA reduced glucose, urea, and creatinine levels, alongside enzyme activities associated with heart and liver damage to levels comparable to healthy controls. Notably, ALA also helped improve the weight gain of the rats, which is an important aspect of overall health.
Overall, our study suggests that ALA may have beneficial effects on certain aspects of hypothyroidism, particularly regarding liver and kidney function, as well as enhancing body weight gain. However, since it was used alongside metformin, it's challenging to ascertain the exact impact of ALA alone.
Our findings revealed that hypothyroidism led to significant changes in various health markers, including noticeable decreases in thyroid hormone levels (T4 and T3) and increases in thyroid-stimulating hormone (TSH). This condition was also linked to a decline in body weight gain and adverse effects on cardiac, renal, and liver functions, manifesting as elevated enzyme levels and waste products in the blood.
When we treated the hypothyroid rats with ALA, they experienced an improvement in T3 and TSH levels. While it didn't restore all hormone levels to normal, ALA reduced glucose, urea, and creatinine levels, alongside enzyme activities associated with heart and liver damage to levels comparable to healthy controls. Notably, ALA also helped improve the weight gain of the rats, which is an important aspect of overall health.
Overall, our study suggests that ALA may have beneficial effects on certain aspects of hypothyroidism, particularly regarding liver and kidney function, as well as enhancing body weight gain. However, since it was used alongside metformin, it's challenging to ascertain the exact impact of ALA alone.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
8
Reduction in indicators
I like it. This isn't my first time taking glutathione. I have hypothyroidism, and it effectively reduces my indicators.
Read More
6
Clearer skin
As someone with hypothyroidism, I often tire easily, so I purchased glutathione based on good reviews. Surprisingly, I haven't felt fatigued, and I believe my skin has become clearer. I intend to keep purchasing it.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Prathima P, Venkaiah K, Reddy MH, Pradeepkiran JA, Sainath SB. Antioxidant effects of α-lipoic acid against epididymal oxidative damage in adult offspring rats exposed to maternal hypothyroidism stress. Reprod Toxicol. 2024;125:108555. doi:10.1016/j.reprotox.2024.108555
- Khoder NM, Sawie HG, Sharada HM, Hosny EN, Khadrawy YA, et al. Metformin and alpha lipoic acid ameliorate hypothyroidism and its complications in adult male rats. J Diabetes Metab Disord. 2022;21:1327. doi:10.1007/s40200-022-01063-7
- Khadrawy YA, Khoder NM, Sawie HG, Sharada HM, Hosny EN, et al. The Neuroprotective Effect of α-Lipoic Acid and/or Metformin against the Behavioral and Neurochemical Changes Induced by Hypothyroidism in Rat. Neuroendocrinology. 2022;112:1129. doi:10.1159/000524367
- Lamberigts C, Wang Y, Dierckx T, Buys N, Everaert N, et al. The influence of thyroid state on hypothalamic AMP-activated protein kinase pathways in broilers. Gen Comp Endocrinol. 2021;311:113838. doi:10.1016/j.ygcen.2021.113838
- Baki AM, Aydın AF, Vural P, Olgaç V, Doğru Abbasoğlu S, et al. α-Lipoic Acid Ameliorates The Changes in Prooxidant-Antioxidant Balance in Liver and Brain Tissues of Propylthiouracil-Induced Hypothyroid Rats. Cell J. 2020;22:117. doi:10.22074/cellj.2020.7049
- Ibrahim AA, Mohammed NA, Eid KA, Abomughaid MM, Abdelazim AM, et al. Hypothyroidism: morphological and metabolic changes in the testis of adult albino rat and the amelioration by alpha-lipoic acid. Folia Morphol (Warsz). 2021;80:352. doi:10.5603/FM.a2020.0071
- Tanaka T, Masubuchi Y, Okada R, Nakajima K, Nakamura K, et al. Ameliorating effect of postweaning exposure to antioxidant on disruption of hippocampal neurogenesis induced by developmental hypothyroidism in rats. J Toxicol Sci. 2019;44:357. doi:10.2131/jts.44.357
- Hamano Y. Alleviative effects of α-lipoic acid supplementation on acute heat stress-induced thermal panting and the level of plasma nonesterified fatty acids in hypothyroid broiler chickens. Br Poult Sci. 2012;53:125. doi:10.1080/00071668.2011.651443
