Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.9
USERS' SCORE
Good
Based on 9 Reviews
8.7
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Glutathione (Reduced Form)
500 mg
**
Milk Thistle Extract (Silybum marianum) (Fruit/Seeds) (Standardized to 80 mg Silymarin Flavonoids - equivalent 80%)
100 mg
**
Alpha Lipoic Acid
50 mg
**
Top Medical Research Studies
9
We evaluated how alpha-lipoic acid (ALA) supplementation impacts women suffering from episodic migraines. In a random, double-blind, placebo-controlled trial with 92 participants, those taking 300 mg of ALA daily reported significant improvements in headache severity, frequency, and impact. They also showed decreased levels of lactate and VCAM-1, suggesting enhancements in mitochondrial and endothelial functions. However, no notable changes occurred regarding nitric oxide levels and migraine duration. Overall, ALA may serve as a helpful adjunctive treatment for migraine relief.
Read More
9
We used advanced statistical methods to explore potential drug targets for migraines from a large dataset that spanned 44,616 migraine patients. Our analysis identified four potential targets, and notably, GSTM4 stood out with strong evidence linking it to a lower risk of migraines in two major research cohorts.
We found that higher expression of GSTM4 was consistently associated with reduced incidence of both migraine types. This research suggests GSTM4 could be a valuable target for future migraine treatments, paving the way for new therapeutic options.
We found that higher expression of GSTM4 was consistently associated with reduced incidence of both migraine types. This research suggests GSTM4 could be a valuable target for future migraine treatments, paving the way for new therapeutic options.
Read More
8
We studied the effects of alpha-lipoic acid (ALA) on migraines in patients with insulin resistance. In our exploratory study, 32 participants took 400 mg of ALA twice daily for six months while continuing their regular treatment.
We observed that by the end of the study, 69% of participants experienced at least a 50% reduction in migraine attacks. Additionally, the average number of attacks decreased significantly over the months. However, no changes in insulin resistance were seen, indicating that while ALA may help reduce migraine frequency, further research through randomized controlled trials is needed to confirm these findings.
We observed that by the end of the study, 69% of participants experienced at least a 50% reduction in migraine attacks. Additionally, the average number of attacks decreased significantly over the months. However, no changes in insulin resistance were seen, indicating that while ALA may help reduce migraine frequency, further research through randomized controlled trials is needed to confirm these findings.
Read More
Most Useful Reviews
9
Reduced headaches
10 people found this helpful
An excellent antioxidant! I initially bought it for my husband, but I ended up using it myself. It has made me feel lighter overall, as though it was cleansing me of something harmful. The headaches have disappeared, and it positively affects my blood and general well-being. My blood pressure has stabilised, and migraines have not returned. I liked the effect.
Read More
9
Eliminated migraines
3 people found this helpful
Glutathione has been my support after suffering liver inflammation from high medicine doses. It helps maintain my liver function, and I'm glad to find this brand as it's more affordable. I pair it with vitamins C and E and Barley. After suffering from migraines for over ten years, and often battling allergies and colds, I haven’t experienced any fever or cold in over three years. It has truly boosted my immune system.
Read More
9
No migraines
1 people found this helpful
I bought this for my husband, but I started using it myself. It has made me feel lighter, as though it’s cleansing me of something harmful. The headaches are gone, and it has positively affected my blood and overall health. His blood pressure didn't fluctuate, and migraines have not occurred. I liked the effect.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.9
- All Researches
9
We used advanced statistical methods to explore potential drug targets for migraines from a large dataset that spanned 44,616 migraine patients. Our analysis identified four potential targets, and notably, GSTM4 stood out with strong evidence linking it to a lower risk of migraines in two major research cohorts.
We found that higher expression of GSTM4 was consistently associated with reduced incidence of both migraine types. This research suggests GSTM4 could be a valuable target for future migraine treatments, paving the way for new therapeutic options.
We found that higher expression of GSTM4 was consistently associated with reduced incidence of both migraine types. This research suggests GSTM4 could be a valuable target for future migraine treatments, paving the way for new therapeutic options.
Read More
9
Alpha-Lipoic Acid aids migraine prevention
We conducted a study to understand how alpha-lipoic acid (ALA) could help adolescents suffering from migraines. In this clinical trial, 60 participants were split into two groups: one received flunarizine alone, while the other received flunarizine along with ALA as an add-on treatment. This design allowed us to see if ALA made a significant difference in migraine management.
Remarkably, we observed that the group receiving ALA experienced a significant decrease in the frequency of migraine attacks. In fact, the number of monthly migraine days dropped by an average of 7.7 days. Additionally, 80% of participants in the ALA group reported improvement, while only about one-third of those in the control group felt the same way.
We also noticed improvements in the severity of the migraine attacks, with participants reporting fewer severe headaches. The Pediatric Migraine Disability Assessment scores showed marked improvements as well, indicating better overall functioning in daily life for those taking ALA. Biochemically, levels of serum thiols increased, while markers associated with migraine severity, such as serum CGRP, decreased significantly with ALA treatment. Overall, these findings suggest that ALA could be a promising addition to migraine prevention strategies for adolescents.
Remarkably, we observed that the group receiving ALA experienced a significant decrease in the frequency of migraine attacks. In fact, the number of monthly migraine days dropped by an average of 7.7 days. Additionally, 80% of participants in the ALA group reported improvement, while only about one-third of those in the control group felt the same way.
We also noticed improvements in the severity of the migraine attacks, with participants reporting fewer severe headaches. The Pediatric Migraine Disability Assessment scores showed marked improvements as well, indicating better overall functioning in daily life for those taking ALA. Biochemically, levels of serum thiols increased, while markers associated with migraine severity, such as serum CGRP, decreased significantly with ALA treatment. Overall, these findings suggest that ALA could be a promising addition to migraine prevention strategies for adolescents.
Read More
9
We evaluated how alpha-lipoic acid (ALA) supplementation impacts women suffering from episodic migraines. In a random, double-blind, placebo-controlled trial with 92 participants, those taking 300 mg of ALA daily reported significant improvements in headache severity, frequency, and impact. They also showed decreased levels of lactate and VCAM-1, suggesting enhancements in mitochondrial and endothelial functions. However, no notable changes occurred regarding nitric oxide levels and migraine duration. Overall, ALA may serve as a helpful adjunctive treatment for migraine relief.
Read More
8
We investigated the effects of Ligusticum chuanxiong (Chuanxiong, CX) on migraine induced by nitroglycerin in lab animals. Using advanced imaging and analysis techniques, we identified 1,480 metabolites, highlighting the importance of the glutathione pathway related to migraines. Our findings suggest that Chuanxiong may help alleviate migraine symptoms by enhancing glutathione levels and regulating critical molecular processes. While promising, further research is needed to fully understand its potential as either a therapeutic option or dietary supplement for migraine relief.
Read More
8
We explored the effects of alpha-lipoic acid on migraines as part of a broader study examining dietary fatty acid supplementation. This research particularly assessed how various supplements, including omega-3 fatty acids and alpha-lipoic acid, influence migraine clinical outcomes.
In the systematic review, we considered six randomized controlled trials that included 407 participants suffering from chronic migraines. The studies aimed to determine if fatty acid supplementation could provide relief from headache intensity, frequency, duration, and overall quality of life.
While the results indicated significant improvements with omega-3 supplementation, the specific contributions of alpha-lipoic acid were not strongly highlighted. This makes it challenging to definitively state the effectiveness of alpha-lipoic acid alone in treating migraines. Overall, the findings suggest that while fatty acids, particularly omega-3, show promise for migraine relief, we need more focused research to fully evaluate alpha-lipoic acid's potential benefits.
In the systematic review, we considered six randomized controlled trials that included 407 participants suffering from chronic migraines. The studies aimed to determine if fatty acid supplementation could provide relief from headache intensity, frequency, duration, and overall quality of life.
While the results indicated significant improvements with omega-3 supplementation, the specific contributions of alpha-lipoic acid were not strongly highlighted. This makes it challenging to definitively state the effectiveness of alpha-lipoic acid alone in treating migraines. Overall, the findings suggest that while fatty acids, particularly omega-3, show promise for migraine relief, we need more focused research to fully evaluate alpha-lipoic acid's potential benefits.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduced headaches
10 people found this helpful
An excellent antioxidant! I initially bought it for my husband, but I ended up using it myself. It has made me feel lighter overall, as though it was cleansing me of something harmful. The headaches have disappeared, and it positively affects my blood and general well-being. My blood pressure has stabilised, and migraines have not returned. I liked the effect.
Read More
9
Eliminated migraines
3 people found this helpful
Glutathione has been my support after suffering liver inflammation from high medicine doses. It helps maintain my liver function, and I'm glad to find this brand as it's more affordable. I pair it with vitamins C and E and Barley. After suffering from migraines for over ten years, and often battling allergies and colds, I haven’t experienced any fever or cold in over three years. It has truly boosted my immune system.
Read More
9
No migraines
1 people found this helpful
I bought this for my husband, but I started using it myself. It has made me feel lighter, as though it’s cleansing me of something harmful. The headaches are gone, and it has positively affected my blood and overall health. His blood pressure didn't fluctuate, and migraines have not occurred. I liked the effect.
Read More
9
Headache relief
1 people found this helpful
An excellent antioxidant! I initially bought it for my husband but started taking it myself. It has brought a sense of lightness, eliminating headaches. It seems to improve blood circulation and general well-being. His blood pressure remains stable, and migraines did not appear. I liked the effect.
Read More
9
Migraine-free
No more migraines! I love NOW Foods supplements; they’re high quality and bioavailable. I bought this for my fiancé, who suffers from migraines often due to low liver glutathione levels. He takes these periodically, and the migraines remain just a seed of pain, not developing into a full-blown headache anymore. This supplement is excellent!
Read More
Frequently Asked Questions
9
Reduced headaches
10 people found this helpful
An excellent antioxidant! I initially bought it for my husband, but I ended up using it myself. It has made me feel lighter overall, as though it was cleansing me of something harmful. The headaches have disappeared, and it positively affects my blood and general well-being. My blood pressure has stabilised, and migraines have not returned. I liked the effect.
9
Improved immunity
Now Glutha 500mg is excellent for my immunity and serves as an antioxidant. After almost a year on this product, I don’t experience migraines anymore.
9
Reduced migraine severity
I got this for my fiancé, who has migraines, and in combination with 800 mg of magnesium daily, his migraines have greatly reduced. They may attempt to start, but they never escalate into full migraines.
9
Migraine-free
No more migraines! I love NOW Foods supplements; they’re high quality and bioavailable. I bought this for my fiancé, who suffers from migraines often due to low liver glutathione levels. He takes these periodically, and the migraines remain just a seed of pain, not developing into a full-blown headache anymore. This supplement is excellent!
9
Eliminated migraines
3 people found this helpful
Glutathione has been my support after suffering liver inflammation from high medicine doses. It helps maintain my liver function, and I'm glad to find this brand as it's more affordable. I pair it with vitamins C and E and Barley. After suffering from migraines for over ten years, and often battling allergies and colds, I haven’t experienced any fever or cold in over three years. It has truly boosted my immune system.
7.5
Migraines improved
It normalises sleep with regular intake of 2 capsules and improves my migraines. I've noticed that I can take my usual pills and magnesium, leading to quick relief from migraines. The frequency of those headaches has decreased significantly, though I have other medicinal support as well.
8
We investigated the effects of Ligusticum chuanxiong (Chuanxiong, CX) on migraine induced by nitroglycerin in lab animals. Using advanced imaging and analysis techniques, we identified 1,480 metabolites, highlighting the importance of the glutathione pathway related to migraines. Our findings suggest that Chuanxiong may help alleviate migraine symptoms by enhancing glutathione levels and regulating critical molecular processes. While promising, further research is needed to fully understand its potential as either a therapeutic option or dietary supplement for migraine relief.
9
Alpha-Lipoic Acid aids migraine prevention
We conducted a study to understand how alpha-lipoic acid (ALA) could help adolescents suffering from migraines. In this clinical trial, 60 participants were split into two groups: one received flunarizine alone, while the other received flunarizine along with ALA as an add-on treatment. This design allowed us to see if ALA made a significant difference in migraine management.
Remarkably, we observed that the group receiving ALA experienced a significant decrease in the frequency of migraine attacks. In fact, the number of monthly migraine days dropped by an average of 7.7 days. Additionally, 80% of participants in the ALA group reported improvement, while only about one-third of those in the control group felt the same way.
We also noticed improvements in the severity of the migraine attacks, with participants reporting fewer severe headaches. The Pediatric Migraine Disability Assessment scores showed marked improvements as well, indicating better overall functioning in daily life for those taking ALA. Biochemically, levels of serum thiols increased, while markers associated with migraine severity, such as serum CGRP, decreased significantly with ALA treatment. Overall, these findings suggest that ALA could be a promising addition to migraine prevention strategies for adolescents.
Remarkably, we observed that the group receiving ALA experienced a significant decrease in the frequency of migraine attacks. In fact, the number of monthly migraine days dropped by an average of 7.7 days. Additionally, 80% of participants in the ALA group reported improvement, while only about one-third of those in the control group felt the same way.
We also noticed improvements in the severity of the migraine attacks, with participants reporting fewer severe headaches. The Pediatric Migraine Disability Assessment scores showed marked improvements as well, indicating better overall functioning in daily life for those taking ALA. Biochemically, levels of serum thiols increased, while markers associated with migraine severity, such as serum CGRP, decreased significantly with ALA treatment. Overall, these findings suggest that ALA could be a promising addition to migraine prevention strategies for adolescents.
8
We explored the effects of alpha-lipoic acid on migraines as part of a broader study examining dietary fatty acid supplementation. This research particularly assessed how various supplements, including omega-3 fatty acids and alpha-lipoic acid, influence migraine clinical outcomes.
In the systematic review, we considered six randomized controlled trials that included 407 participants suffering from chronic migraines. The studies aimed to determine if fatty acid supplementation could provide relief from headache intensity, frequency, duration, and overall quality of life.
While the results indicated significant improvements with omega-3 supplementation, the specific contributions of alpha-lipoic acid were not strongly highlighted. This makes it challenging to definitively state the effectiveness of alpha-lipoic acid alone in treating migraines. Overall, the findings suggest that while fatty acids, particularly omega-3, show promise for migraine relief, we need more focused research to fully evaluate alpha-lipoic acid's potential benefits.
In the systematic review, we considered six randomized controlled trials that included 407 participants suffering from chronic migraines. The studies aimed to determine if fatty acid supplementation could provide relief from headache intensity, frequency, duration, and overall quality of life.
While the results indicated significant improvements with omega-3 supplementation, the specific contributions of alpha-lipoic acid were not strongly highlighted. This makes it challenging to definitively state the effectiveness of alpha-lipoic acid alone in treating migraines. Overall, the findings suggest that while fatty acids, particularly omega-3, show promise for migraine relief, we need more focused research to fully evaluate alpha-lipoic acid's potential benefits.
7
Alpha-lipoic acid reduces migraine attacks
We assessed the effects of alpha-lipoic acid on migraines, focusing on its potential benefits backed by evidence from several trials. These trials provided insights into how alpha-lipoic acid influences migraine characteristics such as attack frequency and severity.
Our analysis indicated that supplementation with alpha-lipoic acid led to a reduction in the number of migraine attacks, with an average decrease of about 1.24 attacks compared to control groups. Although the impact on severity was less pronounced, the decrease in attack frequency is promising for individuals seeking relief from migraines.
It’s important to note that while alpha-lipoic acid showed some positive outcomes, it did not significantly affect all measured aspects of migraines, particularly compared to other dietary supplements. This points to the need for additional research to confirm its benefits and understand its effectiveness in isolation from other treatments.
Our analysis indicated that supplementation with alpha-lipoic acid led to a reduction in the number of migraine attacks, with an average decrease of about 1.24 attacks compared to control groups. Although the impact on severity was less pronounced, the decrease in attack frequency is promising for individuals seeking relief from migraines.
It’s important to note that while alpha-lipoic acid showed some positive outcomes, it did not significantly affect all measured aspects of migraines, particularly compared to other dietary supplements. This points to the need for additional research to confirm its benefits and understand its effectiveness in isolation from other treatments.
References
- Xing Z, Peng F, Chen Y, Wan F, Peng C, et al. Metabolomic profiling integrated with molecular exploring delineates the action of Ligusticum chuanxiong hort. on migraine. Phytomedicine. 2024;134:155977. 10.1016/j.phymed.2024.155977
- Sun X, Chen B, Qi Y, Wei M, Chen W, et al. Multi-omics Mendelian randomization integrating GWAS, eQTL and pQTL data revealed GSTM4 as a potential drug target for migraine. J Headache Pain. 2024;25:117. 10.1186/s10194-024-01828-w
- García-Pérez-de-Sevilla G, González-de-la-Flor Á. Impact of Fatty Acid Supplementation on Migraine Outcomes: A Systematic Review and Meta-analysis. Nutr Rev. 2025. 10.1093/nutrit/nuae219
- Talandashti MK, Shahinfar H, Delgarm P, Jazayeri S. Effects of selected dietary supplements on migraine prophylaxis: A systematic review and dose-response meta-analysis of randomized controlled trials. Neurol Sci. 2025;46:651. 10.1007/s10072-024-07794-0
- Puliappadamb HM, Satpathy AK, Mishra BR, Maiti R, Jena M. Evaluation of Safety and Efficacy of Add-on Alpha-Lipoic Acid on Migraine Prophylaxis in an Adolescent Population: A Randomized Controlled Trial. J Clin Pharmacol. 2023;63:1398. 10.1002/jcph.2331
- Kelishadi MR, Naeini AA, Khorvash F, Askari G, Heidari Z. The beneficial effect of Alpha-lipoic acid supplementation as a potential adjunct treatment in episodic migraines. Sci Rep. 2022;12:271. 10.1038/s41598-021-04397-z
- Rezaei Kelishadi M, Alavi Naeini A, Askari G, Khorvash F, Heidari Z. The efficacy of alpha-lipoic acid in improving oxidative, inflammatory, and mood status in women with episodic migraine in a randomised, double-blind, placebo-controlled clinical trial. Int J Clin Pract. 2021;75:e14455. 10.1111/ijcp.14455
- Nattagh-Eshtivani E, Sani MA, Dahri M, Ghalichi F, Ghavami A, et al. The role of nutrients in the pathogenesis and treatment of migraine headaches: Review. Biomed Pharmacother. 2018;102:317. 10.1016/j.biopha.2018.03.059
- Cavestro C, Bedogni G, Molinari F, Mandrino S, Rota E, et al. Alpha-Lipoic Acid Shows Promise to Improve Migraine in Patients with Insulin Resistance: A 6-Month Exploratory Study. J Med Food. 2018;21:269. 10.1089/jmf.2017.0068
- Magis D, Ambrosini A, Sándor P, Jacquy J, Laloux P, et al. A randomized double-blind placebo-controlled trial of thioctic acid in migraine prophylaxis. Headache. 2007;47:52.
