Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.5
USERS' SCORE
Good
Based on 3 Reviews
8.3
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Glutathione (Reduced Form)
500 mg
**
Milk Thistle Extract (Silybum marianum) (Fruit/Seeds) (Standardized to 80 mg Silymarin Flavonoids - equivalent 80%)
100 mg
**
Alpha Lipoic Acid
50 mg
**
Top Medical Research Studies
9.5
We examined how alpha-lipoic acid (ALA) impacts stroke recovery, particularly through a newly developed delivery system designed to target ischemic brain lesions. This system uses bioinspired lipoproteins to carry ALA, allowing it to reach the areas most affected by stroke more effectively than standard methods.
In experiments with mice experiencing a transient middle cerebral artery occlusion (a model for stroke), we observed that the ALA-loaded lipoprotein system accumulated significantly in the ischemic brain tissue—2.29 times more than a nontargeted version. This increased delivery resulted in several positive outcomes, such as restoring neurological function, reducing brain cell death, and lessening inflammation, which is key for healing after a stroke.
Overall, our findings suggest that ALA, when delivered effectively to the right brain areas, has considerable potential to improve recovery from ischemic strokes. This innovative approach opens new avenues for treating strokes and enhancing patient outcomes.
In experiments with mice experiencing a transient middle cerebral artery occlusion (a model for stroke), we observed that the ALA-loaded lipoprotein system accumulated significantly in the ischemic brain tissue—2.29 times more than a nontargeted version. This increased delivery resulted in several positive outcomes, such as restoring neurological function, reducing brain cell death, and lessening inflammation, which is key for healing after a stroke.
Overall, our findings suggest that ALA, when delivered effectively to the right brain areas, has considerable potential to improve recovery from ischemic strokes. This innovative approach opens new avenues for treating strokes and enhancing patient outcomes.
Read More
9
We investigated the effects of silymarin, a compound from Silybum marianum, on stroke-related brain damage in rats. Using a model of acute ischemic stroke, we found that silymarin significantly reduced brain injury and improved neurological outcomes. It helped lower levels of oxidative stress and inflammatory markers, demonstrating its effectiveness in reducing inflammation-linked damage. However, silibinin, another component, did not yield similar benefits. Overall, silymarin shows promise for protecting against stroke, but more research is needed to fully understand its potential in clinical settings.
Read More
In our exploration of neuroprotective agents for treating ischemic stroke, we focused on lipoic acid, a naturally occurring compound that shows promise in this area. However, we noticed that standard lipoic acid has limitations, including low efficacy and instability, which hinder its direct use in treatments.
To address these issues, we synthesized 37 lipoic acid derivatives, with compound AA-9 emerging as the standout performer. Through in vitro experiments using tert-butyl hydroperoxide to mimic oxidative damage, we found that AA-9 demonstrated excellent therapeutic potential and an impressive safety profile.
Our subsequent studies using a rat model of ischemic stroke revealed that AA-9 significantly reduces the impact of stroke. This beneficial effect seems to stem from its antioxidant and anti-inflammatory properties, specifically by activating key cellular pathways that help protect the brain. Additionally, AA-9 outperformed regular alpha-lipoic acid in terms of stability and bioavailability, making it an exciting candidate for further research.
Overall, we believe AA-9 holds great promise as a neuroprotective agent for ischemic stroke and warrants further investigation to unlock its full potential.
To address these issues, we synthesized 37 lipoic acid derivatives, with compound AA-9 emerging as the standout performer. Through in vitro experiments using tert-butyl hydroperoxide to mimic oxidative damage, we found that AA-9 demonstrated excellent therapeutic potential and an impressive safety profile.
Our subsequent studies using a rat model of ischemic stroke revealed that AA-9 significantly reduces the impact of stroke. This beneficial effect seems to stem from its antioxidant and anti-inflammatory properties, specifically by activating key cellular pathways that help protect the brain. Additionally, AA-9 outperformed regular alpha-lipoic acid in terms of stability and bioavailability, making it an exciting candidate for further research.
Overall, we believe AA-9 holds great promise as a neuroprotective agent for ischemic stroke and warrants further investigation to unlock its full potential.
Read More
Most Useful Reviews
7.5
Detoxification benefits
Glutathione is a potent antioxidant that detoxifies hydrogen peroxide and lipid peroxides, hinders rust in the body, and combats skin ageing such as age spots, disease, and overall degradation. It is also beneficial for stroke, myocardial infarction, infertility, blood vessel rejuvenation, cataracts, diabetes prevention, hypoglycaemia, arthritis, and allergies.
Read More
7.5
Skin improvement noted
Glutathione effectively eliminates melanin, the pigment responsible for skin blemishes, and aids in preventing ageing. It's reported to prevent rust in the body, enhance the skin, support stroke and myocardial infarction prevention, rejuvenate blood vessels, and fend off cataracts, diabetes, arthritis, and allergies. I'm taking this supplement with high expectations as I seek to delay ageing and maintain good health. Alongside biotin as beauty supplements, I’ve noticed an improvement in my skin condition.
Read More
7.5
High hopes for efficacy
For beautiful skin, Glutathione is reputed to prevent skin ageing. It is believed to be effective in reducing strokes, myocardial infarction, infertility, rejuvenating blood vessels, and preventing cataracts, diabetes, hypoglycaemia, arthritis, and allergies. I harbour high hopes for its benefits.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.5
- All Researches
9.5
We examined how alpha-lipoic acid (ALA) impacts stroke recovery, particularly through a newly developed delivery system designed to target ischemic brain lesions. This system uses bioinspired lipoproteins to carry ALA, allowing it to reach the areas most affected by stroke more effectively than standard methods.
In experiments with mice experiencing a transient middle cerebral artery occlusion (a model for stroke), we observed that the ALA-loaded lipoprotein system accumulated significantly in the ischemic brain tissue—2.29 times more than a nontargeted version. This increased delivery resulted in several positive outcomes, such as restoring neurological function, reducing brain cell death, and lessening inflammation, which is key for healing after a stroke.
Overall, our findings suggest that ALA, when delivered effectively to the right brain areas, has considerable potential to improve recovery from ischemic strokes. This innovative approach opens new avenues for treating strokes and enhancing patient outcomes.
In experiments with mice experiencing a transient middle cerebral artery occlusion (a model for stroke), we observed that the ALA-loaded lipoprotein system accumulated significantly in the ischemic brain tissue—2.29 times more than a nontargeted version. This increased delivery resulted in several positive outcomes, such as restoring neurological function, reducing brain cell death, and lessening inflammation, which is key for healing after a stroke.
Overall, our findings suggest that ALA, when delivered effectively to the right brain areas, has considerable potential to improve recovery from ischemic strokes. This innovative approach opens new avenues for treating strokes and enhancing patient outcomes.
Read More
9
We investigated the effects of silymarin, a compound from Silybum marianum, on stroke-related brain damage in rats. Using a model of acute ischemic stroke, we found that silymarin significantly reduced brain injury and improved neurological outcomes. It helped lower levels of oxidative stress and inflammatory markers, demonstrating its effectiveness in reducing inflammation-linked damage. However, silibinin, another component, did not yield similar benefits. Overall, silymarin shows promise for protecting against stroke, but more research is needed to fully understand its potential in clinical settings.
Read More
In our exploration of neuroprotective agents for treating ischemic stroke, we focused on lipoic acid, a naturally occurring compound that shows promise in this area. However, we noticed that standard lipoic acid has limitations, including low efficacy and instability, which hinder its direct use in treatments.
To address these issues, we synthesized 37 lipoic acid derivatives, with compound AA-9 emerging as the standout performer. Through in vitro experiments using tert-butyl hydroperoxide to mimic oxidative damage, we found that AA-9 demonstrated excellent therapeutic potential and an impressive safety profile.
Our subsequent studies using a rat model of ischemic stroke revealed that AA-9 significantly reduces the impact of stroke. This beneficial effect seems to stem from its antioxidant and anti-inflammatory properties, specifically by activating key cellular pathways that help protect the brain. Additionally, AA-9 outperformed regular alpha-lipoic acid in terms of stability and bioavailability, making it an exciting candidate for further research.
Overall, we believe AA-9 holds great promise as a neuroprotective agent for ischemic stroke and warrants further investigation to unlock its full potential.
To address these issues, we synthesized 37 lipoic acid derivatives, with compound AA-9 emerging as the standout performer. Through in vitro experiments using tert-butyl hydroperoxide to mimic oxidative damage, we found that AA-9 demonstrated excellent therapeutic potential and an impressive safety profile.
Our subsequent studies using a rat model of ischemic stroke revealed that AA-9 significantly reduces the impact of stroke. This beneficial effect seems to stem from its antioxidant and anti-inflammatory properties, specifically by activating key cellular pathways that help protect the brain. Additionally, AA-9 outperformed regular alpha-lipoic acid in terms of stability and bioavailability, making it an exciting candidate for further research.
Overall, we believe AA-9 holds great promise as a neuroprotective agent for ischemic stroke and warrants further investigation to unlock its full potential.
Read More
8
Silymarin may aid stroke recovery
We explored whether silymarin, extracted from milk thistle, can protect against neuronal damage during a stroke. In our study, male Wistar rats were given a daily dose of silymarin for 15 days before being subjected to a stroke simulation.
The results showed that silymarin significantly improved antioxidant levels and reduced cell death, aiding in functional recovery post-stroke. This suggests that silymarin could potentially slow down neurodegeneration linked to strokes, thanks to its natural antioxidant and anti-apoptotic benefits.
The results showed that silymarin significantly improved antioxidant levels and reduced cell death, aiding in functional recovery post-stroke. This suggests that silymarin could potentially slow down neurodegeneration linked to strokes, thanks to its natural antioxidant and anti-apoptotic benefits.
Read More
7
We investigated the potential of alpha-lipoic acid (ALA) in treating cerebral ischemia, a condition often associated with strokes. The idea behind using ALA is its antioxidant properties, which might help mitigate damage caused during a stroke.
One of the notable findings from the review is the promising application of ALA encapsulated within niosomes for this purpose. Niosomes can enhance the delivery of ALA to the brain, potentially improving cell protection during ischemic events.
However, it's essential to note that while there are indications of ALA's benefits, the study did not conclusively determine its effectiveness in treating stroke independently. This makes it crucial for us to exercise caution when interpreting the results and considering ALA as a therapeutic option for stroke treatment.
One of the notable findings from the review is the promising application of ALA encapsulated within niosomes for this purpose. Niosomes can enhance the delivery of ALA to the brain, potentially improving cell protection during ischemic events.
However, it's essential to note that while there are indications of ALA's benefits, the study did not conclusively determine its effectiveness in treating stroke independently. This makes it crucial for us to exercise caution when interpreting the results and considering ALA as a therapeutic option for stroke treatment.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Detoxification benefits
Glutathione is a potent antioxidant that detoxifies hydrogen peroxide and lipid peroxides, hinders rust in the body, and combats skin ageing such as age spots, disease, and overall degradation. It is also beneficial for stroke, myocardial infarction, infertility, blood vessel rejuvenation, cataracts, diabetes prevention, hypoglycaemia, arthritis, and allergies.
Read More
7.5
Skin improvement noted
Glutathione effectively eliminates melanin, the pigment responsible for skin blemishes, and aids in preventing ageing. It's reported to prevent rust in the body, enhance the skin, support stroke and myocardial infarction prevention, rejuvenate blood vessels, and fend off cataracts, diabetes, arthritis, and allergies. I'm taking this supplement with high expectations as I seek to delay ageing and maintain good health. Alongside biotin as beauty supplements, I’ve noticed an improvement in my skin condition.
Read More
7.5
High hopes for efficacy
For beautiful skin, Glutathione is reputed to prevent skin ageing. It is believed to be effective in reducing strokes, myocardial infarction, infertility, rejuvenating blood vessels, and preventing cataracts, diabetes, hypoglycaemia, arthritis, and allergies. I harbour high hopes for its benefits.
Read More
Frequently Asked Questions
7.5
Detoxification benefits
Glutathione is a potent antioxidant that detoxifies hydrogen peroxide and lipid peroxides, hinders rust in the body, and combats skin ageing such as age spots, disease, and overall degradation. It is also beneficial for stroke, myocardial infarction, infertility, blood vessel rejuvenation, cataracts, diabetes prevention, hypoglycaemia, arthritis, and allergies.
7.5
Skin improvement noted
Glutathione effectively eliminates melanin, the pigment responsible for skin blemishes, and aids in preventing ageing. It's reported to prevent rust in the body, enhance the skin, support stroke and myocardial infarction prevention, rejuvenate blood vessels, and fend off cataracts, diabetes, arthritis, and allergies. I'm taking this supplement with high expectations as I seek to delay ageing and maintain good health. Alongside biotin as beauty supplements, I’ve noticed an improvement in my skin condition.
7.5
High hopes for efficacy
For beautiful skin, Glutathione is reputed to prevent skin ageing. It is believed to be effective in reducing strokes, myocardial infarction, infertility, rejuvenating blood vessels, and preventing cataracts, diabetes, hypoglycaemia, arthritis, and allergies. I harbour high hopes for its benefits.
8
Silymarin may aid stroke recovery
We explored whether silymarin, extracted from milk thistle, can protect against neuronal damage during a stroke. In our study, male Wistar rats were given a daily dose of silymarin for 15 days before being subjected to a stroke simulation.
The results showed that silymarin significantly improved antioxidant levels and reduced cell death, aiding in functional recovery post-stroke. This suggests that silymarin could potentially slow down neurodegeneration linked to strokes, thanks to its natural antioxidant and anti-apoptotic benefits.
The results showed that silymarin significantly improved antioxidant levels and reduced cell death, aiding in functional recovery post-stroke. This suggests that silymarin could potentially slow down neurodegeneration linked to strokes, thanks to its natural antioxidant and anti-apoptotic benefits.
9
We investigated the effects of silymarin, a compound from Silybum marianum, on stroke-related brain damage in rats. Using a model of acute ischemic stroke, we found that silymarin significantly reduced brain injury and improved neurological outcomes. It helped lower levels of oxidative stress and inflammatory markers, demonstrating its effectiveness in reducing inflammation-linked damage. However, silibinin, another component, did not yield similar benefits. Overall, silymarin shows promise for protecting against stroke, but more research is needed to fully understand its potential in clinical settings.
9.5
We examined how alpha-lipoic acid (ALA) impacts stroke recovery, particularly through a newly developed delivery system designed to target ischemic brain lesions. This system uses bioinspired lipoproteins to carry ALA, allowing it to reach the areas most affected by stroke more effectively than standard methods.
In experiments with mice experiencing a transient middle cerebral artery occlusion (a model for stroke), we observed that the ALA-loaded lipoprotein system accumulated significantly in the ischemic brain tissue—2.29 times more than a nontargeted version. This increased delivery resulted in several positive outcomes, such as restoring neurological function, reducing brain cell death, and lessening inflammation, which is key for healing after a stroke.
Overall, our findings suggest that ALA, when delivered effectively to the right brain areas, has considerable potential to improve recovery from ischemic strokes. This innovative approach opens new avenues for treating strokes and enhancing patient outcomes.
In experiments with mice experiencing a transient middle cerebral artery occlusion (a model for stroke), we observed that the ALA-loaded lipoprotein system accumulated significantly in the ischemic brain tissue—2.29 times more than a nontargeted version. This increased delivery resulted in several positive outcomes, such as restoring neurological function, reducing brain cell death, and lessening inflammation, which is key for healing after a stroke.
Overall, our findings suggest that ALA, when delivered effectively to the right brain areas, has considerable potential to improve recovery from ischemic strokes. This innovative approach opens new avenues for treating strokes and enhancing patient outcomes.
In our exploration of neuroprotective agents for treating ischemic stroke, we focused on lipoic acid, a naturally occurring compound that shows promise in this area. However, we noticed that standard lipoic acid has limitations, including low efficacy and instability, which hinder its direct use in treatments.
To address these issues, we synthesized 37 lipoic acid derivatives, with compound AA-9 emerging as the standout performer. Through in vitro experiments using tert-butyl hydroperoxide to mimic oxidative damage, we found that AA-9 demonstrated excellent therapeutic potential and an impressive safety profile.
Our subsequent studies using a rat model of ischemic stroke revealed that AA-9 significantly reduces the impact of stroke. This beneficial effect seems to stem from its antioxidant and anti-inflammatory properties, specifically by activating key cellular pathways that help protect the brain. Additionally, AA-9 outperformed regular alpha-lipoic acid in terms of stability and bioavailability, making it an exciting candidate for further research.
Overall, we believe AA-9 holds great promise as a neuroprotective agent for ischemic stroke and warrants further investigation to unlock its full potential.
To address these issues, we synthesized 37 lipoic acid derivatives, with compound AA-9 emerging as the standout performer. Through in vitro experiments using tert-butyl hydroperoxide to mimic oxidative damage, we found that AA-9 demonstrated excellent therapeutic potential and an impressive safety profile.
Our subsequent studies using a rat model of ischemic stroke revealed that AA-9 significantly reduces the impact of stroke. This beneficial effect seems to stem from its antioxidant and anti-inflammatory properties, specifically by activating key cellular pathways that help protect the brain. Additionally, AA-9 outperformed regular alpha-lipoic acid in terms of stability and bioavailability, making it an exciting candidate for further research.
Overall, we believe AA-9 holds great promise as a neuroprotective agent for ischemic stroke and warrants further investigation to unlock its full potential.
References
- Raza SS, Khan MM, Ashafaq M, Ahmad A, Khuwaja G, et al. Silymarin protects neurons from oxidative stress associated damages in focal cerebral ischemia: a behavioral, biochemical and immunohistological study in Wistar rats. J Neurol Sci. 2011;309:45. 10.1016/j.jns.2011.07.035
- Hou YC, Liou KT, Chern CM, Wang YH, Liao JF, et al. Preventive effect of silymarin in cerebral ischemia-reperfusion-induced brain injury in rats possibly through impairing NF-κB and STAT-1 activation. Phytomedicine. 2010;17:963. 10.1016/j.phymed.2010.03.012
- Mosallaei N, Malaekeh-Nikouei A, Sarraf Shirazi S, Behmadi J, Malaekeh-Nikouei B. A comprehensive review on alpha-lipoic acid delivery by nanoparticles. Bioimpacts. 2024;14:30136. 10.34172/bi.2024.30136
- Luo K, Wang Y, Lu E, Nie W, Yan X, et al. Ischemic Microenvironment-Targeted Bioinspired Lipoprotein Sequentially Penetrates Cerebral Ischemic Lesions to Rescue Ischemic Stroke. ACS Appl Mater Interfaces. 2024;16:49628. 10.1021/acsami.4c08966
- Zhu C, Wang Y, Li Y, Wang T, Ye F, et al. Discovery of neuroprotective Agents: Potent, brain Penetrating, lipoic acid derivatives for the potential treatment of ischemic stroke by regulating oxidative stress and inflammation - a Preliminary study. Bioorg Chem. 2024;147:107339. 10.1016/j.bioorg.2024.107339
