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SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.8
USERS' SCORE
Good
Based on 1 Review
8.6
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Sodium (from Sodium Hyaluronate)
10 mg
< 1 %
Hyaluronic Acid (from Sodium Hyaluronate)
100 mg
†
L-Proline (Free-Form)
100 mg
†
Alpha Lipoic Acid
50 mg
†
Grape Seed Extract (Vitis vinifera)(Standardized for Polyphenols)
25 mg
†
Top Medical Research Studies
9
BHA shows promise for gout relief
-Butyrylated hyaluronic acid ameliorates gout and hyperuricemia in animal models.
High relevance to gout treatment
We explored the benefits of butyrylated hyaluronic acid (BHA) in treating gout by examining its effects in specific animal models. Using Wistar rats, we evaluated how BHA can influence inflammation linked with gouty arthritis, specifically by measuring joint swelling and inflammatory markers after injecting monosodium urate crystals.
Our findings showed that a higher dose of BHA (50 μg) effectively reduced joint swelling and lowered levels of key inflammatory cytokines, indicating a strong anti-inflammatory effect. In another part of our study, we assessed BHA’s impact on hyperuricemia in Balb/C mice, where lower doses (10 μg) were sufficient to exhibit antioxidative properties and significantly decrease uric acid levels.
This first-of-its-kind study suggests that BHA could be a promising approach to alleviate symptoms associated with gouty arthritis and manage hyperuricemia. Overall, our research highlights BHA's potential therapeutic role in addressing these painful conditions.
Our findings showed that a higher dose of BHA (50 μg) effectively reduced joint swelling and lowered levels of key inflammatory cytokines, indicating a strong anti-inflammatory effect. In another part of our study, we assessed BHA’s impact on hyperuricemia in Balb/C mice, where lower doses (10 μg) were sufficient to exhibit antioxidative properties and significantly decrease uric acid levels.
This first-of-its-kind study suggests that BHA could be a promising approach to alleviate symptoms associated with gouty arthritis and manage hyperuricemia. Overall, our research highlights BHA's potential therapeutic role in addressing these painful conditions.
Read More
9
Grape seed procyanidins reduce gout pain
Grape seed-derived procyanidins alleviate gout pain via NLRP3 inflammasome suppression.
Direct approach to gout treatment
We focused on exploring whether grape seed-derived procyanidins could alleviate the pain associated with gout, an inflammatory arthritis that can cause significant discomfort. The study involved using CD-1 mice to assess joint pain and swelling after injections of monosodium urate (MSU) crystals, which are known to trigger gout. We also utilized a murine macrophage cell line to understand how procyanidins interact at a cellular level.
Our findings showed that procyanidins effectively reduced joint swelling and pain associated with gout. Notably, they were able to inhibit the activation of the NLRP3 inflammasome, a key player in the inflammatory response, and decreased the levels of interleukin-1β, a substance that contributes to inflammation. Additionally, procyanidins helped reduce the production of reactive oxygen species (ROS), which are involved in promoting inflammation.
Overall, our research suggests that procyanidins from grape seeds may be a promising food-derived compound for alleviating gout pain by specifically targeting inflammatory processes in macrophages. This could open doors for effective dietary approaches to managing this painful condition.
Our findings showed that procyanidins effectively reduced joint swelling and pain associated with gout. Notably, they were able to inhibit the activation of the NLRP3 inflammasome, a key player in the inflammatory response, and decreased the levels of interleukin-1β, a substance that contributes to inflammation. Additionally, procyanidins helped reduce the production of reactive oxygen species (ROS), which are involved in promoting inflammation.
Overall, our research suggests that procyanidins from grape seeds may be a promising food-derived compound for alleviating gout pain by specifically targeting inflammatory processes in macrophages. This could open doors for effective dietary approaches to managing this painful condition.
Read More
9
Procyanidins reduce uric acid levels
Administration of procyanidins from grape seeds reduces serum uric acid levels and decreases hepatic xanthine dehydrogenase/oxidase activities in oxonate-treated mice.
Direct relevance to gout treatment
We explored how procyanidins extracted from grape seeds can influence uric acid levels in mice with induced hyperuricaemia. In our study, we administered these compounds to mice that had been pretreated with a substance called oxonate, which is known to raise uric acid levels, mimicking the conditions of gout.
The results were promising. Those mice receiving a higher dose of procyanidins, specifically 400 mg/kg for three days, showed a significant decrease in serum uric acid levels—similar to those observed in normal mice. This suggests that grape seed procyanidins may effectively lower uric acid levels, a key aspect in managing gout.
Moreover, we noticed a reduction in the activities of two important enzymes involved in uric acid production—xanthine dehydrogenase and xanthine oxidase—within the liver of the treated mice. However, the relationship between enzyme activity reduction and uric acid levels wasn't straightforward, indicating the possibility of other underlying mechanisms at play.
Notably, the mice treated with grape seed procyanidins maintained normal growth rates, in contrast to those treated with allopurinol, which experienced some growth retardation. These findings highlight the potential of grape seed procyanidins as a natural approach to aid in treating hyperuricaemia, warranting further investigation into their therapeutic applications.
The results were promising. Those mice receiving a higher dose of procyanidins, specifically 400 mg/kg for three days, showed a significant decrease in serum uric acid levels—similar to those observed in normal mice. This suggests that grape seed procyanidins may effectively lower uric acid levels, a key aspect in managing gout.
Moreover, we noticed a reduction in the activities of two important enzymes involved in uric acid production—xanthine dehydrogenase and xanthine oxidase—within the liver of the treated mice. However, the relationship between enzyme activity reduction and uric acid levels wasn't straightforward, indicating the possibility of other underlying mechanisms at play.
Notably, the mice treated with grape seed procyanidins maintained normal growth rates, in contrast to those treated with allopurinol, which experienced some growth retardation. These findings highlight the potential of grape seed procyanidins as a natural approach to aid in treating hyperuricaemia, warranting further investigation into their therapeutic applications.
Read More
Most Useful Reviews
10
Pain-free life
After reading numerous excellent reviews for Hyaluronic Acid, I decided to try it. Initially, I doubled the dosage, and within 48 hours, my gouty arthritis flare-up in my knee was gone. I will continue using it for ongoing success against arthritis and enjoy foods once forbidden due to gout.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.8
9
Microneedles enhance gout treatment
Transdermal delivery of colchicine using dissolvable microneedle arrays for the treatment of acute gout in a rat model.
Limited specific impact from hyaluronic acid
We explored a new approach to treating acute gout using dissolvable microneedles filled with colchicine, a well-known medication for this condition. The microneedles were created with hyaluronic acid, an ingredient often used in skincare, and designed for transdermal delivery—meaning they can deliver medication through the skin without needing needles like those found in injections.
During our study, we evaluated the mechanical properties of these microneedles, ensuring they could effectively penetrate the skin and release the medication. Importantly, our findings showed that using these microneedles allowed for a significant increase in the amount of colchicine that entered the bloodstream compared to traditional gel applications. We also noted no skin irritation after application, indicating that this method is not only effective but also gentle on the skin.
Furthermore, we found that this method significantly reduced swelling and pain in rats with acute gout. By minimizing the gastrointestinal side effects commonly associated with oral colchicine, we hope this innovative delivery system can enhance treatment effectiveness and improve patient adherence to medication. Overall, our study suggests that using hyaluronic acid in microneedles could be a promising way to deliver colchicine for better gout management.
During our study, we evaluated the mechanical properties of these microneedles, ensuring they could effectively penetrate the skin and release the medication. Importantly, our findings showed that using these microneedles allowed for a significant increase in the amount of colchicine that entered the bloodstream compared to traditional gel applications. We also noted no skin irritation after application, indicating that this method is not only effective but also gentle on the skin.
Furthermore, we found that this method significantly reduced swelling and pain in rats with acute gout. By minimizing the gastrointestinal side effects commonly associated with oral colchicine, we hope this innovative delivery system can enhance treatment effectiveness and improve patient adherence to medication. Overall, our study suggests that using hyaluronic acid in microneedles could be a promising way to deliver colchicine for better gout management.
Read More
9
Potential BHA treatment for gout
-Butyrylated Hyaluronic Acid Achieves Anti-Inflammatory Effects In Vitro and in Adjuvant-Induced Immune Activation in Rats.
Relevant study on gout treatment
We aimed to explore how butyrylated hyaluronic acid (BHA) can help with the inflammation associated with gout. In our investigation, we looked at BHA's anti-inflammatory and antioxidative powers using both laboratory tests with LPS-induced cells and a live rat model that simulates gout.
Our results were promising. We saw that BHA significantly reduced the production of key inflammatory molecules, like TNFα, IL-1β, and IL-6, which are all often elevated during gout attacks. Additionally, it reduced the production of harmful reactive oxygen species, which can contribute to inflammation. In the rat model, BHA not only alleviated swelling in the joints and paws, but also decreased the infiltration of inflammatory cells in the affected tissues.
Furthermore, we noted that BHA appeared to work by influencing several important cell signaling pathways that are known to drive inflammation. Specifically, it down-regulated pathways associated with inflammation, providing a further line of evidence for its potential use in treating conditions like gout.
Overall, our study highlights the potential of BHA as a novel treatment option for managing gout-related inflammation, making it a candidate for future pharmacological development.
Our results were promising. We saw that BHA significantly reduced the production of key inflammatory molecules, like TNFα, IL-1β, and IL-6, which are all often elevated during gout attacks. Additionally, it reduced the production of harmful reactive oxygen species, which can contribute to inflammation. In the rat model, BHA not only alleviated swelling in the joints and paws, but also decreased the infiltration of inflammatory cells in the affected tissues.
Furthermore, we noted that BHA appeared to work by influencing several important cell signaling pathways that are known to drive inflammation. Specifically, it down-regulated pathways associated with inflammation, providing a further line of evidence for its potential use in treating conditions like gout.
Overall, our study highlights the potential of BHA as a novel treatment option for managing gout-related inflammation, making it a candidate for future pharmacological development.
Read More
9
BHA shows promise for gout relief
-Butyrylated hyaluronic acid ameliorates gout and hyperuricemia in animal models.
High relevance to gout treatment
We explored the benefits of butyrylated hyaluronic acid (BHA) in treating gout by examining its effects in specific animal models. Using Wistar rats, we evaluated how BHA can influence inflammation linked with gouty arthritis, specifically by measuring joint swelling and inflammatory markers after injecting monosodium urate crystals.
Our findings showed that a higher dose of BHA (50 μg) effectively reduced joint swelling and lowered levels of key inflammatory cytokines, indicating a strong anti-inflammatory effect. In another part of our study, we assessed BHA’s impact on hyperuricemia in Balb/C mice, where lower doses (10 μg) were sufficient to exhibit antioxidative properties and significantly decrease uric acid levels.
This first-of-its-kind study suggests that BHA could be a promising approach to alleviate symptoms associated with gouty arthritis and manage hyperuricemia. Overall, our research highlights BHA's potential therapeutic role in addressing these painful conditions.
Our findings showed that a higher dose of BHA (50 μg) effectively reduced joint swelling and lowered levels of key inflammatory cytokines, indicating a strong anti-inflammatory effect. In another part of our study, we assessed BHA’s impact on hyperuricemia in Balb/C mice, where lower doses (10 μg) were sufficient to exhibit antioxidative properties and significantly decrease uric acid levels.
This first-of-its-kind study suggests that BHA could be a promising approach to alleviate symptoms associated with gouty arthritis and manage hyperuricemia. Overall, our research highlights BHA's potential therapeutic role in addressing these painful conditions.
Read More
9
Grape seed procyanidins reduce gout pain
Grape seed-derived procyanidins alleviate gout pain via NLRP3 inflammasome suppression.
Direct approach to gout treatment
We focused on exploring whether grape seed-derived procyanidins could alleviate the pain associated with gout, an inflammatory arthritis that can cause significant discomfort. The study involved using CD-1 mice to assess joint pain and swelling after injections of monosodium urate (MSU) crystals, which are known to trigger gout. We also utilized a murine macrophage cell line to understand how procyanidins interact at a cellular level.
Our findings showed that procyanidins effectively reduced joint swelling and pain associated with gout. Notably, they were able to inhibit the activation of the NLRP3 inflammasome, a key player in the inflammatory response, and decreased the levels of interleukin-1β, a substance that contributes to inflammation. Additionally, procyanidins helped reduce the production of reactive oxygen species (ROS), which are involved in promoting inflammation.
Overall, our research suggests that procyanidins from grape seeds may be a promising food-derived compound for alleviating gout pain by specifically targeting inflammatory processes in macrophages. This could open doors for effective dietary approaches to managing this painful condition.
Our findings showed that procyanidins effectively reduced joint swelling and pain associated with gout. Notably, they were able to inhibit the activation of the NLRP3 inflammasome, a key player in the inflammatory response, and decreased the levels of interleukin-1β, a substance that contributes to inflammation. Additionally, procyanidins helped reduce the production of reactive oxygen species (ROS), which are involved in promoting inflammation.
Overall, our research suggests that procyanidins from grape seeds may be a promising food-derived compound for alleviating gout pain by specifically targeting inflammatory processes in macrophages. This could open doors for effective dietary approaches to managing this painful condition.
Read More
9
Procyanidins reduce uric acid levels
Administration of procyanidins from grape seeds reduces serum uric acid levels and decreases hepatic xanthine dehydrogenase/oxidase activities in oxonate-treated mice.
Direct relevance to gout treatment
We explored how procyanidins extracted from grape seeds can influence uric acid levels in mice with induced hyperuricaemia. In our study, we administered these compounds to mice that had been pretreated with a substance called oxonate, which is known to raise uric acid levels, mimicking the conditions of gout.
The results were promising. Those mice receiving a higher dose of procyanidins, specifically 400 mg/kg for three days, showed a significant decrease in serum uric acid levels—similar to those observed in normal mice. This suggests that grape seed procyanidins may effectively lower uric acid levels, a key aspect in managing gout.
Moreover, we noticed a reduction in the activities of two important enzymes involved in uric acid production—xanthine dehydrogenase and xanthine oxidase—within the liver of the treated mice. However, the relationship between enzyme activity reduction and uric acid levels wasn't straightforward, indicating the possibility of other underlying mechanisms at play.
Notably, the mice treated with grape seed procyanidins maintained normal growth rates, in contrast to those treated with allopurinol, which experienced some growth retardation. These findings highlight the potential of grape seed procyanidins as a natural approach to aid in treating hyperuricaemia, warranting further investigation into their therapeutic applications.
The results were promising. Those mice receiving a higher dose of procyanidins, specifically 400 mg/kg for three days, showed a significant decrease in serum uric acid levels—similar to those observed in normal mice. This suggests that grape seed procyanidins may effectively lower uric acid levels, a key aspect in managing gout.
Moreover, we noticed a reduction in the activities of two important enzymes involved in uric acid production—xanthine dehydrogenase and xanthine oxidase—within the liver of the treated mice. However, the relationship between enzyme activity reduction and uric acid levels wasn't straightforward, indicating the possibility of other underlying mechanisms at play.
Notably, the mice treated with grape seed procyanidins maintained normal growth rates, in contrast to those treated with allopurinol, which experienced some growth retardation. These findings highlight the potential of grape seed procyanidins as a natural approach to aid in treating hyperuricaemia, warranting further investigation into their therapeutic applications.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.6
10
Pain-free life
After reading numerous excellent reviews for Hyaluronic Acid, I decided to try it. Initially, I doubled the dosage, and within 48 hours, my gouty arthritis flare-up in my knee was gone. I will continue using it for ongoing success against arthritis and enjoy foods once forbidden due to gout.
Read More
