Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.7
USERS' SCORE
Good
Based on 4 Reviews
8.4
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Iron (elemental) (from 90 mg Ferrous Bisglycinate)(Ferrochel™)
18 mg
100%
Top Medical Research Studies
8
We explored how iron levels impact depression and hippocampal health. By studying mice under chronic mild stress and using an iron chelator, we observed that excessive iron leads to synaptic damage in the brain. This harmful effect was linked to the downregulation of crucial proteins involved in brain health.
Interestingly, when we activated a protein called Nrf2, we saw improvements in iron balance and a reduction in depression symptoms. Our findings suggest that focusing on Nrf2 and managing iron levels could be key in developing better treatments for depression.
Interestingly, when we activated a protein called Nrf2, we saw improvements in iron balance and a reduction in depression symptoms. Our findings suggest that focusing on Nrf2 and managing iron levels could be key in developing better treatments for depression.
Read More
8
Iron and vitamin D impact depression
We explored whether maternal iron and vitamin D levels during pregnancy could impact depression symptoms later on. By measuring various iron biomarkers and vitamin D metabolites, we assessed the mental health of nearly 2,000 pregnant participants in their third trimester. Our findings showed that higher levels of both iron and vitamin D were associated with significantly fewer depression symptoms. Interestingly, many women experienced lower vitamin D levels postpartum, suggesting the need for continued monitoring beyond pregnancy.
Read More
8
We investigated how dietary iron intake affects depressive symptoms among adults using data from the National Health and Nutrition Examination Survey. Our analysis revealed that higher iron intake is linked to lower rates of depression.
Interestingly, we discovered that this relationship varies with body mass index (BMI). For individuals with a BMI under 25, the connection was U-shaped, indicating that too little or too much iron can impact mood.
However, it’s important to note that the study was cross-sectional and relied on self-reported data, making firm conclusions challenging.
Interestingly, we discovered that this relationship varies with body mass index (BMI). For individuals with a BMI under 25, the connection was U-shaped, indicating that too little or too much iron can impact mood.
However, it’s important to note that the study was cross-sectional and relied on self-reported data, making firm conclusions challenging.
Read More
Most Useful Reviews
9
Depression relief
1 people found this helpful
This product helped with my evening depression. I often felt unwell in the evenings, potentially due to iron deficiency, which led me to purchase it. After starting, my evening depression subsided and I began waking up feeling better. Now I can move through the day without fluctuations. I’d like to increase the dosage gradually, possibly trying 36mg in the future.
Read More
8
Improved stability
My physical condition is stable. I was diagnosed with iron deficiency anaemia and hospitalised for a brief period, but it didn’t last long. This treatment suits me as the iron content is just right. I no longer have to worry about dizziness or depression, and I’m thoroughly enjoying my time. Although it comes in the form of a large capsule, I can take it all at once.
Read More
7.5
Increased energy
Women should take one tablet daily to relieve depression. Unlike heme iron supplements with low absorption rates in Japan, this chelated iron has an excellent absorption rate. I found it energising; when I take it, I feel more vitality than when I don’t. I'm no longer bedridden, and my ferritin levels may have improved.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.7
- All Researches
9
We evaluated how brain iron levels affect depression and cognitive function in unmedicated individuals with major depressive disorder (MDD) undergoing mindfulness-based cognitive therapy (MBCT).
Using advanced imaging techniques, we noticed participants with MDD had lower brain iron levels in specific regions compared to healthy controls.
Participants who started with lower iron levels experienced greater improvements in their depression after receiving MBCT. Our findings suggest that brain iron might play a role in MDD symptoms and treatment response.
Using advanced imaging techniques, we noticed participants with MDD had lower brain iron levels in specific regions compared to healthy controls.
Participants who started with lower iron levels experienced greater improvements in their depression after receiving MBCT. Our findings suggest that brain iron might play a role in MDD symptoms and treatment response.
Read More
8
We examined how Kaixinsan (KXS), a traditional Chinese medicine, affects depression-like behaviors in mice undergoing adriamycin treatment for breast cancer. By dividing forty mice into groups, we observed their responses through various tests.
The results showed that KXS significantly improved the depression-related behaviors linked to chemotherapy. It appeared to work by reducing ferroptosis—a type of cell death—in the prefrontal cortex, suggesting a protective role against these adverse effects.
The results showed that KXS significantly improved the depression-related behaviors linked to chemotherapy. It appeared to work by reducing ferroptosis—a type of cell death—in the prefrontal cortex, suggesting a protective role against these adverse effects.
Read More
8
Iron and vitamin D impact depression
We explored whether maternal iron and vitamin D levels during pregnancy could impact depression symptoms later on. By measuring various iron biomarkers and vitamin D metabolites, we assessed the mental health of nearly 2,000 pregnant participants in their third trimester. Our findings showed that higher levels of both iron and vitamin D were associated with significantly fewer depression symptoms. Interestingly, many women experienced lower vitamin D levels postpartum, suggesting the need for continued monitoring beyond pregnancy.
Read More
8
We explored how iron levels impact depression and hippocampal health. By studying mice under chronic mild stress and using an iron chelator, we observed that excessive iron leads to synaptic damage in the brain. This harmful effect was linked to the downregulation of crucial proteins involved in brain health.
Interestingly, when we activated a protein called Nrf2, we saw improvements in iron balance and a reduction in depression symptoms. Our findings suggest that focusing on Nrf2 and managing iron levels could be key in developing better treatments for depression.
Interestingly, when we activated a protein called Nrf2, we saw improvements in iron balance and a reduction in depression symptoms. Our findings suggest that focusing on Nrf2 and managing iron levels could be key in developing better treatments for depression.
Read More
8
We investigated how dietary iron intake affects depressive symptoms among adults using data from the National Health and Nutrition Examination Survey. Our analysis revealed that higher iron intake is linked to lower rates of depression.
Interestingly, we discovered that this relationship varies with body mass index (BMI). For individuals with a BMI under 25, the connection was U-shaped, indicating that too little or too much iron can impact mood.
However, it’s important to note that the study was cross-sectional and relied on self-reported data, making firm conclusions challenging.
Interestingly, we discovered that this relationship varies with body mass index (BMI). For individuals with a BMI under 25, the connection was U-shaped, indicating that too little or too much iron can impact mood.
However, it’s important to note that the study was cross-sectional and relied on self-reported data, making firm conclusions challenging.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Depression relief
1 people found this helpful
This product helped with my evening depression. I often felt unwell in the evenings, potentially due to iron deficiency, which led me to purchase it. After starting, my evening depression subsided and I began waking up feeling better. Now I can move through the day without fluctuations. I’d like to increase the dosage gradually, possibly trying 36mg in the future.
Read More
8
Improved stability
My physical condition is stable. I was diagnosed with iron deficiency anaemia and hospitalised for a brief period, but it didn’t last long. This treatment suits me as the iron content is just right. I no longer have to worry about dizziness or depression, and I’m thoroughly enjoying my time. Although it comes in the form of a large capsule, I can take it all at once.
Read More
7.5
Increased energy
Women should take one tablet daily to relieve depression. Unlike heme iron supplements with low absorption rates in Japan, this chelated iron has an excellent absorption rate. I found it energising; when I take it, I feel more vitality than when I don’t. I'm no longer bedridden, and my ferritin levels may have improved.
Read More
7.5
Effect on ADHD
This is often seen as a supplement for women, yet it's also effective for depression and ADHD. However, I must note that men should not exceed 36mg.
Read More
Frequently Asked Questions
9
Depression relief
1 people found this helpful
This product helped with my evening depression. I often felt unwell in the evenings, potentially due to iron deficiency, which led me to purchase it. After starting, my evening depression subsided and I began waking up feeling better. Now I can move through the day without fluctuations. I’d like to increase the dosage gradually, possibly trying 36mg in the future.
8
Improved stability
My physical condition is stable. I was diagnosed with iron deficiency anaemia and hospitalised for a brief period, but it didn’t last long. This treatment suits me as the iron content is just right. I no longer have to worry about dizziness or depression, and I’m thoroughly enjoying my time. Although it comes in the form of a large capsule, I can take it all at once.
7.5
Increased energy
Women should take one tablet daily to relieve depression. Unlike heme iron supplements with low absorption rates in Japan, this chelated iron has an excellent absorption rate. I found it energising; when I take it, I feel more vitality than when I don’t. I'm no longer bedridden, and my ferritin levels may have improved.
7.5
Effect on ADHD
This is often seen as a supplement for women, yet it's also effective for depression and ADHD. However, I must note that men should not exceed 36mg.
7
We set out to explore the connection between iron levels and mental health in pregnant women, focusing on how iron treatment may influence depressive symptoms. Our study recruited participants in their first trimester and followed them through their second and third trimesters, assessing their iron status and psychosocial wellbeing along the way.
Findings revealed that improvements in ferritin levels during the first and second trimesters were associated with fewer depressive symptoms and a better overall quality of life. This suggests that boosting iron levels in early pregnancy could potentially benefit mental health. Moreover, we discovered that increases in hemoglobin were linked to reduced anxiety, particularly feelings of fear, highlighting another positive aspect of improved iron status.
However, the results were more mixed in the later stages of pregnancy. While improvements in transferrin saturation from the second to the third trimester were connected to greater anxiety and a decline in quality of life, the initial positive effects underline the importance of monitoring and managing iron levels throughout pregnancy.
Overall, our findings hint at a beneficial relationship between iron status and psychosocial wellbeing, particularly in early pregnancy. However, more extensive studies are needed to confirm these promising results and better understand the nuances of this connection.
Findings revealed that improvements in ferritin levels during the first and second trimesters were associated with fewer depressive symptoms and a better overall quality of life. This suggests that boosting iron levels in early pregnancy could potentially benefit mental health. Moreover, we discovered that increases in hemoglobin were linked to reduced anxiety, particularly feelings of fear, highlighting another positive aspect of improved iron status.
However, the results were more mixed in the later stages of pregnancy. While improvements in transferrin saturation from the second to the third trimester were connected to greater anxiety and a decline in quality of life, the initial positive effects underline the importance of monitoring and managing iron levels throughout pregnancy.
Overall, our findings hint at a beneficial relationship between iron status and psychosocial wellbeing, particularly in early pregnancy. However, more extensive studies are needed to confirm these promising results and better understand the nuances of this connection.
7
We undertook a detailed study to examine the effects of iron on major depressive disorder (MDD) and recurrent depression (rMDD) using a method called Mendelian randomisation. This approach allows us to look at how genetic data can help us understand the causal relationships between micronutrient levels and depression.
Our findings suggest that there’s some weak evidence indicating that higher levels of serum iron might actually protect against the risk of experiencing major depression. We observed that with each standard increase in serum iron, the odds of developing rMDD decreased slightly. This implies that maintaining good iron levels could potentially play a role in mood regulation.
However, it's important to note that while we found some positive associations related to iron, our results didn't show a strong or definitive effect of iron or other micronutrients on depression overall. In fact, the study also raised concerns about the possibility of adverse effects from excessive selenium and magnesium levels, which warrants further investigation.
Overall, while iron might have some beneficial associations regarding depression, the evidence isn’t robust enough to recommend supplementation without considering the potential risks involved. Future studies should focus on larger-scale trials to provide clearer insights into the efficacy and safety of micronutrient treatments for depression.
Our findings suggest that there’s some weak evidence indicating that higher levels of serum iron might actually protect against the risk of experiencing major depression. We observed that with each standard increase in serum iron, the odds of developing rMDD decreased slightly. This implies that maintaining good iron levels could potentially play a role in mood regulation.
However, it's important to note that while we found some positive associations related to iron, our results didn't show a strong or definitive effect of iron or other micronutrients on depression overall. In fact, the study also raised concerns about the possibility of adverse effects from excessive selenium and magnesium levels, which warrants further investigation.
Overall, while iron might have some beneficial associations regarding depression, the evidence isn’t robust enough to recommend supplementation without considering the potential risks involved. Future studies should focus on larger-scale trials to provide clearer insights into the efficacy and safety of micronutrient treatments for depression.
7
Iron deficiency linked to depression
We examined how iron status relates to depressive symptoms in nonpregnant women aged 20-44 using the NHANES data from 2005-2010. Our findings showed that women with iron deficiency experienced higher rates of depressive symptoms compared to those with sufficient iron, particularly among low-income individuals.
However, while initial analyses hinted at a link, adjustments for confounders lessened these connections. This suggests that while there’s some association between iron deficiency and depressive symptoms, it's not as strong as initially thought.
However, while initial analyses hinted at a link, adjustments for confounders lessened these connections. This suggests that while there’s some association between iron deficiency and depressive symptoms, it's not as strong as initially thought.
8
We investigated how dietary iron intake affects depressive symptoms among adults using data from the National Health and Nutrition Examination Survey. Our analysis revealed that higher iron intake is linked to lower rates of depression.
Interestingly, we discovered that this relationship varies with body mass index (BMI). For individuals with a BMI under 25, the connection was U-shaped, indicating that too little or too much iron can impact mood.
However, it’s important to note that the study was cross-sectional and relied on self-reported data, making firm conclusions challenging.
Interestingly, we discovered that this relationship varies with body mass index (BMI). For individuals with a BMI under 25, the connection was U-shaped, indicating that too little or too much iron can impact mood.
However, it’s important to note that the study was cross-sectional and relied on self-reported data, making firm conclusions challenging.
References
- Huang S, Guo J, Jiang R, Ma K, Lin F, et al. Four-way decomposition of the effects of nutrient supplement and physical exercise on depression among older Chinese: a nationwide cross-sectional analysis. BMC Public Health. 2024;24:3469. doi:10.1186/s12889-024-20995-8
- Pobee RA, Setorglo J, Klevor M, Murray-Kolb LE. Associations between iron status and psychosocial wellbeing among pregnant women in Cape Coast, Ghana: a longitudinal study. Public Health Nutr. 2024. doi:10.1017/S1368980024002088
- Carnegie RE, Zheng J, Borges MC, Jones HJ, Wade KH, et al. Micronutrients and Major Depression: A Mendelian Randomisation Study. Nutrients. 2024;16. doi:10.3390/nu16213690
- Ouyang M, Cui J, Wang H, Liang Z, Pi D, et al. [ alleviates adriamycin-induced depression-like behaviors in mice by reducing ferroptosis in the prefrontal cortex]. Nan Fang Yi Ke Da Xue Xue Bao. 2024;44:1441. doi:10.12122/j.issn.1673-4254.2024.08.02
- Evanchuk JL, Kozyrskyj A, Vaghef-Mehrabani E, Lamers Y, Giesbrecht GF, et al. Maternal Iron and Vitamin D Status during the Second Trimester Is Associated with Third Trimester Depression Symptoms among Pregnant Participants in the APrON Cohort. J Nutr. 2024;154:174. doi:10.1016/j.tjnut.2023.10.029
- Ciulei MA, Ahluwalia N, McCormick BJJ, Teti DM, Murray-Kolb LE. Iron Deficiency is Related to Depressive Symptoms in United States Nonpregnant Women of Reproductive Age: A Cross-Sectional Analysis of NHANES 2005-2010. J Nutr. 2023;153:3521. doi:10.1016/j.tjnut.2023.09.023
- Zeng T, Li J, Xie L, Dong Z, Chen Q, et al. Nrf2 regulates iron-dependent hippocampal synapses and functional connectivity damage in depression. J Neuroinflammation. 2023;20:212. doi:10.1186/s12974-023-02875-x
- Tian S, Wu L, Zheng H, Zhong X, Yu X, et al. Body mass index modifies the relationship between dietary iron intake and depressive symptoms among adults: A national population-based cohort. J Affect Disord. 2023;340:907. doi:10.1016/j.jad.2023.08.105
- Jakary A, Lupo JM, Mackin S, Yin A, Murray D, et al. Evaluation of major depressive disorder using 7 Tesla phase sensitive neuroimaging before and after mindfulness-based cognitive therapy. J Affect Disord. 2023;335:383. doi:10.1016/j.jad.2023.05.038
