' 
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Iron (elemental) (from 90 mg Ferrous Bisglycinate)(Ferrochel™)
18 mg
100%
Top Medical Research Studies
8
Cardamonin aids in osteoporosis treatment
Cardamonin attenuates iron overload-induced osteoblast oxidative stress through the HIF-1α/ROS pathway.
Addresses iron's role in osteoporosis
We investigated how excess iron in the body affects osteoporosis and how a compound called Cardamonin could help combat this issue. The study involved creating a mouse model with iron overload and assessing the severity of osteoporosis using advanced imaging and staining techniques.
We focused on understanding the cellular effects of high iron levels on osteoblasts, the cells responsible for bone formation. We discovered that iron overload triggers oxidative stress in these cells, which can impede their function and lead to weaker bones. Our findings showed that Cardamonin can mitigate these adverse effects by reducing the buildup of reactive oxygen species (ROS) and promoting healthier bone formation.
Ultimately, we found that by targeting specific pathways related to oxidative stress, Cardamonin offers a promising therapeutic option for addressing osteoporosis exacerbated by iron overload. This research highlights the importance of maintaining proper iron balance for bone health.
We focused on understanding the cellular effects of high iron levels on osteoblasts, the cells responsible for bone formation. We discovered that iron overload triggers oxidative stress in these cells, which can impede their function and lead to weaker bones. Our findings showed that Cardamonin can mitigate these adverse effects by reducing the buildup of reactive oxygen species (ROS) and promoting healthier bone formation.
Ultimately, we found that by targeting specific pathways related to oxidative stress, Cardamonin offers a promising therapeutic option for addressing osteoporosis exacerbated by iron overload. This research highlights the importance of maintaining proper iron balance for bone health.
Read More
9
Zuogui Pills mitigate osteoporosis effects
Zuogui Pills alleviate iron overload-induced osteoporosis by attenuating ROS-mediated osteoblast apoptosis via the PI3K-AKT pathway and mitigating mitochondrial damage.
Study on iron and osteoporosis
We investigated the interplay between iron overload and osteoporosis, specifically focusing on how Zuogui Pills (ZGP) might help alleviate this condition. Using both in vivo and in vitro models, we looked at the effects of ZGP on bone health when faced with excess iron, which can lead to oxidative stress and increased bone loss.
Through various experimental methods, including advanced imaging and staining techniques, we found that ZGP exhibits significant antioxidant and anti-apoptotic properties, primarily through pathways that reduce oxidative stress and support bone cell health. The activities of ZGP appear to bolster bone strength by promoting osteoblast functions while limiting their programmed cell death, a common issue in conditions associated with iron overload.
Our findings suggest that employing ZGP might be a promising approach for addressing osteoporosis associated with iron overload. By enhancing bone density and overall health, ZGP could represent a valuable strategy for those grappling with this often-overlooked aspect of osteoporosis.
Through various experimental methods, including advanced imaging and staining techniques, we found that ZGP exhibits significant antioxidant and anti-apoptotic properties, primarily through pathways that reduce oxidative stress and support bone cell health. The activities of ZGP appear to bolster bone strength by promoting osteoblast functions while limiting their programmed cell death, a common issue in conditions associated with iron overload.
Our findings suggest that employing ZGP might be a promising approach for addressing osteoporosis associated with iron overload. By enhancing bone density and overall health, ZGP could represent a valuable strategy for those grappling with this often-overlooked aspect of osteoporosis.
Read More
8
Innovative treatment for osteoporosis
Europium-Containing Nanospheres for Treating Ovariectomy-Induced Osteoporosis: Targeted Bone Remodeling and Macrophage Polarization Modulation.
Moderately relevant new findings
We investigated the effectiveness of iron-rich nanoparticles, specifically designed to tackle osteoporosis, a condition marked by weakened bones. Our approach utilized superparamagnetic iron oxide nanoparticles embedded with europium ions, created to enhance treatment. These nanoparticles, called SPIO:Eu@PLGA, were engineered to selectively influence immune cells, possibly leading to improved bone health.
In our research, we employed a model using ovariectomized rats, a common approach for studying osteoporosis. We aimed to understand how our nanospheres could not only modify macrophage behavior but also encourage bone-forming cells while inhibiting those that break down bone. Our findings indicated that the combination of europium with iron could uniquely harness the biological responses needed to combat osteoporosis effectively.
Overall, the inclusion of europium in iron nanoparticles presents a promising avenue for osteoporosis therapy, pushing beyond traditional treatments that often have limitations. By targeting specific pathways in bone remodeling, we believe this novel approach offers hope for improved outcomes in osteoporosis care.
In our research, we employed a model using ovariectomized rats, a common approach for studying osteoporosis. We aimed to understand how our nanospheres could not only modify macrophage behavior but also encourage bone-forming cells while inhibiting those that break down bone. Our findings indicated that the combination of europium with iron could uniquely harness the biological responses needed to combat osteoporosis effectively.
Overall, the inclusion of europium in iron nanoparticles presents a promising avenue for osteoporosis therapy, pushing beyond traditional treatments that often have limitations. By targeting specific pathways in bone remodeling, we believe this novel approach offers hope for improved outcomes in osteoporosis care.
Read More
Most Useful Reviews
8.8
Optimises bone health
The product is well packaged and cost-effective. It aids in optimising bone health and electrolyte balance while helping to reduce osteoporosis.
Read More
8
Prevents deterioration
I take it for iron supplementation as a preventive measure against osteoporosis and anaemia. Without intervention, it could worsen.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8
- All Researches
9
Zuogui Pills mitigate osteoporosis effects
Zuogui Pills alleviate iron overload-induced osteoporosis by attenuating ROS-mediated osteoblast apoptosis via the PI3K-AKT pathway and mitigating mitochondrial damage.
Study on iron and osteoporosis
We investigated the interplay between iron overload and osteoporosis, specifically focusing on how Zuogui Pills (ZGP) might help alleviate this condition. Using both in vivo and in vitro models, we looked at the effects of ZGP on bone health when faced with excess iron, which can lead to oxidative stress and increased bone loss.
Through various experimental methods, including advanced imaging and staining techniques, we found that ZGP exhibits significant antioxidant and anti-apoptotic properties, primarily through pathways that reduce oxidative stress and support bone cell health. The activities of ZGP appear to bolster bone strength by promoting osteoblast functions while limiting their programmed cell death, a common issue in conditions associated with iron overload.
Our findings suggest that employing ZGP might be a promising approach for addressing osteoporosis associated with iron overload. By enhancing bone density and overall health, ZGP could represent a valuable strategy for those grappling with this often-overlooked aspect of osteoporosis.
Through various experimental methods, including advanced imaging and staining techniques, we found that ZGP exhibits significant antioxidant and anti-apoptotic properties, primarily through pathways that reduce oxidative stress and support bone cell health. The activities of ZGP appear to bolster bone strength by promoting osteoblast functions while limiting their programmed cell death, a common issue in conditions associated with iron overload.
Our findings suggest that employing ZGP might be a promising approach for addressing osteoporosis associated with iron overload. By enhancing bone density and overall health, ZGP could represent a valuable strategy for those grappling with this often-overlooked aspect of osteoporosis.
Read More
8
Magnetic fields improve bone health
A 0.2 T-0.4 T Static Magnetic Field Improves the Bone Quality of Mice Subjected to Hindlimb Unloading and Reloading Through the Dual Regulation of BMSCs via Iron Metabolism.
Study evaluated iron's indirect role
We investigated the impact of static magnetic fields on bone health, specifically looking at how they might affect osteoporosis, a condition related to fragile bones. In this study, mice were subjected to hindlimb unloading to simulate the osteoporosis that can occur in bedridden patients or astronauts. After a recovery phase involving exposure to a magnetic field, we examined changes in bone quality and iron metabolism.
Our findings revealed that exposure to a 0.2 T-0.4 T static magnetic field improved mechanical properties of bones and altered the balance of bone-forming and fat cells in the marrow. Interestingly, we observed that while the magnetic field treatment did influence iron and calcium levels in the tibia, the study did not isolate iron treatment alone as a factor.
Instead, it highlighted the complex interplay of magnetic fields in enhancing bone metabolism and influencing stem cells, leading to improved bone quality. Overall, this research points toward promising directions for non-invasive treatments for osteoporosis, especially for specific vulnerable groups like elderly patients or those on long space missions.
Our findings revealed that exposure to a 0.2 T-0.4 T static magnetic field improved mechanical properties of bones and altered the balance of bone-forming and fat cells in the marrow. Interestingly, we observed that while the magnetic field treatment did influence iron and calcium levels in the tibia, the study did not isolate iron treatment alone as a factor.
Instead, it highlighted the complex interplay of magnetic fields in enhancing bone metabolism and influencing stem cells, leading to improved bone quality. Overall, this research points toward promising directions for non-invasive treatments for osteoporosis, especially for specific vulnerable groups like elderly patients or those on long space missions.
Read More
8
Innovative treatment for osteoporosis
Europium-Containing Nanospheres for Treating Ovariectomy-Induced Osteoporosis: Targeted Bone Remodeling and Macrophage Polarization Modulation.
Moderately relevant new findings
We investigated the effectiveness of iron-rich nanoparticles, specifically designed to tackle osteoporosis, a condition marked by weakened bones. Our approach utilized superparamagnetic iron oxide nanoparticles embedded with europium ions, created to enhance treatment. These nanoparticles, called SPIO:Eu@PLGA, were engineered to selectively influence immune cells, possibly leading to improved bone health.
In our research, we employed a model using ovariectomized rats, a common approach for studying osteoporosis. We aimed to understand how our nanospheres could not only modify macrophage behavior but also encourage bone-forming cells while inhibiting those that break down bone. Our findings indicated that the combination of europium with iron could uniquely harness the biological responses needed to combat osteoporosis effectively.
Overall, the inclusion of europium in iron nanoparticles presents a promising avenue for osteoporosis therapy, pushing beyond traditional treatments that often have limitations. By targeting specific pathways in bone remodeling, we believe this novel approach offers hope for improved outcomes in osteoporosis care.
In our research, we employed a model using ovariectomized rats, a common approach for studying osteoporosis. We aimed to understand how our nanospheres could not only modify macrophage behavior but also encourage bone-forming cells while inhibiting those that break down bone. Our findings indicated that the combination of europium with iron could uniquely harness the biological responses needed to combat osteoporosis effectively.
Overall, the inclusion of europium in iron nanoparticles presents a promising avenue for osteoporosis therapy, pushing beyond traditional treatments that often have limitations. By targeting specific pathways in bone remodeling, we believe this novel approach offers hope for improved outcomes in osteoporosis care.
Read More
8
Cardamonin aids in osteoporosis treatment
Cardamonin attenuates iron overload-induced osteoblast oxidative stress through the HIF-1α/ROS pathway.
Addresses iron's role in osteoporosis
We investigated how excess iron in the body affects osteoporosis and how a compound called Cardamonin could help combat this issue. The study involved creating a mouse model with iron overload and assessing the severity of osteoporosis using advanced imaging and staining techniques.
We focused on understanding the cellular effects of high iron levels on osteoblasts, the cells responsible for bone formation. We discovered that iron overload triggers oxidative stress in these cells, which can impede their function and lead to weaker bones. Our findings showed that Cardamonin can mitigate these adverse effects by reducing the buildup of reactive oxygen species (ROS) and promoting healthier bone formation.
Ultimately, we found that by targeting specific pathways related to oxidative stress, Cardamonin offers a promising therapeutic option for addressing osteoporosis exacerbated by iron overload. This research highlights the importance of maintaining proper iron balance for bone health.
We focused on understanding the cellular effects of high iron levels on osteoblasts, the cells responsible for bone formation. We discovered that iron overload triggers oxidative stress in these cells, which can impede their function and lead to weaker bones. Our findings showed that Cardamonin can mitigate these adverse effects by reducing the buildup of reactive oxygen species (ROS) and promoting healthier bone formation.
Ultimately, we found that by targeting specific pathways related to oxidative stress, Cardamonin offers a promising therapeutic option for addressing osteoporosis exacerbated by iron overload. This research highlights the importance of maintaining proper iron balance for bone health.
Read More
7
Iron nanoparticles linked to osteoporosis
Superparamagnetic Iron Oxide Nanoparticle Implantation and Magnetic Field Exposure Modulate Bone Microarchitecture Following Spinal Cord Injury in Adult Male Rats.
Uses iron with magnetic field intervention
We investigated the impact of iron oxide nanoparticles on osteoporosis caused by spinal cord injury (SCI). In our study, we observed that rats were divided into different groups to compare the effects of these nanoparticles, magnetic field exposure, and a control treatment.
Our findings revealed that after one week of treatment, the group receiving both iron nanoparticles and magnetic field exposure showed a notable improvement in bone structure, specifically an increase in trabecular thickness. Meanwhile, the group treated only with the magnetic field also experienced significant benefits.
However, all groups demonstrated some level of bone loss when compared to healthy controls, except for the group exposed to magnetic field treatment. This suggests that while iron treatment has potential benefits, the addition of magnetic field exposure enhanced these positive outcomes.
Overall, we highlighted the importance of combining therapies to best support bone health after SCI, as iron alone did not completely prevent bone loss. Our research underscores the potential for future studies to refine these methods for better patient care.
Our findings revealed that after one week of treatment, the group receiving both iron nanoparticles and magnetic field exposure showed a notable improvement in bone structure, specifically an increase in trabecular thickness. Meanwhile, the group treated only with the magnetic field also experienced significant benefits.
However, all groups demonstrated some level of bone loss when compared to healthy controls, except for the group exposed to magnetic field treatment. This suggests that while iron treatment has potential benefits, the addition of magnetic field exposure enhanced these positive outcomes.
Overall, we highlighted the importance of combining therapies to best support bone health after SCI, as iron alone did not completely prevent bone loss. Our research underscores the potential for future studies to refine these methods for better patient care.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Optimises bone health
The product is well packaged and cost-effective. It aids in optimising bone health and electrolyte balance while helping to reduce osteoporosis.
8
Prevents deterioration
I take it for iron supplementation as a preventive measure against osteoporosis and anaemia. Without intervention, it could worsen.
