Overview
SCIENTIFIC SCORE
Questionable
Based on 10 Researches
5
USERS' SCORE
Good
Based on 16 Reviews
8.3
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
L-Carnosine (B-alanyl-L-histidine)
500 mg
*
Top Medical Research Studies
2
We systematically reviewed studies to understand how L-Carnosine might help children with autism spectrum disorders (ASD). Our focus was on randomized controlled trials, which are the gold standard in research, ensuring that results are reliable.
The research included four double-blinded, placebo-controlled trials and one open-label trial, totaling 215 participants. We assessed the effectiveness of L-Carnosine in improving social, communication, and behavioral skills, as well as addressing sleep disorders and gastrointestinal issues. While we hoped to find promising results, the meta-analysis revealed no significant improvements when comparing L-Carnosine to placebo.
Specifically, measures like the Gilliam Autism Rating Scale and the Childhood Autism Rating Scale showed no notable differences between the two groups. Current evidence does not support the use of L-Carnosine as an effective treatment for ASD in children, highlighting the need for further research and a larger array of studies in this area.
The research included four double-blinded, placebo-controlled trials and one open-label trial, totaling 215 participants. We assessed the effectiveness of L-Carnosine in improving social, communication, and behavioral skills, as well as addressing sleep disorders and gastrointestinal issues. While we hoped to find promising results, the meta-analysis revealed no significant improvements when comparing L-Carnosine to placebo.
Specifically, measures like the Gilliam Autism Rating Scale and the Childhood Autism Rating Scale showed no notable differences between the two groups. Current evidence does not support the use of L-Carnosine as an effective treatment for ASD in children, highlighting the need for further research and a larger array of studies in this area.
Read More
1
Carnosine shows no significant effects
We conducted a randomized, double-blind, placebo-controlled clinical trial to investigate whether l-carnosine supplementation could affect autism. The study included 36 autistic children, split evenly between a carnosine group and a placebo group. For two months, one group received a daily dose of 500 mg of carnosine, while the other group took a placebo.
Our findings revealed that l-carnosine supplementation did not lead to any significant changes in the plasma concentrations of advanced glycation end products or precursors of advanced lipoxidation end products. These markers are often linked to oxidative stress, which is known to be elevated in individuals with autism. It was interesting to note that about 63.9% of the children had a normal nutritional status despite the oxidative stress concerns.
Overall, we concluded that l-carnosine supplementation does not appear to influence the levels of these markers in autistic children. This suggests that more research is needed to explore effective treatments for oxidative stress in autism and to understand the condition better.
Our findings revealed that l-carnosine supplementation did not lead to any significant changes in the plasma concentrations of advanced glycation end products or precursors of advanced lipoxidation end products. These markers are often linked to oxidative stress, which is known to be elevated in individuals with autism. It was interesting to note that about 63.9% of the children had a normal nutritional status despite the oxidative stress concerns.
Overall, we concluded that l-carnosine supplementation does not appear to influence the levels of these markers in autistic children. This suggests that more research is needed to explore effective treatments for oxidative stress in autism and to understand the condition better.
Read More
8
We assessed the impact of L-carnosine on anxiety behaviors in a specific mouse model of autism spectrum disorder (ASD). This study focused on CD157 knockout (KO) mice, which exhibit characteristics relevant to autism.
Interestingly, we observed that oral supplementation of L-carnosine effectively reduced the release of corticosterone, a stress hormone, in response to acute stress situations. This hormone is essential in understanding stress-related disorders, including anxiety.
Furthermore, our findings highlight that L-carnosine appears to alleviate anxiety-like behaviors in these mice. This suggests that by regulating stress responses, L-carnosine could potentially serve as a beneficial supplement for individuals with ASD experiencing anxiety.
Interestingly, we observed that oral supplementation of L-carnosine effectively reduced the release of corticosterone, a stress hormone, in response to acute stress situations. This hormone is essential in understanding stress-related disorders, including anxiety.
Furthermore, our findings highlight that L-carnosine appears to alleviate anxiety-like behaviors in these mice. This suggests that by regulating stress responses, L-carnosine could potentially serve as a beneficial supplement for individuals with ASD experiencing anxiety.
Read More
Most Useful Reviews
9
Great behaviour control
53 people found this helpful
I deemed this supplement worthwhile after some research. I have two sons; one with autism. This supplement has markedly increased my son's therapy reports and improved his control over behaviour and emotions. Additionally, my seven-year-old has now consistently slept through the night for three weeks.
Read More
9
Significant improvements noted
36 people found this helpful
This supplement is excellent for addressing brain dysfunction, and we observed commendable results in my nephew with autism, particularly when combined with lipoic acid and DHA. Improvement was noticeable within a few days, and we plan to continue using it to support cognitive function and prevent Alzheimer's.
Read More
7.5
Helps overall development
11 people found this helpful
My son has autism, and this supplement, one of 22, has positively impacted his behaviour, cognitive skills, comprehension, and social abilities.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 10 Researches
5
- All Researches
8
We assessed the impact of L-carnosine on anxiety behaviors in a specific mouse model of autism spectrum disorder (ASD). This study focused on CD157 knockout (KO) mice, which exhibit characteristics relevant to autism.
Interestingly, we observed that oral supplementation of L-carnosine effectively reduced the release of corticosterone, a stress hormone, in response to acute stress situations. This hormone is essential in understanding stress-related disorders, including anxiety.
Furthermore, our findings highlight that L-carnosine appears to alleviate anxiety-like behaviors in these mice. This suggests that by regulating stress responses, L-carnosine could potentially serve as a beneficial supplement for individuals with ASD experiencing anxiety.
Interestingly, we observed that oral supplementation of L-carnosine effectively reduced the release of corticosterone, a stress hormone, in response to acute stress situations. This hormone is essential in understanding stress-related disorders, including anxiety.
Furthermore, our findings highlight that L-carnosine appears to alleviate anxiety-like behaviors in these mice. This suggests that by regulating stress responses, L-carnosine could potentially serve as a beneficial supplement for individuals with ASD experiencing anxiety.
Read More
8
We examined the effects of L-carnosine, a dietary supplement, on social deficits in CD157KO mice, which model some behaviors seen in autism spectrum disorder (ASD). In tests designed to measure social behavior, we found that oral supplementation with L-carnosine helped reduce these social deficits.
Interestingly, after the treatment, there was an increase in specific neurons related to oxytocin production in the brain, particularly in areas linked to social behavior. Although L-carnosine didn’t change the overall levels of oxytocin and its receptors in one part of the brain, it did increase oxytocin concentrations in the cerebrospinal fluid of the mice.
These findings suggest that L-carnosine supplementation might help enhance social recognition by boosting oxytocin levels. This aligns with the ongoing search for safe nutritional interventions to assist individuals with autism in our society.
Interestingly, after the treatment, there was an increase in specific neurons related to oxytocin production in the brain, particularly in areas linked to social behavior. Although L-carnosine didn’t change the overall levels of oxytocin and its receptors in one part of the brain, it did increase oxytocin concentrations in the cerebrospinal fluid of the mice.
These findings suggest that L-carnosine supplementation might help enhance social recognition by boosting oxytocin levels. This aligns with the ongoing search for safe nutritional interventions to assist individuals with autism in our society.
Read More
8
We investigated how l-carnosine might help counteract the neurotoxic effects of propionic acid (PA), a substance linked to autism. Our study employed a controlled design, where we compared various groups of Syrian hamsters, including those treated with PA, clindamycin-induced PA, and those given carnosine and carnitine as potential protective supplements.
During the experiment, we monitored levels of important neurotransmitters like dopamine and GABA in several parts of the brain. We observed promising results showing that both carnosine and carnitine could reduce the negative impacts of PA on the brain. While these findings are encouraging, it's crucial to note that we did not test l-carnosine’s direct effects specifically in treating autism, nor did we find evidence that linked it to improvements in autistic behaviors.
During the experiment, we monitored levels of important neurotransmitters like dopamine and GABA in several parts of the brain. We observed promising results showing that both carnosine and carnitine could reduce the negative impacts of PA on the brain. While these findings are encouraging, it's crucial to note that we did not test l-carnosine’s direct effects specifically in treating autism, nor did we find evidence that linked it to improvements in autistic behaviors.
Read More
8
l-Carnosine benefits autistic behavior
We observed a growing interest in l-carnosine as a potential treatment for autism, focusing on how it might alleviate some of the symptoms associated with this condition. Through double-blind, placebo-controlled trials, researchers investigated the effects of this antioxidant on autistic behavior.
The promising aspect of these studies is that they highlighted significant improvements in behavior when participants took l-carnosine. Additionally, indirect markers of oxidative stress, which appear to be higher in individuals with autism, were addressed. The idea is that by reducing oxidative stress in the body, l-carnosine may help support brain function and overall well-being.
However, while the results point towards benefits, more research is needed to fully understand how effective l-carnosine can be in the long term and across different individuals. Overall, our exploration into this antioxidant's role in treating autism is an exciting step towards finding new avenues for support and intervention.
The promising aspect of these studies is that they highlighted significant improvements in behavior when participants took l-carnosine. Additionally, indirect markers of oxidative stress, which appear to be higher in individuals with autism, were addressed. The idea is that by reducing oxidative stress in the body, l-carnosine may help support brain function and overall well-being.
However, while the results point towards benefits, more research is needed to fully understand how effective l-carnosine can be in the long term and across different individuals. Overall, our exploration into this antioxidant's role in treating autism is an exciting step towards finding new avenues for support and intervention.
Read More
5
We conducted a double-blind, randomized clinical trial to investigate how l-carnosine supplementation affects sleep disorders and the severity of autism in children. Our study involved 43 autistic participants, aged between 4 and 16 years, who were divided into two groups—one receiving 500 mg of l-carnosine daily and the other receiving a placebo for two months.
While we found that l-carnosine supplementation did not significantly change the overall severity of autism symptoms or anthropometric measures, it did lead to some interesting results regarding sleep. Specifically, we observed a notable reduction in sleep duration and parasomnias, as well as a decrease in the total sleep disorder score among those receiving l-carnosine compared to the control group.
These findings suggest that l-carnosine may be beneficial for improving certain sleep disturbances common in autistic children. However, it is important to note that while we saw improvements in sleep-related issues, the core symptoms of autism remained unaffected.
While we found that l-carnosine supplementation did not significantly change the overall severity of autism symptoms or anthropometric measures, it did lead to some interesting results regarding sleep. Specifically, we observed a notable reduction in sleep duration and parasomnias, as well as a decrease in the total sleep disorder score among those receiving l-carnosine compared to the control group.
These findings suggest that l-carnosine may be beneficial for improving certain sleep disturbances common in autistic children. However, it is important to note that while we saw improvements in sleep-related issues, the core symptoms of autism remained unaffected.
Read More
User Reviews
USERS' SCORE
Good
Based on 16 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Great behaviour control
53 people found this helpful
I deemed this supplement worthwhile after some research. I have two sons; one with autism. This supplement has markedly increased my son's therapy reports and improved his control over behaviour and emotions. Additionally, my seven-year-old has now consistently slept through the night for three weeks.
Read More
9
Significant improvements noted
36 people found this helpful
This supplement is excellent for addressing brain dysfunction, and we observed commendable results in my nephew with autism, particularly when combined with lipoic acid and DHA. Improvement was noticeable within a few days, and we plan to continue using it to support cognitive function and prevent Alzheimer's.
Read More
7.5
Helps overall development
11 people found this helpful
My son has autism, and this supplement, one of 22, has positively impacted his behaviour, cognitive skills, comprehension, and social abilities.
Read More
7.5
Increases sociability
This supplement is essential for my family. My son has been taking it for years, and ever since, he has become more talkative. He has mild autism and rarely speaks, so this has truly helped.
Read More
7.5
Improved communication
Helps with language development for autism.
Read More
Frequently Asked Questions
9
Significant improvements noted
36 people found this helpful
This supplement is excellent for addressing brain dysfunction, and we observed commendable results in my nephew with autism, particularly when combined with lipoic acid and DHA. Improvement was noticeable within a few days, and we plan to continue using it to support cognitive function and prevent Alzheimer's.
9
Improved sleep quality
52 people found this helpful
I read a study indicating that this medication aids with sleep disturbances and fosters speech development in children with autism. After several courses, I've noticed positive changes: my child's sleep issues have vanished, and their speech has progressed. We started with a half-capsule dosage, which can be diluted if necessary. The results have been encouraging for others who tried it as well, and I rely solely on scientific support. It seems beneficial for children aged 4 to 5 years.
6
Slight language improvement
In children with autism, this treatment aims to enhance language response, showing a slight effect, awaiting longer-term observation.
7.5
Increases sociability
This supplement is essential for my family. My son has been taking it for years, and ever since, he has become more talkative. He has mild autism and rarely speaks, so this has truly helped.
7.5
Helps overall development
11 people found this helpful
My son has autism, and this supplement, one of 22, has positively impacted his behaviour, cognitive skills, comprehension, and social abilities.
7.5
Enhanced mental state
7 people found this helpful
L-carnosine is beneficial for muscle performance and recovery and improves the mental state and behaviour of children with autism and those with attention deficit disorder. It protects against cognitive decline associated with aging and rejuvenates the skin and body. The capsules are tasteless and odourless, making them easy to take.
8
We assessed the impact of L-carnosine on anxiety behaviors in a specific mouse model of autism spectrum disorder (ASD). This study focused on CD157 knockout (KO) mice, which exhibit characteristics relevant to autism.
Interestingly, we observed that oral supplementation of L-carnosine effectively reduced the release of corticosterone, a stress hormone, in response to acute stress situations. This hormone is essential in understanding stress-related disorders, including anxiety.
Furthermore, our findings highlight that L-carnosine appears to alleviate anxiety-like behaviors in these mice. This suggests that by regulating stress responses, L-carnosine could potentially serve as a beneficial supplement for individuals with ASD experiencing anxiety.
Interestingly, we observed that oral supplementation of L-carnosine effectively reduced the release of corticosterone, a stress hormone, in response to acute stress situations. This hormone is essential in understanding stress-related disorders, including anxiety.
Furthermore, our findings highlight that L-carnosine appears to alleviate anxiety-like behaviors in these mice. This suggests that by regulating stress responses, L-carnosine could potentially serve as a beneficial supplement for individuals with ASD experiencing anxiety.
8
We examined the effects of L-carnosine, a dietary supplement, on social deficits in CD157KO mice, which model some behaviors seen in autism spectrum disorder (ASD). In tests designed to measure social behavior, we found that oral supplementation with L-carnosine helped reduce these social deficits.
Interestingly, after the treatment, there was an increase in specific neurons related to oxytocin production in the brain, particularly in areas linked to social behavior. Although L-carnosine didn’t change the overall levels of oxytocin and its receptors in one part of the brain, it did increase oxytocin concentrations in the cerebrospinal fluid of the mice.
These findings suggest that L-carnosine supplementation might help enhance social recognition by boosting oxytocin levels. This aligns with the ongoing search for safe nutritional interventions to assist individuals with autism in our society.
Interestingly, after the treatment, there was an increase in specific neurons related to oxytocin production in the brain, particularly in areas linked to social behavior. Although L-carnosine didn’t change the overall levels of oxytocin and its receptors in one part of the brain, it did increase oxytocin concentrations in the cerebrospinal fluid of the mice.
These findings suggest that L-carnosine supplementation might help enhance social recognition by boosting oxytocin levels. This aligns with the ongoing search for safe nutritional interventions to assist individuals with autism in our society.
2
We systematically reviewed studies to understand how L-Carnosine might help children with autism spectrum disorders (ASD). Our focus was on randomized controlled trials, which are the gold standard in research, ensuring that results are reliable.
The research included four double-blinded, placebo-controlled trials and one open-label trial, totaling 215 participants. We assessed the effectiveness of L-Carnosine in improving social, communication, and behavioral skills, as well as addressing sleep disorders and gastrointestinal issues. While we hoped to find promising results, the meta-analysis revealed no significant improvements when comparing L-Carnosine to placebo.
Specifically, measures like the Gilliam Autism Rating Scale and the Childhood Autism Rating Scale showed no notable differences between the two groups. Current evidence does not support the use of L-Carnosine as an effective treatment for ASD in children, highlighting the need for further research and a larger array of studies in this area.
The research included four double-blinded, placebo-controlled trials and one open-label trial, totaling 215 participants. We assessed the effectiveness of L-Carnosine in improving social, communication, and behavioral skills, as well as addressing sleep disorders and gastrointestinal issues. While we hoped to find promising results, the meta-analysis revealed no significant improvements when comparing L-Carnosine to placebo.
Specifically, measures like the Gilliam Autism Rating Scale and the Childhood Autism Rating Scale showed no notable differences between the two groups. Current evidence does not support the use of L-Carnosine as an effective treatment for ASD in children, highlighting the need for further research and a larger array of studies in this area.
5
We conducted a double-blind, randomized clinical trial to investigate how l-carnosine supplementation affects sleep disorders and the severity of autism in children. Our study involved 43 autistic participants, aged between 4 and 16 years, who were divided into two groups—one receiving 500 mg of l-carnosine daily and the other receiving a placebo for two months.
While we found that l-carnosine supplementation did not significantly change the overall severity of autism symptoms or anthropometric measures, it did lead to some interesting results regarding sleep. Specifically, we observed a notable reduction in sleep duration and parasomnias, as well as a decrease in the total sleep disorder score among those receiving l-carnosine compared to the control group.
These findings suggest that l-carnosine may be beneficial for improving certain sleep disturbances common in autistic children. However, it is important to note that while we saw improvements in sleep-related issues, the core symptoms of autism remained unaffected.
While we found that l-carnosine supplementation did not significantly change the overall severity of autism symptoms or anthropometric measures, it did lead to some interesting results regarding sleep. Specifically, we observed a notable reduction in sleep duration and parasomnias, as well as a decrease in the total sleep disorder score among those receiving l-carnosine compared to the control group.
These findings suggest that l-carnosine may be beneficial for improving certain sleep disturbances common in autistic children. However, it is important to note that while we saw improvements in sleep-related issues, the core symptoms of autism remained unaffected.
4
l-Carnosine shows limited autism benefits
We conducted a comprehensive study to explore how l-carnosine, when added to the medication risperidone, might help manage symptoms in children diagnosed with autism spectrum disorder (ASD).
Over a span of 10 weeks, seventy drug-free children aged 4 to 12 participated in our randomized, double-blind, placebo-controlled trial. Aimed at assessing l-carnosine's effectiveness, we measured changes in the children's irritability and other behavior symptoms using the Aberrant Behavior Checklist-Community (ABC-C).
While our findings did not reveal a significant improvement in the irritability scores, we did observe that l-carnosine was associated with notable enhancements in the hyperactivity and noncompliance subscales when compared to the placebo group. This suggests that while l-carnosine may not significantly reduce irritability, it could help with managing hyperactive and noncompliant behaviors in children with autism.
It is important to note that no differences were found between the two groups regarding extrapyramidal symptoms or other side effects, meaning that l-carnosine appears to be well-tolerated. Despite its potential for improving certain behaviors, the lack of significant change in irritability highlights that further research is needed to fully understand its effects in autism treatment.
Over a span of 10 weeks, seventy drug-free children aged 4 to 12 participated in our randomized, double-blind, placebo-controlled trial. Aimed at assessing l-carnosine's effectiveness, we measured changes in the children's irritability and other behavior symptoms using the Aberrant Behavior Checklist-Community (ABC-C).
While our findings did not reveal a significant improvement in the irritability scores, we did observe that l-carnosine was associated with notable enhancements in the hyperactivity and noncompliance subscales when compared to the placebo group. This suggests that while l-carnosine may not significantly reduce irritability, it could help with managing hyperactive and noncompliant behaviors in children with autism.
It is important to note that no differences were found between the two groups regarding extrapyramidal symptoms or other side effects, meaning that l-carnosine appears to be well-tolerated. Despite its potential for improving certain behaviors, the lack of significant change in irritability highlights that further research is needed to fully understand its effects in autism treatment.
References
- Tsuji T, Furuhara K, Guo E, Wu Y, Zhong J, et al. Oral Supplementation of L-Carnosine Attenuates Acute-Stress-Induced Corticosterone Release and Mitigates Anxiety in CD157 Knockout Mice. Nutrients. 2024;16. doi:10.3390/nu16172821
- Tsuji T, Furuhara K, Gerasimenko M, Shabalova A, Cherepanov SM, et al. Oral Supplementation with L-Carnosine Attenuates Social Recognition Deficits in CD157KO Mice via Oxytocin Release. Nutrients. 2022;14. doi:10.3390/nu14040803
- Raghavan K, Dedeepiya VD, Ikewaki N, Sonoda T, Iwasaki M, et al. Improvement of behavioural pattern and alpha-synuclein levels in autism spectrum disorder after consumption of a beta-glucan food supplement in a randomised, parallel-group pilot clinical study. BMJ Neurol Open. 2022;4:e000203. doi:10.1136/bmjno-2021-000203
- Abraham DA, Undela K, Narasimhan U, Rajanandh MG. Effect of L-Carnosine in children with autism spectrum disorders: a systematic review and meta-analysis of randomised controlled trials. Amino Acids. 2021;53:575. doi:10.1007/s00726-021-02960-6
- Ann Abraham D, Narasimhan U, Christy S, Muhasaparur Ganesan R. Effect of L-Carnosine as adjunctive therapy in the management of children with autism spectrum disorder: a randomized controlled study. Amino Acids. 2020;52:1521. doi:10.1007/s00726-020-02909-1
- Ghodsi R, Kheirouri S, Nosrati R. Carnosine supplementation does not affect serum concentrations of advanced glycation and precursors of lipoxidation end products in autism: a randomized controlled clinical trial. Ann Clin Biochem. 2019;56:148. doi:10.1177/0004563218796860
- Mehrazad-Saber Z, Kheirouri S, Noorazar SG. Effects of l-Carnosine Supplementation on Sleep Disorders and Disease Severity in Autistic Children: A Randomized, Controlled Clinical Trial. Basic Clin Pharmacol Toxicol. 2018;123:72. doi:10.1111/bcpt.12979
- Hajizadeh-Zaker R, Ghajar A, Mesgarpour B, Afarideh M, Mohammadi MR, et al. l-Carnosine As an Adjunctive Therapy to Risperidone in Children with Autistic Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial. J Child Adolesc Psychopharmacol. 2018;28:74. doi:10.1089/cap.2017.0026
- El-Ansary A, Shaker G, Siddiqi NJ, Al-Ayadhi LY. Possible ameliorative effects of antioxidants on propionic acid / clindamycin - induced neurotoxicity in Syrian hamsters. Gut Pathog. 2013;5:32. doi:10.1186/1757-4749-5-32
- McGinnis WR. Oxidative stress in autism. Altern Ther Health Med. 2004;10:22.
