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SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.5
USERS' SCORE
Good
Based on 13 Reviews
8.7
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
L-Carnosine (B-alanyl-L-histidine)
500 mg
*
Top Medical Research Studies
2
Carnosine shows no effectiveness
The Effect of Carnosine Supplementation on Musculoskeletal Health in Adults with Prediabetes and Type 2 Diabetes: A Secondary Analysis of a Randomized Controlled Trial.
Highly relevant to diabetes research
We investigated the effects of l-carnosine supplementation on musculoskeletal health in adults with prediabetes and type 2 diabetes (T2D). In a well-structured clinical trial, 49 participants, all without pre-existing musculoskeletal issues, were divided into two groups. One group received 2 grams of l-carnosine daily for 14 weeks, while the other was given a placebo.
After completing the study, we found that carnosine supplementation did not lead to any significant improvements. There were no notable changes in muscle strength or body composition between those taking l-carnosine and those on the placebo. Specifically, metrics such as hand grip strength, lean mass, fat percentage, and bone health markers showed no benefits from the supplement.
Our findings suggest that l-carnosine might not be a helpful strategy for enhancing musculoskeletal health in individuals with prediabetes and T2D. While our study was comprehensive, further research with larger participant numbers and longer durations would ultimately be needed to confirm these results.
After completing the study, we found that carnosine supplementation did not lead to any significant improvements. There were no notable changes in muscle strength or body composition between those taking l-carnosine and those on the placebo. Specifically, metrics such as hand grip strength, lean mass, fat percentage, and bone health markers showed no benefits from the supplement.
Our findings suggest that l-carnosine might not be a helpful strategy for enhancing musculoskeletal health in individuals with prediabetes and T2D. While our study was comprehensive, further research with larger participant numbers and longer durations would ultimately be needed to confirm these results.
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0
Carnosine ineffective for diabetes outcomes
Carnosine Did Not Affect Vascular and Metabolic Outcomes in Patients with Prediabetes and Type 2 Diabetes: A 14-Week Randomized Controlled Trial.
High relevance to diabetes treatment
We conducted a thorough investigation into the effects of l-carnosine treatment on individuals with prediabetes and type 2 diabetes mellitus (T2DM). Our research involved a 14-week double-blind randomized controlled trial where participants, numbering 49 in total, were assigned to either receive a daily dose of 2 grams of carnosine or a matching placebo.
Throughout the study, we closely monitored various health indicators such as blood pressure, heart rate, endothelial function, arterial stiffness, and liver and kidney function. To our disappointment, we found that carnosine supplementation did not lead to any significant improvements in these cardiovascular and metabolic markers compared to the placebo group.
In conclusion, our findings suggest that l-carnosine is unlikely to be an effective strategy for reducing cardiovascular disease risk in those with prediabetes and T2DM who maintain good glycemic control. Such insights underscore the need for continued research into other potential therapies for these populations.
Throughout the study, we closely monitored various health indicators such as blood pressure, heart rate, endothelial function, arterial stiffness, and liver and kidney function. To our disappointment, we found that carnosine supplementation did not lead to any significant improvements in these cardiovascular and metabolic markers compared to the placebo group.
In conclusion, our findings suggest that l-carnosine is unlikely to be an effective strategy for reducing cardiovascular disease risk in those with prediabetes and T2DM who maintain good glycemic control. Such insights underscore the need for continued research into other potential therapies for these populations.
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9
l-carnosine may shield against diabetes
Corrigendum to "Leucine-glycine and carnosine dipeptides prevent diabetes induced by multiple low-doses of streptozotocin in an experimental model of adult mice".
Highly relevant diabetes treatment study
We investigated the potential impacts of l-carnosine on managing diabetes, particularly its protective effects against diabetes induced by multiple low doses of streptozotocin in adult mice. Through the study, we observed that l-carnosine, alongside leucine-glycine dipeptides, played a significant role in preventing the onset of diabetes in our experimental model.
The research design employed strategies that included appropriate control groups, allowing us to make comparisons and draw meaningful conclusions. As a result, it appears that l-carnosine may effectively mitigate some of the diabetes-linked effects observed in the mice treated with streptozotocin.
Overall, the findings suggest that incorporating l-carnosine might offer a novel approach in diabetes prevention strategies. As we move forward, further studies could help clarify the underlying mechanisms and broader implications for human health in managing diabetes.
The research design employed strategies that included appropriate control groups, allowing us to make comparisons and draw meaningful conclusions. As a result, it appears that l-carnosine may effectively mitigate some of the diabetes-linked effects observed in the mice treated with streptozotocin.
Overall, the findings suggest that incorporating l-carnosine might offer a novel approach in diabetes prevention strategies. As we move forward, further studies could help clarify the underlying mechanisms and broader implications for human health in managing diabetes.
Read More
Most Useful Reviews
9.5
Controlled diabetes levels
Amazing. My nutritionist recommended L-Carnosine when I had a slow-healing wound due to diabetes. Combined with exercise, I experienced full recovery, and my HbA1c level dropped to 5.7. While I can't say my diabetes is reversed, my sugar levels are certainly managed, so I continue taking it alongside Vitamin C for immune support.
Read More
8
Promising early results
L-Carnosine. Significant effects will likely emerge long-term. I'm taking this to alleviate the impact of type 2 diabetes, and so far, the results are promising. I am very happy with their part in my process.
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8.8
Nerve damage relief
Now L-Carnosine is great. I use it for nerve damage, eye disorders (cataracts), and kidney issues linked to diabetes. I have neuropathy and eye concerns that I hope to improve with this supplement.
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Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.5
9
l-carnosine may shield against diabetes
Corrigendum to "Leucine-glycine and carnosine dipeptides prevent diabetes induced by multiple low-doses of streptozotocin in an experimental model of adult mice".
Highly relevant diabetes treatment study
We investigated the potential impacts of l-carnosine on managing diabetes, particularly its protective effects against diabetes induced by multiple low doses of streptozotocin in adult mice. Through the study, we observed that l-carnosine, alongside leucine-glycine dipeptides, played a significant role in preventing the onset of diabetes in our experimental model.
The research design employed strategies that included appropriate control groups, allowing us to make comparisons and draw meaningful conclusions. As a result, it appears that l-carnosine may effectively mitigate some of the diabetes-linked effects observed in the mice treated with streptozotocin.
Overall, the findings suggest that incorporating l-carnosine might offer a novel approach in diabetes prevention strategies. As we move forward, further studies could help clarify the underlying mechanisms and broader implications for human health in managing diabetes.
The research design employed strategies that included appropriate control groups, allowing us to make comparisons and draw meaningful conclusions. As a result, it appears that l-carnosine may effectively mitigate some of the diabetes-linked effects observed in the mice treated with streptozotocin.
Overall, the findings suggest that incorporating l-carnosine might offer a novel approach in diabetes prevention strategies. As we move forward, further studies could help clarify the underlying mechanisms and broader implications for human health in managing diabetes.
Read More
9
Carnosine protects diabetic kidneys
[Carnosine protects against diabetic nephropathy in rats by activating the AKT/mTOR pathway and restoring autophagy in the renal tissue].
Directly addresses diabetes treatment
We explored the potential of l-carnosine as a protective agent against kidney damage in rats suffering from diabetes. To do this, we created diabetic rat models using a combination of a high-fat diet and a substance called streptozotocin. These rats were then divided into groups and given daily doses of carnosine at varying levels—100, 300, and 900 mg/kg.
We closely monitored the rats' body weights and blood glucose levels throughout the study. After the treatment period, we collected various samples, including kidneys, to assess kidney function and structural changes. Our findings were quite revealing; diabetic rats without carnosine treatment exhibited numerous health issues, such as weight loss, high blood glucose levels, and kidney deformities.
However, the diabetic rats that received carnosine showed noticeable improvements. They had healthier appearances, increased body weight, and lower blood glucose levels. Furthermore, carnosine treatment positively impacted kidney function and structure, reducing oxidative stress markers and enhancing important cellular pathways associated with kidney health.
Overall, we found that l-carnosine appears to protect against diabetic nephropathy in these rat models, mainly by managing oxidative stress and supporting essential cellular functions. This study opens the door for further research on l-carnosine as a potential therapeutic option in diabetes treatment.
We closely monitored the rats' body weights and blood glucose levels throughout the study. After the treatment period, we collected various samples, including kidneys, to assess kidney function and structural changes. Our findings were quite revealing; diabetic rats without carnosine treatment exhibited numerous health issues, such as weight loss, high blood glucose levels, and kidney deformities.
However, the diabetic rats that received carnosine showed noticeable improvements. They had healthier appearances, increased body weight, and lower blood glucose levels. Furthermore, carnosine treatment positively impacted kidney function and structure, reducing oxidative stress markers and enhancing important cellular pathways associated with kidney health.
Overall, we found that l-carnosine appears to protect against diabetic nephropathy in these rat models, mainly by managing oxidative stress and supporting essential cellular functions. This study opens the door for further research on l-carnosine as a potential therapeutic option in diabetes treatment.
Read More
9
Carnosine's role in kidney protection
Carnosine alleviates kidney tubular epithelial injury by targeting NRF2 mediated ferroptosis in diabetic nephropathy.
Strong relevance to diabetes treatment
We investigated the potential of l-carnosine (CAR) to alleviate kidney damage associated with diabetes. The study focused on the phenomenon known as ferroptosis, a type of cell death linked to iron buildup and oxidative stress, which contributes significantly to kidney injury in diabetic nephropathy.
Our findings revealed that CAR, alongside a compound known as Fer-1, effectively reduced kidney damage and inhibited ferroptosis in a mouse model of diabetes induced by streptozotocin (STZ). We also explored the effects of CAR in human kidney tubular epithelial cells (HK2) exposed to high glucose or erastin, both known inducers of ferroptosis. Remarkably, CAR treatment was shown to rescue the cells from this damage.
Importantly, we noted that the protective effects of CAR were lost when a key antioxidant protein, NRF2, was specifically knocked down in HK2 cells. This suggests that CAR's mechanism of action is closely tied to NRF2, highlighting its role in combating ferroptosis and, ultimately, kidney injury in diabetes.
Our findings revealed that CAR, alongside a compound known as Fer-1, effectively reduced kidney damage and inhibited ferroptosis in a mouse model of diabetes induced by streptozotocin (STZ). We also explored the effects of CAR in human kidney tubular epithelial cells (HK2) exposed to high glucose or erastin, both known inducers of ferroptosis. Remarkably, CAR treatment was shown to rescue the cells from this damage.
Importantly, we noted that the protective effects of CAR were lost when a key antioxidant protein, NRF2, was specifically knocked down in HK2 cells. This suggests that CAR's mechanism of action is closely tied to NRF2, highlighting its role in combating ferroptosis and, ultimately, kidney injury in diabetes.
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8
Effects of L-carnosine on diabetes
Combined loss of glyoxalase 1 and aldehyde dehydrogenase 3a1 amplifies dicarbonyl stress, impairs proteasome activity resulting in hyperglycemia and activated retinal angiogenesis.
Moderate relevance regarding treatment
In our exploration of how L-carnosine treatment affects diabetes, we focused on the interplay between detoxification enzymes, particularly glyoxalase 1 (GLO1) and aldehyde dehydrogenase 3A1 (ALDH3A1). We generated a unique combination of zebrafish that lacked both GLO1 and ALDH3A1 to better understand how their absence influences metabolic processes, especially dicarbonyl stress.
Through our observations, we found that the absence of these enzymes led to an increase in methylglyoxal (MG) and its harmful derivative MG-H1. This accumulation had dire consequences, resulting in impaired proteasome function, which in turn disrupted glucose control and spurred abnormal blood vessel growth in the eye. Encouragingly, we also noted that treatment with L-carnosine could reverse some of these detrimental effects, underscoring its potential role as a therapeutic intervention.
While we recognize that L-carnosine was part of a broader treatment landscape, its protective impact against the harmful accumulation triggered by enzyme loss highlights its significance. Future research could build on these findings to understand L-carnosine's specific contributions and clarify its effectiveness in diabetes management.
Through our observations, we found that the absence of these enzymes led to an increase in methylglyoxal (MG) and its harmful derivative MG-H1. This accumulation had dire consequences, resulting in impaired proteasome function, which in turn disrupted glucose control and spurred abnormal blood vessel growth in the eye. Encouragingly, we also noted that treatment with L-carnosine could reverse some of these detrimental effects, underscoring its potential role as a therapeutic intervention.
While we recognize that L-carnosine was part of a broader treatment landscape, its protective impact against the harmful accumulation triggered by enzyme loss highlights its significance. Future research could build on these findings to understand L-carnosine's specific contributions and clarify its effectiveness in diabetes management.
Read More
8
Carnosine's potential in diabetes
The protective role of carnosine against type 2 diabetes-induced cognitive impairment.
Moderate relevance to diabetes research
We explored the potential role of l-carnosine in managing cognitive impairment associated with type 2 diabetes mellitus (T2DM). This condition, which affects memory and executive function, has become increasingly prevalent and poses a serious challenge to the quality of life for many individuals. While current treatments remain limited, the focus has shifted toward finding effective and accessible alternatives.
Carnosine, a naturally occurring dipeptide with antioxidant and anti-inflammatory properties, emerges as a promising candidate. Research suggests that it may help protect against neurodegenerative diseases and improve glucose regulation in diabetes. We examined its neuroprotective effects in the context of T2DM and noted that its mechanisms might offer therapeutic support in reducing cognitive decline.
Though our findings highlight its potential, further investigation is warranted to establish a comprehensive understanding of its benefits for individuals with diabetes. We aim to provide a foundation for future research and therapeutic approaches that could enhance the lives of those affected by these intertwined health challenges.
Carnosine, a naturally occurring dipeptide with antioxidant and anti-inflammatory properties, emerges as a promising candidate. Research suggests that it may help protect against neurodegenerative diseases and improve glucose regulation in diabetes. We examined its neuroprotective effects in the context of T2DM and noted that its mechanisms might offer therapeutic support in reducing cognitive decline.
Though our findings highlight its potential, further investigation is warranted to establish a comprehensive understanding of its benefits for individuals with diabetes. We aim to provide a foundation for future research and therapeutic approaches that could enhance the lives of those affected by these intertwined health challenges.
Read More
User Reviews
USERS' SCORE
Good
Based on 13 Reviews
8.7
9.5
Effective for diabetes
Health must-have. One of the most effective supplements available. My mother deals with toxic stress and diabetes, and L-Carnosine is literally the answer to her overall health issues, also helping with age-related fatigue. Thanks, Now and iHerb.
9.5
Blood sugar control
I bought this for my mother, who has type 2 diabetes. Initially, one capsule didn’t show results, but after suggesting two before lunch and one before dinner, her blood sugar returned to normal. We’re happy with this product.
9.5
Controlled diabetes levels
Amazing. My nutritionist recommended L-Carnosine when I had a slow-healing wound due to diabetes. Combined with exercise, I experienced full recovery, and my HbA1c level dropped to 5.7. While I can't say my diabetes is reversed, my sugar levels are certainly managed, so I continue taking it alongside Vitamin C for immune support.
Read More
8.8
Good for diabetes
A good product that slows the ageing process, acts as an excellent antioxidant, benefits athletes, enhances recovery, and helps with diabetes by reducing glycation. I take it in courses.
8.8
Prevents diabetes effects
It helps alleviate the aging process, repairs skin cells, and may aid in treating Alzheimer’s, Parkinson’s, and autism. Importantly, it prevents diabetes as well.
