Last update
8/15/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 3 Researches
5.3
USERS' SCORE
Good
Based on 1021 Reviews
8
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
L-Lysine (from 637 mg L-Lysine Hydrochloride)
500 mg
**
Top Medical Research Studies
4
We explored how dietary changes and supplements impact skin conditions like herpes labialis. Specifically, we found that L-lysine can be effective as a preventive measure against herpes outbreaks. However, it doesn’t help shorten the duration of active lesions once they appear. Despite popular beliefs around diet's role in such conditions, we observed that high-quality evidence supporting dietary changes for other skin issues like rosacea is lacking. Additionally, certain vitamins and minerals showed promise in treating conditions like hidradenitis suppurativa.
Read More
4
L-lysine shows limited effectiveness
We reviewed existing studies to find out if L-lysine can help prevent herpes simplex virus outbreaks. Our investigation showed that taking L-lysine supplements daily in doses under 1 gram doesn’t seem effective, even when combined with low-arginine diets. However, we noted that higher doses, over 3 grams, might improve how patients feel about their condition.
Despite some positive reports, more thorough studies with doses above 1.2 grams are needed to better understand its potential benefits, especially for those with certain health conditions.
Despite some positive reports, more thorough studies with doses above 1.2 grams are needed to better understand its potential benefits, especially for those with certain health conditions.
Read More
8
This study focused on the potential benefits of L-lysine in treating pityriasis rosea (PR) in an 11-year-old girl. After starting a 30-day course of L-lysine, we observed that new skin eruptions stopped after just four days. The existing lesions also showed improvement, suggesting L-lysine may help accelerate healing.
While existing treatments like acyclovir are common, this case hints that L-lysine could be a safe alternative worth considering for PR management.
While existing treatments like acyclovir are common, this case hints that L-lysine could be a safe alternative worth considering for PR management.
Read More
Most Useful Reviews
9
Must-have medication
120 people found this helpful
Lysine is essential for treating herpes and is always part of my regimen. I start with a loading dose before reducing it, and I combine it with vitamin C, zinc, and vitamin D. It works because lysine inhibits the herpes virus, which thrives on arginine.
Read More
10
Herpes free!
83 people found this helpful
Excellent! My frequent herpes outbreaks have disappeared. I take lysine 1-3 times daily, and I'm thrilled with the results.
Read More
9
Works well
74 people found this helpful
A reliable remedy for treating herpes; it effectively does the job!
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 3 Researches
5.3
- All Researches
8
This study focused on the potential benefits of L-lysine in treating pityriasis rosea (PR) in an 11-year-old girl. After starting a 30-day course of L-lysine, we observed that new skin eruptions stopped after just four days. The existing lesions also showed improvement, suggesting L-lysine may help accelerate healing.
While existing treatments like acyclovir are common, this case hints that L-lysine could be a safe alternative worth considering for PR management.
While existing treatments like acyclovir are common, this case hints that L-lysine could be a safe alternative worth considering for PR management.
Read More
4
We explored how dietary changes and supplements impact skin conditions like herpes labialis. Specifically, we found that L-lysine can be effective as a preventive measure against herpes outbreaks. However, it doesn’t help shorten the duration of active lesions once they appear. Despite popular beliefs around diet's role in such conditions, we observed that high-quality evidence supporting dietary changes for other skin issues like rosacea is lacking. Additionally, certain vitamins and minerals showed promise in treating conditions like hidradenitis suppurativa.
Read More
4
L-lysine shows limited effectiveness
We reviewed existing studies to find out if L-lysine can help prevent herpes simplex virus outbreaks. Our investigation showed that taking L-lysine supplements daily in doses under 1 gram doesn’t seem effective, even when combined with low-arginine diets. However, we noted that higher doses, over 3 grams, might improve how patients feel about their condition.
Despite some positive reports, more thorough studies with doses above 1.2 grams are needed to better understand its potential benefits, especially for those with certain health conditions.
Despite some positive reports, more thorough studies with doses above 1.2 grams are needed to better understand its potential benefits, especially for those with certain health conditions.
Read More
User Reviews
USERS' SCORE
Good
Based on 1021 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Must-have medication
120 people found this helpful
Lysine is essential for treating herpes and is always part of my regimen. I start with a loading dose before reducing it, and I combine it with vitamin C, zinc, and vitamin D. It works because lysine inhibits the herpes virus, which thrives on arginine.
Read More
10
Herpes free!
83 people found this helpful
Excellent! My frequent herpes outbreaks have disappeared. I take lysine 1-3 times daily, and I'm thrilled with the results.
Read More
9
Works well
74 people found this helpful
A reliable remedy for treating herpes; it effectively does the job!
Read More
9
Essential for herpes management
59 people found this helpful
A very effective drug for herpes. I always include it in my treatment protocol, beginning with a loading dose and then reducing it. It pairs well with vitamin C, zinc, and vitamin D. Lysine acts on the herpes virus, preventing its replication.
Read More
9
Effective for sister
47 people found this helpful
I bought this for my sister, who had constant herpes. She was amazed that it didn’t appear for nearly a year.
Read More
Frequently Asked Questions
9
Rapid healing
7 people found this helpful
I have personally found this amino acid to be highly effective. I have herpes type 1 and 2. When I start experiencing symptoms, I drink one tablet on an empty stomach before meals. Within a day, the herpes begins to diminish, and after four days, my skin clears up completely. I switched from using ointment and acyclovir, which heavily impacted my liver, to l-lysine and I'm thoroughly satisfied with the results.
10
Herpes relief
12 people found this helpful
L-lysine has been a real solution for my recurring herpes issues. After suffering from outbreaks every 20 days, since I began taking 1 gram twice daily, I haven't had any herpes for about three months. The quality is indisputable, and while the one-gram capsules are a bit large, they are manageable.
9
Works well
74 people found this helpful
A reliable remedy for treating herpes; it effectively does the job!
9
Reduced outbreak frequency
10 people found this helpful
A high-quality remedy for herpes. After trying numerous options, I discovered lysine and decided to give it a go. I only experience outbreaks once a year now, compared to monthly before. I take one 500mg tablet before breakfast for three months, followed by a one-month break. When I have a cold, I take three tablets and recover in three days. The large tablets can be a bit challenging, but their size is worth it.
9
No relapses
5 people found this helpful
I purchased L-lysine to treat herpes and reduce relapses. It really helps! I take 500 mg on an empty stomach in the morning and at lunch. I've been doing this for three months with no relapses, whereas they had occurred monthly before.
9
Must-have medication
120 people found this helpful
Lysine is essential for treating herpes and is always part of my regimen. I start with a loading dose before reducing it, and I combine it with vitamin C, zinc, and vitamin D. It works because lysine inhibits the herpes virus, which thrives on arginine.
9
Essential for herpes management
59 people found this helpful
A very effective drug for herpes. I always include it in my treatment protocol, beginning with a loading dose and then reducing it. It pairs well with vitamin C, zinc, and vitamin D. Lysine acts on the herpes virus, preventing its replication.
9
Stabilises herpes condition
9 people found this helpful
This greatly aids my wife, who suffers from chronic herpes outbreaks around her eyes. Since starting Lysine at a substantial dose of two tablets daily, her herpes has stabilised. During stressful times, she increases the dose to four. This has been incredibly helpful, and she highly recommends it to others with herpes.
4
We explored how dietary changes and supplements impact skin conditions like herpes labialis. Specifically, we found that L-lysine can be effective as a preventive measure against herpes outbreaks. However, it doesn’t help shorten the duration of active lesions once they appear. Despite popular beliefs around diet's role in such conditions, we observed that high-quality evidence supporting dietary changes for other skin issues like rosacea is lacking. Additionally, certain vitamins and minerals showed promise in treating conditions like hidradenitis suppurativa.
4
L-lysine shows limited effectiveness
We reviewed existing studies to find out if L-lysine can help prevent herpes simplex virus outbreaks. Our investigation showed that taking L-lysine supplements daily in doses under 1 gram doesn’t seem effective, even when combined with low-arginine diets. However, we noted that higher doses, over 3 grams, might improve how patients feel about their condition.
Despite some positive reports, more thorough studies with doses above 1.2 grams are needed to better understand its potential benefits, especially for those with certain health conditions.
Despite some positive reports, more thorough studies with doses above 1.2 grams are needed to better understand its potential benefits, especially for those with certain health conditions.
8
This study focused on the potential benefits of L-lysine in treating pityriasis rosea (PR) in an 11-year-old girl. After starting a 30-day course of L-lysine, we observed that new skin eruptions stopped after just four days. The existing lesions also showed improvement, suggesting L-lysine may help accelerate healing.
While existing treatments like acyclovir are common, this case hints that L-lysine could be a safe alternative worth considering for PR management.
While existing treatments like acyclovir are common, this case hints that L-lysine could be a safe alternative worth considering for PR management.
References
- Jamgochian M, Alamgir M, Rao B. Diet in Dermatology: Review of Diet's Influence on the Conditions of Rosacea, Hidradenitis Suppurativa, Herpes Labialis, and Vitiligo. Am J Lifestyle Med. 2023;17:152. 10.1177/15598276211026592
- Pedrazini MC, Groppo FC. L-lysine therapy to control the clinical evolution of pityriasis rosea: Clinical case report and literature review. Dermatol Ther. 2021;34:e14679. 10.1111/dth.14679
- Mailoo VJ, Rampes S. Lysine for Herpes Simplex Prophylaxis: A Review of the Evidence. Integr Med (Encinitas). 2017;16:42.
