We aimed to evaluate how myo-inositol supplementation affects women with gestational diabetes through a meta-analysis of randomized controlled trials. Our search included multiple databases, leading to the analysis of four studies involving 317 participants. The results showed that myo-inositol significantly reduced the need for insulin and improved insulin sensitivity. However, it did not influence birth weight, cesarean delivery rates, or NICU admissions. These findings suggest myo-inositol could be a helpful addition to managing gestational diabetes, but further research is needed.
Read More
9.5
Inositol reduces gestational diabetes risk
Myoinositols Prevent Gestational Diabetes Mellitus and Related Complications: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
We investigated the effectiveness of myoinositol supplements in preventing gestational diabetes mellitus (GDM) and its associated complications in pregnant women at high risk for GDM.
By reviewing data from eight randomized controlled trials involving around 1,795 participants, we found that inositol not only halved the incidence of GDM but also significantly reduced fasting and glucose levels in tests.
Furthermore, myoinositol appeared to lower the need for insulin and decrease the risk of conditions like preeclampsia and preterm birth. These findings suggest a promising role for myoinositol in GDM prevention.
Read More
8
Myo-inositol improves glycemic control
Effect of dietary myo-inositol supplementation on the insulin resistance and the prevention of gestational diabetes mellitus: an open-label, randomized controlled trial.
This study explored the impact of myo-inositol (MI) supplementation on preventing gestational diabetes mellitus (GDM) in 200 pregnant women. Participants were divided into two groups: one receiving MI and folic acid, and the other receiving only folic acid.
The findings revealed that those taking MI had a significantly lower incidence of GDM compared to the control group. Additionally, those in the MI group showed better glycemic control and improved insulin sensitivity. Overall, integrating MI might offer an effective way to enhance the health of pregnant women and reduce GDM risk.
Read More
Most Useful Reviews
7.5
Supports emotional stability
Works well! I gave it to my mother for emotional peace, and she found it beneficial. Her nerves have strengthened, and it has positively impacted her diabetes.
Read More
7.5
Diabetes support
I take it as prescribed by my endocrinologist. It effectively reduces the risk of diabetes, heart and vascular diseases, and lowers blood pressure.
Read More
7.5
Calming for diabetes
4 people found this helpful
Feeling overwhelmed? You need this product. Research indicates L-theanine's benefits include reducing the risk of diabetes and cardiovascular diseases, lowering blood pressure, and improving the immune system. My personal experience is positive; after a month of taking this supplement, I handle work stress better, family relationships have improved, and I've experienced less apathy. If you relate to my struggles, consider ordering these pills; change is essential.
We investigated the effectiveness of myoinositol supplements in preventing gestational diabetes mellitus (GDM) and its associated complications in pregnant women at high risk for GDM.
By reviewing data from eight randomized controlled trials involving around 1,795 participants, we found that inositol not only halved the incidence of GDM but also significantly reduced fasting and glucose levels in tests.
Furthermore, myoinositol appeared to lower the need for insulin and decrease the risk of conditions like preeclampsia and preterm birth. These findings suggest a promising role for myoinositol in GDM prevention.
Read More
9
New drug shows promise for diabetes
Xelaglifam, a novel GPR40/FFAR1 agonist, exhibits enhanced β-arrestin recruitment and sustained glycemic control for type 2 diabetes.
We evaluated the effectiveness of Xelaglifam, a new drug designed to activate specific receptors that help manage Type 2 diabetes. Our study compared its performance against another drug, Fasiglifam.
Through tests in the lab and on rats, we found that Xelaglifam boosts insulin secretion and lowers blood sugar levels effectively without causing hypoglycemia.
Additionally, its ability to improve glucose tolerance suggests it could be a valuable treatment option for those managing this condition, potentially working well alongside existing medications.
Read More
8
D-Pinitol and ice plant benefits
The Glucose-Lowering Effect of and D-Pinitol: Studies on Insulin Secretion in INS-1 Cells and the Reduction of Blood Glucose in Diabetic Rats.
We explored the effects of ice plant extract and its compound D-pinitol on insulin secretion and blood sugar levels in diabetic rats. By utilizing the glucose-stimulated insulin secretion test and measuring various insulin-related factors, we discovered that both substances significantly boosted insulin secretion.
Additionally, ice plant extract helped reduce weight gain and improved glucose tolerance. These findings suggest that ice plant and D-pinitol could serve as beneficial functional foods for managing diabetes and supporting insulin signaling in the body.
Read More
8
Histatin 1 enhances diabetic wound healing
Human salivary histatin 1 regulating IP3R1/GRP75/VDAC1 mediated mitochondrial-associated endoplasmic reticulum membranes (MAMs) inhibits cell senescence for diabetic wound repair.
We explored how Histatin 1, found in human saliva, helps combat aging in human umbilical vein endothelial cells (HUVECs) to improve diabetic wound healing. The study revealed that this peptide reduces cell senescence and works by enhancing mitochondrial function and reducing oxidative stress.
In laboratory settings, Histatin 1 decreased markers of aging in cells and improved their function. Furthermore, in a mouse model of diabetes, it promoted wound healing through increased blood vessel formation.
Overall, Histatin 1 shows promise as a solution for improving skin repair in diabetic patients.
Read More
8
Myo-inositol improves glycemic control
Effect of dietary myo-inositol supplementation on the insulin resistance and the prevention of gestational diabetes mellitus: an open-label, randomized controlled trial.
This study explored the impact of myo-inositol (MI) supplementation on preventing gestational diabetes mellitus (GDM) in 200 pregnant women. Participants were divided into two groups: one receiving MI and folic acid, and the other receiving only folic acid.
The findings revealed that those taking MI had a significantly lower incidence of GDM compared to the control group. Additionally, those in the MI group showed better glycemic control and improved insulin sensitivity. Overall, integrating MI might offer an effective way to enhance the health of pregnant women and reduce GDM risk.
Works well! I gave it to my mother for emotional peace, and she found it beneficial. Her nerves have strengthened, and it has positively impacted her diabetes.
Read More
7.5
Diabetes support
I take it as prescribed by my endocrinologist. It effectively reduces the risk of diabetes, heart and vascular diseases, and lowers blood pressure.
Read More
7.5
Calming for diabetes
4 people found this helpful
Feeling overwhelmed? You need this product. Research indicates L-theanine's benefits include reducing the risk of diabetes and cardiovascular diseases, lowering blood pressure, and improving the immune system. My personal experience is positive; after a month of taking this supplement, I handle work stress better, family relationships have improved, and I've experienced less apathy. If you relate to my struggles, consider ordering these pills; change is essential.
Read More
7.5
Reduces diabetes risk
1 people found this helpful
This substance is one of the most potent natural antidepressants, capable of eliminating both psychological and physical stress. It boosts cognitive abilities, strengthens the immune system, and enhances mood without causing drowsiness. Additionally, theanine supports mental performance, normalises blood pressure, helps combat depression, increases dopamine levels, and ensures efficient cardiovascular function. It also energises the body, lowers the risk of diabetes, regulates cholesterol levels, promotes relaxation, and stimulates cognitive processes. I specifically ordered it to avoid cognitive decline until spring.
Read More
6
Benefits for diabetes
1 people found this helpful
This supplement proves to be more beneficial than it appears. Studies show L-theanine reduces the risk of diabetes and cardiovascular diseases, lowers blood pressure, and enhances the immune system. It also protects against cognitive dysfunction and aids in alleviating depressive and anxious states, improving memory and energy. I noticed an uplift in my mood and sleep quality while taking it, though the effects diminished quickly after discontinuation. The quality of this manufacturer’s vitamins and supplements is commendable, and I recommend it.
Diabetes is a chronic medical condition that occurs when the body either does not produce enough insulin or cannot effectively use the insulin it produces. Insulin is a hormone made by the pancreas that helps glucose from food enter the cells, providing them with energy. When diabetes is present, it leads to elevated levels of glucose in the blood, which can cause serious health complications if left unmanaged. There are primarily two types: Type 1 diabetes, which is an autoimmune condition where the body attacks insulin-producing cells, and Type 2 diabetes, which is often associated with lifestyle factors such as obesity and lack of physical activity, leading to insulin resistance.
Managing diabetes typically involves a combination of lifestyle changes, such as a balanced diet and regular exercise, along with monitoring blood sugar levels and, in many cases, medication or insulin therapy. Education is crucial for those with diabetes to understand how their condition works and how to manage it effectively. The goal of diabetes management is to keep blood sugar levels within a target range, helping to prevent complications such as heart disease, nerve damage, and kidney failure. Regular check-ups and consultations with healthcare professionals are essential to ensure optimal care.
L-theanine is a naturally occurring amino acid most commonly found in tea leaves, particularly green tea, and is known for its potential calming effects. While caffeine can lead to increased alertness and focus, L-theanine promotes relaxation without causing drowsiness, making it a popular supplement among those seeking to enhance their mental performance while also managing stress. It is believed to work by influencing the production of neurotransmitters, such as serotonin and dopamine, which can positively affect mood and cognitive function.
Many users report that L-theanine may enhance the benefits of caffeine, leading to improved focus and reduced feelings of jitteriness when consumed together. This unique combination is often sought after by students and professionals during periods of intense concentration or study. As a dietary supplement, L-theanine is available in various forms, including capsules, powders, and tea, allowing individuals to choose the method that best fits their lifestyle. Typically, dosages range from 100 to 400 mg per day, depending on the intended effects and individual tolerance.
Based on user reviews, the timeline for experiencing results from this supplement can vary, but many users report noticeable effects within a month. One reviewer mentioned, "after a month of taking this supplement...I've experienced less apathy" and found improvements in managing stress, which can be particularly beneficial for those with diabetes Read Review. Another user highlighted the supplement's efficacy in improving their diabetes management, indicating a positive impact on their health after usage Read Review.
In addition, users report other benefits such as enhanced cognitive function and mood, often linked to prolonged usage. Overall, while individual experiences can differ, a consistent timeframe of about four weeks is commonly noted for those seeking results, particularly relating to diabetes control and overall wellness Read Review.
This supplement, particularly myo-inositol, has garnered attention in scientific research for its potential benefits in managing diabetes, specifically gestational diabetes. Studies indicate that myo-inositol supplementation significantly reduces the incidence of gestational diabetes and improves glycemic control among pregnant women at risk. For instance, a systematic review found that myo-inositol halved the occurrence of gestational diabetes while also lowering fasting glucose levels and insulin requirements in high-risk pregnant women [10]. Additionally, another study on pregnant women revealed that those taking myo-inositol exhibited improved insulin sensitivity and lower GDM rates compared to those who didn't [3].
Beyond myo-inositol, research also supports the use of other natural supplements like D-pinitol for managing blood sugar levels effectively. D-pinitol, alongside ice plant extract, showed positive effects in boosting insulin secretion and improving glucose tolerance in diabetic models [1]. Altogether, these findings highlight the promising potential of these supplements in enhancing diabetes management strategies and warrant their consideration as adjuncts in clinical practice.
Users report a range of positive improvements after using this supplement, particularly highlighting enhanced emotional well-being and better management of diabetes. For example, one reviewer shared that their mother experienced a significant boost in emotional peace and noted strengthened nerves alongside positive effects on her diabetes management Read Review. Others have praised its ability to alleviate stress and improve overall mood, with one user noting improvements in work stress handling and family relationships after a month of use Read Review.
Additionally, the supplement is frequently associated with benefits such as cognitive enhancements, improved sleep quality, and lowered blood pressure. For instance, several users conveyed that they felt boosts in mood and cognitive function, experiencing better energy and memory Read Review. While individual experiences may vary, the general consensus indicates that this supplement can lead to meaningful improvements in both emotional and physical health.
Users report that combining this supplement, particularly L-theanine, with other supplements or taking it alongside prescribed medications can yield significant benefits for managing diabetes. For instance, one user stated that after giving the supplement to their mother, it positively impacted her emotional well-being and diabetes management, highlighting its potential for strengthening both mental and physical health Read Review. Another reviewer noted that they take it as part of a regimen prescribed by their endocrinologist, emphasizing its effectiveness in lowering the risk of diabetes and related health issues like hypertension Read Review.
Moreover, users have praised the supplement for its multifaceted benefits, including stress reduction and cognitive enhancement, which can inadvertently support diabetes management by improving overall emotional health Read Review. Several reviews highlight L-theanine's properties in regulating blood pressure and enhancing immune function while simultaneously reducing the risk of diabetes, suggesting that it can be a valuable addition to a comprehensive diabetes management plan Read Review. Overall, user experiences indicate that this supplement works well in conjunction with other health measures, promoting better control of diabetes and overall wellness.
Users have reported varied experiences with L-Theanine in relation to diabetes management, often highlighting its potential benefits. For instance, one user noted that their mother experienced a positive impact on her diabetes after taking the supplement, which also provided emotional peace and strengthened her nerves Read Review. Additionally, another user indicated that their endocrinologist prescribed L-Theanine specifically due to its effectiveness in reducing the risk of diabetes along with other cardiovascular diseases and for lowering blood pressure Read Review.
Further evidence from users suggests that regular use of L-Theanine may facilitate improvements in overall health and stress management, leading to better blood sugar control. Reports claim it enhances immune function, normalizes blood pressure, and bolsters cognitive performance—all factors that could contribute to better diabetes management Read ReviewRead Review. However, specific dosing recommendations were not detailed within the user reviews provided, so potential users should consult health professionals for individualized advice.
7.5
Calming for diabetes
4 people found this helpful
Feeling overwhelmed? You need this product. Research indicates L-theanine's benefits include reducing the risk of diabetes and cardiovascular diseases, lowering blood pressure, and improving the immune system. My personal experience is positive; after a month of taking this supplement, I handle work stress better, family relationships have improved, and I've experienced less apathy. If you relate to my struggles, consider ordering these pills; change is essential.
7.5
Supports emotional stability
Works well! I gave it to my mother for emotional peace, and she found it beneficial. Her nerves have strengthened, and it has positively impacted her diabetes.
6
Benefits for diabetes
1 people found this helpful
This supplement proves to be more beneficial than it appears. Studies show L-theanine reduces the risk of diabetes and cardiovascular diseases, lowers blood pressure, and enhances the immune system. It also protects against cognitive dysfunction and aids in alleviating depressive and anxious states, improving memory and energy. I noticed an uplift in my mood and sleep quality while taking it, though the effects diminished quickly after discontinuation. The quality of this manufacturer’s vitamins and supplements is commendable, and I recommend it.
7.5
Diabetes support
I take it as prescribed by my endocrinologist. It effectively reduces the risk of diabetes, heart and vascular diseases, and lowers blood pressure.
7.5
Reduces diabetes risk
1 people found this helpful
This substance is one of the most potent natural antidepressants, capable of eliminating both psychological and physical stress. It boosts cognitive abilities, strengthens the immune system, and enhances mood without causing drowsiness. Additionally, theanine supports mental performance, normalises blood pressure, helps combat depression, increases dopamine levels, and ensures efficient cardiovascular function. It also energises the body, lowers the risk of diabetes, regulates cholesterol levels, promotes relaxation, and stimulates cognitive processes. I specifically ordered it to avoid cognitive decline until spring.
9.5
Inositol reduces gestational diabetes risk
Myoinositols Prevent Gestational Diabetes Mellitus and Related Complications: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
We investigated the effectiveness of myoinositol supplements in preventing gestational diabetes mellitus (GDM) and its associated complications in pregnant women at high risk for GDM.
By reviewing data from eight randomized controlled trials involving around 1,795 participants, we found that inositol not only halved the incidence of GDM but also significantly reduced fasting and glucose levels in tests.
Furthermore, myoinositol appeared to lower the need for insulin and decrease the risk of conditions like preeclampsia and preterm birth. These findings suggest a promising role for myoinositol in GDM prevention.
8
Myo-inositol improves glycemic control
Effect of dietary myo-inositol supplementation on the insulin resistance and the prevention of gestational diabetes mellitus: an open-label, randomized controlled trial.
This study explored the impact of myo-inositol (MI) supplementation on preventing gestational diabetes mellitus (GDM) in 200 pregnant women. Participants were divided into two groups: one receiving MI and folic acid, and the other receiving only folic acid.
The findings revealed that those taking MI had a significantly lower incidence of GDM compared to the control group. Additionally, those in the MI group showed better glycemic control and improved insulin sensitivity. Overall, integrating MI might offer an effective way to enhance the health of pregnant women and reduce GDM risk.
8
D-Pinitol and ice plant benefits
The Glucose-Lowering Effect of and D-Pinitol: Studies on Insulin Secretion in INS-1 Cells and the Reduction of Blood Glucose in Diabetic Rats.
We explored the effects of ice plant extract and its compound D-pinitol on insulin secretion and blood sugar levels in diabetic rats. By utilizing the glucose-stimulated insulin secretion test and measuring various insulin-related factors, we discovered that both substances significantly boosted insulin secretion.
Additionally, ice plant extract helped reduce weight gain and improved glucose tolerance. These findings suggest that ice plant and D-pinitol could serve as beneficial functional foods for managing diabetes and supporting insulin signaling in the body.
References
Lee D, Kim SJ, Choi YJ, Rho YH, Kang TS, et al. The Glucose-Lowering Effect of and D-Pinitol: Studies on Insulin Secretion in INS-1 Cells and the Reduction of Blood Glucose in Diabetic Rats. Nutrients. 2025;17. doi:10.3390/nu17010193
Xian T, Liu Y, Ye Y, Peng B, Huang J, et al. Human salivary histatin 1 regulating IP3R1/GRP75/VDAC1 mediated mitochondrial-associated endoplasmic reticulum membranes (MAMs) inhibits cell senescence for diabetic wound repair. Free Radic Biol Med. 2024;225:164. doi:10.1016/j.freeradbiomed.2024.09.046
Asimakopoulos G, Pergialiotis V, Antsaklis P, Theodora M, Loutradis D, et al. Effect of dietary myo-inositol supplementation on the insulin resistance and the prevention of gestational diabetes mellitus: an open-label, randomized controlled trial. Arch Gynecol Obstet. 2024;310:1895. doi:10.1007/s00404-024-07618-8
Chen H, Xiong J, Li Z, Chen Y, Zhang M, et al. Influence of myo-inositol on metabolic status for gestational diabetes: a meta-analysis of randomized controlled trials. J Matern Fetal Neonatal Med. 2024;37:2228450. doi:10.1080/14767058.2023.2228450
Yoon J, Lee DG, Song H, Hong D, Park JS, et al. Xelaglifam, a novel GPR40/FFAR1 agonist, exhibits enhanced β-arrestin recruitment and sustained glycemic control for type 2 diabetes. Biomed Pharmacother. 2024;177:117044. doi:10.1016/j.biopha.2024.117044
Long L, Huang Q, Song T, Dai Z. Myo-inositol rescued insulin resistance and dyslipidemia in db/db mice. J Appl Biomed. 2024;22:74. doi:10.32725/jab.2024.009
Aguilar-Guadarrama AB, Díaz-Román MA, Osorio-García M, Déciga-Campos M, Rios MY. Chemical Constituents from Agave applanata and Its Antihyperglycemic, Anti-inflammatory, and Antimicrobial Activities Associated with Its Tissue Repair Capability. Planta Med. 2024;90:397. doi:10.1055/a-2270-5527
Citarrella R, Chianetta R, Amodeo S, Mirarchi L, Licata A, et al. Effectiveness of a Food Supplement Based on Glucomannan, D-Chiro-Inositol, Blume and Inulin in Patients with Metabolic Syndrome. Nutrients. 2024;16. doi:10.3390/nu16020249
Factor PA, Corpuz H. The Efficacy and Safety of Myo-inositol Supplementation for the Prevention of Gestational Diabetes Mellitus in Overweight and Obese Pregnant Women: A Systematic Review and Meta-Analysis. J ASEAN Fed Endocr Soc. 2023;38:102. doi:10.15605/jafes.038.02.11
Greff D, Váncsa S, Váradi A, Szinte J, Park S, et al. Myoinositols Prevent Gestational Diabetes Mellitus and Related Complications: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients. 2023;15. doi:10.3390/nu15194224