Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.3
USERS' SCORE
Good
Based on 17 Reviews
8
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Magnesium (elemental) (from Magnesium Oxide, Magnesium Citrate and Magnesium Aspartate)
400 mg
95%
Top Medical Research Studies
9
We conducted a systematic review and meta-analysis exploring how dietary magnesium (Mg) intake connects with depression among adults. By reviewing data from over 63,000 individuals, we found that those with the highest magnesium intake had a 34% lower chance of experiencing depression compared to those with the lowest intake.
Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk.
Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk.
Read More
8
This study examined how magnesium deficiency relates to depression in adults aged 20 to 60. By using the National Health and Nutrition Examination Survey data from 2005 to 2018, we analyzed the magnesium depletion score (MDS) while assessing depression through the Patient Health Questionnaire-9.
Our findings reveal a positive association: as the MDS increases, so does the likelihood of depression. Each one-unit rise in MDS raises the odds of depression. However, results varied with different MDS levels. While these results are promising, further research is necessary to understand the underlying mechanisms better.
Our findings reveal a positive association: as the MDS increases, so does the likelihood of depression. Each one-unit rise in MDS raises the odds of depression. However, results varied with different MDS levels. While these results are promising, further research is necessary to understand the underlying mechanisms better.
Read More
8
We examined the role of magnesium levels in relation to depressive symptoms through a comprehensive analysis of data from Taiwan's Nutrition and Health Survey. Involving 2,196 participants, we employed logistic and linear regression methods to assess these relationships.
Our findings revealed that higher magnesium levels correlated with fewer depressive symptoms. Interestingly, this connection was stronger in individuals with elevated C-reactive protein (CRP) levels, suggesting that inflammation influences how magnesium affects mood.
Overall, maintaining adequate magnesium levels might be beneficial, especially for those dealing with inflammation.
Our findings revealed that higher magnesium levels correlated with fewer depressive symptoms. Interestingly, this connection was stronger in individuals with elevated C-reactive protein (CRP) levels, suggesting that inflammation influences how magnesium affects mood.
Overall, maintaining adequate magnesium levels might be beneficial, especially for those dealing with inflammation.
Read More
Most Useful Reviews
9
Reduced anxiety
16 people found this helpful
Every woman should consider magnesium, as deficiency can lead to heart issues and affect mental health, causing anxiety and depression. After taking one capsule daily, my leg cramps vanished, I became calmer, and my insomnia improved significantly. I find it a bargain for six months' supply.
Read More
9
Stopped medication
8 people found this helpful
I take magnesium to help relieve depression, which recent research suggests benefits mental disorders. I realise when my mood disorder affects my intake. While results vary, I believe staying below 300mg daily is important. I find magnesium to be a preferable alternative to psychiatric medications.
Read More
9
Stress relief
8 people found this helpful
Magnesium serves as a natural anti-stress agent, aiding the nervous system and reducing anxiety and insomnia. I combined it with vitamin B6, primarily for stress reduction and sleep improvement, which has worked well for me. I also noticed my eyes were less puffy after sleep.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.3
- All Researches
9.5
Magnesium and Vitamin D effective for depression
We explored the effectiveness of magnesium coupled with vitamin D in easing depressive symptoms among individuals with long-COVID. Our study involved 60 participants suffering from mild to moderate depression, hypomagnesemia, and vitamin D deficiency.
Over four months, those who received both magnesium and vitamin D showed significant improvements in their depression scores compared to those who only took vitamin D. Specifically, a notable 73% of the magnesium group achieved significant relief, positioning this combination as a promising treatment for depression linked to long-COVID.
Mild side effects were noted but did not lead to any withdrawals, indicating the safety of this treatment option.
Over four months, those who received both magnesium and vitamin D showed significant improvements in their depression scores compared to those who only took vitamin D. Specifically, a notable 73% of the magnesium group achieved significant relief, positioning this combination as a promising treatment for depression linked to long-COVID.
Mild side effects were noted but did not lead to any withdrawals, indicating the safety of this treatment option.
Read More
9
We conducted a systematic review and meta-analysis exploring how dietary magnesium (Mg) intake connects with depression among adults. By reviewing data from over 63,000 individuals, we found that those with the highest magnesium intake had a 34% lower chance of experiencing depression compared to those with the lowest intake.
Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk.
Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk.
Read More
8
We examined how various nutrient patterns affect depressive symptoms in older adults through a detailed study involving over 1,000 participants.
By evaluating nutrient intake and depressive symptoms over more than 15 years, we found that those with a diet high in magnesium and several other nutrients had significantly lower odds of experiencing depressive symptoms.
This suggests that nutrients, particularly magnesium, might play a crucial role in supporting mental health in older adults.
By evaluating nutrient intake and depressive symptoms over more than 15 years, we found that those with a diet high in magnesium and several other nutrients had significantly lower odds of experiencing depressive symptoms.
This suggests that nutrients, particularly magnesium, might play a crucial role in supporting mental health in older adults.
Read More
8
Magnesium deficiency correlates with depression
This study examined the relationship between magnesium deficiency, measured by the Magnesium Depletion Score (MDS), and depression among U.S. adults. We analyzed data from the National Health and Nutrition Examination Survey, focusing on those with moderate to severe depression.
Our findings revealed a significant link—higher MDS scores led to an increased risk of depression. Specifically, for each unit rise in MDS, the chance of developing depression increased by 13%. Interestingly, those with severe magnesium deficiency saw a staggering 58% rise in depression likelihood. This suggests that improving magnesium levels could be beneficial for both preventing and treating depression.
Our findings revealed a significant link—higher MDS scores led to an increased risk of depression. Specifically, for each unit rise in MDS, the chance of developing depression increased by 13%. Interestingly, those with severe magnesium deficiency saw a staggering 58% rise in depression likelihood. This suggests that improving magnesium levels could be beneficial for both preventing and treating depression.
Read More
8
This study examined how magnesium deficiency relates to depression in adults aged 20 to 60. By using the National Health and Nutrition Examination Survey data from 2005 to 2018, we analyzed the magnesium depletion score (MDS) while assessing depression through the Patient Health Questionnaire-9.
Our findings reveal a positive association: as the MDS increases, so does the likelihood of depression. Each one-unit rise in MDS raises the odds of depression. However, results varied with different MDS levels. While these results are promising, further research is necessary to understand the underlying mechanisms better.
Our findings reveal a positive association: as the MDS increases, so does the likelihood of depression. Each one-unit rise in MDS raises the odds of depression. However, results varied with different MDS levels. While these results are promising, further research is necessary to understand the underlying mechanisms better.
Read More
User Reviews
USERS' SCORE
Good
Based on 17 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduced anxiety
16 people found this helpful
Every woman should consider magnesium, as deficiency can lead to heart issues and affect mental health, causing anxiety and depression. After taking one capsule daily, my leg cramps vanished, I became calmer, and my insomnia improved significantly. I find it a bargain for six months' supply.
Read More
9
Stopped medication
8 people found this helpful
I take magnesium to help relieve depression, which recent research suggests benefits mental disorders. I realise when my mood disorder affects my intake. While results vary, I believe staying below 300mg daily is important. I find magnesium to be a preferable alternative to psychiatric medications.
Read More
9
Stress relief
8 people found this helpful
Magnesium serves as a natural anti-stress agent, aiding the nervous system and reducing anxiety and insomnia. I combined it with vitamin B6, primarily for stress reduction and sleep improvement, which has worked well for me. I also noticed my eyes were less puffy after sleep.
Read More
9
Muscle relaxation
3 people found this helpful
I’ve been using magnesium for years, taking one capsule daily. It has significantly reduced my night cramps and overall, magnesium is crucial for reducing stress, insomnia, and even depression. It supports muscle relaxation and promotes better health for bones and teeth.
Read More
9
Vital nutrient
3 people found this helpful
After battling cancer and enduring chemotherapy, magnesium became essential for my recovery and overcoming depression. It also aids my children, especially for muscle recovery. Overall, magnesium's contribution to serotonin production makes it a necessary nutrient for everyone.
Read More
Frequently Asked Questions
7.5
Improved mood
714 people found this helpful
Taking magnesium in the evenings, I initially saw little improvement other than stronger sleep. After about a month and a half, I realised I had not experienced night cramps for a long while. I became less irritable and my mood stabilised, showing no signs of depression.
9
Cumulative effects
The product arrived undamaged, and the effects are good. My irritability and depression have vanished, but do not expect immediate results; the benefits accumulate over time.
9
Boosted energy
1 people found this helpful
This product has significantly improved my overall health. I've noticed that fatigue and irritability have disappeared after using it, though results take time. The effect is cumulative, but it has certainly contributed to my mood and mental well-being.
7.5
Better sleep
15 people found this helpful
Prior to using this product, I consulted my doctor due to my insomnia and light sleeping. After taking it, I now sleep soundly through the night without waking up and feel less tired in the morning. It seems to have alleviated my depression too; I'm very pleased.
9
Stress relief
8 people found this helpful
Magnesium serves as a natural anti-stress agent, aiding the nervous system and reducing anxiety and insomnia. I combined it with vitamin B6, primarily for stress reduction and sleep improvement, which has worked well for me. I also noticed my eyes were less puffy after sleep.
7.5
Nervous system support
2 people found this helpful
Magnesium, particularly with vitamin B6, normalises the nervous system under stress, depression, and neurosis. Stress increases magnesium demand, making it crucial as we age.
9
Stopped medication
8 people found this helpful
I take magnesium to help relieve depression, which recent research suggests benefits mental disorders. I realise when my mood disorder affects my intake. While results vary, I believe staying below 300mg daily is important. I find magnesium to be a preferable alternative to psychiatric medications.
7
Magnesium complex shows antidepressant promise
We explored the antidepressant effects of a new imipramine-magnesium (IMI-Mg) complex in male mice. Using established behavioral tests like the forced swim and tail suspension tests, we found that this complex notably reduced immobility time, indicating potential antidepressant-like activity.
Importantly, the results were comparable to administering imipramine and magnesium individually. This promising finding suggests the IMI-Mg complex could pave the way for enhanced treatment approaches, improving safety and patient adherence in depression therapies.
Importantly, the results were comparable to administering imipramine and magnesium individually. This promising finding suggests the IMI-Mg complex could pave the way for enhanced treatment approaches, improving safety and patient adherence in depression therapies.
9
We conducted a systematic review and meta-analysis exploring how dietary magnesium (Mg) intake connects with depression among adults. By reviewing data from over 63,000 individuals, we found that those with the highest magnesium intake had a 34% lower chance of experiencing depression compared to those with the lowest intake.
Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk.
Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk.
8
Magnesium deficiency correlates with depression
This study examined the relationship between magnesium deficiency, measured by the Magnesium Depletion Score (MDS), and depression among U.S. adults. We analyzed data from the National Health and Nutrition Examination Survey, focusing on those with moderate to severe depression.
Our findings revealed a significant link—higher MDS scores led to an increased risk of depression. Specifically, for each unit rise in MDS, the chance of developing depression increased by 13%. Interestingly, those with severe magnesium deficiency saw a staggering 58% rise in depression likelihood. This suggests that improving magnesium levels could be beneficial for both preventing and treating depression.
Our findings revealed a significant link—higher MDS scores led to an increased risk of depression. Specifically, for each unit rise in MDS, the chance of developing depression increased by 13%. Interestingly, those with severe magnesium deficiency saw a staggering 58% rise in depression likelihood. This suggests that improving magnesium levels could be beneficial for both preventing and treating depression.
9.5
Magnesium and Vitamin D effective for depression
We explored the effectiveness of magnesium coupled with vitamin D in easing depressive symptoms among individuals with long-COVID. Our study involved 60 participants suffering from mild to moderate depression, hypomagnesemia, and vitamin D deficiency.
Over four months, those who received both magnesium and vitamin D showed significant improvements in their depression scores compared to those who only took vitamin D. Specifically, a notable 73% of the magnesium group achieved significant relief, positioning this combination as a promising treatment for depression linked to long-COVID.
Mild side effects were noted but did not lead to any withdrawals, indicating the safety of this treatment option.
Over four months, those who received both magnesium and vitamin D showed significant improvements in their depression scores compared to those who only took vitamin D. Specifically, a notable 73% of the magnesium group achieved significant relief, positioning this combination as a promising treatment for depression linked to long-COVID.
Mild side effects were noted but did not lead to any withdrawals, indicating the safety of this treatment option.
References
- Serefko A, Lachowicz-Radulska J, Szopa A, Herbet M, Czylkowska A, et al. The Novel Imipramine-Magnesium Complex Exerts Antidepressant-like Activity in Mice Subjected to the Forced Swim Test and the Tail Suspension Test. Molecules. 2025;30. 10.3390/molecules30030519
- Bardinet J, Pouchieu C, Chuy V, Merle B, Pellay H, et al. Association between nutrient patterns and odds of depressive symptomatology: a population-based cohort of older adults followed during 15-y. Eur J Nutr. 2025;64:88. 10.1007/s00394-025-03597-x
- Rodríguez-Morán M, Guerrero-Romero F, Barragán-Zuñiga J, Gamboa-Gómez CI, Weyman-Vela Y, et al. Combined oral supplementation with magnesium plus vitamin D alleviates mild to moderate depressive symptoms related to long-COVID: an open-label randomized, controlled clinical trial. Magnes Res. 2024;37:49. 10.1684/mrh.2024.0535
- Zhao W, Jin H. Magnesium depletion score and depression: a positive correlation among US adults. Front Public Health. 2024;12:1486434. 10.3389/fpubh.2024.1486434
- Carnegie RE, Zheng J, Borges MC, Jones HJ, Wade KH, et al. Micronutrients and Major Depression: A Mendelian Randomisation Study. Nutrients. 2024;16. 10.3390/nu16213690
- Cai Z, She J, Liu X, Li R, Guo S, et al. Associations between magnesium depletion score and depression among individuals aged 20 to 60 years. J Trace Elem Med Biol. 2024;86:127543. 10.1016/j.jtemb.2024.127543
- Strodl E, Bambling M, Parnam S, Ritchie G, Cramb S, et al. Probiotics and magnesium orotate for the treatment of major depressive disorder: a randomised double blind controlled trial. Sci Rep. 2024;14:20841. 10.1038/s41598-024-71093-z
- Hajhashemy Z, Shirani F, Askari G. Dietary Magnesium Intake in Relation to Depression in Adults: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis of Epidemiologic Studies. Nutr Rev. 2025;83:217. 10.1093/nutrit/nuae056
- Abdelmoneam AH, Khafagy GM, Elbeh KA, Hasan MDA. Impact of Magnesium and Ferritin Deficiency on Depression Among Adolescent Students. J Prim Care Community Health. 2024;15:21501319241252570. 10.1177/21501319241252570
- Chou MH, Yang YK, Wang JD, Lin CY, Lin SH. Elevated C-Reactive Protein Levels Modify the Effect of Magnesium on Depressive Symptoms: A Population-Based Study. Nutrients. 2023;15. 10.3390/nu15071560
- Chou MH, Yang YK, Wang JD, Lin CY, Lin SH. The Association of Serum and Dietary Magnesium with Depressive Symptoms. Nutrients. 2023;15. 10.3390/nu15030774
- Li Z, Chen K, Shao Q, Lu H, Zhang X, et al. Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress. J Neuroinflammation. 2023;20:16. 10.1186/s12974-023-02696-y
- Wang H, Jin M, Xie M, Yang Y, Xue F, et al. Protective role of antioxidant supplementation for depression and anxiety: A meta-analysis of randomized clinical trials. J Affect Disord. 2023;323:264. 10.1016/j.jad.2022.11.072
- Saba S, Faizi F, Sepandi M, Nehrir B. Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery. Magnes Res. 2022;35:62. 10.1684/mrh.2022.0503
- Abiri B, Sarbakhsh P, Vafa M. Randomized study of the effects of vitamin D and/or magnesium supplementation on mood, serum levels of BDNF, inflammation, and SIRT1 in obese women with mild to moderate depressive symptoms. Nutr Neurosci. 2022;25:2123. 10.1080/1028415X.2021.1945859
- Miller ES, Sakowicz A, Roy A, Wang A, Yang A, et al. Is peripartum magnesium sulfate associated with a reduction in postpartum depressive symptoms?. Am J Obstet Gynecol MFM. 2021;3:100407. 10.1016/j.ajogmf.2021.100407
