Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.5
USERS' SCORE
Moderately Good
Based on 12 Reviews
7.2
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Magnesium (elemental) (from Magnesium Oxide, Magnesium Citrate and Magnesium Aspartate)
400 mg
95%
Top Medical Research Studies
9
We explored the impact of a new treatment, Marial®, on patients suffering from gastroesophageal reflux disease (GERD). In a large survey involving 56 gastroenterological offices across Italy, patients were treated with either proton pump inhibitors (PPIs), a combination of PPIs and an additional remedy, or the Marial® formulation containing magnesium alginate. The results showed that both Marial® and the combination therapy significantly reduced heartburn symptoms, with Marial® proving to be more effective than the combination. Overall, patients reported a marked improvement in their GERD-related symptoms.
Read More
8
GutGard® shows promise for heartburn
In a well-designed phase III trial, we explored how GutGard®, a licorice extract, helps relieve heartburn related to gastroesophageal reflux. Over 28 days, participants were randomly assigned to receive either GutGard® or a placebo without knowing which one they had.
Remarkably, those taking GutGard® reported quicker relief from their GER symptoms, particularly heartburn, compared to those on the placebo. This suggests that GutGard® may offer an effective, safe option for managing heartburn symptoms.
Remarkably, those taking GutGard® reported quicker relief from their GER symptoms, particularly heartburn, compared to those on the placebo. This suggests that GutGard® may offer an effective, safe option for managing heartburn symptoms.
Read More
7
Rapid relief, similar effectiveness observed
We conducted a study to see how well a fixed-dose combination of esomeprazole and magnesium hydroxide works for heartburn compared to enteric-coated esomeprazole. By using a crossover design, forty-nine healthy subjects received each treatment, allowing us to closely observe the effects.
Our findings showed that the combination drug reached maximum concentration faster and achieved gastric pH levels that suggest quicker acid suppression. Despite these advantages, the overall effectiveness in reducing gastric acidity was similar for both treatments. This indicates that while magnesium may enhance the speed of relief, it doesn't significantly outperform traditional esomeprazole.
Our findings showed that the combination drug reached maximum concentration faster and achieved gastric pH levels that suggest quicker acid suppression. Despite these advantages, the overall effectiveness in reducing gastric acidity was similar for both treatments. This indicates that while magnesium may enhance the speed of relief, it doesn't significantly outperform traditional esomeprazole.
Read More
Most Useful Reviews
9
No heartburn experienced
I find this magnesium is fantastic as I experience no heartburn and feel relaxed shortly after taking it at night. It also helps with my menopausal palpitations. Thank you for offering such great value for money!
Read More
9
Assists digestion
I have purchased this magnesium several times. The capsules are medium-large but tasteless. It provides energy and supports proper digestion without causing heartburn. The price is optimal, so I highly recommend it.
Read More
9
Muscle relaxation
I took it as it relaxes muscles and alleviates anxiety. Being vegan and kosher was important to me. It effectively relaxes muscles that tense up after mental stress, and the large package is worth the price. It's excellent value, with no side effects or taste, is easy to swallow, and doesn't cause heartburn, promoting restful sleep and providing essential minerals.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.5
- All Researches
9
We explored the impact of a new treatment, Marial®, on patients suffering from gastroesophageal reflux disease (GERD). In a large survey involving 56 gastroenterological offices across Italy, patients were treated with either proton pump inhibitors (PPIs), a combination of PPIs and an additional remedy, or the Marial® formulation containing magnesium alginate. The results showed that both Marial® and the combination therapy significantly reduced heartburn symptoms, with Marial® proving to be more effective than the combination. Overall, patients reported a marked improvement in their GERD-related symptoms.
Read More
8
GutGard® shows promise for heartburn
In a well-designed phase III trial, we explored how GutGard®, a licorice extract, helps relieve heartburn related to gastroesophageal reflux. Over 28 days, participants were randomly assigned to receive either GutGard® or a placebo without knowing which one they had.
Remarkably, those taking GutGard® reported quicker relief from their GER symptoms, particularly heartburn, compared to those on the placebo. This suggests that GutGard® may offer an effective, safe option for managing heartburn symptoms.
Remarkably, those taking GutGard® reported quicker relief from their GER symptoms, particularly heartburn, compared to those on the placebo. This suggests that GutGard® may offer an effective, safe option for managing heartburn symptoms.
Read More
7
Rapid relief, similar effectiveness observed
We conducted a study to see how well a fixed-dose combination of esomeprazole and magnesium hydroxide works for heartburn compared to enteric-coated esomeprazole. By using a crossover design, forty-nine healthy subjects received each treatment, allowing us to closely observe the effects.
Our findings showed that the combination drug reached maximum concentration faster and achieved gastric pH levels that suggest quicker acid suppression. Despite these advantages, the overall effectiveness in reducing gastric acidity was similar for both treatments. This indicates that while magnesium may enhance the speed of relief, it doesn't significantly outperform traditional esomeprazole.
Our findings showed that the combination drug reached maximum concentration faster and achieved gastric pH levels that suggest quicker acid suppression. Despite these advantages, the overall effectiveness in reducing gastric acidity was similar for both treatments. This indicates that while magnesium may enhance the speed of relief, it doesn't significantly outperform traditional esomeprazole.
Read More
7
We investigated how different types of mineral waters might assist in treating patients with gastroesophageal reflux disease (GERD). Ninety patients were split into three groups: a control group receiving standard treatment, one group drinking boric sodium bicarbonate water, and another consuming highly mineralized sodium-magnesium water.
While basic treatment showed little effectiveness, the boric water alleviated some symptoms, and the magnesium water notably improved dyspepsia and liver function. Overall, our findings support the use of mineral waters as part of a comprehensive GERD treatment plan.
While basic treatment showed little effectiveness, the boric water alleviated some symptoms, and the magnesium water notably improved dyspepsia and liver function. Overall, our findings support the use of mineral waters as part of a comprehensive GERD treatment plan.
Read More
7
We investigated the effectiveness of dietary changes and natural remedies in treating gastrointestinal symptoms in a 73-year-old woman with newly diagnosed Parkinson's disease. The patient faced constipation and acid reflux after starting medication. By increasing her vegetable intake, fiber, protein, and hydration while reducing sugars, she saw improvements in her symptoms. Notably, integrating apple cider vinegar, deglycyrrhizinated licorice, probiotics, and magnesium citrate helped alleviate her acid reflux significantly—50% improvement within just five days. Ultimately, she achieved complete symptom resolution in one month, highlighting the promise of diet and natural treatments.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 12 Reviews
7.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
No heartburn experienced
I find this magnesium is fantastic as I experience no heartburn and feel relaxed shortly after taking it at night. It also helps with my menopausal palpitations. Thank you for offering such great value for money!
Read More
9
Assists digestion
I have purchased this magnesium several times. The capsules are medium-large but tasteless. It provides energy and supports proper digestion without causing heartburn. The price is optimal, so I highly recommend it.
Read More
9
Muscle relaxation
I took it as it relaxes muscles and alleviates anxiety. Being vegan and kosher was important to me. It effectively relaxes muscles that tense up after mental stress, and the large package is worth the price. It's excellent value, with no side effects or taste, is easy to swallow, and doesn't cause heartburn, promoting restful sleep and providing essential minerals.
Read More
6
Calmness achieved
5 people found this helpful
Six months ago, I discovered through my nutritionist that I had a significant magnesium deficiency, which contributed to my insomnia, twitching, and irritability. After starting magnesium supplementation, I became calmer and could converse with my child without raising my voice. This positive change is making us both happier, and my son is now taking magnesium too.
Read More
4
Effective magnesium
2 people found this helpful
Magnesium was within the expiry date, and the packaging was as advertised. Despite being large, the capsules are easy to swallow and have no notable taste. I've experienced deep sleep and a reduction in sweet cravings. However, magnesium oxide might not suit everyone, particularly those with gastrointestinal issues, as it can induce heartburn.
Read More
Frequently Asked Questions
9
Money well spent
This magnesium supplement offers excellent value for money, as it has eliminated my heartburn and has not caused diarrhoea.
9
Heartburn relief
This product, containing magnesium oxide, has significantly improved my indigestion, heartburn, and constipation. It also enhances sleep and reduces muscle cramps, taken at night with no aftertaste.
6
Heartburn relief
203 people found this helpful
Magnesium met the expiry date. The capsules are large yet easy to swallow and have no distinct taste. I've found benefits such as deep sleep and reduced cravings for sweets. However, the primary ingredient, magnesium oxide, may not suit everyone, especially those with stomach issues, as it can cause heartburn and intestinal discomfort.
9
No heartburn experienced
I find this magnesium is fantastic as I experience no heartburn and feel relaxed shortly after taking it at night. It also helps with my menopausal palpitations. Thank you for offering such great value for money!
9
Muscle relaxation
I took it as it relaxes muscles and alleviates anxiety. Being vegan and kosher was important to me. It effectively relaxes muscles that tense up after mental stress, and the large package is worth the price. It's excellent value, with no side effects or taste, is easy to swallow, and doesn't cause heartburn, promoting restful sleep and providing essential minerals.
2
Heartburn relief
1 people found this helpful
I ordered without checking the magnesium form, swayed by the price. This form is poorly absorbed, so I wouldn't recommend it if you lack magnesium; however, it does help with heartburn.
4
Digestive aid
1 people found this helpful
This magnesium combines oxide, citrate, and ascorbate. Magnesium oxide helps with heartburn, but it is poorly absorbed orally. Citrate dissolves easily and is well absorbed. I recommend this blend for those with gastritis, though if you have frequent diarrhoea, magnesium glycinate might be a better option.
4
Effective magnesium
2 people found this helpful
Magnesium was within the expiry date, and the packaging was as advertised. Despite being large, the capsules are easy to swallow and have no notable taste. I've experienced deep sleep and a reduction in sweet cravings. However, magnesium oxide might not suit everyone, particularly those with gastrointestinal issues, as it can induce heartburn.
8
GutGard® shows promise for heartburn
In a well-designed phase III trial, we explored how GutGard®, a licorice extract, helps relieve heartburn related to gastroesophageal reflux. Over 28 days, participants were randomly assigned to receive either GutGard® or a placebo without knowing which one they had.
Remarkably, those taking GutGard® reported quicker relief from their GER symptoms, particularly heartburn, compared to those on the placebo. This suggests that GutGard® may offer an effective, safe option for managing heartburn symptoms.
Remarkably, those taking GutGard® reported quicker relief from their GER symptoms, particularly heartburn, compared to those on the placebo. This suggests that GutGard® may offer an effective, safe option for managing heartburn symptoms.
7
Our observational study focused on 40 patients suffering from gastroesophageal reflux disease (GERD) treated with a gel combining sodium hyaluronic acid and magnesium alginate. This gel works to hydrate and protect the mucosal tissues in the digestive tract.
We split our patients into two groups: one receiving the gel and the other using conventional treatments alongside proton pump inhibitors. Throughout the follow-up, many reported a significant reduction in heartburn symptoms, with some patients finding relief in just five days.
While the results are encouraging, further research is needed to fully understand the extent of magnesium’s benefits in treating GERD.
We split our patients into two groups: one receiving the gel and the other using conventional treatments alongside proton pump inhibitors. Throughout the follow-up, many reported a significant reduction in heartburn symptoms, with some patients finding relief in just five days.
While the results are encouraging, further research is needed to fully understand the extent of magnesium’s benefits in treating GERD.
9
We explored the impact of a new treatment, Marial®, on patients suffering from gastroesophageal reflux disease (GERD). In a large survey involving 56 gastroenterological offices across Italy, patients were treated with either proton pump inhibitors (PPIs), a combination of PPIs and an additional remedy, or the Marial® formulation containing magnesium alginate. The results showed that both Marial® and the combination therapy significantly reduced heartburn symptoms, with Marial® proving to be more effective than the combination. Overall, patients reported a marked improvement in their GERD-related symptoms.
7
We investigated the effectiveness of dietary changes and natural remedies in treating gastrointestinal symptoms in a 73-year-old woman with newly diagnosed Parkinson's disease. The patient faced constipation and acid reflux after starting medication. By increasing her vegetable intake, fiber, protein, and hydration while reducing sugars, she saw improvements in her symptoms. Notably, integrating apple cider vinegar, deglycyrrhizinated licorice, probiotics, and magnesium citrate helped alleviate her acid reflux significantly—50% improvement within just five days. Ultimately, she achieved complete symptom resolution in one month, highlighting the promise of diet and natural treatments.
References
- Raj JP, Saxena U, Belhekar MN, Mamde A, Darak H, et al. Efficacy and Safety of GutGard® in Managing Gastroesophageal Reflux-Related Symptoms: A Phase III, Single-Centre, Double-Blind, Randomized Placebo-Controlled Trial. Complement Med Res. 2025;32:26. 10.1159/000543367
- Kim Y, Bae S, Jeon I, Kwon J, Hong SH, et al. Pharmacokinetics and Pharmacodynamics of a Fixed-Dose Combination of Esomeprazole and Magnesium Hydroxide Compared to the Enteric-Coated Esomeprazole. Clin Ther. 2024;46:870. 10.1016/j.clinthera.2024.08.006
- Dragomiretska NV, Babov KD, Gushcha SG, Zabolotna IB, Plakida AL, et al. Application of mineral waters in the complex treatment of patients with gastroesophageal reflux disease. Minerva Gastroenterol Dietol. 2020;66:225. 10.23736/S1121-421X.20.02601-X
- Neiworth-Petshow EM, Baldwin-Sayre C. Naturopathic Treatment of Gastrointestinal Dysfunction in the Setting of Parkinson's Disease. Integr Med (Encinitas). 2018;17:44.
- Bianchetti M, Peralta S, Nicita R, Aragona SE, Ciprandi G. Emerging from gastroesophageal reflux (EMERGE): An Italian survey - II the viewpoint of the patient. J Biol Regul Homeost Agents. 2018;32:983.
- Aragona SE, Mereghetti G, Bianchetti M, Mangiavillano B, Zurlo T, et al. Regenerative medicine in the treatment of gastro-esophageal reflux disease and laryngo-pharyngeal reflux. From research to cure. J Biol Regul Homeost Agents. 2017;31:207.
