We explored how zinc affects acne through a systematic review and meta-analysis that looked at two main questions. First, we wanted to know if there are differences in zinc levels between people with acne and those without. Second, we examined how effective zinc treatments are for managing acne.
Our findings showed that individuals with acne had noticeably lower serum zinc levels compared to those in the control group. Furthermore, when we looked at treatments, those who received zinc showed a significant reduction in their inflammatory papule count—a common symptom of acne. Importantly, we noted that side effects from zinc supplementation were similar to those seen in other treatments, suggesting that zinc is safe to use.
Overall, acne patients appear to benefit from improved zinc levels, especially when zinc is used either on its own or alongside other acne treatments. This gives hope for those looking for effective ways to tackle acne issues!
Read More
9
Zinc shows promise against acne
An Open-label Study Comparing Oral Zinc to Lymecycline in the Treatment of Acne Vulgaris.
We aimed to explore how effective zinc sulphate is in treating mild to moderate acne compared to the well-known antibiotic lymecycline. In our study, we involved 100 participants who were randomly assigned to receive either zinc sulphate or lymecycline.
To measure the effectiveness of the treatments, we used the Global Acne Grading System and a special questionnaire focused on acne's impact on quality of life. After four and twelve weeks of treatment, we found that both treatments significantly reduced acne severity.
However, the results showed something interesting. The patients who took zinc sulphate reported greater improvements in their quality of life than those on lymecycline. This indicates that zinc not only helps with acne but may also lead to a better overall experience during treatment.
Our findings suggest that zinc sulphate could be a compelling alternative to lymecycline, providing similar clinical benefits without the risk of antibiotic resistance associated with long-term antibiotic use.
Read More
9
Zinc compounds as acne treatment
Zinc(II) Complexes of Amino Acids as New Active Ingredients for Anti-Acne Dermatological Preparations.
We examined the potential of zinc compounds, particularly zinc-amino acid complexes, to effectively treat acne. This study focused on how these zinc formulations could not only help with acne but also ensure safety for the skin.
Initially, we checked the cytotoxicity of the zinc complexes on human skin cells, demonstrating their safety. We then evaluated their antibacterial properties, which are crucial for combating acne-causing bacteria. After finding promising results, we selected zinc complexes with glycine and histidine to create unique gel formulations.
The next steps involved thorough testing of these gel preparations for stability, purity, and tolerability. We confirmed that they maintained their quality over time, showed no irritation or allergic reactions in a patch test with 25 volunteers, and exhibited high microbiological purity.
Ultimately, our findings suggest that these zinc-based gels can be a valuable topical option for acne treatment due to their strong antibacterial performance and minimal toxicity to skin cells. Our dermatological formulations appear safe and effective, contributing positively to acne management.
Read More
Most Useful Reviews
9
Significant improvement
I have shared this link with many friends to assist others! I am new to taking vitamins as I dislike swallowing pills, but these tablets are fantastic! They are not too big, making them easy to take. As a college student under stress, I have had significant acne issues. After a few weeks of taking this, I noticed a remarkable difference. I now occasionally get a pimple, which is normal. Additionally, it has aided in alleviating my anxiety and muscle spasms. I will definitely continue to take them and order from Amazon, as I haven't found a better price for 250 tablets. I highly recommend this to anyone considering purchasing; you won't be disappointed.
Read More
7.5
Reduced acne
I bought it for the first time as a trial. I believe it has helped as my acne has decreased. The only downside is the tablets are quite large, making them slightly inconvenient to swallow.
Read More
0
New acne appeared
1 people found this helpful
Everything was fine; I took it at night for sleep, and my sleep was sound. However, at my age, I developed prickly subcutaneous acne on my face. I stopped taking it, returned to regular magnesium, and the new acne ceased. The previous ones have been under treatment for a week and still hurt and remain on my face. I suspect this may be due to the zinc or vitamin D3.
Treatment of Resistant Acne Vulgaris in Adolescents Using Dietary Supplementation with Magnesium, Phosphate and Fatty Acids (Omega 6 and 7): Comparison with 13-Cis-Retinoic Acid.
We examined how dietary supplementation with magnesium, among other nutrients, could help treat acne vulgaris. In a six-month study, one group received this natural supplement while another was given isotretinoin.
Notably, all participants in the magnesium group reported complete regression of their symptoms, contrasting with 68% in the isotretinoin group. This significant difference suggests that magnesium can be highly effective for acne treatment, offering a promising alternative with fewer side effects.
Read More
9.5
Zinc's role in acne treatment
Ultrasound-triggered interfacial engineering-based microneedle for bacterial infection acne treatment.
We investigated the effectiveness of a novel microneedle patch designed for acne treatment, which incorporates zinc-based nanoparticles. This patch combines sodium hyaluronate with zinc porphyrin-based metal-organic frameworks and zinc oxide. By using ultrasound to release activated oxygen, we observed a remarkable antibacterial efficiency, achieving a 99.73% reduction in acne-causing bacteria within just 15 minutes.
Zinc plays a crucial role in this innovative approach. Not only does it help eliminate harmful bacteria, but it also appears to enhance skin health. The presence of zinc ions promotes the up-regulation of genes associated with DNA replication, which supports the growth of fibroblasts. This is a vital process for skin repair and rejuvenation, showing that zinc can potentially contribute to both the treatment and recovery of acne-affected skin.
Overall, our findings suggest that this microneedle patch, which utilizes zinc and ultrasound-responsive technology, represents a promising strategy for effectively managing acne without relying on traditional antibiotics.
Read More
9
Calcium filler shows promise for scars
Combined use of microfocused ultrasound and a calcium hydroxylapatite dermal filler for treating atrophic acne scars: A pilot study.
We explored the effectiveness of combining microfocused ultrasound with a calcium hydroxylapatite dermal filler for treating acne scars. This approach was evaluated in a group of healthy adults aged 35-55, who had moderate to severe facial scars from acne.
During the treatment, ultrasound was applied in a cross-hatch pattern to stimulate the skin, followed by injections of a diluted calcium hydroxylapatite filler mixed with lidocaine for comfort. The results were assessed 90 days later, focusing on changes in scar severity and overall satisfaction of the subjects.
The findings revealed significant improvement in acne scars, particularly in those with severe scarring. The majority of participants reported being satisfied with their results, and no adverse side effects were noted. While calcium hydroxylapatite alone was not isolated in this study, its combination with ultrasound showed promising results for reducing scar visibility.
We investigated how zinc treatment affects acne, particularly focusing on its potential benefits for those suffering from acne rosacea. The study observed that zinc sulfate solution at a concentration of 5% played a notable role in reducing the severity of acne rosacea symptoms.
Findings indicated that around 40% to 60% of patients experienced a moderate to good response after using zinc. This suggests that zinc could be helpful for individuals looking for alternatives or supplements in their acne treatment regimen.
However, it's important to acknowledge that while zinc showed positive results, the isolated effect of zinc alone cannot be fully determined. It might have worked in conjunction with other treatment factors, which complicates our understanding of its effectiveness.
Therefore, we emphasize the need for further studies to clarify exactly how zinc contributes to acne treatment outcomes and to evaluate its role alongside other therapies.
Read More
9
Zinc oxide nanoparticles combat acne
Development and Evaluation of Topical Zinc Oxide Nanogels Formulation Using and Its Effect on Acne Vulgaris.
We assessed the potential of zinc oxide nanoparticles in combating acne. Using biogenically synthesized zinc oxide, we mixed it with a polymer to create a topical nanogel aimed at treating acne. Through rigorous testing against acne-causing bacteria, we observed that these biogenic nanoparticles showed a promising antibacterial effect, particularly against Gram-positive bacteria.
Notably, the particle size of our biogenic zinc oxide nanoparticles measured around 20 nm, indicating a high degree of purity. When pitted against chemogenic counterparts, the biogenic version proved to be more effective. This suggests that zinc oxide, especially when produced biogenically, could be a valuable addition to skincare products targeting acne.
Moreover, the study highlights the environment-friendly aspect of using biogenic zinc oxide in skincare formulations, making it a preferable choice for those concerned about sustainability. Our findings suggest that these hybrid nanogels could serve as an effective solution against skin infections associated with acne, adding to their appeal in modern skincare.
I have shared this link with many friends to assist others! I am new to taking vitamins as I dislike swallowing pills, but these tablets are fantastic! They are not too big, making them easy to take. As a college student under stress, I have had significant acne issues. After a few weeks of taking this, I noticed a remarkable difference. I now occasionally get a pimple, which is normal. Additionally, it has aided in alleviating my anxiety and muscle spasms. I will definitely continue to take them and order from Amazon, as I haven't found a better price for 250 tablets. I highly recommend this to anyone considering purchasing; you won't be disappointed.
Read More
7.5
Reduced acne
I bought it for the first time as a trial. I believe it has helped as my acne has decreased. The only downside is the tablets are quite large, making them slightly inconvenient to swallow.
Read More
0
New acne appeared
1 people found this helpful
Everything was fine; I took it at night for sleep, and my sleep was sound. However, at my age, I developed prickly subcutaneous acne on my face. I stopped taking it, returned to regular magnesium, and the new acne ceased. The previous ones have been under treatment for a week and still hurt and remain on my face. I suspect this may be due to the zinc or vitamin D3.
Read More
Frequently Asked Questions
Acne is a common skin condition that affects people of all ages, though it's especially prevalent among teenagers and young adults. It occurs when hair follicles become clogged with oil and dead skin cells, leading to the formation of pimples, blackheads, and cysts. The main factors contributing to acne include excess oil production, hormonal changes, and the presence of bacteria on the skin. Acne can manifest in various forms, from mild cases with just a few breakouts to more severe forms that can cause significant inflammation and scarring.
Treatment for acne varies depending on its severity and can range from over-the-counter topical treatments like benzoyl peroxide and salicylic acid to prescription medications including retinoids and antibiotics. Lifestyle adjustments, such as maintaining a balanced diet and proper skin hygiene, may also contribute to managing and reducing breakouts. Despite being a common skin issue, the psychological impact of acne should not be underestimated, as it can affect self-esteem and overall quality of life.
Calcium magnesium refers to a dietary supplement that combines two essential minerals, calcium and magnesium, which play critical roles in maintaining various bodily functions. Calcium is vital for building and maintaining strong bones and teeth, while magnesium supports muscle function, energy production, and the regulation of calcium levels in the body. Together, these minerals work synergistically to promote overall health, particularly in areas such as bone density, cardiovascular health, and muscle function.
Supplements that contain both calcium and magnesium can be particularly beneficial for individuals who may be deficient in these minerals due to dietary restrictions or health conditions. They are available in various forms, including tablets, capsules, and powders. When considering a calcium magnesium supplement, it's essential to choose a product with the right ratio of these minerals, as well as other supporting vitamins and minerals like vitamin D, which enhances calcium absorption. Always consult with a healthcare provider before starting any new supplement regimen to ensure it aligns with your health needs and goals.
Based on user reviews, it seems that individuals taking this supplement for acne generally notice improvements within a few weeks. For instance, one user mentioned they saw a "remarkable difference" after starting the supplement, indicating that their acne issues significantly improved in a matter of weeks Read Review. Another reviewer confirmed that their acne had decreased after trying the product, suggesting it can be effective relatively quickly, although it was their first trial Read Review.
However, it's important to note that results can vary from person to person. One user mentioned that they experienced new acne after starting the supplement and had to discontinue its use Read Review. Therefore, while many users report seeing positive changes within a few weeks, some may experience different results. It might be worthwhile to give the supplement a few weeks to assess its effectiveness for your specific skin type.
This supplement, particularly zinc, has garnered attention in research for its potential role in managing acne. A systematic review highlighted that individuals with acne tend to have lower serum zinc levels than those without, and zinc supplementation has been associated with a significant reduction in inflammatory papules, a common acne symptom [26]. Furthermore, a comparative study showed that patients taking zinc reported greater quality of life improvements than those on traditional antibiotic treatments, suggesting that zinc could be a compelling alternative option for those looking to avoid antibiotics [23].
On the other hand, while there are numerous studies indicating zinc's potential antibacterial and anti-inflammatory effects, its exact efficacy as a standalone treatment for acne is still being debated. Several studies stress that more focused research is necessary to fully comprehend zinc’s impact [21], [24]. Overall, existing scientific evidence supports the inclusion of zinc in acne treatment regimens, yet further investigation is required to determine optimal usage and its efficacy in isolation versus as part of combination therapy.
Based on user reviews, several individuals have reported beneficial improvements in their symptoms after taking the supplement. One user noted a "remarkable difference" in their acne within a few weeks of starting the vitamins, highlighting a significant reduction in breakouts and an overall enhancement in their skin condition Read Review. Another reviewer reported a decrease in acne as well, suggesting effectiveness for first-time users Read Review.
However, it is crucial to acknowledge that results can differ from individual to individual. For instance, one reviewer experienced new acne breakouts after starting the supplement, leading them to discontinue use Read Review. This variability in outcomes serves as a reminder that while many users have found success with the product, personal experiences can vary widely based on individual skin types and sensitivities. It's advisable to allow a few weeks to gauge individual reactions and effectiveness.
Users report varied experiences regarding the effectiveness of Calcium Magnesium supplements for treating acne, but there is no consensus on the right dose. While some users, such as one who mentioned a significant reduction in acne after a few weeks of use, recommend the product for its overall benefits alongside reducing breakouts, they do not specify the dosage taken Read Review. Another user noted a similar decrease in acne with their trial of the product, although they did not provide information on the dosage or how long they had been taking it Read Review.
On the other hand, there is a contrasting report where a user experienced new acne breakouts after starting the supplement, suggesting that the formulation might not be suitable for everyone, possibly due to other ingredients like zinc or vitamin D3 Read Review. Overall, while many find benefits, the ideal dosage seems individual, highlighting the need for further research or personal experimentation to determine what works best for each person's skin.
9
Significant improvement
I have shared this link with many friends to assist others! I am new to taking vitamins as I dislike swallowing pills, but these tablets are fantastic! They are not too big, making them easy to take. As a college student under stress, I have had significant acne issues. After a few weeks of taking this, I noticed a remarkable difference. I now occasionally get a pimple, which is normal. Additionally, it has aided in alleviating my anxiety and muscle spasms. I will definitely continue to take them and order from Amazon, as I haven't found a better price for 250 tablets. I highly recommend this to anyone considering purchasing; you won't be disappointed.
7.5
Reduced acne
I bought it for the first time as a trial. I believe it has helped as my acne has decreased. The only downside is the tablets are quite large, making them slightly inconvenient to swallow.
0
New acne appeared
1 people found this helpful
Everything was fine; I took it at night for sleep, and my sleep was sound. However, at my age, I developed prickly subcutaneous acne on my face. I stopped taking it, returned to regular magnesium, and the new acne ceased. The previous ones have been under treatment for a week and still hurt and remain on my face. I suspect this may be due to the zinc or vitamin D3.
8
Zinc effective for acne treatment
Serum zinc levels and efficacy of zinc treatment in acne vulgaris: A systematic review and meta-analysis.
We explored how zinc affects acne through a systematic review and meta-analysis that looked at two main questions. First, we wanted to know if there are differences in zinc levels between people with acne and those without. Second, we examined how effective zinc treatments are for managing acne.
Our findings showed that individuals with acne had noticeably lower serum zinc levels compared to those in the control group. Furthermore, when we looked at treatments, those who received zinc showed a significant reduction in their inflammatory papule count—a common symptom of acne. Importantly, we noted that side effects from zinc supplementation were similar to those seen in other treatments, suggesting that zinc is safe to use.
Overall, acne patients appear to benefit from improved zinc levels, especially when zinc is used either on its own or alongside other acne treatments. This gives hope for those looking for effective ways to tackle acne issues!
9
Zinc shows promise against acne
An Open-label Study Comparing Oral Zinc to Lymecycline in the Treatment of Acne Vulgaris.
We aimed to explore how effective zinc sulphate is in treating mild to moderate acne compared to the well-known antibiotic lymecycline. In our study, we involved 100 participants who were randomly assigned to receive either zinc sulphate or lymecycline.
To measure the effectiveness of the treatments, we used the Global Acne Grading System and a special questionnaire focused on acne's impact on quality of life. After four and twelve weeks of treatment, we found that both treatments significantly reduced acne severity.
However, the results showed something interesting. The patients who took zinc sulphate reported greater improvements in their quality of life than those on lymecycline. This indicates that zinc not only helps with acne but may also lead to a better overall experience during treatment.
Our findings suggest that zinc sulphate could be a compelling alternative to lymecycline, providing similar clinical benefits without the risk of antibiotic resistance associated with long-term antibiotic use.
We explored the potential benefits of zinc in treating acne based on a review of available literature. This review examined various studies focusing on the use of zinc for acne vulgaris, along with its effectiveness for other skin conditions like leishmaniasis and hidradenitis suppurativa.
Through our search in MEDLINE, we found that zinc seems to have both antioxidant and immunomodulatory properties, which may contribute to its effectiveness in treating inflammatory conditions, including acne. While the evidence is promising, especially for those with zinc deficiency, it’s important to note that there’s still a need for further research to clarify how effective zinc can be when used on its own, without other treatments.
Patients experiencing acne might benefit from additional strategies, including zinc supplementation. However, the exact role of zinc as a standalone therapy still requires more investigation through large controlled trials.
We explored the impact of zinc on treating acne by analyzing a case where a patient with a history of severe acne transitioned to zinc gluconate therapy. Although the patient experienced an initial response to zinc, it was not conclusively isolated from other treatments.
The findings suggest that while zinc can be a helpful component in acne management, its effectiveness is still under scrutiny. Many factors are at play in acne treatment and improvement might also relate to other therapies implemented simultaneously.
In the case we observed, the treatment approach included zinc along with anti-PD-1 therapy, but the exact benefit of zinc alone remained unclear. Thus, while zinc has potential as a treatment for acne, more focused research is needed to fully understand its role.
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de Souza Pereira R. Treatment of Resistant Acne Vulgaris in Adolescents Using Dietary Supplementation with Magnesium, Phosphate and Fatty Acids (Omega 6 and 7): Comparison with 13-Cis-Retinoic Acid. J Diet Suppl. 2023;20:706. 10.1080/19390211.2022.2100550
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Algarin YA, Pulumati A, Jaalouk D, Tan J, Nouri K. The role of vitamins and nutrients in rosacea. Arch Dermatol Res. 2024;316:142. 10.1007/s00403-024-02895-4
Akman TC, Yazici M, Atila A, Mertoglu C. Analysis of Isotretinoin-Induced Alterations in the Levels of Plasma Trace Elements: Investigation of the Relationship Between Magnesium, Phosphorus, Potassium, Zinc, and Treatment-Related Side Effects. Biol Trace Elem Res. 2024;202:4858. 10.1007/s12011-023-04053-9
Li L, Hajam I, McGee JS, Tang Z, Zhang Y, et al. Comparative Transcriptome Analysis of Acne vulgaris, Rosacea, and Hidradenitis Suppurativa Supports High Dose Dietary Zinc as a Therapeutic Agent. medRxiv. 2023. 10.1101/2023.11.28.23299152
Shields A, Ly S, Wafae B, Chang YF, Manjaly P, et al. Safety and Effectiveness of Oral Nutraceuticals for Treating Acne: A Systematic Review. JAMA Dermatol. 2023;159:1373. 10.1001/jamadermatol.2023.3949
Tan YY, Wong LS, Nyam KL, Wittayanarakul K, Zawawi NA, et al. Development and Evaluation of Topical Zinc Oxide Nanogels Formulation Using and Its Effect on Acne Vulgaris. Molecules. 2023;28. 10.3390/molecules28196749
Xiang Y, Lu J, Mao C, Zhu Y, Wang C, et al. Ultrasound-triggered interfacial engineering-based microneedle for bacterial infection acne treatment. Sci Adv. 2023;9:eadf0854. 10.1126/sciadv.adf0854
Towersey L, Correia P, Fajgenbaum Feiges M, Euzébio Gonçalves Junior J, Sant'Anna B, et al. Assessment of the Benefit of a Deep Cleansing Gel Containing Salicylic Acid 2%, Zinc Gluconate 0.2% and Lipohydroxy Acids 0.05% in Patients with Mild to Moderate Truncal Acne: Results from an Exploratory Study. Clin Cosmet Investig Dermatol. 2023;16:119. 10.2147/CCID.S394123
Salah E. Oral Zinc as a Novel Adjuvant and Sparing Therapy for Systemic Isotretinoin in Acne Vulgaris: A Preliminary Comparative Study. J Clin Aesthet Dermatol. 2022;15:58.
Naji HH, Al-Azawi RSA, Ibrahim NJ, Kzar HH. Investigation of the Role of Zn/Cu Index and its Correlation with Physiological Activity of SOD 1 and GRx in Males with Acne Vulgaris. Arch Razi Inst. 2022;77:623. 10.22092/ARI.2021.356857.1928
Poizeau F, Plantier F, Bell H, Moyal-Barracco M. Vulvar Fordyce adenitis: A cohort of 45 women. Ann Dermatol Venereol. 2021;148:221. 10.1016/j.annder.2021.04.001
Tolino E, Skroza N, Mambrin A, Proietti I, Bernardini N, et al. An Open-label Study Comparing Oral Zinc to Lymecycline in the Treatment of Acne Vulgaris. J Clin Aesthet Dermatol. 2021;14:56.
Maillard A, Pastor D, Merat R. Anti-PD-1-Induced Hidradenitis Suppurativa. Dermatopathology (Basel). 2021;8:37. 10.3390/dermatopathology8010007
Abendrot M, Płuciennik E, Felczak A, Zawadzka K, Piątczak E, et al. Zinc(II) Complexes of Amino Acids as New Active Ingredients for Anti-Acne Dermatological Preparations. Int J Mol Sci. 2021;22. 10.3390/ijms22041641
Yee BE, Richards P, Sui JY, Marsch AF. Serum zinc levels and efficacy of zinc treatment in acne vulgaris: A systematic review and meta-analysis. Dermatol Ther. 2020;33:e14252. 10.1111/dth.14252