Last update
5/30/2026
Reviewed By
Infographics
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 31 Researches
7.6
USERS' SCORE
Good
Based on 2 Reviews
8.3
Supplement Facts
Serving Size: 3 Tablets
Amount Per Serving
%DV
Vitamin D-3 (as Cholecalciferol)
25 mcg (1,000 IU)
125%
Calcium (from Aquamin® TG Seaweed Derived Minerals and Calcium Citrate)
400 mg
31%
Magnesium (from Magnesium Oxide, Magnesium Glycinate, Magnesium Taurinate, Magnesium Citrate and Aquamin® TG Seaweed Derived Minerals)
800 mg
190%
Zinc (from L-OptiZinc® Monomethionine)
15 mg
136%
Top Medical Research Studies
8
We explored how zinc affects acne through a systematic review and meta-analysis that looked at two main questions. First, we wanted to know if there are differences in zinc levels between people with acne and those without. Second, we examined how effective zinc treatments are for managing acne.
Our findings showed that individuals with acne had noticeably lower serum zinc levels compared to those in the control group. Furthermore, when we looked at treatments, those who received zinc showed a significant reduction in their inflammatory papule count—a common symptom of acne. Importantly, we noted that side effects from zinc supplementation were similar to those seen in other treatments, suggesting that zinc is safe to use.
Overall, acne patients appear to benefit from improved zinc levels, especially when zinc is used either on its own or alongside other acne treatments. This gives hope for those looking for effective ways to tackle acne issues!
Our findings showed that individuals with acne had noticeably lower serum zinc levels compared to those in the control group. Furthermore, when we looked at treatments, those who received zinc showed a significant reduction in their inflammatory papule count—a common symptom of acne. Importantly, we noted that side effects from zinc supplementation were similar to those seen in other treatments, suggesting that zinc is safe to use.
Overall, acne patients appear to benefit from improved zinc levels, especially when zinc is used either on its own or alongside other acne treatments. This gives hope for those looking for effective ways to tackle acne issues!
Read More
9
We aimed to explore how effective zinc sulphate is in treating mild to moderate acne compared to the well-known antibiotic lymecycline. In our study, we involved 100 participants who were randomly assigned to receive either zinc sulphate or lymecycline.
To measure the effectiveness of the treatments, we used the Global Acne Grading System and a special questionnaire focused on acne's impact on quality of life. After four and twelve weeks of treatment, we found that both treatments significantly reduced acne severity.
However, the results showed something interesting. The patients who took zinc sulphate reported greater improvements in their quality of life than those on lymecycline. This indicates that zinc not only helps with acne but may also lead to a better overall experience during treatment.
Our findings suggest that zinc sulphate could be a compelling alternative to lymecycline, providing similar clinical benefits without the risk of antibiotic resistance associated with long-term antibiotic use.
To measure the effectiveness of the treatments, we used the Global Acne Grading System and a special questionnaire focused on acne's impact on quality of life. After four and twelve weeks of treatment, we found that both treatments significantly reduced acne severity.
However, the results showed something interesting. The patients who took zinc sulphate reported greater improvements in their quality of life than those on lymecycline. This indicates that zinc not only helps with acne but may also lead to a better overall experience during treatment.
Our findings suggest that zinc sulphate could be a compelling alternative to lymecycline, providing similar clinical benefits without the risk of antibiotic resistance associated with long-term antibiotic use.
Read More
9
We examined the potential of zinc compounds, particularly zinc-amino acid complexes, to effectively treat acne. This study focused on how these zinc formulations could not only help with acne but also ensure safety for the skin.
Initially, we checked the cytotoxicity of the zinc complexes on human skin cells, demonstrating their safety. We then evaluated their antibacterial properties, which are crucial for combating acne-causing bacteria. After finding promising results, we selected zinc complexes with glycine and histidine to create unique gel formulations.
The next steps involved thorough testing of these gel preparations for stability, purity, and tolerability. We confirmed that they maintained their quality over time, showed no irritation or allergic reactions in a patch test with 25 volunteers, and exhibited high microbiological purity.
Ultimately, our findings suggest that these zinc-based gels can be a valuable topical option for acne treatment due to their strong antibacterial performance and minimal toxicity to skin cells. Our dermatological formulations appear safe and effective, contributing positively to acne management.
Initially, we checked the cytotoxicity of the zinc complexes on human skin cells, demonstrating their safety. We then evaluated their antibacterial properties, which are crucial for combating acne-causing bacteria. After finding promising results, we selected zinc complexes with glycine and histidine to create unique gel formulations.
The next steps involved thorough testing of these gel preparations for stability, purity, and tolerability. We confirmed that they maintained their quality over time, showed no irritation or allergic reactions in a patch test with 25 volunteers, and exhibited high microbiological purity.
Ultimately, our findings suggest that these zinc-based gels can be a valuable topical option for acne treatment due to their strong antibacterial performance and minimal toxicity to skin cells. Our dermatological formulations appear safe and effective, contributing positively to acne management.
Read More
Most Useful Reviews
7
Reduced acne
I bought it for the first time as a trial. I believe it has helped as my acne has decreased. The only downside is the tablets are quite large, making them slightly inconvenient to swallow.
Read More
7
Significant improvement
I have shared this link with many friends to assist others! I am new to taking vitamins as I dislike swallowing pills, but these tablets are fantastic! They are not too big, making them easy to take. As a college student under stress, I have had significant acne issues. After a few weeks of taking this, I noticed a remarkable difference. I now occasionally get a pimple, which is normal. Additionally, it has aided in alleviating my anxiety and muscle spasms. I will definitely continue to take them and order from Amazon, as I haven't found a better price for 250 tablets. I highly recommend this to anyone considering purchasing; you won't be disappointed.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 31 Researches
7.6
- All Researches
9.5
We investigated the effectiveness of a novel microneedle patch designed for acne treatment, which incorporates zinc-based nanoparticles. This patch combines sodium hyaluronate with zinc porphyrin-based metal-organic frameworks and zinc oxide. By using ultrasound to release activated oxygen, we observed a remarkable antibacterial efficiency, achieving a 99.73% reduction in acne-causing bacteria within just 15 minutes.
Zinc plays a crucial role in this innovative approach. Not only does it help eliminate harmful bacteria, but it also appears to enhance skin health. The presence of zinc ions promotes the up-regulation of genes associated with DNA replication, which supports the growth of fibroblasts. This is a vital process for skin repair and rejuvenation, showing that zinc can potentially contribute to both the treatment and recovery of acne-affected skin.
Overall, our findings suggest that this microneedle patch, which utilizes zinc and ultrasound-responsive technology, represents a promising strategy for effectively managing acne without relying on traditional antibiotics.
Zinc plays a crucial role in this innovative approach. Not only does it help eliminate harmful bacteria, but it also appears to enhance skin health. The presence of zinc ions promotes the up-regulation of genes associated with DNA replication, which supports the growth of fibroblasts. This is a vital process for skin repair and rejuvenation, showing that zinc can potentially contribute to both the treatment and recovery of acne-affected skin.
Overall, our findings suggest that this microneedle patch, which utilizes zinc and ultrasound-responsive technology, represents a promising strategy for effectively managing acne without relying on traditional antibiotics.
Read More
9
We explored the effectiveness of combining microfocused ultrasound with a calcium hydroxylapatite dermal filler for treating acne scars. This approach was evaluated in a group of healthy adults aged 35-55, who had moderate to severe facial scars from acne.
During the treatment, ultrasound was applied in a cross-hatch pattern to stimulate the skin, followed by injections of a diluted calcium hydroxylapatite filler mixed with lidocaine for comfort. The results were assessed 90 days later, focusing on changes in scar severity and overall satisfaction of the subjects.
The findings revealed significant improvement in acne scars, particularly in those with severe scarring. The majority of participants reported being satisfied with their results, and no adverse side effects were noted. While calcium hydroxylapatite alone was not isolated in this study, its combination with ultrasound showed promising results for reducing scar visibility.
During the treatment, ultrasound was applied in a cross-hatch pattern to stimulate the skin, followed by injections of a diluted calcium hydroxylapatite filler mixed with lidocaine for comfort. The results were assessed 90 days later, focusing on changes in scar severity and overall satisfaction of the subjects.
The findings revealed significant improvement in acne scars, particularly in those with severe scarring. The majority of participants reported being satisfied with their results, and no adverse side effects were noted. While calcium hydroxylapatite alone was not isolated in this study, its combination with ultrasound showed promising results for reducing scar visibility.
Read More
9
Supplement outperformed isotretinoin in acne treatment
A single-blind randomized study compared two approaches for treating resistant acne in adolescents: dietary supplementation with magnesium, phosphate, and omega fatty acids (calcium salts), versus isotretinoin treatment. Over 6 months, all 257 patients receiving the dietary supplement reported complete symptom regression, compared to 187 of 275 patients (68%) on isotretinoin—a statistically significant difference.
The supplement group experienced faster, more complete recovery without notable side effects. These findings suggest that a natural formulation combining anti-inflammatory magnesium and bactericidal fatty acids may outperform standard pharmaceutical treatment for severe acne.
The supplement group experienced faster, more complete recovery without notable side effects. These findings suggest that a natural formulation combining anti-inflammatory magnesium and bactericidal fatty acids may outperform standard pharmaceutical treatment for severe acne.
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9
We investigated how zinc treatment affects acne, particularly focusing on its potential benefits for those suffering from acne rosacea. The study observed that zinc sulfate solution at a concentration of 5% played a notable role in reducing the severity of acne rosacea symptoms.
Findings indicated that around 40% to 60% of patients experienced a moderate to good response after using zinc. This suggests that zinc could be helpful for individuals looking for alternatives or supplements in their acne treatment regimen.
However, it's important to acknowledge that while zinc showed positive results, the isolated effect of zinc alone cannot be fully determined. It might have worked in conjunction with other treatment factors, which complicates our understanding of its effectiveness.
Therefore, we emphasize the need for further studies to clarify exactly how zinc contributes to acne treatment outcomes and to evaluate its role alongside other therapies.
Findings indicated that around 40% to 60% of patients experienced a moderate to good response after using zinc. This suggests that zinc could be helpful for individuals looking for alternatives or supplements in their acne treatment regimen.
However, it's important to acknowledge that while zinc showed positive results, the isolated effect of zinc alone cannot be fully determined. It might have worked in conjunction with other treatment factors, which complicates our understanding of its effectiveness.
Therefore, we emphasize the need for further studies to clarify exactly how zinc contributes to acne treatment outcomes and to evaluate its role alongside other therapies.
Read More
9
We assessed the potential of zinc oxide nanoparticles in combating acne. Using biogenically synthesized zinc oxide, we mixed it with a polymer to create a topical nanogel aimed at treating acne. Through rigorous testing against acne-causing bacteria, we observed that these biogenic nanoparticles showed a promising antibacterial effect, particularly against Gram-positive bacteria.
Notably, the particle size of our biogenic zinc oxide nanoparticles measured around 20 nm, indicating a high degree of purity. When pitted against chemogenic counterparts, the biogenic version proved to be more effective. This suggests that zinc oxide, especially when produced biogenically, could be a valuable addition to skincare products targeting acne.
Moreover, the study highlights the environment-friendly aspect of using biogenic zinc oxide in skincare formulations, making it a preferable choice for those concerned about sustainability. Our findings suggest that these hybrid nanogels could serve as an effective solution against skin infections associated with acne, adding to their appeal in modern skincare.
Notably, the particle size of our biogenic zinc oxide nanoparticles measured around 20 nm, indicating a high degree of purity. When pitted against chemogenic counterparts, the biogenic version proved to be more effective. This suggests that zinc oxide, especially when produced biogenically, could be a valuable addition to skincare products targeting acne.
Moreover, the study highlights the environment-friendly aspect of using biogenic zinc oxide in skincare formulations, making it a preferable choice for those concerned about sustainability. Our findings suggest that these hybrid nanogels could serve as an effective solution against skin infections associated with acne, adding to their appeal in modern skincare.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
7
Reduced acne
I bought it for the first time as a trial. I believe it has helped as my acne has decreased. The only downside is the tablets are quite large, making them slightly inconvenient to swallow.
Read More
7
Significant improvement
I have shared this link with many friends to assist others! I am new to taking vitamins as I dislike swallowing pills, but these tablets are fantastic! They are not too big, making them easy to take. As a college student under stress, I have had significant acne issues. After a few weeks of taking this, I noticed a remarkable difference. I now occasionally get a pimple, which is normal. Additionally, it has aided in alleviating my anxiety and muscle spasms. I will definitely continue to take them and order from Amazon, as I haven't found a better price for 250 tablets. I highly recommend this to anyone considering purchasing; you won't be disappointed.
Read More
Frequently Asked Questions
7
Significant improvement
I have shared this link with many friends to assist others! I am new to taking vitamins as I dislike swallowing pills, but these tablets are fantastic! They are not too big, making them easy to take. As a college student under stress, I have had significant acne issues. After a few weeks of taking this, I noticed a remarkable difference. I now occasionally get a pimple, which is normal. Additionally, it has aided in alleviating my anxiety and muscle spasms. I will definitely continue to take them and order from Amazon, as I haven't found a better price for 250 tablets. I highly recommend this to anyone considering purchasing; you won't be disappointed.
7
Reduced acne
I bought it for the first time as a trial. I believe it has helped as my acne has decreased. The only downside is the tablets are quite large, making them slightly inconvenient to swallow.
8
We explored how zinc affects acne through a systematic review and meta-analysis that looked at two main questions. First, we wanted to know if there are differences in zinc levels between people with acne and those without. Second, we examined how effective zinc treatments are for managing acne.
Our findings showed that individuals with acne had noticeably lower serum zinc levels compared to those in the control group. Furthermore, when we looked at treatments, those who received zinc showed a significant reduction in their inflammatory papule count—a common symptom of acne. Importantly, we noted that side effects from zinc supplementation were similar to those seen in other treatments, suggesting that zinc is safe to use.
Overall, acne patients appear to benefit from improved zinc levels, especially when zinc is used either on its own or alongside other acne treatments. This gives hope for those looking for effective ways to tackle acne issues!
Our findings showed that individuals with acne had noticeably lower serum zinc levels compared to those in the control group. Furthermore, when we looked at treatments, those who received zinc showed a significant reduction in their inflammatory papule count—a common symptom of acne. Importantly, we noted that side effects from zinc supplementation were similar to those seen in other treatments, suggesting that zinc is safe to use.
Overall, acne patients appear to benefit from improved zinc levels, especially when zinc is used either on its own or alongside other acne treatments. This gives hope for those looking for effective ways to tackle acne issues!
9
We aimed to explore how effective zinc sulphate is in treating mild to moderate acne compared to the well-known antibiotic lymecycline. In our study, we involved 100 participants who were randomly assigned to receive either zinc sulphate or lymecycline.
To measure the effectiveness of the treatments, we used the Global Acne Grading System and a special questionnaire focused on acne's impact on quality of life. After four and twelve weeks of treatment, we found that both treatments significantly reduced acne severity.
However, the results showed something interesting. The patients who took zinc sulphate reported greater improvements in their quality of life than those on lymecycline. This indicates that zinc not only helps with acne but may also lead to a better overall experience during treatment.
Our findings suggest that zinc sulphate could be a compelling alternative to lymecycline, providing similar clinical benefits without the risk of antibiotic resistance associated with long-term antibiotic use.
To measure the effectiveness of the treatments, we used the Global Acne Grading System and a special questionnaire focused on acne's impact on quality of life. After four and twelve weeks of treatment, we found that both treatments significantly reduced acne severity.
However, the results showed something interesting. The patients who took zinc sulphate reported greater improvements in their quality of life than those on lymecycline. This indicates that zinc not only helps with acne but may also lead to a better overall experience during treatment.
Our findings suggest that zinc sulphate could be a compelling alternative to lymecycline, providing similar clinical benefits without the risk of antibiotic resistance associated with long-term antibiotic use.
7
Zinc's effects on acne treatment
We explored the potential benefits of zinc in treating acne based on a review of available literature. This review examined various studies focusing on the use of zinc for acne vulgaris, along with its effectiveness for other skin conditions like leishmaniasis and hidradenitis suppurativa.
Through our search in MEDLINE, we found that zinc seems to have both antioxidant and immunomodulatory properties, which may contribute to its effectiveness in treating inflammatory conditions, including acne. While the evidence is promising, especially for those with zinc deficiency, it’s important to note that there’s still a need for further research to clarify how effective zinc can be when used on its own, without other treatments.
Patients experiencing acne might benefit from additional strategies, including zinc supplementation. However, the exact role of zinc as a standalone therapy still requires more investigation through large controlled trials.
Through our search in MEDLINE, we found that zinc seems to have both antioxidant and immunomodulatory properties, which may contribute to its effectiveness in treating inflammatory conditions, including acne. While the evidence is promising, especially for those with zinc deficiency, it’s important to note that there’s still a need for further research to clarify how effective zinc can be when used on its own, without other treatments.
Patients experiencing acne might benefit from additional strategies, including zinc supplementation. However, the exact role of zinc as a standalone therapy still requires more investigation through large controlled trials.
7
We explored the impact of zinc on treating acne by analyzing a case where a patient with a history of severe acne transitioned to zinc gluconate therapy. Although the patient experienced an initial response to zinc, it was not conclusively isolated from other treatments.
The findings suggest that while zinc can be a helpful component in acne management, its effectiveness is still under scrutiny. Many factors are at play in acne treatment and improvement might also relate to other therapies implemented simultaneously.
In the case we observed, the treatment approach included zinc along with anti-PD-1 therapy, but the exact benefit of zinc alone remained unclear. Thus, while zinc has potential as a treatment for acne, more focused research is needed to fully understand its role.
The findings suggest that while zinc can be a helpful component in acne management, its effectiveness is still under scrutiny. Many factors are at play in acne treatment and improvement might also relate to other therapies implemented simultaneously.
In the case we observed, the treatment approach included zinc along with anti-PD-1 therapy, but the exact benefit of zinc alone remained unclear. Thus, while zinc has potential as a treatment for acne, more focused research is needed to fully understand its role.
References
- Li X, Zeng X, Kim D, Jiang J, Wei F, et al. Krüppel-like factor 4 (KLF4) facilitates lipid production in immortalized human sebocytes via regulating the expression of SREBP1. Biochem Biophys Res Commun. 2023;667:146. 10.1016/j.bbrc.2023.05.043
- Antonino A, Francesco A. Prospective and randomized comparative study of calcium hydroxylapatite vs calcium hydroxylapatite plus HIFU in treatment of moderate-to-severe acne scars. J Cosmet Dermatol. 2021;20:53. 10.1111/jocd.13472
- Ahn B, Lee SH, Kim JH, Goh A, Park SG, et al. Identification and validation of amino acid-based mild exfoliating agents through a de novo screening method. J Cosmet Dermatol. 2019;18:1404. 10.1111/jocd.12871
- Casabona G. Combined use of microfocused ultrasound and a calcium hydroxylapatite dermal filler for treating atrophic acne scars: A pilot study. J Cosmet Laser Ther. 2018;20:301. 10.1080/14764172.2017.1406606
- Zouboulis CC, Seltmann H, Abdel-Naser MB, Hossini AM, Menon GK, et al. Effects of Extracellular Calcium and 1,25 dihydroxyvitamin D3 on Sebaceous Gland Cells In vitro and In vivo. Acta Derm Venereol. 2017;97:313. 10.2340/00015555-2525
- de Souza Pereira R. Treatment of Resistant Acne Vulgaris in Adolescents Using Dietary Supplementation with Magnesium, Phosphate and Fatty Acids (Omega 6 and 7): Comparison with 13-Cis-Retinoic Acid. J Diet Suppl. 2023;20:706. 10.1080/19390211.2022.2100550
- Welch K, Latifzada MA, Frykstrand S, Strømme M. Investigation of the Antibacterial Effect of Mesoporous Magnesium Carbonate. ACS Omega. 2016;1:907. 10.1021/acsomega.6b00124
- Li M, Tang Y, Lin C, Huang Q, Lei D, et al. Serum Macroelement and Microelement Concentrations in Patients with Polycystic Ovary Syndrome: a Cross-Sectional Study. Biol Trace Elem Res. 2017;176:73. 10.1007/s12011-016-0782-4
- Lee WJ, Kim SL, Choe YS, Jang YH, Lee SJ, et al. Magnesium Ascorbyl Phosphate Regulates the Expression of Inflammatory Biomarkers in Cultured Sebocytes. Ann Dermatol. 2015;27:376. 10.5021/ad.2015.27.4.376
- Pezza M, Carlomagno V, Sammarco E, Trischitta A, Ceddia C, et al. Association of Myo-Inositol and Microlipodispersed Magnesium in Androgen-Dependent Dermatological Diseases: A Retrospective Study. Pharmaceuticals (Basel). 2025;18. 10.3390/ph18020251
- Li L, Hajam I, McGee JS, Tang Z, Zhang Y, et al. Comparative transcriptome analysis of acne vulgaris, rosacea, and hidradenitis suppurativa supports high-dose dietary zinc as a therapeutic agent. Exp Dermatol. 2024;33:e15145. 10.1111/exd.15145
- Algarin YA, Pulumati A, Jaalouk D, Tan J, Nouri K. The role of vitamins and nutrients in rosacea. Arch Dermatol Res. 2024;316:142. 10.1007/s00403-024-02895-4
- Akman TC, Yazici M, Atila A, Mertoglu C. Analysis of Isotretinoin-Induced Alterations in the Levels of Plasma Trace Elements: Investigation of the Relationship Between Magnesium, Phosphorus, Potassium, Zinc, and Treatment-Related Side Effects. Biol Trace Elem Res. 2024;202:4858. 10.1007/s12011-023-04053-9
- Li L, Hajam I, McGee JS, Tang Z, Zhang Y, et al. Comparative Transcriptome Analysis of Acne vulgaris, Rosacea, and Hidradenitis Suppurativa Supports High Dose Dietary Zinc as a Therapeutic Agent. medRxiv. 2023. 10.1101/2023.11.28.23299152
- Shields A, Ly S, Wafae B, Chang YF, Manjaly P, et al. Safety and Effectiveness of Oral Nutraceuticals for Treating Acne: A Systematic Review. JAMA Dermatol. 2023;159:1373. 10.1001/jamadermatol.2023.3949
- Tan YY, Wong LS, Nyam KL, Wittayanarakul K, Zawawi NA, et al. Development and Evaluation of Topical Zinc Oxide Nanogels Formulation Using and Its Effect on Acne Vulgaris. Molecules. 2023;28. 10.3390/molecules28196749
- Xiang Y, Lu J, Mao C, Zhu Y, Wang C, et al. Ultrasound-triggered interfacial engineering-based microneedle for bacterial infection acne treatment. Sci Adv. 2023;9:eadf0854. 10.1126/sciadv.adf0854
- Towersey L, Correia P, Fajgenbaum Feiges M, Euzébio Gonçalves Junior J, Sant'Anna B, et al. Assessment of the Benefit of a Deep Cleansing Gel Containing Salicylic Acid 2%, Zinc Gluconate 0.2% and Lipohydroxy Acids 0.05% in Patients with Mild to Moderate Truncal Acne: Results from an Exploratory Study. Clin Cosmet Investig Dermatol. 2023;16:119. 10.2147/CCID.S394123
- Salah E. Oral Zinc as a Novel Adjuvant and Sparing Therapy for Systemic Isotretinoin in Acne Vulgaris: A Preliminary Comparative Study. J Clin Aesthet Dermatol. 2022;15:58. PubMed
- Naji HH, Al-Azawi RSA, Ibrahim NJ, Kzar HH. Investigation of the Role of Zn/Cu Index and its Correlation with Physiological Activity of SOD 1 and GRx in Males with Acne Vulgaris. Arch Razi Inst. 2022;77:623. 10.22092/ARI.2021.356857.1928
- Searle T, Ali FR, Al-Niaimi F. Zinc in dermatology. J Dermatolog Treat. 2022;33:2455. 10.1080/09546634.2022.2062282
- Poizeau F, Plantier F, Bell H, Moyal-Barracco M. Vulvar Fordyce adenitis: A cohort of 45 women. Ann Dermatol Venereol. 2021;148:221. 10.1016/j.annder.2021.04.001
- Tolino E, Skroza N, Mambrin A, Proietti I, Bernardini N, et al. An Open-label Study Comparing Oral Zinc to Lymecycline in the Treatment of Acne Vulgaris. J Clin Aesthet Dermatol. 2021;14:56. PubMed
- Maillard A, Pastor D, Merat R. Anti-PD-1-Induced Hidradenitis Suppurativa. Dermatopathology (Basel). 2021;8:37. 10.3390/dermatopathology8010007
- Abendrot M, Płuciennik E, Felczak A, Zawadzka K, Piątczak E, et al. Zinc(II) Complexes of Amino Acids as New Active Ingredients for Anti-Acne Dermatological Preparations. Int J Mol Sci. 2021;22. 10.3390/ijms22041641
- Yee BE, Richards P, Sui JY, Marsch AF. Serum zinc levels and efficacy of zinc treatment in acne vulgaris: A systematic review and meta-analysis. Dermatol Ther. 2020;33:e14252. 10.1111/dth.14252
- Crainic D, Popescu R, Vlad CD, Serban DV, Popa D, et al. Topical Zinc Oxide Nanoparticle Formulations for Acne Vulgaris: A Systematic Review of Pre-Clinical and Early-Phase Clinical Evidence. Biomedicines. 2025;13. 10.3390/biomedicines13092156
- Zhang XD, Bai XS, Teng C, Chilukuri S, Teng J, et al. Managing Rosacea with Nanodiamond-zinc Oxide: Real-world Evidence for Reduction in Redness and Acne Lesions. J Clin Aesthet Dermatol. 2025;18:35. PubMed
- Gu X, Wang B, Zhang T, Zhang Q, Mao B, et al. Zinc-Enriched subsp. CCFM1195 Alleviates -Induced Skin Lesions in Mice by Mitigating Inflammatory Responses and Oxidative Stress. Nutrients. 2025;17. 10.3390/nu17111803
- Zhang F, Wang T, Wang W, Lv Y, Qu Y, et al. ZnO colludes with C. acnes in healing delay and Scar hyperplasia by barrier destruction. J Nanobiotechnology. 2025;23:404. 10.1186/s12951-025-03414-x
- Zhu J, Wen T, Ma Y, Zeng Q, Li P, et al. Biomimetic hyaluronic acid-stabilized zinc oxide nanoparticles in acne treatment: A preclinical and clinical approach. J Control Release. 2025;382:113754. 10.1016/j.jconrel.2025.113754
