Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 17 Researches
7.5
USERS' SCORE
Good
Based on 7 Reviews
8.3
Supplement Facts
Serving Size: 3 Tablets
Amount Per Serving
%DV
Vitamin D-3 (as Cholecalciferol)
25 mcg (1,000 IU)
125%
Calcium (from Aquamin® TG Seaweed Derived Minerals and Calcium Citrate)
400 mg
31%
Magnesium (from Magnesium Oxide, Magnesium Glycinate, Magnesium Taurinate, Magnesium Citrate and Aquamin® TG Seaweed Derived Minerals)
800 mg
190%
Zinc (from L-OptiZinc® Monomethionine)
15 mg
136%

Top Medical Research Studies

We set out to understand how zinc supplementation could affect vitamin D status and leptin levels in postmenopausal women. The study involved 51 healthy postmenopausal women aged between 44 and 76 from Granada, Spain. They were divided into two groups: one receiving a zinc supplement of 50 mg daily for eight weeks and the other receiving a placebo.

Our findings revealed that zinc supplementation significantly improved vitamin D status in these women. Particularly, those who had reached menopause at a younger age saw a notable increase in their vitamin D levels after taking zinc.

Additionally, we discovered a connection between zinc and leptin levels, a hormone that regulates energy balance. Both dietary zinc intake and its plasma levels were found to be inversely related to serum leptin levels—meaning as zinc levels increased, leptin levels tended to decrease.

Overall, these results suggest that zinc supplementation may play a beneficial role during menopause by enhancing vitamin D levels and influencing leptin balance among postmenopausal women.
Read More
9
Magnesium aids menopause-related issues
We explored the connection between magnesium deficiency and various challenges commonly faced by postmenopausal women, such as chronic pain, memory decline, and mood disorders. Our research specifically focused on how magnesium supplementation can help in alleviating these issues in ovariectomized and aged female mice—modeling the postmenopausal state.

We administered magnesium-L-threonate to these mice to assess its effects on pain sensitivity, memory function, and emotional behavior through behavioral tests. We found that this treatment not only prevented but also reversed many of the disturbances associated with aging and menopause.

Additionally, we noted significant changes at the molecular level, such as increased levels of inflammatory markers in the brain and spinal cord of untreated mice, which were significantly normalized with magnesium treatment. Notably, low magnesium levels in various body fluids were also addressed by this supplementation, suggesting its potential as a therapeutic approach for menopause-related disorders.

In summary, while estrogen loss during menopause leads to neuroinflammation and related health issues, magnesium supplementation presents a promising option to support postmenopausal health.
Read More
We evaluated the impact of a zinc-containing vaginal moisturizer gel on postmenopausal women experiencing genitourinary symptoms of menopause (GSM). Some women hesitate to use hormonal treatments like vaginal estrogen, which can be highly effective. To explore an alternative, we asked 37 participants to apply the gel daily for two weeks while tracking their symptoms.

Throughout the study, we used various methods to assess improvement. The Vaginal Health Index, which measures vaginal health, showed significant improvement after treatment. We also noted that participants reported reduced levels of vaginal pain and dryness on a visual analog scale, with the most notable benefit occurring for vaginal dryness. Additionally, the vulvovaginal symptom questionnaire indicated a substantial decrease in overall symptoms. Notably, side effects were minor and infrequent, which is encouraging for those considering this option.

In summary, our findings suggest that a novel zinc-containing vaginal moisturizer gel can effectively alleviate postmenopausal vulvovaginal symptoms without serious side effects, providing a viable solution for women who prefer non-hormonal treatments.
Read More

Most Useful Reviews

9
Supports menopause health
I truly appreciate this supplement! I've been taking it for years due to my osteopenia condition. Its quality and effectiveness are unquestionable. I also take vitamins D and K alongside it and recommend it to all women experiencing menopause.
Read More
9
Strengthens nerves during menopause
Excellent! This is a wonderful complex to use during menopause for both nerve and bone health. After two weeks, I noticed my nerves felt stronger, and my irritability decreased. The tablets are large, but I found that soaking them in water for a few minutes makes them easy to consume. They taste quite pleasant, and I wish everyone great health!
Read More
9
Essential for menopause
很好!顶级补充剂,您必须拥有,特别是对经历和经历更年期的女性来说。
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 17 Researches
7.5
  • All Researches
9
Magnesium aids menopause-related issues
We explored the connection between magnesium deficiency and various challenges commonly faced by postmenopausal women, such as chronic pain, memory decline, and mood disorders. Our research specifically focused on how magnesium supplementation can help in alleviating these issues in ovariectomized and aged female mice—modeling the postmenopausal state.

We administered magnesium-L-threonate to these mice to assess its effects on pain sensitivity, memory function, and emotional behavior through behavioral tests. We found that this treatment not only prevented but also reversed many of the disturbances associated with aging and menopause.

Additionally, we noted significant changes at the molecular level, such as increased levels of inflammatory markers in the brain and spinal cord of untreated mice, which were significantly normalized with magnesium treatment. Notably, low magnesium levels in various body fluids were also addressed by this supplementation, suggesting its potential as a therapeutic approach for menopause-related disorders.

In summary, while estrogen loss during menopause leads to neuroinflammation and related health issues, magnesium supplementation presents a promising option to support postmenopausal health.
Read More
9
Magnesium's impact on bone health
Our exploration centered on the effects of magnesium, particularly from nanofiltrated deep ocean water (DOW), in addressing osteoporosis, a common concern during menopause. In our study, we used ovariectomized female Sprague-Dawley rats, a model that simulates menopausal conditions. We administered varying amounts of DOW daily over eight weeks to observe its impact on bone health.

We found that DOW supplementation significantly increased bone density and reduced bone loss related to menopause. This was particularly notable as the rats that received DOW showed improved bone structure and reduced adiposity in their bones. More specifically, the lowest doses of DOW led to increased expression of a key protein called RUNX2, which plays an essential role in the formation of bone cells known as osteoblasts.

In human osteoblasts, DOW also raised levels of osteocalcin and alkaline phosphatase—both vital for promoting bone health. Overall, our findings demonstrated that magnesium-rich DOW can enhance osteoblast differentiation, contributing positively to bone structure integrity during menopause. This work highlights how incorporating magnesium into our diets or supplements could be beneficial for bone health as we age.
Read More
9
Isoflavones, probiotics boost bone health
We explored the impact of a novel red clover extract rich in isoflavones and probiotics on bone health in postmenopausal osteopenic women. In a year-long double-blind trial with 78 participants, we compared this treatment alongside standard supplements against a placebo. Results showed that the extract substantially reduced bone mineral density loss and improved certain estrogen metabolism markers. However, it did not affect other bone turnover indicators significantly. Overall, combining the extract with calcium and magnesium proved beneficial for bone health in this demographic.
Read More
9
Magnesium reduces menopause symptoms
We explored the effects of a nutraceutical blend, including magnesium, on menopause symptoms through a crossover trial involving 43 postmenopausal women.

Participants experienced significant reductions in menopause symptoms, as measured by the Menopause Rating Scale, after using the nutraceuticals.

Additionally, improvements were noted in cardiovascular risk factors, such as lower cholesterol levels and blood pressure.

Overall, this study suggests that magnesium, combined with other nutrients, may provide meaningful relief for postmenopausal symptoms.
Read More
We set out to understand how zinc supplementation could affect vitamin D status and leptin levels in postmenopausal women. The study involved 51 healthy postmenopausal women aged between 44 and 76 from Granada, Spain. They were divided into two groups: one receiving a zinc supplement of 50 mg daily for eight weeks and the other receiving a placebo.

Our findings revealed that zinc supplementation significantly improved vitamin D status in these women. Particularly, those who had reached menopause at a younger age saw a notable increase in their vitamin D levels after taking zinc.

Additionally, we discovered a connection between zinc and leptin levels, a hormone that regulates energy balance. Both dietary zinc intake and its plasma levels were found to be inversely related to serum leptin levels—meaning as zinc levels increased, leptin levels tended to decrease.

Overall, these results suggest that zinc supplementation may play a beneficial role during menopause by enhancing vitamin D levels and influencing leptin balance among postmenopausal women.
Read More

User Reviews

USERS' SCORE
Good
Based on 7 Reviews
8.3
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Supports menopause health
I truly appreciate this supplement! I've been taking it for years due to my osteopenia condition. Its quality and effectiveness are unquestionable. I also take vitamins D and K alongside it and recommend it to all women experiencing menopause.
Read More
9
Strengthens nerves during menopause
Excellent! This is a wonderful complex to use during menopause for both nerve and bone health. After two weeks, I noticed my nerves felt stronger, and my irritability decreased. The tablets are large, but I found that soaking them in water for a few minutes makes them easy to consume. They taste quite pleasant, and I wish everyone great health!
Read More
9
Essential for menopause
很好!顶级补充剂,您必须拥有,特别是对经历和经历更年期的女性来说。
Read More
9
Prevents osteoporosis
I regularly take this magnesium supplement, which contains calcium crucial for preventing osteoporosis during menopause.
Read More
7.5
Improves menopause symptoms
I started taking magnesium to alleviate various menopause symptoms after earlier experiences left my stomach uneasy. This time, with added calcium, it didn’t pose any problems swallowing. Gradually, I'm finding my menopause symptoms easing as I adjust my lifestyle habits. Now, I tend to use it on days when I feel a bit constipated or slightly weak, and it helps without causing discomfort.
Read More

Frequently Asked Questions

9
Strengthens nerves during menopause
Excellent! This is a wonderful complex to use during menopause for both nerve and bone health. After two weeks, I noticed my nerves felt stronger, and my irritability decreased. The tablets are large, but I found that soaking them in water for a few minutes makes them easy to consume. They taste quite pleasant, and I wish everyone great health!
9
Supports menopause health
I truly appreciate this supplement! I've been taking it for years due to my osteopenia condition. Its quality and effectiveness are unquestionable. I also take vitamins D and K alongside it and recommend it to all women experiencing menopause.
7.5
Improves menopause symptoms
I started taking magnesium to alleviate various menopause symptoms after earlier experiences left my stomach uneasy. This time, with added calcium, it didn’t pose any problems swallowing. Gradually, I'm finding my menopause symptoms easing as I adjust my lifestyle habits. Now, I tend to use it on days when I feel a bit constipated or slightly weak, and it helps without causing discomfort.
6
Prevents osteoporosis
Magnesium and calcium are crucial for the nervous and muscular systems. Adequate intake helps prevent the rapid weakening of bone tissue, particularly during menopause.
7.5
Supports women's health
I ordered this upon my gynaecologist’s recommendation to support women’s health during menopause. It's a plus that it includes vitamin D3, which enhances calcium absorption.
8
Calcium maltobionate supports bone health
We conducted a study to investigate how calcium maltobionate affects bone density in healthy Japanese women, particularly focusing on those who are pre- and post-menopausal. In a well-structured trial, 48 women aged between 30 and 69 were randomly divided into two groups: one received calcium maltobionate tablets while the other took a placebo designed to mimic the calcium content.

Over 24 weeks, we measured changes in facial and calcaneal bone density along with bone resorption markers. Our results indicated that facial bone mineral density declines more rapidly than that of other areas like the lumbar spine. Importantly, we observed that continuous intake of calcium maltobionate helped to slow down this decline in bone density for women in both menopausal stages, suggesting its potential role in osteoporosis prevention.

Overall, we found that facial bone mineral density may serve as an important indicator of bone health in middle-aged women. While our study highlights the beneficial aspects of calcium maltobionate, it’s essential to note that the individual effects of calcium itself could not be isolated from the compound used in the treatment.
7
Calcium aids bone health
This systematic review aimed to understand how different traditional Chinese exercises, combined with calcium supplementation, can improve bone mineral density (BMD) in postmenopausal women. Researchers examined a variety of approaches—such as Tai Chi and Baduanjin—while comparing these exercises to control groups that either did not participate in exercise or received only calcium supplements.

The results revealed that exercises like Tai Chi were effective in improving BMD across multiple sites in the body, including the lumbar spine and femoral neck. When calcium supplementation was paired with these exercises, particularly with Baduanjin, there were notable increases in bone density. However, it’s important to note that while calcium showed some benefit, it was mostly in conjunction with the exercise interventions, making it hard to fully separate the effects of calcium from those of the exercises.

Ultimately, while both calcium supplementation and traditional Chinese exercises like Tai Chi and Baduanjin can contribute to bone health in menopausal women, the study highlights that the exercises may be the most effective method for preventing bone loss.
9
Magnesium aids menopause-related issues
We explored the connection between magnesium deficiency and various challenges commonly faced by postmenopausal women, such as chronic pain, memory decline, and mood disorders. Our research specifically focused on how magnesium supplementation can help in alleviating these issues in ovariectomized and aged female mice—modeling the postmenopausal state.

We administered magnesium-L-threonate to these mice to assess its effects on pain sensitivity, memory function, and emotional behavior through behavioral tests. We found that this treatment not only prevented but also reversed many of the disturbances associated with aging and menopause.

Additionally, we noted significant changes at the molecular level, such as increased levels of inflammatory markers in the brain and spinal cord of untreated mice, which were significantly normalized with magnesium treatment. Notably, low magnesium levels in various body fluids were also addressed by this supplementation, suggesting its potential as a therapeutic approach for menopause-related disorders.

In summary, while estrogen loss during menopause leads to neuroinflammation and related health issues, magnesium supplementation presents a promising option to support postmenopausal health.
9
Magnesium's impact on bone health
Our exploration centered on the effects of magnesium, particularly from nanofiltrated deep ocean water (DOW), in addressing osteoporosis, a common concern during menopause. In our study, we used ovariectomized female Sprague-Dawley rats, a model that simulates menopausal conditions. We administered varying amounts of DOW daily over eight weeks to observe its impact on bone health.

We found that DOW supplementation significantly increased bone density and reduced bone loss related to menopause. This was particularly notable as the rats that received DOW showed improved bone structure and reduced adiposity in their bones. More specifically, the lowest doses of DOW led to increased expression of a key protein called RUNX2, which plays an essential role in the formation of bone cells known as osteoblasts.

In human osteoblasts, DOW also raised levels of osteocalcin and alkaline phosphatase—both vital for promoting bone health. Overall, our findings demonstrated that magnesium-rich DOW can enhance osteoblast differentiation, contributing positively to bone structure integrity during menopause. This work highlights how incorporating magnesium into our diets or supplements could be beneficial for bone health as we age.

References

  1. Suehiro D, Ikeda N, Hirooka K, Ihara A, Fukami K, et al. Decrease in Facial Bone Density with Aging and Maintenance Effect of Calcium Maltobionate Ingestion in Japanese Adult Women: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial. Nutrients. 2025;17. 10.3390/nu17020262
  2. Hou J, Mao H, Xie P, Cui Y, Rong M. The effect of different traditional Chinese exercises on bone mineral density in menopausal women: a systematic review and network meta-analysis. Front Public Health. 2024;12:1430608. 10.3389/fpubh.2024.1430608
  3. Atteia HH, Ahmed SF, Askar ME, Sakr AT. Utilizing a Combination of Supplements Comprising Boric Acid, Magnesium, Vitamin D3, and Extra Virgin Olive Oil to Improve Metabolism in Menopausal Ovariectomized Rats. Biol Trace Elem Res. 2024. 10.1007/s12011-024-04476-y
  4. Zhang J, Mai CL, Xiong Y, Lin ZJ, Jie YT, et al. The Causal Role of Magnesium Deficiency in the Neuroinflammation, Pain Hypersensitivity and Memory/Emotional Deficits in Ovariectomized and Aged Female Mice. J Inflamm Res. 2021;14:6633. 10.2147/JIR.S330894
  5. Chen PC, Lee YC, Jao HY, Wang CP, Jacobs A, et al. Supplementation of nanofiltrated deep ocean water ameliorate the progression of osteoporosis in ovariectomized rat via regulating osteoblast differentiation. J Food Biochem. 2020;44:e13236. 10.1111/jfbc.13236
  6. Kolanu BR, Vadakedath S, Boddula V, Kandi V. Activities of Serum Magnesium and Thyroid Hormones in Pre-, Peri-, and Post-menopausal Women. Cureus. 2020;12:e6554. 10.7759/cureus.6554
  7. Wright HH, Kruger MC, Schutte WD, Wentzel-Viljoen E, Kruger IM, et al. Magnesium Intake Predicts Bone Turnover in Postmenopausal Black South African Women. Nutrients. 2019;11. 10.3390/nu11102519
  8. Lambert MNT, Thybo CB, Lykkeboe S, Rasmussen LM, Frette X, et al. Combined bioavailable isoflavones and probiotics improve bone status and estrogen metabolism in postmenopausal osteopenic women: a randomized controlled trial. Am J Clin Nutr. 2017;106:909. 10.3945/ajcn.117.153353
  9. McCabe D, Lisy K, Lockwood C, Colbeck M. The impact of essential fatty acid, B vitamins, vitamin C, magnesium and zinc supplementation on stress levels in women: a systematic review. JBI Database System Rev Implement Rep. 2017;15:402. 10.11124/JBISRIR-2016-002965
  10. Trimarco V, Rozza F, Izzo R, De Leo V, Cappelli V, et al. Effects of a new combination of nutraceuticals on postmenopausal symptoms and metabolic profile: a crossover, randomized, double-blind trial. Int J Womens Health. 2016;8:581.
  11. Zhao Y, Wang Y, Hu L, Chen H, Xiao X, et al. Excess dietary zinc drives a Cushing's-like syndrome in ovariectomized mice - Implications for postmenopausal obesity. Biochem Biophys Res Commun. 2022;630:101. 10.1016/j.bbrc.2022.09.042
  12. Vázquez-Lorente H, Molina-López J, Herrera-Quintana L, Gamarra-Morales Y, Quintero-Osso B, et al. Erythrocyte Zn concentration and antioxidant response after supplementation with Zn in a postmenopausal population. A double-blind randomized trial. Exp Gerontol. 2022;162:111766. 10.1016/j.exger.2022.111766
  13. Vázquez-Lorente H, Herrera-Quintana L, Molina-López J, Gamarra Y, Planells E. Effect of zinc supplementation on circulating concentrations of homocysteine, vitamin B, and folate in a postmenopausal population. J Trace Elem Med Biol. 2022;71:126942. 10.1016/j.jtemb.2022.126942
  14. Vázquez-Lorente H, Molina-López J, Herrera-Quintana L, Gamarra-Morales Y, López-González B, et al. Effectiveness of eight-week zinc supplementation on vitamin D status and leptin levels in a population of postmenopausal women: a double-blind randomized trial. J Trace Elem Med Biol. 2021;65:126730. 10.1016/j.jtemb.2021.126730
  15. Csikós A, Kozma B, Pór Á, Kovács I, Lampé R, et al. Zinc Transporter 9 (SLC30A9) Expression Is Decreased in the Vaginal Tissues of Menopausal Women. Biol Trace Elem Res. 2021;199:4011. 10.1007/s12011-020-02525-w
  16. Damjanovich P, Sipos AG, Larson K, Cunningham TD, Takacs P, et al. Cervicovaginal lavage fluid zinc level as a marker of vaginal atrophy. Menopause. 2020;27:776. 10.1097/GME.0000000000001536
  17. Takacs P, Kozma B, Erdodi B, Jakab A, Larson K, et al. Zinc-containing Vaginal Moisturizer Gel Improves Postmenopausal Vulvovaginal Symptoms: A Pilot Study. J Menopausal Med. 2019;25:63. 10.6118/jmm.2019.25.1.63
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