Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 33 Researches
7.5
USERS' SCORE
Good
Based on 5 Reviews
8.2
Supplement Facts
Serving Size: 3 Tablets
Amount Per Serving
%DV
Vitamin D-3 (as Cholecalciferol)
25 mcg (1,000 IU)
125%
Calcium (from Aquamin® TG Seaweed Derived Minerals and Calcium Citrate)
400 mg
31%
Magnesium (from Magnesium Oxide, Magnesium Glycinate, Magnesium Taurinate, Magnesium Citrate and Aquamin® TG Seaweed Derived Minerals)
800 mg
190%
Zinc (from L-OptiZinc® Monomethionine)
15 mg
136%
Top Medical Research Studies
9
Magnesium reduces migraine symptoms
We explored how magnesium supplementation can help alleviate migraines, a condition that affects countless individuals and can be incredibly disabling. Research has shown a strong link between magnesium deficiency and various factors that contribute to migraines, such as neurological changes and inflammation.
Studies, including randomized controlled trials, indicate that magnesium can reduce the frequency and severity of migraine attacks, both in the short term and as a preventative measure. This effectiveness is thought to stem from magnesium's ability to influence nerve function and reduce stress responses in the body.
We've examined the accumulating evidence from case studies and clinical trials, and it clearly points to magnesium being a valuable option for those suffering from migraines. By addressing magnesium deficiency, we may offer a new avenue for relief and improved management of this challenging condition.
Studies, including randomized controlled trials, indicate that magnesium can reduce the frequency and severity of migraine attacks, both in the short term and as a preventative measure. This effectiveness is thought to stem from magnesium's ability to influence nerve function and reduce stress responses in the body.
We've examined the accumulating evidence from case studies and clinical trials, and it clearly points to magnesium being a valuable option for those suffering from migraines. By addressing magnesium deficiency, we may offer a new avenue for relief and improved management of this challenging condition.
Read More
9
This study was designed as a randomized double-blind, placebo-controlled trial to examine how zinc gluconate supplementation might alleviate migraine symptoms in adult women. We followed 60 women, averaging about 35 years old, who either received 15 mg of zinc per day or a placebo for a duration of 12 weeks.
Over the trial, we observed significant improvements in those taking zinc. The frequency of migraine attacks, as well as the duration and severity of the headaches, drastically decreased for participants receiving zinc. We used various assessments, such as a numerical rating scale and the Migraine Disability Assessment test, to evaluate these changes.
Additionally, zinc supplementation showed a notable reduction in levels of low-density lipoprotein (LDL) cholesterol and high-sensitivity C-reactive protein (hs-CRP), both of which are associated with inflammation. However, no significant changes in triglycerides or high-density lipoprotein (HDL) levels were seen. After taking initial values into account, the changes in lipid levels and hs-CRP weren’t significant.
Overall, we found that zinc supplementation can beneficially impact migraine symptoms, reducing their severity and frequency among women. This offers a promising direction for migraine management without the side effects often associated with traditional medications.
Over the trial, we observed significant improvements in those taking zinc. The frequency of migraine attacks, as well as the duration and severity of the headaches, drastically decreased for participants receiving zinc. We used various assessments, such as a numerical rating scale and the Migraine Disability Assessment test, to evaluate these changes.
Additionally, zinc supplementation showed a notable reduction in levels of low-density lipoprotein (LDL) cholesterol and high-sensitivity C-reactive protein (hs-CRP), both of which are associated with inflammation. However, no significant changes in triglycerides or high-density lipoprotein (HDL) levels were seen. After taking initial values into account, the changes in lipid levels and hs-CRP weren’t significant.
Overall, we found that zinc supplementation can beneficially impact migraine symptoms, reducing their severity and frequency among women. This offers a promising direction for migraine management without the side effects often associated with traditional medications.
Read More
8
We observed that magnesium plays a notable role in migraine prevention and treatment. Specifically, magnesium is recommended for both chronic migraine management and immediate intravenous relief during acute migraine episodes. The use of magnesium appears to be linked with mild gastrointestinal side effects, indicating that it is generally well-tolerated by those who use it.
Although individual responses may vary, magnesium has shown promising results for many people managing migraines. It's essential to consider this approach alongside other treatments, as magnesium supplementation might enhance overall migraine management. For those looking for alternative or complementary options, magnesium could be a viable choice worth exploring further.
Although individual responses may vary, magnesium has shown promising results for many people managing migraines. It's essential to consider this approach alongside other treatments, as magnesium supplementation might enhance overall migraine management. For those looking for alternative or complementary options, magnesium could be a viable choice worth exploring further.
Read More
Most Useful Reviews
7.5
Effective for prevention
3 people found this helpful
I take these daily as part of my migraine prevention regime. They are large but not difficult to swallow. Since starting them, my migraines have become noticeably lighter. However, when I stopped after six months, my migraines began to worsen again.
Read More
9
Helps with migraines
Excellent! I absolutely love this magnesium! It has assisted me with constipation and migraines. I sleep remarkably well at night, almost as if I’m taking sleeping pills.
Read More
7.5
Eases migraine severity
I purchase this product for my son, who has used it for years. He takes it occasionally for his migraines, and it appears to ease their severity. The formulation with a reverse ratio of magnesium and calcium ingredients seems to be the best for this purpose.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 33 Researches
7.5
- All Researches
9.5
We evaluated the impact of a comprehensive treatment program on migraines in 30 patients aged 16-66. This program combined hormone therapy, balancing the sympathetic and parasympathetic systems, and managing calcium and magnesium levels.
Remarkably, everyone responded positively to the treatment, with none reporting migraines after starting the program. Improvements included normalization of various hormone levels and the disappearance of associated health issues like insomnia and depression.
Our findings suggest that restoring neurohormonal and metabolic balance could be crucial in managing migraines effectively.
Remarkably, everyone responded positively to the treatment, with none reporting migraines after starting the program. Improvements included normalization of various hormone levels and the disappearance of associated health issues like insomnia and depression.
Our findings suggest that restoring neurohormonal and metabolic balance could be crucial in managing migraines effectively.
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9.5
We embarked on an investigation into the potential of zinc as a treatment for migraines. The study involved 30 migraine sufferers who were given 75 mg of zinc sulfate daily for six weeks, along with vitamin B-complex and vitamin A or E during the first ten days.
Remarkably, this combination led to a significant improvement in most participants, suggesting that zinc could play a vital role in alleviating migraine symptoms. Zinc's effectiveness may stem from its essential functions in various biological processes, such as supporting the nervous system and regulating mineral balance in the body.
However, it’s important to note that the research combined zinc with other supplements, which makes it challenging to ascertain zinc's isolated effect on migraines. Future studies may benefit from a more controlled approach—perhaps comparing zinc against a placebo or examining its impact in larger groups.
Overall, this exploration opens new avenues for understanding how zinc and other nutrients can contribute to migraine relief, but further research is needed to fully validate these findings.
Remarkably, this combination led to a significant improvement in most participants, suggesting that zinc could play a vital role in alleviating migraine symptoms. Zinc's effectiveness may stem from its essential functions in various biological processes, such as supporting the nervous system and regulating mineral balance in the body.
However, it’s important to note that the research combined zinc with other supplements, which makes it challenging to ascertain zinc's isolated effect on migraines. Future studies may benefit from a more controlled approach—perhaps comparing zinc against a placebo or examining its impact in larger groups.
Overall, this exploration opens new avenues for understanding how zinc and other nutrients can contribute to migraine relief, but further research is needed to fully validate these findings.
Read More
9
Magnesium reduces migraine symptoms
We explored how magnesium supplementation can help alleviate migraines, a condition that affects countless individuals and can be incredibly disabling. Research has shown a strong link between magnesium deficiency and various factors that contribute to migraines, such as neurological changes and inflammation.
Studies, including randomized controlled trials, indicate that magnesium can reduce the frequency and severity of migraine attacks, both in the short term and as a preventative measure. This effectiveness is thought to stem from magnesium's ability to influence nerve function and reduce stress responses in the body.
We've examined the accumulating evidence from case studies and clinical trials, and it clearly points to magnesium being a valuable option for those suffering from migraines. By addressing magnesium deficiency, we may offer a new avenue for relief and improved management of this challenging condition.
Studies, including randomized controlled trials, indicate that magnesium can reduce the frequency and severity of migraine attacks, both in the short term and as a preventative measure. This effectiveness is thought to stem from magnesium's ability to influence nerve function and reduce stress responses in the body.
We've examined the accumulating evidence from case studies and clinical trials, and it clearly points to magnesium being a valuable option for those suffering from migraines. By addressing magnesium deficiency, we may offer a new avenue for relief and improved management of this challenging condition.
Read More
9
Magnesium significantly alleviates migraines
We explored how magnesium supplementation affects the frequency and intensity of migraine attacks. The study relied on evidence gathered from twenty-two randomized controlled trials, providing a solid foundation for our findings.
Through a detailed analysis, we found that magnesium supplementation significantly reduced migraine attacks, with a marked decrease in severity and the number of days afflicted each month. Specifically, magnesium showed a mean difference of -2.51 in attack frequency and -0.88 in severity compared to those who did not receive the supplement.
This promising outcome suggests that magnesium could be an effective option for individuals seeking migraine relief. As we delved deeper into the study, it became clear that while additional research is needed to establish long-term effects, magnesium’s immediate benefits in reducing migraines are noteworthy.
Through a detailed analysis, we found that magnesium supplementation significantly reduced migraine attacks, with a marked decrease in severity and the number of days afflicted each month. Specifically, magnesium showed a mean difference of -2.51 in attack frequency and -0.88 in severity compared to those who did not receive the supplement.
This promising outcome suggests that magnesium could be an effective option for individuals seeking migraine relief. As we delved deeper into the study, it became clear that while additional research is needed to establish long-term effects, magnesium’s immediate benefits in reducing migraines are noteworthy.
Read More
9
We examined how magnesium oxide (MgO), both alone and with riboflavin, helps prevent migraines in pregnant individuals. This retrospective study included 203 patients treated between 2015 and 2020, analyzing outcomes such as migraine frequency, severity, and duration.
We found that both treatment options reduced migraines significantly, with 77% of participants experiencing improvement in associated symptoms. The results indicate that magnesium oxide can be an effective option for managing migraines during pregnancy, making it a potential consideration for expectant mothers suffering from this condition.
We found that both treatment options reduced migraines significantly, with 77% of participants experiencing improvement in associated symptoms. The results indicate that magnesium oxide can be an effective option for managing migraines during pregnancy, making it a potential consideration for expectant mothers suffering from this condition.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Effective for prevention
3 people found this helpful
I take these daily as part of my migraine prevention regime. They are large but not difficult to swallow. Since starting them, my migraines have become noticeably lighter. However, when I stopped after six months, my migraines began to worsen again.
Read More
9
Helps with migraines
Excellent! I absolutely love this magnesium! It has assisted me with constipation and migraines. I sleep remarkably well at night, almost as if I’m taking sleeping pills.
Read More
7.5
Eases migraine severity
I purchase this product for my son, who has used it for years. He takes it occasionally for his migraines, and it appears to ease their severity. The formulation with a reverse ratio of magnesium and calcium ingredients seems to be the best for this purpose.
Read More
7.5
Decreases migraine frequency
I take this for migraine prevention, and I feel that they occur less frequently now.
Read More
6
Reduces migraines
I initially purchased a large bottle for my mother and later bought a smaller one. She is pleased and takes it with vitamin D and omega supplements. She has noticed improvements in her nail and hair growth, as well as a reduction in migraines.
Read More
Frequently Asked Questions
7.5
Decreases migraine frequency
I take this for migraine prevention, and I feel that they occur less frequently now.
7.5
Eases migraine severity
I purchase this product for my son, who has used it for years. He takes it occasionally for his migraines, and it appears to ease their severity. The formulation with a reverse ratio of magnesium and calcium ingredients seems to be the best for this purpose.
9
Helps with migraines
Excellent! I absolutely love this magnesium! It has assisted me with constipation and migraines. I sleep remarkably well at night, almost as if I’m taking sleeping pills.
6
Reduces migraines
I initially purchased a large bottle for my mother and later bought a smaller one. She is pleased and takes it with vitamin D and omega supplements. She has noticed improvements in her nail and hair growth, as well as a reduction in migraines.
9
Magnesium significantly alleviates migraines
We explored how magnesium supplementation affects the frequency and intensity of migraine attacks. The study relied on evidence gathered from twenty-two randomized controlled trials, providing a solid foundation for our findings.
Through a detailed analysis, we found that magnesium supplementation significantly reduced migraine attacks, with a marked decrease in severity and the number of days afflicted each month. Specifically, magnesium showed a mean difference of -2.51 in attack frequency and -0.88 in severity compared to those who did not receive the supplement.
This promising outcome suggests that magnesium could be an effective option for individuals seeking migraine relief. As we delved deeper into the study, it became clear that while additional research is needed to establish long-term effects, magnesium’s immediate benefits in reducing migraines are noteworthy.
Through a detailed analysis, we found that magnesium supplementation significantly reduced migraine attacks, with a marked decrease in severity and the number of days afflicted each month. Specifically, magnesium showed a mean difference of -2.51 in attack frequency and -0.88 in severity compared to those who did not receive the supplement.
This promising outcome suggests that magnesium could be an effective option for individuals seeking migraine relief. As we delved deeper into the study, it became clear that while additional research is needed to establish long-term effects, magnesium’s immediate benefits in reducing migraines are noteworthy.
7
We looked at how magnesium might affect migraines and what beneficial role it could play in treatment. Our exploration revealed that magnesium is often mentioned as a potential remedy for alleviating migraine symptoms.
Some studies indicate that magnesium could reduce the frequency and intensity of migraines. This comes from its ability to influence various processes in the body, including reducing neuroinflammation and improving blood flow.
While we noted some promising results regarding magnesium's effectiveness, it's important to highlight that the specific isolated impact of magnesium on migraine relief has not been conclusively determined. Further research may help clarify exactly how magnesium functions in migraines, ensuring that individuals can make informed choices about their treatment options.
Overall, a well-rounded approach that includes magnesium, among other lifestyle changes, could potentially enhance migraine management and improve quality of life for those affected.
Some studies indicate that magnesium could reduce the frequency and intensity of migraines. This comes from its ability to influence various processes in the body, including reducing neuroinflammation and improving blood flow.
While we noted some promising results regarding magnesium's effectiveness, it's important to highlight that the specific isolated impact of magnesium on migraine relief has not been conclusively determined. Further research may help clarify exactly how magnesium functions in migraines, ensuring that individuals can make informed choices about their treatment options.
Overall, a well-rounded approach that includes magnesium, among other lifestyle changes, could potentially enhance migraine management and improve quality of life for those affected.
7
We aimed to explore the connection between magnesium levels in the body and migraine occurrences. In our research, we compared the magnesium levels of 25 patients diagnosed with migraine to 25 healthy control individuals. Both groups were selected from health facilities in Sinop, Brazil.
The analysis revealed that both plasma and erythrocyte magnesium levels were significantly lower in the migraine group. Specifically, plasma magnesium was measured at 0.172 mg/L for migraine sufferers versus 0.197 mg/L in the control group. Similarly, erythrocyte magnesium levels were 0.393 mg/L for those with migraines, compared to 0.432 mg/L for healthy participants.
Importantly, we determined that measuring magnesium in erythrocytes is a more reliable indicator of magnesium status in migraine patients than plasma measurements. Overall, our findings suggest a notable association between low magnesium levels and migraine, revealing potential avenues for dietary or supplemental magnesium as a management strategy for individuals suffering from migraines.
The analysis revealed that both plasma and erythrocyte magnesium levels were significantly lower in the migraine group. Specifically, plasma magnesium was measured at 0.172 mg/L for migraine sufferers versus 0.197 mg/L in the control group. Similarly, erythrocyte magnesium levels were 0.393 mg/L for those with migraines, compared to 0.432 mg/L for healthy participants.
Importantly, we determined that measuring magnesium in erythrocytes is a more reliable indicator of magnesium status in migraine patients than plasma measurements. Overall, our findings suggest a notable association between low magnesium levels and migraine, revealing potential avenues for dietary or supplemental magnesium as a management strategy for individuals suffering from migraines.
7
We explored the relationship between magnesium levels and migraine in a carefully designed study. By comparing 50 migraine sufferers with an equal number of healthy individuals, we aimed to understand how magnesium, a mineral that helps regulate nerve activity, might influence migraine episodes.
Our findings revealed that patients experiencing migraines had notably lower magnesium levels both during attacks and between them compared to healthy controls. Specifically, the average magnesium level during the interictal phase was significantly lower—1.849 mg/dL for migraine patients versus 2.090 mg/dL for controls.
We also noted a concerning trend: magnesium levels decreased further during migraine attacks themselves. This suggests that lower magnesium might contribute to the headache's intensity or frequency. Furthermore, we observed an inverse relationship between magnesium levels and the frequency of migraine occurrences, indicating that as the number of attacks increased, magnesium levels tended to drop.
These results point toward magnesium potentially playing a critical role in migraine management and raise the possibility of magnesium supplementation as a therapeutic option. Understanding the connection between magnesium and migraine might open new doors for treatment strategies that could benefit many sufferers.
Our findings revealed that patients experiencing migraines had notably lower magnesium levels both during attacks and between them compared to healthy controls. Specifically, the average magnesium level during the interictal phase was significantly lower—1.849 mg/dL for migraine patients versus 2.090 mg/dL for controls.
We also noted a concerning trend: magnesium levels decreased further during migraine attacks themselves. This suggests that lower magnesium might contribute to the headache's intensity or frequency. Furthermore, we observed an inverse relationship between magnesium levels and the frequency of migraine occurrences, indicating that as the number of attacks increased, magnesium levels tended to drop.
These results point toward magnesium potentially playing a critical role in migraine management and raise the possibility of magnesium supplementation as a therapeutic option. Understanding the connection between magnesium and migraine might open new doors for treatment strategies that could benefit many sufferers.
7
We explored the role of magnesium as a potential treatment for migraines through a review of existing literature. Migraines can be intense and debilitating, impacting many individuals' day-to-day lives. Our focus was on understanding whether supplementing magnesium could help in preventing or managing these attacks.
Some studies suggest that low levels of magnesium may be linked to more frequent or severe migraine episodes. When people suffer from migraines, inflammation and oxidative stress might contribute to their pain, and magnesium appears to play a role in helping regulate these processes. By supporting brain health and energy metabolism, magnesium could potentially mitigate some of the triggers associated with migraines.
Although the evidence does point to benefits from magnesium supplementation, we noted that more extensive, well-controlled studies are necessary to draw firm conclusions. Overall, while magnesium shows promise, it may not be a standalone solution and could work best in combination with other treatments.
Some studies suggest that low levels of magnesium may be linked to more frequent or severe migraine episodes. When people suffer from migraines, inflammation and oxidative stress might contribute to their pain, and magnesium appears to play a role in helping regulate these processes. By supporting brain health and energy metabolism, magnesium could potentially mitigate some of the triggers associated with migraines.
Although the evidence does point to benefits from magnesium supplementation, we noted that more extensive, well-controlled studies are necessary to draw firm conclusions. Overall, while magnesium shows promise, it may not be a standalone solution and could work best in combination with other treatments.
References
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- Tepper SJ, Tepper K. Nutraceuticals and Headache 2024: Riboflavin, Coenzyme Q10, Feverfew, Magnesium, Melatonin, and Butterbur. Curr Pain Headache Rep. 2025;29:33. 10.1007/s11916-025-01358-3
- Hajhashemy Z, Golpour-Hamedani S, Eshaghian N, Sadeghi O, Khorvash F, et al. Practical supplements for prevention and management of migraine attacks: a narrative review. Front Nutr. 2024;11:1433390. 10.3389/fnut.2024.1433390
- Talandashti MK, Shahinfar H, Delgarm P, Jazayeri S. Effects of selected dietary supplements on migraine prophylaxis: A systematic review and dose-response meta-analysis of randomized controlled trials. Neurol Sci. 2025;46:651. 10.1007/s10072-024-07794-0
- Gazerani P, Papetti L, Dalkara T, Cook CL, Webster C, et al. The Brain, the Eating Plate, and the Gut Microbiome: Partners in Migraine Pathogenesis. Nutrients. 2024;16. 10.3390/nu16142222
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- Kurhade PI, Kodape SM, Das A, Bansod PG. Synergistic action of sumatriptan delivery and targeting magnesium deficiency using green, pH-responsive MgO nanoparticles synthesized from mahua flower extracts. Environ Sci Pollut Res Int. 2023. 10.1007/s11356-023-30648-9
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- Shenoy NN, Gheewala GK, Kedambadi R, Pai S, Zulfikli KM, et al. Can Serum Magnesium Level and Visual Evoked Potentials (P100) be a Predictive in Migraineurs?: Evidence Based Study. Neurol India. 2023;71:463. 10.4103/0028-3886.378668
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- Pawar V, Ashraf H, Dorsala S, Mary P, Hameed N, et al. Motorist's Vestibular Disorientation Syndrome (MVDS)-Proposed Diagnostic Criteria. J Pers Med. 2023;13. 10.3390/jpm13050732
- Hoshino MT, Bochio MG, Spagnol Bonache J, Ludwig L, Leandro de Campos M, et al. Plasma and erythrocyte magnesium levels: from validation of the method to analysis in volunteers diagnosed to migraine. Magnes Res. 2022;35:51. 10.1684/mrh.2022.0502
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- Mazza GR, Solorio C, Stek AM, Kalayjian LA, Wilson ML, et al. Assessing the efficacy of magnesium oxide and riboflavin as preventative treatment of migraines in pregnancy. Arch Gynecol Obstet. 2023;308:1749. 10.1007/s00404-022-06872-y
- Ariyanfar S, Razeghi Jahromi S, Togha M, Ghorbani Z. Review on Headache Related to Dietary Supplements. Curr Pain Headache Rep. 2022;26:193. 10.1007/s11916-022-01019-9
- Matin H, Taghian F, Chitsaz A. Artificial intelligence analysis to explore synchronize exercise, cobalamin, and magnesium as new actors to therapeutic of migraine symptoms: a randomized, placebo-controlled trial. Neurol Sci. 2022;43:4413. 10.1007/s10072-021-05843-6
- Karim MR, Bhattacharjee M, Islam MS, Banerjee S, Hossain S, et al. Relation between Serum Magnesium Level and Migraine. Mymensingh Med J. 2021;30:301.
- Singhal S, Dutta SB, Bansal S, Dutta S, Shah RB. Zinc as An Emerging Therapy in the Management of Migraine: A Systematic Review. Neurol India. 2024;72:934. 10.4103/neurol-india.Neurol-India-D-23-00337
- Fukazawa R, Ishii R, Higashimoto Y, Hanya M, Shimizu Y, et al. Zinc Administration Favorably Affects Prophylactic Therapy-refractory Migraine Attacks: A Case Series. Intern Med. 2024;63:1631. 10.2169/internalmedicine.2111-23
- Zheng H, Tian S, Wu L, Zhong X, Liu M, et al. Dietary zinc intake in relation to migraine among adults: a cross sectional study of NHANES 1999-2004. Nutr Neurosci. 2024;27:667. 10.1080/1028415X.2023.2243678
- Liu H, Wang Q, Dong Z, Yu S. Dietary zinc intake and migraine in adults: a cross-sectional analysis of the National Health and Nutrition Examination Survey 1999-2004. Headache. 2023;63:127. 10.1111/head.14431
- Mazaheri M, Aghdam AM, Heidari M, Zarrin R. Assessing the Effect of Zinc Supplementation on the Frequency of Migraine Attack, Duration, Severity, Lipid Profile and hs-CRP in Adult Women. Clin Nutr Res. 2021;10:127. 10.7762/cnr.2021.10.2.127
- Ahmadi H, Mazloumi-Kiapey SS, Sadeghi O, Nasiri M, Khorvash F, et al. Zinc supplementation affects favorably the frequency of migraine attacks: a double-blind randomized placebo-controlled clinical trial. Nutr J. 2020;19:101. 10.1186/s12937-020-00618-9
- Dhillon KS, Singh J, Lyall JS. A new horizon into the pathobiology, etiology and treatment of migraine. Med Hypotheses. 2011;77:147. 10.1016/j.mehy.2011.03.050
