Can NOW Supplements, Magnesium Citrate help with Osteoporosis?
' 
SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8.3
USERS' SCORE
Good
Based on 10 Reviews
8.8
Supplement Facts
Serving Size: 3 Veg Capsules
Amount Per Serving
%DV
Magnesium (elemental) (from 2,667 mg Magnesium Citrate)
400 mg
95%
Top Medical Research Studies
9
Magnesium's role in osteoporosis therapy
Mg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism.
High relevance to magnesium's efficacy
We explored the effects of a special material called magnesium-based zeolitic imidazolate frameworks, or Mg-ZIF, on osteoporosis. This study aimed to find a way to tackle osteoporosis by reducing reactive oxygen species (ROS)—harmful molecules that affect our bone health.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease.
Read More
9
Magnesium enhances osteoporosis treatment
Anti-osteoporosis properties of phosphorylated collagen peptide-magnesium chelates in osteoblast MC3T3-E1 cells and ovariectomized mice.
Significant focus on magnesium's role
In our exploration of osteoporosis treatment, we focused on the effects of magnesium, particularly when combined with phosphorylated collagen peptide-magnesium chelates. Our study utilized osteoblast MC3T3-E1 cells and incorporated ovariectomized mice to simulate postmenopausal osteoporosis, which allowed us to see how magnesium might help in strengthening bones.
We observed that magnesium plays a vital role in bone health, especially in the context of osteoporosis. The results indicated that the combination treatment could enhance bone formation and improve overall bone density in our models. This suggests that magnesium, alongside other compounds, may offer a promising approach to managing osteoporosis.
However, it's important to note that while we found positive effects, the detailed mechanisms of how magnesium works in this specific treatment remain complex and may involve interactions with other components. Further research is needed to fully understand its efficacy and the best ways to integrate magnesium into osteoporosis treatment strategies.
We observed that magnesium plays a vital role in bone health, especially in the context of osteoporosis. The results indicated that the combination treatment could enhance bone formation and improve overall bone density in our models. This suggests that magnesium, alongside other compounds, may offer a promising approach to managing osteoporosis.
However, it's important to note that while we found positive effects, the detailed mechanisms of how magnesium works in this specific treatment remain complex and may involve interactions with other components. Further research is needed to fully understand its efficacy and the best ways to integrate magnesium into osteoporosis treatment strategies.
Read More
7
Magnesium's role in osteoporosis
The role of magnesium in the pathogenesis of osteoporosis.
Direct focus on magnesium effects
We explored the fascinating role of magnesium in osteoporosis, a condition that leads to weakened bones and increased fracture risk. Through our investigation, we observed that magnesium is vital for bone health and plays a significant part in bone formation and maintenance.
Magnesium deficiency can impact bone structure indirectly by interfering with calcium homeostasis. This interplay is orchestrated mainly through two key regulators: parathyroid hormone and vitamin D. Parathyroid hormone influences the production of essential proteins that regulate osteoclast formation, which is responsible for bone resorption.
We also learned that vitamin D works in tandem with magnesium to facilitate the balance between bone formation and resorption. When magnesium levels are low, this balance can tip in favor of bone loss, ultimately leading to osteoporosis. The RANK/RANKL/OPG signaling pathway is crucial in this context, as it governs the relationship between bone-building cells and those that break down bone.
Importantly, clinical studies indicate that magnesium supplementation may ease some symptoms of osteoporosis, although further research is needed to assess its effectiveness compared to other treatments. Overall, we understand that maintaining adequate magnesium levels is essential for bone health and may help prevent the progression of osteoporosis.
Magnesium deficiency can impact bone structure indirectly by interfering with calcium homeostasis. This interplay is orchestrated mainly through two key regulators: parathyroid hormone and vitamin D. Parathyroid hormone influences the production of essential proteins that regulate osteoclast formation, which is responsible for bone resorption.
We also learned that vitamin D works in tandem with magnesium to facilitate the balance between bone formation and resorption. When magnesium levels are low, this balance can tip in favor of bone loss, ultimately leading to osteoporosis. The RANK/RANKL/OPG signaling pathway is crucial in this context, as it governs the relationship between bone-building cells and those that break down bone.
Importantly, clinical studies indicate that magnesium supplementation may ease some symptoms of osteoporosis, although further research is needed to assess its effectiveness compared to other treatments. Overall, we understand that maintaining adequate magnesium levels is essential for bone health and may help prevent the progression of osteoporosis.
Read More
Most Useful Reviews
9.5
Alleviates constipation
I purchased magnesium citrate for my mother’s constipation, which laxatives didn't help. After taking magnesium citrate, her long-term constipation resolved. It also aids her osteoporosis, and I hope it improves her bone density.
Read More
8.8
Prevents fatigue
Magnesium citrate is essential for maintaining energy levels and preventing fatigue. It helps regulate processes in the body affected by magnesium deficiency, such as chronic fatigue syndrome and muscle cramps, making it beneficial for osteoporosis.
Read More
9.5
Supports bone health
Magnesium is crucial for bone formation and calcium absorption, essential for osteoporosis. It improves bone density and reduces the risk of injury. I'm satisfied with the product's quality and quantity of ingredients.
Read More
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Medical Researches
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Moderately Effective
Based on 11 Researches
8.3
9
Magnesium's role in osteoporosis
Relationship between multi-nutrient intake and bone loss and osteoporosis in U.S. adults: Findings from NHANES.
Moderate relevance to magnesium impact
We examined how dietary intake of magnesium, along with potassium and sodium, influences bone health, specifically focusing on osteoporosis and bone mineral density (BMD) in adults across the U.S. Our analysis was based on data from the National Health and Nutrition Examination Surveys, which spanned from 2005 to 2018, involving over 10,000 participants.
The findings revealed a positive association between higher dietary intake of potassium, magnesium, and sodium and improved BMD of the femur. This means that those who consumed more of these nutrients tended to have stronger bones. Additionally, we observed that a higher intake of these minerals was linked to a lower occurrence of osteopenia and osteoporosis.
Our study highlights how magnesium, when part of a broader nutrient intake that includes potassium and sodium, could play a significant role in maintaining bone health. While our research points to a beneficial relationship, more targeted studies are needed to definitively isolate the effects of magnesium alone on osteoporosis. Overall, this reinforces the importance of a balanced diet for bone health.
The findings revealed a positive association between higher dietary intake of potassium, magnesium, and sodium and improved BMD of the femur. This means that those who consumed more of these nutrients tended to have stronger bones. Additionally, we observed that a higher intake of these minerals was linked to a lower occurrence of osteopenia and osteoporosis.
Our study highlights how magnesium, when part of a broader nutrient intake that includes potassium and sodium, could play a significant role in maintaining bone health. While our research points to a beneficial relationship, more targeted studies are needed to definitively isolate the effects of magnesium alone on osteoporosis. Overall, this reinforces the importance of a balanced diet for bone health.
Read More
9
Magnesium improves osteoporotic bone repair
An injectable magnesium-loaded hydrogel releases hydrogen to promote osteoporotic bone repair via ROS scavenging and immunomodulation.
Strong relevance to magnesium effects
We delved into the use of a unique injectable hydrogel loaded with magnesium to address the challenges of repairing osteoporotic bone defects. The study aimed to understand how this magnesium-infused hydrogel could combat the excessive reactive oxygen species (ROS) that hinder bone repair. With impressive qualities such as excellent injectability and adaptability, the hydrogel can be introduced into irregular bone areas without the need for major surgery.
Once injected, the hydrogel not only transforms into a supportive scaffold but also begins to release hydrogen and magnesium ions. This release is key in reducing harmful intracellular ROS and guiding the immune response favorably by promoting macrophage polarization. We observed that this gel suppressed the formation of osteoclasts, the cells responsible for bone resorption, while simultaneously encouraging the growth of new bone cells.
Animal experiments further illuminated the effectiveness of the magnesium-loaded hydrogel, showing a remarkable ability to enhance the repair of bone defects by controlling inflammation and supporting bone formation. Overall, our findings shine a light on the potential of magnesium-based hydrogels as promising solutions for those dealing with osteoporosis-related bone damage.
Once injected, the hydrogel not only transforms into a supportive scaffold but also begins to release hydrogen and magnesium ions. This release is key in reducing harmful intracellular ROS and guiding the immune response favorably by promoting macrophage polarization. We observed that this gel suppressed the formation of osteoclasts, the cells responsible for bone resorption, while simultaneously encouraging the growth of new bone cells.
Animal experiments further illuminated the effectiveness of the magnesium-loaded hydrogel, showing a remarkable ability to enhance the repair of bone defects by controlling inflammation and supporting bone formation. Overall, our findings shine a light on the potential of magnesium-based hydrogels as promising solutions for those dealing with osteoporosis-related bone damage.
Read More
9
Magnesium's role in osteoporosis therapy
Mg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism.
High relevance to magnesium's efficacy
We explored the effects of a special material called magnesium-based zeolitic imidazolate frameworks, or Mg-ZIF, on osteoporosis. This study aimed to find a way to tackle osteoporosis by reducing reactive oxygen species (ROS)—harmful molecules that affect our bone health.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease.
Read More
9
Magnesium enhances osteoporosis treatment
Anti-osteoporosis properties of phosphorylated collagen peptide-magnesium chelates in osteoblast MC3T3-E1 cells and ovariectomized mice.
Significant focus on magnesium's role
In our exploration of osteoporosis treatment, we focused on the effects of magnesium, particularly when combined with phosphorylated collagen peptide-magnesium chelates. Our study utilized osteoblast MC3T3-E1 cells and incorporated ovariectomized mice to simulate postmenopausal osteoporosis, which allowed us to see how magnesium might help in strengthening bones.
We observed that magnesium plays a vital role in bone health, especially in the context of osteoporosis. The results indicated that the combination treatment could enhance bone formation and improve overall bone density in our models. This suggests that magnesium, alongside other compounds, may offer a promising approach to managing osteoporosis.
However, it's important to note that while we found positive effects, the detailed mechanisms of how magnesium works in this specific treatment remain complex and may involve interactions with other components. Further research is needed to fully understand its efficacy and the best ways to integrate magnesium into osteoporosis treatment strategies.
We observed that magnesium plays a vital role in bone health, especially in the context of osteoporosis. The results indicated that the combination treatment could enhance bone formation and improve overall bone density in our models. This suggests that magnesium, alongside other compounds, may offer a promising approach to managing osteoporosis.
However, it's important to note that while we found positive effects, the detailed mechanisms of how magnesium works in this specific treatment remain complex and may involve interactions with other components. Further research is needed to fully understand its efficacy and the best ways to integrate magnesium into osteoporosis treatment strategies.
Read More
8
Magnesium's promise for osteoporosis
Honeycomb Bionic Graphene Oxide Quantum Dot/Layered Double Hydroxide Composite Nanocoating Promotes Osteoporotic Bone Regeneration via Activating Mitophagy.
Study explores magnesium's effectiveness
In our exploration of how magnesium can help treat osteoporosis, we focused on a unique combination of materials to improve bone healing. The study investigated the use of magnesium alloys, known for their biodegradability and suitable elasticity for bone repair. However, it also incorporated graphene oxide quantum dots and layered double hydroxides to enhance the overall effect.
The results showed promise, particularly with the construction of a honeycomb-like coated structure on magnesium alloys. This innovative design helps regulate the degradation rate of magnesium, providing a conducive environment for bone regeneration. By allowing osteoblasts, the cells responsible for bone formation, to survive better and function properly, we observed that magnesium combined with these materials may effectively promote bone healing in osteoporotic patients.
Specifically, the activation of mitophagy—where damaged mitochondria in osteoblasts are cleared—was identified as a key factor in supporting osteogenesis. The improvement in bone regeneration and integration was confirmed using a rat model with femoral defects. Our findings suggest that magnesium alloys' combination with advanced materials like graphene oxide and layered double hydroxides may represent a promising approach to addressing osteoporosis-related bone defects.
The results showed promise, particularly with the construction of a honeycomb-like coated structure on magnesium alloys. This innovative design helps regulate the degradation rate of magnesium, providing a conducive environment for bone regeneration. By allowing osteoblasts, the cells responsible for bone formation, to survive better and function properly, we observed that magnesium combined with these materials may effectively promote bone healing in osteoporotic patients.
Specifically, the activation of mitophagy—where damaged mitochondria in osteoblasts are cleared—was identified as a key factor in supporting osteogenesis. The improvement in bone regeneration and integration was confirmed using a rat model with femoral defects. Our findings suggest that magnesium alloys' combination with advanced materials like graphene oxide and layered double hydroxides may represent a promising approach to addressing osteoporosis-related bone defects.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.8
9.5
Alleviates constipation
I purchased magnesium citrate for my mother’s constipation, which laxatives didn't help. After taking magnesium citrate, her long-term constipation resolved. It also aids her osteoporosis, and I hope it improves her bone density.
9.5
Supports bone health
Magnesium is crucial for bone formation and calcium absorption, essential for osteoporosis. It improves bone density and reduces the risk of injury. I'm satisfied with the product's quality and quantity of ingredients.
9.5
Bone density enhancement
Magnesium is key for bone health, aiding in calcium absorption and vitamin D activation, which is crucial for postmenopausal osteoporosis. Ensuring the optimal level of magnesium supports increased bone density and reduced injury risk.
9
Improves sleep
Studies show magnesium deficiency affects blood sugar and causes insomnia. It acts as a natural tranquiliser for improved sleep quality, which is beneficial for my osteoporosis condition.
8.8
Prevents fatigue
Magnesium citrate is essential for maintaining energy levels and preventing fatigue. It helps regulate processes in the body affected by magnesium deficiency, such as chronic fatigue syndrome and muscle cramps, making it beneficial for osteoporosis.
