Overview
SCIENTIFIC SCORE
Questionable
Based on 19 Researches
6.7
USERS' SCORE
Good
Based on 5 Reviews
8
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Folate
167 mcg DFE(100 mcg folic acid)
42%
Vitamin B-12 (as Cyanocobalamin)
1 mg (1,000 mcg)
41,667%
Top Medical Research Studies
8
We examined the relationship between folate and Alzheimer's disease (AD) through a comprehensive analysis combining data from various studies. Our findings indicate that folate may provide protective effects against Alzheimer's, which is promising for those concerned about this challenging condition.
Specifically, we noted that individuals with higher folate levels could experience a decreased risk of developing Alzheimer's. This suggests that ensuring adequate folate intake could be beneficial for brain health.
However, it’s essential to understand that the impact of folate isn't a cure-all. While the association with Alzheimer's is favorable, more research is needed to clarify how folate levels might influence the progression or onset of this complex disorder.
Overall, our analysis underscores the potential of folate as part of a broader strategy for supporting cognitive health as we age.
Specifically, we noted that individuals with higher folate levels could experience a decreased risk of developing Alzheimer's. This suggests that ensuring adequate folate intake could be beneficial for brain health.
However, it’s essential to understand that the impact of folate isn't a cure-all. While the association with Alzheimer's is favorable, more research is needed to clarify how folate levels might influence the progression or onset of this complex disorder.
Overall, our analysis underscores the potential of folate as part of a broader strategy for supporting cognitive health as we age.
Read More
9
We focused on the potential of folic acid supplementation as a way to influence cognitive impairment, especially in Alzheimer's disease (AD) patients. By reviewing multiple randomized controlled trials, we aimed to clarify the effectiveness of folic acid in improving cognitive function for those facing various levels of cognitive decline.
Our analysis revealed that folic acid supplementation may offer benefits for individuals with Mild Cognitive Impairment (MCI), suggesting even modest doses could have a positive impact. Notably, we found that doses of three milligrams or more of folic acid were particularly effective in enhancing cognitive abilities among Alzheimer's patients.
This evidence makes folic acid a promising candidate for helping delay cognitive decline in adults. While more extensive studies may be required, the results provide encouragement for using nutritional strategies as part of a comprehensive approach to managing cognitive impairment.
Our analysis revealed that folic acid supplementation may offer benefits for individuals with Mild Cognitive Impairment (MCI), suggesting even modest doses could have a positive impact. Notably, we found that doses of three milligrams or more of folic acid were particularly effective in enhancing cognitive abilities among Alzheimer's patients.
This evidence makes folic acid a promising candidate for helping delay cognitive decline in adults. While more extensive studies may be required, the results provide encouragement for using nutritional strategies as part of a comprehensive approach to managing cognitive impairment.
Read More
8
We explored the potential benefits of folic acid supplementation in reducing the risk of Alzheimer's disease (AD) through a Mendelian randomization analysis. By analyzing genetic data from recent studies, we assessed the causal relationship between folate intake and AD.
Our findings revealed an encouraging association: both fixed-effect and random-effect models indicated that folic acid supplementation could lead to a reduced risk of developing Alzheimer's, with odds ratios suggesting a significant decrease in risk. This was based on the data from seven specific genetic markers.
However, we also conducted a reverse analysis which showed no causal link between AD and folic acid supplementation. While our results hint at a protective effect of folic acid against Alzheimer's, further research is needed to confirm these findings and determine the underlying mechanisms involved.
Overall, this study sheds light on the potential of folic acid as a preventive strategy for Alzheimer's disease and contributes valuable insights into its etiology.
Our findings revealed an encouraging association: both fixed-effect and random-effect models indicated that folic acid supplementation could lead to a reduced risk of developing Alzheimer's, with odds ratios suggesting a significant decrease in risk. This was based on the data from seven specific genetic markers.
However, we also conducted a reverse analysis which showed no causal link between AD and folic acid supplementation. While our results hint at a protective effect of folic acid against Alzheimer's, further research is needed to confirm these findings and determine the underlying mechanisms involved.
Overall, this study sheds light on the potential of folic acid as a preventive strategy for Alzheimer's disease and contributes valuable insights into its etiology.
Read More
Most Useful Reviews
7.5
Effective B-12 benefits
41 people found this helpful
Wonderful, tasty sublingual B-12 – beneficial for Alzheimer's too! I value this B-12, priced reasonably, and believe shots are the best method. The sublingual forms taste delightful, akin to childhood candy. I take them for energy and blood sugar stability. I give these to my Mum, as they are helpful for Alzheimer's, supporting cognitive function.
Read More
6
Prevention of Alzheimer
7 people found this helpful
A memory tonic is why I purchased it, as I sometimes feel I forget important things, be they small everyday details or significant topics. At 28 years old, I ponder the possibility of having Alzheimer's in the future, so I decided to use it. It won't harm me and is certainly beneficial, helping me immensely.
Read More
7
Health improvement noted
It is wise to have a vitamin B12 test if you suspect a deficiency. I previously suffered from coldness in my extremities, which was diagnosed as a vitamin B12 deficiency. Thankfully, I now feel my health has improved, and the cold sensation has dissipated. This vitamin is crucial for maintaining the nervous system and protecting against Alzheimer's disease.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 19 Researches
6.7
- All Researches
9
Folate shows potential in Alzheimer's
We dove into a fascinating study that looked at the relationship between homocysteine, a compound linked to Alzheimer's disease, and treatments like folic acid (FA) and S-adenosylmethionine (SAM). By evaluating both living rat models and isolated hippocampal neurons, we observed how elevated levels of homocysteine can lead to Alzheimer’s-like changes in the brain.
Specifically, the study found that high homocysteine levels increased the expression of presenilin 1 (PS1), which is often implicated in the pathology of Alzheimer's, while also decreasing the activity of an important protein phosphatase known as PP2A. The researchers then tested whether FA and SAM could mitigate these harmful effects.
Encouragingly, both FA and SAM showed promise in reducing the neurodegeneration caused by high homocysteine, primarily by adjusting the methylation levels of PS1 and PP2A. This suggests that these treatments may help counteract some of the brain changes associated with Alzheimer's, presenting a potential pathway for further exploration in preventive or therapeutic strategies.
Specifically, the study found that high homocysteine levels increased the expression of presenilin 1 (PS1), which is often implicated in the pathology of Alzheimer's, while also decreasing the activity of an important protein phosphatase known as PP2A. The researchers then tested whether FA and SAM could mitigate these harmful effects.
Encouragingly, both FA and SAM showed promise in reducing the neurodegeneration caused by high homocysteine, primarily by adjusting the methylation levels of PS1 and PP2A. This suggests that these treatments may help counteract some of the brain changes associated with Alzheimer's, presenting a potential pathway for further exploration in preventive or therapeutic strategies.
Read More
9
We focused on the potential of folic acid supplementation as a way to influence cognitive impairment, especially in Alzheimer's disease (AD) patients. By reviewing multiple randomized controlled trials, we aimed to clarify the effectiveness of folic acid in improving cognitive function for those facing various levels of cognitive decline.
Our analysis revealed that folic acid supplementation may offer benefits for individuals with Mild Cognitive Impairment (MCI), suggesting even modest doses could have a positive impact. Notably, we found that doses of three milligrams or more of folic acid were particularly effective in enhancing cognitive abilities among Alzheimer's patients.
This evidence makes folic acid a promising candidate for helping delay cognitive decline in adults. While more extensive studies may be required, the results provide encouragement for using nutritional strategies as part of a comprehensive approach to managing cognitive impairment.
Our analysis revealed that folic acid supplementation may offer benefits for individuals with Mild Cognitive Impairment (MCI), suggesting even modest doses could have a positive impact. Notably, we found that doses of three milligrams or more of folic acid were particularly effective in enhancing cognitive abilities among Alzheimer's patients.
This evidence makes folic acid a promising candidate for helping delay cognitive decline in adults. While more extensive studies may be required, the results provide encouragement for using nutritional strategies as part of a comprehensive approach to managing cognitive impairment.
Read More
8
We examined the relationship between folate and Alzheimer's disease (AD) through a comprehensive analysis combining data from various studies. Our findings indicate that folate may provide protective effects against Alzheimer's, which is promising for those concerned about this challenging condition.
Specifically, we noted that individuals with higher folate levels could experience a decreased risk of developing Alzheimer's. This suggests that ensuring adequate folate intake could be beneficial for brain health.
However, it’s essential to understand that the impact of folate isn't a cure-all. While the association with Alzheimer's is favorable, more research is needed to clarify how folate levels might influence the progression or onset of this complex disorder.
Overall, our analysis underscores the potential of folate as part of a broader strategy for supporting cognitive health as we age.
Specifically, we noted that individuals with higher folate levels could experience a decreased risk of developing Alzheimer's. This suggests that ensuring adequate folate intake could be beneficial for brain health.
However, it’s essential to understand that the impact of folate isn't a cure-all. While the association with Alzheimer's is favorable, more research is needed to clarify how folate levels might influence the progression or onset of this complex disorder.
Overall, our analysis underscores the potential of folate as part of a broader strategy for supporting cognitive health as we age.
Read More
8
We explored the potential benefits of enhancing mitochondrial one-carbon metabolism, specifically through folate, to address Alzheimer's disease (AD). The study utilized a fly model where researchers overexpressed a toxic protein associated with AD, known as amyloid β (Aβ).
In our findings, we observed that increasing one-carbon metabolism through a genetic alteration significantly improved mitochondrial function and had neuroprotective effects in these AD models. Notably, we also tested exogenous folate in the form of folinic acid, which showed promise in improving mitochondrial health in both cells and fly models linked to AD.
Furthermore, we discovered a connection between genetic variations in the human equivalent of the fly gene and the risk of AD. Additionally, findings indicated that a higher intake of folate may reduce the risk of developing Alzheimer’s. Overall, our research suggests that enhancing folate-dependent metabolism could serve as a promising strategy in combating the progression of Alzheimer's disease.
In our findings, we observed that increasing one-carbon metabolism through a genetic alteration significantly improved mitochondrial function and had neuroprotective effects in these AD models. Notably, we also tested exogenous folate in the form of folinic acid, which showed promise in improving mitochondrial health in both cells and fly models linked to AD.
Furthermore, we discovered a connection between genetic variations in the human equivalent of the fly gene and the risk of AD. Additionally, findings indicated that a higher intake of folate may reduce the risk of developing Alzheimer’s. Overall, our research suggests that enhancing folate-dependent metabolism could serve as a promising strategy in combating the progression of Alzheimer's disease.
Read More
8
We examined the connection between dietary folate and the risk of developing Alzheimer disease. In a large-scale study with over 192,000 participants, we analyzed data gathered from dietary questionnaires and tracked cases of Alzheimer disease over a median follow-up of 13.35 years.
Our findings highlighted that higher folate intake, along with other 1-carbon metabolism nutrients, is associated with a reduced risk of Alzheimer disease. Specifically, participants who consumed a high amount of folate had their risk of developing Alzheimer disease lowered significantly. The results indicated that for those with lower genetic risk, high folate intake could further decrease their risk of Alzheimer disease by more than 75%.
Although we saw promising associations, it’s important to note that while folate showed a positive correlation with reduced Alzheimer disease risk, we cannot isolate its effects completely from other nutrients. Overall, our research underscores the potential benefits of incorporating folate-rich foods into the diet to combat Alzheimer disease, particularly for individuals at higher genetic risk.
Our findings highlighted that higher folate intake, along with other 1-carbon metabolism nutrients, is associated with a reduced risk of Alzheimer disease. Specifically, participants who consumed a high amount of folate had their risk of developing Alzheimer disease lowered significantly. The results indicated that for those with lower genetic risk, high folate intake could further decrease their risk of Alzheimer disease by more than 75%.
Although we saw promising associations, it’s important to note that while folate showed a positive correlation with reduced Alzheimer disease risk, we cannot isolate its effects completely from other nutrients. Overall, our research underscores the potential benefits of incorporating folate-rich foods into the diet to combat Alzheimer disease, particularly for individuals at higher genetic risk.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Effective B-12 benefits
41 people found this helpful
Wonderful, tasty sublingual B-12 – beneficial for Alzheimer's too! I value this B-12, priced reasonably, and believe shots are the best method. The sublingual forms taste delightful, akin to childhood candy. I take them for energy and blood sugar stability. I give these to my Mum, as they are helpful for Alzheimer's, supporting cognitive function.
Read More
6
Prevention of Alzheimer
7 people found this helpful
A memory tonic is why I purchased it, as I sometimes feel I forget important things, be they small everyday details or significant topics. At 28 years old, I ponder the possibility of having Alzheimer's in the future, so I decided to use it. It won't harm me and is certainly beneficial, helping me immensely.
Read More
7
Health improvement noted
It is wise to have a vitamin B12 test if you suspect a deficiency. I previously suffered from coldness in my extremities, which was diagnosed as a vitamin B12 deficiency. Thankfully, I now feel my health has improved, and the cold sensation has dissipated. This vitamin is crucial for maintaining the nervous system and protecting against Alzheimer's disease.
Read More
6
Enhancing memory function
I found it very helpful as a memory stimulant, which is why I bought it. Sometimes, I feel I forget important matters, from daily tasks to major topics. Being 28, I decided to incorporate this vital vitamin into my routine to enhance my memory and guard against forgetfulness or Alzheimer's in the future. It is advantageous to my well-being.
Read More
6
Memory enhancement benefits
My girls are mad! A memory stimulant is why I bought it, as I occasionally forget important things, whether everyday or significant topics. At 28, I consider the potential of Alzheimer’s disease in my future. Hence, I decided to try it, as it should not harm me and can be beneficial. I'm sharing my feelings about its ingredients, like folic acid, which support the nervous system.
Read More
Frequently Asked Questions
6
Prevention of Alzheimer
7 people found this helpful
A memory tonic is why I purchased it, as I sometimes feel I forget important things, be they small everyday details or significant topics. At 28 years old, I ponder the possibility of having Alzheimer's in the future, so I decided to use it. It won't harm me and is certainly beneficial, helping me immensely.
6
Enhancing memory function
I found it very helpful as a memory stimulant, which is why I bought it. Sometimes, I feel I forget important matters, from daily tasks to major topics. Being 28, I decided to incorporate this vital vitamin into my routine to enhance my memory and guard against forgetfulness or Alzheimer's in the future. It is advantageous to my well-being.
6
Memory enhancement benefits
My girls are mad! A memory stimulant is why I bought it, as I occasionally forget important things, whether everyday or significant topics. At 28, I consider the potential of Alzheimer’s disease in my future. Hence, I decided to try it, as it should not harm me and can be beneficial. I'm sharing my feelings about its ingredients, like folic acid, which support the nervous system.
7
Health improvement noted
It is wise to have a vitamin B12 test if you suspect a deficiency. I previously suffered from coldness in my extremities, which was diagnosed as a vitamin B12 deficiency. Thankfully, I now feel my health has improved, and the cold sensation has dissipated. This vitamin is crucial for maintaining the nervous system and protecting against Alzheimer's disease.
8
We examined the relationship between folate and Alzheimer's disease (AD) through a comprehensive analysis combining data from various studies. Our findings indicate that folate may provide protective effects against Alzheimer's, which is promising for those concerned about this challenging condition.
Specifically, we noted that individuals with higher folate levels could experience a decreased risk of developing Alzheimer's. This suggests that ensuring adequate folate intake could be beneficial for brain health.
However, it’s essential to understand that the impact of folate isn't a cure-all. While the association with Alzheimer's is favorable, more research is needed to clarify how folate levels might influence the progression or onset of this complex disorder.
Overall, our analysis underscores the potential of folate as part of a broader strategy for supporting cognitive health as we age.
Specifically, we noted that individuals with higher folate levels could experience a decreased risk of developing Alzheimer's. This suggests that ensuring adequate folate intake could be beneficial for brain health.
However, it’s essential to understand that the impact of folate isn't a cure-all. While the association with Alzheimer's is favorable, more research is needed to clarify how folate levels might influence the progression or onset of this complex disorder.
Overall, our analysis underscores the potential of folate as part of a broader strategy for supporting cognitive health as we age.
7
We assessed the effects of combining folate with various phytochemicals to understand its potential role in treating Alzheimer's disease. The study examined how these combinations could enhance antioxidant, anti-inflammatory, and anti-AChE (acetylcholinesterase) activities, which are crucial in managing neurodegenerative conditions.
During our evaluation, we noted that folate, when paired with other compounds like Quercetin and Swertiamarin, showed significant synergistic effects. Specifically, the combinations demonstrated improved antioxidant and anti-inflammatory properties, which are essential in combating Alzheimer’s symptoms. However, while the research highlights these synergistic benefits, it remains challenging to isolate the direct impact of folate alone on Alzheimer.
The findings hint at folate’s potential as a part of a dietary treatment strategy, especially when combined with other effective phytochemicals. Nonetheless, the study does not provide sufficient evidence to confirm its standalone effectiveness in Alzheimer treatment. Thus, further research is required to fully understand folate's specific contributions.
During our evaluation, we noted that folate, when paired with other compounds like Quercetin and Swertiamarin, showed significant synergistic effects. Specifically, the combinations demonstrated improved antioxidant and anti-inflammatory properties, which are essential in combating Alzheimer’s symptoms. However, while the research highlights these synergistic benefits, it remains challenging to isolate the direct impact of folate alone on Alzheimer.
The findings hint at folate’s potential as a part of a dietary treatment strategy, especially when combined with other effective phytochemicals. Nonetheless, the study does not provide sufficient evidence to confirm its standalone effectiveness in Alzheimer treatment. Thus, further research is required to fully understand folate's specific contributions.
4
No significant benefit observed
We explored the effects of combined folic acid (FA) and vitamin D3 (VD3) on cognitive function in patients diagnosed with mild cognitive impairment (MCI) accompanied by vitamin D deficiency. In a well-structured study that included 402 participants, individuals were randomly assigned to receive either a placebo, folic acid alone, or a combination of folic acid with a significant dosage of vitamin D3 for a duration of 24 weeks.
Our main measure of cognitive function was the Montreal Cognitive Assessment (MoCA). The results were telling. While we had anticipated that the combination treatment might lead to improvements, the overall findings showed that there was no significant benefit. Specifically, the group receiving both FA and VD3 did not demonstrate notable enhancements in cognitive function compared to the placebo or FA-only groups.
Given that some of the results indicated potential positive effects within specific analyses, we recognize that this area may require further exploration. The limitations in substantial achievements raise the question of whether the role of folic acid is indeed underestimated in managing cognitive decline. More extensive studies over longer periods could help clarify these findings and offer additional insights into the potential of folate in addressing Alzheimer's and cognitive impairment concerns.
Our main measure of cognitive function was the Montreal Cognitive Assessment (MoCA). The results were telling. While we had anticipated that the combination treatment might lead to improvements, the overall findings showed that there was no significant benefit. Specifically, the group receiving both FA and VD3 did not demonstrate notable enhancements in cognitive function compared to the placebo or FA-only groups.
Given that some of the results indicated potential positive effects within specific analyses, we recognize that this area may require further exploration. The limitations in substantial achievements raise the question of whether the role of folic acid is indeed underestimated in managing cognitive decline. More extensive studies over longer periods could help clarify these findings and offer additional insights into the potential of folate in addressing Alzheimer's and cognitive impairment concerns.
7
Folate and DHA's short-term effects
We conducted a randomized controlled trial to explore how folic acid (FA) combined with docosahexaenoic acid (DHA) affects cognitive function in older adults with mild cognitive impairment (MCI). Over six months, 160 participants were randomly assigned to receive FA and DHA, either separately or together, while a control group received a placebo.
During the first phase of the study, we saw promising results: patients taking FA, DHA, or both showed improvements in cognitive performance compared to those in the control group. After moving into a follow-up period without any treatment, we reassessed cognitive abilities and found that the initial benefits began to diminish.
Notably, all intervention groups showed reduced scores in cognitive tests as time progressed, indicating that the improvements they experienced during treatment did not last once supplementation ended. These results suggest that while folate and DHA can positively affect cognitive function in the short term, their effectiveness lessens once intervention ceases.
Additionally, we observed significant decreases in certain biomarkers related to cognitive decline, like homocysteine (Hcy) and amyloid-β (Aβ) levels, which correlated with cognitive performance during the follow-up period.
During the first phase of the study, we saw promising results: patients taking FA, DHA, or both showed improvements in cognitive performance compared to those in the control group. After moving into a follow-up period without any treatment, we reassessed cognitive abilities and found that the initial benefits began to diminish.
Notably, all intervention groups showed reduced scores in cognitive tests as time progressed, indicating that the improvements they experienced during treatment did not last once supplementation ended. These results suggest that while folate and DHA can positively affect cognitive function in the short term, their effectiveness lessens once intervention ceases.
Additionally, we observed significant decreases in certain biomarkers related to cognitive decline, like homocysteine (Hcy) and amyloid-β (Aβ) levels, which correlated with cognitive performance during the follow-up period.
8
We examined the connection between dietary folate and the risk of developing Alzheimer disease. In a large-scale study with over 192,000 participants, we analyzed data gathered from dietary questionnaires and tracked cases of Alzheimer disease over a median follow-up of 13.35 years.
Our findings highlighted that higher folate intake, along with other 1-carbon metabolism nutrients, is associated with a reduced risk of Alzheimer disease. Specifically, participants who consumed a high amount of folate had their risk of developing Alzheimer disease lowered significantly. The results indicated that for those with lower genetic risk, high folate intake could further decrease their risk of Alzheimer disease by more than 75%.
Although we saw promising associations, it’s important to note that while folate showed a positive correlation with reduced Alzheimer disease risk, we cannot isolate its effects completely from other nutrients. Overall, our research underscores the potential benefits of incorporating folate-rich foods into the diet to combat Alzheimer disease, particularly for individuals at higher genetic risk.
Our findings highlighted that higher folate intake, along with other 1-carbon metabolism nutrients, is associated with a reduced risk of Alzheimer disease. Specifically, participants who consumed a high amount of folate had their risk of developing Alzheimer disease lowered significantly. The results indicated that for those with lower genetic risk, high folate intake could further decrease their risk of Alzheimer disease by more than 75%.
Although we saw promising associations, it’s important to note that while folate showed a positive correlation with reduced Alzheimer disease risk, we cannot isolate its effects completely from other nutrients. Overall, our research underscores the potential benefits of incorporating folate-rich foods into the diet to combat Alzheimer disease, particularly for individuals at higher genetic risk.
References
- Ye M, Yang X, Yan J, Yao Y, Lv H, et al. Causal relationship between B vitamins and neuropsychiatric disorders: A systematic review and meta-analysis. Neurosci Biobehav Rev. 2025;170:106068. doi:10.1016/j.neubiorev.2025.106068
- Irum I, Khan F, Sufyan M, Benish Ali SH, Rehman S. Developing multifaceted drug synergistic therapeutic strategy against neurological disorders. Comput Biol Med. 2025;185:109495. doi:10.1016/j.compbiomed.2024.109495
- Yu Y, Chen CZ, Celardo I, Tan BWZ, Hurcomb JD, et al. Enhancing mitochondrial one-carbon metabolism is neuroprotective in Alzheimer's disease models. Cell Death Dis. 2024;15:856. doi:10.1038/s41419-024-07179-3
- Liu W, Zheng D, Li X, Wang T, Wang L, et al. Effects of Vitamin D3 Combined with Folic Acid on Domain and Specific Cognitive Function among Patients with Mild Cognitive Impairment: A Randomized Clinical Trial. J Prev Alzheimers Dis. 2024;11:1626. doi:10.14283/jpad.2024.165
- Bai D, Fan J, Li M, Dong C, Gao Y, et al. Cognitive Function After Stopping Folic Acid and DHA Intervention: An Extended Follow-Up Results from the Randomized, Double Blind, Placebo-Controlled Trial in Older Adults with Mild Cognitive Impairment. J Alzheimers Dis Rep. 2024;8:1285. doi:10.3233/ADR-240033
- Wang Y, Mi N, Liao K, Li Y, Sun Y, et al. Associations among dietary 1-carbon metabolism nutrients, genetic risk, and Alzheimer disease: a prospective cohort study. Am J Clin Nutr. 2024;120:1009. doi:10.1016/j.ajcnut.2024.08.027
- Li T, Steibel JP, Willette AA. Vitamin B6, B12, and Folate's Influence on Neural Networks in the UK Biobank Cohort. Nutrients. 2024;16. doi:10.3390/nu16132050
- Wang M, Fang M, Zang W. Effects of folic acid supplementation on cognitive function and inflammation in elderly patients with mild cognitive impairment: A systematic review and meta-analysis of randomized controlled trials. Arch Gerontol Geriatr. 2024;126:105540. doi:10.1016/j.archger.2024.105540
- Sun S, Lu W, Zhang C, Wang G, Hou Y, et al. Folic acid and S-adenosylmethionine reverse Homocysteine-induced Alzheimer's disease-like pathological changes in rat hippocampus by modulating PS1 and PP2A methylation levels. Brain Res. 2024;1841:149095. doi:10.1016/j.brainres.2024.149095
- Tang Y, Zhou X, Cao J, Li Z, Yin W, et al. Synergistic effect of folate and MTHFR C677T on hippocampal subfields and perfusion in Alzheimer's disease. Prog Neuropsychopharmacol Biol Psychiatry. 2024;134:111071. doi:10.1016/j.pnpbp.2024.111071
- Lee CY, Chan L, Hu CJ, Hong CT, Chen JH. Role of vitamin B12 and folic acid in treatment of Alzheimer's disease: a meta-analysis of randomized control trials. Aging (Albany NY). 2024;16:7856. doi:10.18632/aging.205788
- Xu M, Zhu Y, Chen J, Li J, Qin J, et al. Effects of folic acid supplementation on cognitive impairment: A meta-analysis of randomized controlled trials. J Evid Based Med. 2024;17:134. doi:10.1111/jebm.12588
- Sun X, He C, Yang S, Li W, Qu H. Mendelian randomization to evaluate the effect of folic acid supplement on the risk of Alzheimer disease. Medicine (Baltimore). 2024;103:e37021. doi:10.1097/MD.0000000000037021
- Ling Y, Yuan S, Huang X, Tan S, Cheng H, et al. Associations of Folate/Folic Acid Supplementation Alone and in Combination With Other B Vitamins on Dementia Risk and Brain Structure: Evidence From 466 224 UK Biobank Participants. J Gerontol A Biol Sci Med Sci. 2024;79. doi:10.1093/gerona/glad266
- Tu MC, Chung HW, Hsu YH, Yang JJ, Wu WC. Neurovascular Correlates of Cobalamin, Folate, and Homocysteine in Dementia. J Alzheimers Dis. 2023;96:1329. doi:10.3233/JAD-230763
- Ekundayo BE, Adewale OB, Obafemi BA, Ntwasa MM, Lebelo SL, et al. Synergistic Effect of Donepezil and Neurotropic B Vitamins on Dysregulated Antioxidant, Inflammation and Neurotransmitter Status in Aluminium Chloride-Induced Neurotoxicity in Rats. Cell Biochem Funct. 2024;42:e70028. doi:10.1002/cbf.70028
- Hooshmand B, Appold F, Fissler P, Perneczky R, Otto M, et al. Markers of Vitamin B12 Status in Relation to Cerebrospinal Fluid Biomarkers of Alzheimer's Disease and Cognitive Performance. Ann Neurol. 2023;94:223. doi:10.1002/ana.26673
- Wang L, Zhou C, Yu H, Hao L, Ju M, et al. Vitamin D, Folic Acid and Vitamin B Can Reverse Vitamin D Deficiency-Induced Learning and Memory Impairment by Altering 27-Hydroxycholesterol and S-Adenosylmethionine. Nutrients. 2022;15. doi:10.3390/nu15010132
- Song Y, Quan M, Li T, Jia J. Serum Homocysteine, Vitamin B12, Folate, and Their Association with Mild Cognitive Impairment and Subtypes of Dementia. J Alzheimers Dis. 2022;90:681. doi:10.3233/JAD-220410
