Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.3
USERS' SCORE
Good
Based on 14 Reviews
8
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Folate
167 mcg DFE(100 mcg folic acid)
42%
Vitamin B-12 (as Cyanocobalamin)
1 mg (1,000 mcg)
41,667%
Top Medical Research Studies
8
We explored a novel oral delivery system using vitamin B12, fucoidan, and concanavalin A to enhance insulin effectiveness for diabetes management. This smart nanosystem targets inflammation while regulating blood glucose levels efficiently. Our findings indicated that when tested on type I diabetic mice, the nanosystem significantly lowered blood sugar and reduced inflammatory markers, such as TNF-α and interleukin-6. Notably, the system ensures safe and effective delivery, presenting a promising alternative to traditional insulin methods.
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8
We explored how vitamin B12 might protect against nerve damage caused by diabetes. In a research study, diabetic rats received B12 supplements for four months. By examining their brains, we found that B12 reduced nerve cell death and supported healthy brain functions, even under diabetic conditions. The treatment improved important markers related to nerve support and minimized harmful inflammatory responses. This suggests that vitamin B12 could be a valuable addition for helping diabetic patients maintain better brain health.
Read More
7
We explored the connection between folate metabolites and diabetic kidney disease (DKD), a serious complication that affects around 40% of individuals with type 2 diabetes. Our investigation drew on data from a large U.S. survey spanning nearly a decade, from 2011 to 2020, focusing on various forms of folate to see how they relate to DKD.
Through our research, we discovered that higher levels of total folate and 5-Methyl-THF were associated with a lower risk of DKD. Specifically, those in the highest quintile of these folate forms had an odds ratio (OR) of 0.73, indicating a protective effect. In contrast, certain other forms of folate, like RBC folate and UMFA, were linked to an increased risk of DKD, with ORs exceeding 1.4. This suggests that not all folate is beneficial when it comes to this condition.
Overall, our findings highlight the potential importance of promoting 5-Methyl-THF while minimizing UMFA for better diabetes management. It's clear that a balanced approach to folate intake could be crucial for maintaining kidney health in those with diabetes.
Through our research, we discovered that higher levels of total folate and 5-Methyl-THF were associated with a lower risk of DKD. Specifically, those in the highest quintile of these folate forms had an odds ratio (OR) of 0.73, indicating a protective effect. In contrast, certain other forms of folate, like RBC folate and UMFA, were linked to an increased risk of DKD, with ORs exceeding 1.4. This suggests that not all folate is beneficial when it comes to this condition.
Overall, our findings highlight the potential importance of promoting 5-Methyl-THF while minimizing UMFA for better diabetes management. It's clear that a balanced approach to folate intake could be crucial for maintaining kidney health in those with diabetes.
Read More
Most Useful Reviews
9
Improved blood sugar
4 people found this helpful
I bought this vitamin for my sister, who suffers from diabetes, on her doctor's advice. After starting it, she has improved significantly; her blood sugar stabilised, and she feels her body responding better to her diet.
Read More
9
Effective for nerves
1 people found this helpful
This product has great quality, with natural ingredients and a lovely taste. It is crucial for the nervous system and diabetes management, as it helps prevent nerve capillary erosion and contains folic acid, enhancing its benefits for diabetics.
Read More
9
Nerve protection
Diabetics who take Metformin daily may develop a B12 deficiency leading to nerve damage. Taking these B12 supplements helps protect against that nerve damage effectively.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.3
- All Researches
9
We evaluated the impact of 5-methyltetrahydrofolate (5-MTHF) and an aqueous extract on diabetes by examining their effects in a rat model with induced diabetes. Our findings were based on a combination of in silico docking studies and in vitro assays, which indicated that folates bind effectively with proteins that regulate glucose metabolism.
In our tests, we observed that 5-MTHF demonstrated stronger inhibitory action on alpha-amylase than folic acid, indicating its potential for managing blood sugar levels. When we administered 5-MTHF and the aqueous extract to diabetic Wistar rats, both supplements contributed to significant reductions in fasting blood glucose and improvements in glucose tolerance.
Furthermore, alongside controlling blood sugar, we noted that supplementation helped reduce obesity, address hyperlipidemia, and enhance antioxidant enzyme levels. Remarkably, the higher dosage of 5-MTHF provided better results than the aqueous extract and higher doses of folic acid, suggesting its effectiveness as a treatment option. By incorporating the aqueous extract, we also found an increase in serum folate levels, indicating its role as a folate source enriched with other beneficial phytochemicals.
Overall, we highlighted the promising effects of both the aqueous extract and 5-MTHF, emphasizing their potential as dietary supplements for diabetes management and its associated complications.
In our tests, we observed that 5-MTHF demonstrated stronger inhibitory action on alpha-amylase than folic acid, indicating its potential for managing blood sugar levels. When we administered 5-MTHF and the aqueous extract to diabetic Wistar rats, both supplements contributed to significant reductions in fasting blood glucose and improvements in glucose tolerance.
Furthermore, alongside controlling blood sugar, we noted that supplementation helped reduce obesity, address hyperlipidemia, and enhance antioxidant enzyme levels. Remarkably, the higher dosage of 5-MTHF provided better results than the aqueous extract and higher doses of folic acid, suggesting its effectiveness as a treatment option. By incorporating the aqueous extract, we also found an increase in serum folate levels, indicating its role as a folate source enriched with other beneficial phytochemicals.
Overall, we highlighted the promising effects of both the aqueous extract and 5-MTHF, emphasizing their potential as dietary supplements for diabetes management and its associated complications.
Read More
9
We explored the potential connection between red blood cell (RBC) folate levels and diabetic nephropathy (DN) in individuals with type 2 diabetes mellitus. Using data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2011 to 2018, we carried out a cross-sectional analysis involving 3,070 adults diagnosed with type 2 diabetes.
Our findings reveal a noteworthy positive relationship between RBC folate levels and the risk of developing diabetic nephropathy. Specifically, even after adjusting for various influencing factors, our analysis indicated that higher levels of RBC folate were linked to an increased risk of DN, with a significant odds ratio of 1.38. This suggests that as RBC folate levels rise, so does the likelihood of experiencing complications related to kidney function in diabetes.
Furthermore, our subgroup analysis supported these findings, showing consistent patterns across different groups. The curve fitting we conducted also pointed to a linear relationship between RBC folate and diabetic nephropathy, indicating that higher folate concentrations in the blood are indeed associated with heightened risk.
Overall, our study suggests that RBC folate might serve as an important indicator of folate status and its implications for kidney health in those with type 2 diabetes. As we delve deeper into the implications of these findings, it becomes clear that folate levels deserve consideration in the broader context of diabetes management.
Our findings reveal a noteworthy positive relationship between RBC folate levels and the risk of developing diabetic nephropathy. Specifically, even after adjusting for various influencing factors, our analysis indicated that higher levels of RBC folate were linked to an increased risk of DN, with a significant odds ratio of 1.38. This suggests that as RBC folate levels rise, so does the likelihood of experiencing complications related to kidney function in diabetes.
Furthermore, our subgroup analysis supported these findings, showing consistent patterns across different groups. The curve fitting we conducted also pointed to a linear relationship between RBC folate and diabetic nephropathy, indicating that higher folate concentrations in the blood are indeed associated with heightened risk.
Overall, our study suggests that RBC folate might serve as an important indicator of folate status and its implications for kidney health in those with type 2 diabetes. As we delve deeper into the implications of these findings, it becomes clear that folate levels deserve consideration in the broader context of diabetes management.
Read More
9
We explored the effectiveness of vitamin B12 in treating diabetic ocular nerve palsy, a complication that can occur in people with diabetes. In a recent study, fifty individuals with this condition were divided into two groups. One group received steroid treatments while the other was treated with vitamin B12 injections.
After assessing ocular movements at three points during treatment, we observed a notable improvement in those receiving vitamin B12 compared to those receiving steroids. Specifically, the vitamin B12 group showed an enhancement of eye movements by an average of 1.04, while the steroid group had a lesser improvement of 0.75. This difference was statistically significant, suggesting that vitamin B12 may be more effective in aiding recovery of eye movement in these patients.
Importantly, treating diabetic neuropathy with vitamin supplementation not only addresses possible nutritional deficiencies but could also improve overall quality of life for patients. This study highlights the potential benefits of vitamin B12 therapy, making it an appealing option for individuals dealing with the effects of diabetic-related nerve issues.
After assessing ocular movements at three points during treatment, we observed a notable improvement in those receiving vitamin B12 compared to those receiving steroids. Specifically, the vitamin B12 group showed an enhancement of eye movements by an average of 1.04, while the steroid group had a lesser improvement of 0.75. This difference was statistically significant, suggesting that vitamin B12 may be more effective in aiding recovery of eye movement in these patients.
Importantly, treating diabetic neuropathy with vitamin supplementation not only addresses possible nutritional deficiencies but could also improve overall quality of life for patients. This study highlights the potential benefits of vitamin B12 therapy, making it an appealing option for individuals dealing with the effects of diabetic-related nerve issues.
Read More
8
B12 in multi-nutrient diabetes study
We explored how a combination of nutrients, including B12, impacts people with diabetic neuropathy. In a study with 73 individuals suffering from type 2 diabetes, participants were split into two groups: one received the combination of nutrients while the other received a placebo for six months.
Our findings revealed that this nutrient blend significantly improved pain levels, vibration perception, and B12 levels in participants. However, it’s important to note that the overall efficacy of B12 in this context is just part of a broader treatment approach rather than a standalone solution.
Our findings revealed that this nutrient blend significantly improved pain levels, vibration perception, and B12 levels in participants. However, it’s important to note that the overall efficacy of B12 in this context is just part of a broader treatment approach rather than a standalone solution.
Read More
8
We investigated how gastrectomy impacts the risk of type 2 diabetes in gastric cancer survivors. Analyzing data from over 150,000 patients, we observed that those who underwent total gastrectomy had a higher chance of developing diabetes, especially if they didn't take vitamin B12 supplements. Surprisingly, patients who had subtotal gastrectomy enjoyed a lower risk of diabetes. Furthermore, B12 supplementation appeared to shield those who underwent total gastrectomy from heightened diabetes risk. This highlights the importance of monitoring and managing vitamin levels post-surgery.
Read More
User Reviews
USERS' SCORE
Good
Based on 14 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved blood sugar
4 people found this helpful
I bought this vitamin for my sister, who suffers from diabetes, on her doctor's advice. After starting it, she has improved significantly; her blood sugar stabilised, and she feels her body responding better to her diet.
Read More
9
Effective for nerves
1 people found this helpful
This product has great quality, with natural ingredients and a lovely taste. It is crucial for the nervous system and diabetes management, as it helps prevent nerve capillary erosion and contains folic acid, enhancing its benefits for diabetics.
Read More
9
Nerve protection
Diabetics who take Metformin daily may develop a B12 deficiency leading to nerve damage. Taking these B12 supplements helps protect against that nerve damage effectively.
Read More
9
Reduced numbness
Since my mother started diabetes medication, she experienced uncomfortable numbness in her hands and feet. I chose Now Foods vitamin B12 to help alleviate these symptoms. After using two cans, her symptoms have decreased significantly, and the numbness is almost minimal now. I intend to continue taking it during her medication.
Read More
9
Improved condition
An excellent drug, my mother-in-law, who has diabetes, takes metformin, which disrupts B12 absorption. I began to feel better, and the tingling in my fingers stopped.
Read More
Frequently Asked Questions
9
Reduced numbness
Since my mother started diabetes medication, she experienced uncomfortable numbness in her hands and feet. I chose Now Foods vitamin B12 to help alleviate these symptoms. After using two cans, her symptoms have decreased significantly, and the numbness is almost minimal now. I intend to continue taking it during her medication.
9
Improved condition
An excellent drug, my mother-in-law, who has diabetes, takes metformin, which disrupts B12 absorption. I began to feel better, and the tingling in my fingers stopped.
2
Not effective
I found this not helpful at all. Despite having diabetes, it did not work for me. Sugar affects my nerves, and I didn’t see any results from it, so I switched to vitamin B from the pharmacy.
9
Improved blood sugar
4 people found this helpful
I bought this vitamin for my sister, who suffers from diabetes, on her doctor's advice. After starting it, she has improved significantly; her blood sugar stabilised, and she feels her body responding better to her diet.
9
Nerve protection
Diabetics who take Metformin daily may develop a B12 deficiency leading to nerve damage. Taking these B12 supplements helps protect against that nerve damage effectively.
7.5
Nerve impulse benefits
This B group vitamin is essential, especially if you suffer from diabetes and leg pain. Methylcobalamin absorbs well compared to cyanocobalamin. I recommend combining it with methyl folic acid B9 for improved effects on nerve impulses and the nervous system.
8
B12 in multi-nutrient diabetes study
We explored how a combination of nutrients, including B12, impacts people with diabetic neuropathy. In a study with 73 individuals suffering from type 2 diabetes, participants were split into two groups: one received the combination of nutrients while the other received a placebo for six months.
Our findings revealed that this nutrient blend significantly improved pain levels, vibration perception, and B12 levels in participants. However, it’s important to note that the overall efficacy of B12 in this context is just part of a broader treatment approach rather than a standalone solution.
Our findings revealed that this nutrient blend significantly improved pain levels, vibration perception, and B12 levels in participants. However, it’s important to note that the overall efficacy of B12 in this context is just part of a broader treatment approach rather than a standalone solution.
8
We investigated how gastrectomy impacts the risk of type 2 diabetes in gastric cancer survivors. Analyzing data from over 150,000 patients, we observed that those who underwent total gastrectomy had a higher chance of developing diabetes, especially if they didn't take vitamin B12 supplements. Surprisingly, patients who had subtotal gastrectomy enjoyed a lower risk of diabetes. Furthermore, B12 supplementation appeared to shield those who underwent total gastrectomy from heightened diabetes risk. This highlights the importance of monitoring and managing vitamin levels post-surgery.
8
We examined the relationship between B vitamin intake and the risk of developing type 2 diabetes (T2D) through a large study in Shanghai. Using data from nearly 45,000 adults, we found that higher consumption of B vitamins, particularly B1, B2, B6, B9, and B12, was linked to a lower risk of T2D.
Our analysis also suggested that inflammation played a mediating role in this effect. While we did not find a significant link with B3, vitamin B6 was notably influential in reducing T2D risk. Overall, incorporating these B vitamins in our diet may help mitigate T2D, at least in part, through controlling inflammation.
Our analysis also suggested that inflammation played a mediating role in this effect. While we did not find a significant link with B3, vitamin B6 was notably influential in reducing T2D risk. Overall, incorporating these B vitamins in our diet may help mitigate T2D, at least in part, through controlling inflammation.
8
We explored how vitamin B12 might protect against nerve damage caused by diabetes. In a research study, diabetic rats received B12 supplements for four months. By examining their brains, we found that B12 reduced nerve cell death and supported healthy brain functions, even under diabetic conditions. The treatment improved important markers related to nerve support and minimized harmful inflammatory responses. This suggests that vitamin B12 could be a valuable addition for helping diabetic patients maintain better brain health.
References
- Didangelos T, Karlafti E, Kotzakioulafi E, Giannoulaki P, Kontoninas Z, et al. Efficacy and Safety of the Combination of Palmitoylethanolamide, Superoxide Dismutase, Alpha Lipoic Acid, Vitamins B12, B1, B6, E, Mg, Zn and Nicotinamide for 6 Months in People with Diabetic Neuropathy. Nutrients. 2024;16. doi:10.3390/nu16183045
- Kim G, Han KD, Cho SH, Oh R, Lee YB, et al. Association between gastrectomy and the risk of type 2 diabetes in gastric cancer survivors: A nationwide cohort study. Diabetes Metab. 2024;50:101569. doi:10.1016/j.diabet.2024.101569
- Zhu Y, Ying T, Xu M, Chen Q, Wu M, et al. Joint B Vitamin Intake and Type 2 Diabetes Risk: The Mediating Role of Inflammation in a Prospective Shanghai Cohort. Nutrients. 2024;16. doi:10.3390/nu16121901
- Gautam S, Mittal C, Ranjan A, Singh G. Association of Diabetic Peripheral Neuropathy with Micronutrients. J Assoc Physicians India. 2024;72:65. doi:10.59556/japi.72.0493
- Zhou J, Ma H, Guan M, Feng J, Dong X, et al. Anti-inflammatory Fucoidan-ConA oral insulin nanosystems for smart blood glucose regulation. Int J Pharm. 2024;659:124250. doi:10.1016/j.ijpharm.2024.124250
- Hakola L, Mramba LK, Uusitalo U, Andrén Aronsson C, Hummel S, et al. Intake of B vitamins and the risk of developing islet autoimmunity and type 1 diabetes in the TEDDY study. Eur J Nutr. 2024;63:1329. doi:10.1007/s00394-024-03346-6
- Suryavanshi U, Angadi KK, Reddy VS, Reddy GB. Neuroprotective role of vitamin B12 in streptozotocin-induced type 1 diabetic rats. Chem Biol Interact. 2024;387:110823. doi:10.1016/j.cbi.2023.110823
- Chai Y, Chen C, Yin X, Wang X, Yu W, et al. Effects of water-soluble vitamins on glycemic control and insulin resistance in adult type 2 diabetes: an umbrella review of meta-analyses. Asia Pac J Clin Nutr. 2025;34:118. doi:10.6133/apjcn.202502_34(1).0012
- Chen L, Liu R, He X, Fang J, Zhou L, et al. Synergistically effects of n-3 PUFA and B vitamins prevent diabetic cognitive dysfunction through promoting TET2-mediated active DNA demethylation. Clin Nutr. 2025;45:111. doi:10.1016/j.clnu.2025.01.002
- Pathikkal A, Bhaskar TK, Prasanthan A, Haritha PK, Puthusseri B, et al. 5-Methyltetrahydrofolate and aqueous extract of () ameliorate diabetes and associated complications in STZ-induced diabetic rats. 3 Biotech. 2025;15:15. doi:10.1007/s13205-024-04170-9
- Liang Y, Ding L, Tao M, Zhu Y. The association of metabolic profile of folate with diabetic kidney disease: evidence from 2011-2020 cycles of the NHANES. Ren Fail. 2024;46:2420830. doi:10.1080/0886022X.2024.2420830
- Yu P, Ji Y, Wang H, Liu K. Association between RBC folate and diabetic nephropathy in Type2 diabetes mellitus patients: a cross-sectional study. Sci Rep. 2024;14:24692. doi:10.1038/s41598-024-76456-0
- N I, Shyam Kumar S. The Effectiveness of Steroid Versus Vitamin Therapy in the Improvement of Extraocular Movements in Patients With Diabetic Cranial Nerve Palsy: A Comparative Study. Cureus. 2024;16:e75656. doi:10.7759/cureus.75656
- Abu-Zahab ZA, Qureshi H, Adham GM, Elzefzafy WM, Zalam SS, et al. Frequency of comorbid diseases with high serum Vitamin B12 levels in patients attending King Salman Medical City (KSAMC), at Madinah. Int J Health Sci (Qassim). 2025;19:15.
- Zhao X, An X, Cui Y, Dong L, Fang Z, et al. TangBi Formula for Painful Diabetic Distal Symmetric Polyneuropathy: A Multicenter, Randomized, Double-Blind, Placebo-Controlled and Parallel-Group Trial. J Diabetes. 2025;17:e70045. doi:10.1111/1753-0407.70045
- Asghar S, Tanvir H, Riaz A, Ejaz MH, Akram M, et al. Prevalence of Vitamin B12 Deficiency in Patients With Type 2 Diabetes Mellitus on Metformin Therapy: A Cross-Sectional Study. Cureus. 2024;16:e72184. doi:10.7759/cureus.72184
