Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8
USERS' SCORE
Good
Based on 2 Reviews
8.2
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Folate
167 mcg DFE(100 mcg folic acid)
42%
Vitamin B-12 (as Cyanocobalamin)
1 mg (1,000 mcg)
41,667%
Top Medical Research Studies
8
We aimed to investigate how vitamin B12 can affect the symptoms and overall well-being of fibromyalgia patients. In our study, we worked with individuals diagnosed with fibromyalgia based on established criteria. Participants were given a daily dose of 1000 mcg of oral vitamin B12 to take for fifty days.
Before and after the treatment period, we assessed the patients' conditions using various questionnaires designed to measure pain severity, anxiety, and overall health. Our findings revealed that this short course of vitamin B12 significantly reduced the severity of fibromyalgia symptoms and improved anxiety levels.
Such results suggest that vitamin B12 could play an important role as an adjunctive therapy for managing fibromyalgia. We believe there is potential for further research in this area to enhance treatment options for individuals living with this condition.
Before and after the treatment period, we assessed the patients' conditions using various questionnaires designed to measure pain severity, anxiety, and overall health. Our findings revealed that this short course of vitamin B12 significantly reduced the severity of fibromyalgia symptoms and improved anxiety levels.
Such results suggest that vitamin B12 could play an important role as an adjunctive therapy for managing fibromyalgia. We believe there is potential for further research in this area to enhance treatment options for individuals living with this condition.
Read More
7
Vitamin B12 deficiency linked to fatigue
We investigated the connection between vitamin B12 deficiency and the prevalence of fatigue and neurological symptoms in patients with fibromyalgia. By analyzing charts from 2,142 patients diagnosed with fibromyalgia between 2015 and 2020, we set out to see how these symptoms related to B12 levels.
The results were striking: 42.4% of the patients exhibited B12 deficiency, with those lacking sufficient levels reporting higher instances of fatigue and memory loss. Even after considering the impact of vitamin D levels, we found a significant association between B12 deficiency and fatigue, suggesting that addressing this deficiency might help alleviate one of the most burdensome aspects of fibromyalgia.
This study is groundbreaking in highlighting the role of vitamin B12 for patients experiencing fatigue related to fibromyalgia, reinforcing the importance of regular monitoring of vitamin levels in this population. Notably, we found this trend whether we considered the cutoff for B12 deficiency at 400 ng/L or a lower threshold.
The results were striking: 42.4% of the patients exhibited B12 deficiency, with those lacking sufficient levels reporting higher instances of fatigue and memory loss. Even after considering the impact of vitamin D levels, we found a significant association between B12 deficiency and fatigue, suggesting that addressing this deficiency might help alleviate one of the most burdensome aspects of fibromyalgia.
This study is groundbreaking in highlighting the role of vitamin B12 for patients experiencing fatigue related to fibromyalgia, reinforcing the importance of regular monitoring of vitamin levels in this population. Notably, we found this trend whether we considered the cutoff for B12 deficiency at 400 ng/L or a lower threshold.
Read More
9
Mitochondrial myopathy mistaken for fibromyalgia
We explored the intriguing case of a 41-year-old woman who was initially diagnosed with fibromyalgia due to her symptoms, which included fatigue, headaches, and exercise intolerance. Despite undergoing a variety of treatments typical for fibromyalgia—such as pain relievers and antidepressants—she experienced no relief. This led her to further medical investigation.
Through biochemical and genetic studies stemming from a muscle biopsy, she was eventually diagnosed with mitochondrial myopathy, a condition that can often be overlooked. As part of her treatment, she began taking a combination of supplements, which included coenzyme Q10, creatine, carnitine, and folic acid. Over several months, she reported significant improvement in her overall condition.
While folate was included in her regimen, it’s important to note that we cannot isolate its impact on fibromyalgia symptoms without further dedicated studies. This case highlights that what appears to be fibromyalgia may sometimes have an underlying cause, such as mitochondrial myopathy, and the treatment for that condition can lead to symptom resolution.
Through biochemical and genetic studies stemming from a muscle biopsy, she was eventually diagnosed with mitochondrial myopathy, a condition that can often be overlooked. As part of her treatment, she began taking a combination of supplements, which included coenzyme Q10, creatine, carnitine, and folic acid. Over several months, she reported significant improvement in her overall condition.
While folate was included in her regimen, it’s important to note that we cannot isolate its impact on fibromyalgia symptoms without further dedicated studies. This case highlights that what appears to be fibromyalgia may sometimes have an underlying cause, such as mitochondrial myopathy, and the treatment for that condition can lead to symptom resolution.
Read More
Most Useful Reviews
7.5
Improves energy levels
1 people found this helpful
This is a fantastic product at an excellent price. Chewable and tastes pleasant, it's in the most bioavailable form, which is methylcobalamin. I incorporate it into my fibromyalgia regimen, and it has significantly helped with my energy levels and the numbness and tingling sensations. It’s important to note that it doesn’t produce “energy” in the way that substances like caffeine or certain nootropics do, so don’t expect that. Instead, it operates subtly, much like you would expect from a vitamin supplement.
Read More
6
Helpful B vitamins
I have taken these vitamins for many years, changing them every three months. I find that a complex of B vitamins is very beneficial for managing my fibromyalgia.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8
- All Researches
9
Mitochondrial myopathy mistaken for fibromyalgia
We explored the intriguing case of a 41-year-old woman who was initially diagnosed with fibromyalgia due to her symptoms, which included fatigue, headaches, and exercise intolerance. Despite undergoing a variety of treatments typical for fibromyalgia—such as pain relievers and antidepressants—she experienced no relief. This led her to further medical investigation.
Through biochemical and genetic studies stemming from a muscle biopsy, she was eventually diagnosed with mitochondrial myopathy, a condition that can often be overlooked. As part of her treatment, she began taking a combination of supplements, which included coenzyme Q10, creatine, carnitine, and folic acid. Over several months, she reported significant improvement in her overall condition.
While folate was included in her regimen, it’s important to note that we cannot isolate its impact on fibromyalgia symptoms without further dedicated studies. This case highlights that what appears to be fibromyalgia may sometimes have an underlying cause, such as mitochondrial myopathy, and the treatment for that condition can lead to symptom resolution.
Through biochemical and genetic studies stemming from a muscle biopsy, she was eventually diagnosed with mitochondrial myopathy, a condition that can often be overlooked. As part of her treatment, she began taking a combination of supplements, which included coenzyme Q10, creatine, carnitine, and folic acid. Over several months, she reported significant improvement in her overall condition.
While folate was included in her regimen, it’s important to note that we cannot isolate its impact on fibromyalgia symptoms without further dedicated studies. This case highlights that what appears to be fibromyalgia may sometimes have an underlying cause, such as mitochondrial myopathy, and the treatment for that condition can lead to symptom resolution.
Read More
8
We explored how combining melatonin with folic acid can impact fibromyalgia, particularly when induced by reserpine in a rat model. The study involved injecting male Sprague-Dawley rats with reserpine for three days, followed by treatment with melatonin, folic acid, or both for a period of twenty-one days.
Our findings were promising; the treatment helped in reducing behavioral issues and addressing oxidative stress, which plays a big role in fibromyalgia. Specifically, we observed that when both melatonin and folic acid were given together, they were more effective than when administered separately. This suggests that folate, especially when paired with another treatment, could enhance overall management strategies for this condition.
Interestingly, while folic acid alone wasn’t tested in isolation, its contribution to the combined treatment demonstrated notable benefits in reducing inflammation and other fibromyalgia symptoms. Thus, this combination approach could be a vital avenue for those suffering from this chronic pain condition, as it seems to tackle multiple aspects of the disorder.
Overall, the research illustrates a step towards better therapies for fibromyalgia, highlighting the potential of folate when used alongside other treatments.
Our findings were promising; the treatment helped in reducing behavioral issues and addressing oxidative stress, which plays a big role in fibromyalgia. Specifically, we observed that when both melatonin and folic acid were given together, they were more effective than when administered separately. This suggests that folate, especially when paired with another treatment, could enhance overall management strategies for this condition.
Interestingly, while folic acid alone wasn’t tested in isolation, its contribution to the combined treatment demonstrated notable benefits in reducing inflammation and other fibromyalgia symptoms. Thus, this combination approach could be a vital avenue for those suffering from this chronic pain condition, as it seems to tackle multiple aspects of the disorder.
Overall, the research illustrates a step towards better therapies for fibromyalgia, highlighting the potential of folate when used alongside other treatments.
Read More
8
We aimed to understand how vitamin B12 injections, paired with oral folic acid, could potentially help individuals suffering from myalgic encephalomyelitis (ME) and fibromyalgia. In a study involving 38 patients who received vitamin B12 injections at least once a week for a duration ranging from six months to several years, we categorized the responders into two groups: Good responders and Mild responders.
Our findings revealed that those classified as Good responders experienced significantly better outcomes. They reported using more frequent and higher doses of B12, alongside increased daily intake of folic acid, all while requiring less reliance on strong pain medications like opioids. This points to a possible connection between adequate levels of these nutrients and improved health for those with ME and fibromyalgia.
However, it is essential to note that the Mild responders, despite using the treatment, did not show as remarkable improvement. They used higher levels of analgesics and were often more affected by fibromyalgia, underscoring a more complex relationship between vitamin supplementation and symptom relief.
The study highlighted the importance of individual responses to treatment and suggested monitoring for thyroid dysfunction, which may affect outcomes. Also, the potential for vitamin B12 and folic acid to interact negatively with certain medications, particularly opioids, warrants attention in future research.
Our findings revealed that those classified as Good responders experienced significantly better outcomes. They reported using more frequent and higher doses of B12, alongside increased daily intake of folic acid, all while requiring less reliance on strong pain medications like opioids. This points to a possible connection between adequate levels of these nutrients and improved health for those with ME and fibromyalgia.
However, it is essential to note that the Mild responders, despite using the treatment, did not show as remarkable improvement. They used higher levels of analgesics and were often more affected by fibromyalgia, underscoring a more complex relationship between vitamin supplementation and symptom relief.
The study highlighted the importance of individual responses to treatment and suggested monitoring for thyroid dysfunction, which may affect outcomes. Also, the potential for vitamin B12 and folic acid to interact negatively with certain medications, particularly opioids, warrants attention in future research.
Read More
8
We aimed to investigate how vitamin B12 can affect the symptoms and overall well-being of fibromyalgia patients. In our study, we worked with individuals diagnosed with fibromyalgia based on established criteria. Participants were given a daily dose of 1000 mcg of oral vitamin B12 to take for fifty days.
Before and after the treatment period, we assessed the patients' conditions using various questionnaires designed to measure pain severity, anxiety, and overall health. Our findings revealed that this short course of vitamin B12 significantly reduced the severity of fibromyalgia symptoms and improved anxiety levels.
Such results suggest that vitamin B12 could play an important role as an adjunctive therapy for managing fibromyalgia. We believe there is potential for further research in this area to enhance treatment options for individuals living with this condition.
Before and after the treatment period, we assessed the patients' conditions using various questionnaires designed to measure pain severity, anxiety, and overall health. Our findings revealed that this short course of vitamin B12 significantly reduced the severity of fibromyalgia symptoms and improved anxiety levels.
Such results suggest that vitamin B12 could play an important role as an adjunctive therapy for managing fibromyalgia. We believe there is potential for further research in this area to enhance treatment options for individuals living with this condition.
Read More
7
Vitamin B12 deficiency linked to fatigue
We investigated the connection between vitamin B12 deficiency and the prevalence of fatigue and neurological symptoms in patients with fibromyalgia. By analyzing charts from 2,142 patients diagnosed with fibromyalgia between 2015 and 2020, we set out to see how these symptoms related to B12 levels.
The results were striking: 42.4% of the patients exhibited B12 deficiency, with those lacking sufficient levels reporting higher instances of fatigue and memory loss. Even after considering the impact of vitamin D levels, we found a significant association between B12 deficiency and fatigue, suggesting that addressing this deficiency might help alleviate one of the most burdensome aspects of fibromyalgia.
This study is groundbreaking in highlighting the role of vitamin B12 for patients experiencing fatigue related to fibromyalgia, reinforcing the importance of regular monitoring of vitamin levels in this population. Notably, we found this trend whether we considered the cutoff for B12 deficiency at 400 ng/L or a lower threshold.
The results were striking: 42.4% of the patients exhibited B12 deficiency, with those lacking sufficient levels reporting higher instances of fatigue and memory loss. Even after considering the impact of vitamin D levels, we found a significant association between B12 deficiency and fatigue, suggesting that addressing this deficiency might help alleviate one of the most burdensome aspects of fibromyalgia.
This study is groundbreaking in highlighting the role of vitamin B12 for patients experiencing fatigue related to fibromyalgia, reinforcing the importance of regular monitoring of vitamin levels in this population. Notably, we found this trend whether we considered the cutoff for B12 deficiency at 400 ng/L or a lower threshold.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Improves energy levels
1 people found this helpful
This is a fantastic product at an excellent price. Chewable and tastes pleasant, it's in the most bioavailable form, which is methylcobalamin. I incorporate it into my fibromyalgia regimen, and it has significantly helped with my energy levels and the numbness and tingling sensations. It’s important to note that it doesn’t produce “energy” in the way that substances like caffeine or certain nootropics do, so don’t expect that. Instead, it operates subtly, much like you would expect from a vitamin supplement.
Read More
6
Helpful B vitamins
I have taken these vitamins for many years, changing them every three months. I find that a complex of B vitamins is very beneficial for managing my fibromyalgia.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Fusco R, Siracusa R, D'Amico R, Peritore AF, Cordaro M, et al. Melatonin Plus Folic Acid Treatment Ameliorates Reserpine-Induced Fibromyalgia: An Evaluation of Pain, Oxidative Stress, and Inflammation. Antioxidants (Basel). 2019;8. 10.3390/antiox8120628
- Regland B, Forsmark S, Halaouate L, Matousek M, Peilot B, et al. Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia. PLoS One. 2015;10:e0124648. 10.1371/journal.pone.0124648
- Abdullah M, Vishwanath S, Elbalkhi A, Ambrus JL. Mitochondrial myopathy presenting as fibromyalgia: a case report. J Med Case Rep. 2012;6:55. 10.1186/1752-1947-6-55
- Gharibpoor F, Ghavidel-Parsa B, Sattari N, Bidari A, Nejatifar F, et al. Effect of vitamin B12 on the symptom severity and psychological profile of fibromyalgia patients; a prospective pre-post study. BMC Rheumatol. 2022;6:51. 10.1186/s41927-022-00282-y
- Munipalli B, Strothers S, Rivera F, Malavet P, Mitri G, et al. Association of Vitamin B12, Vitamin D, and Thyroid-Stimulating Hormone With Fatigue and Neurologic Symptoms in Patients With Fibromyalgia. Mayo Clin Proc Innov Qual Outcomes. 2022;6:381. 10.1016/j.mayocpiqo.2022.06.003
