Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.2
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Folate
167 mcg DFE(100 mcg folic acid)
42%
Vitamin B-12 (as Cyanocobalamin)
1 mg (1,000 mcg)
41,667%
Top Medical Research Studies
7
We aimed to understand how folic acid might influence sexual function in postmenopausal women, a group that often experiences sexual dysfunction. For this investigation, we conducted a solid triple-blind randomized controlled trial in Tehran, Iran, involving 100 participants recruited from health centers. Each woman in the study received either 5 mg of folic acid or a placebo daily for eight weeks, always on an empty stomach.
To assess the impact of the treatment, we conducted evaluations using the Female Sexual Function Index at three different times: before the intervention began, then after four weeks, and again at eight weeks. The results indicated that folic acid may have a positive effect on sexual function, suggesting it could be a beneficial option for women navigating postmenopause.
While our findings are promising, they should be interpreted with caution due to the small sample size and relatively short follow-up period. Larger studies will be crucial to confirming these effects and paving the way for broader recommendations about folic acid as a treatment option for sexual health in postmenopausal women.
To assess the impact of the treatment, we conducted evaluations using the Female Sexual Function Index at three different times: before the intervention began, then after four weeks, and again at eight weeks. The results indicated that folic acid may have a positive effect on sexual function, suggesting it could be a beneficial option for women navigating postmenopause.
While our findings are promising, they should be interpreted with caution due to the small sample size and relatively short follow-up period. Larger studies will be crucial to confirming these effects and paving the way for broader recommendations about folic acid as a treatment option for sexual health in postmenopausal women.
Read More
4
We conducted a phase III double-blind, placebo-controlled trial to assess the effects of folic acid supplementation on hot flushes in postmenopausal women. This study, which took place across nine hospitals in England, involved 164 women who reported experiencing at least 50 hot flushes each week. Participants were randomly assigned to take either a daily 5 mg folic acid tablet or a placebo for 12 weeks.
Throughout this period, we asked participants to document the frequency and severity of their hot flushes using a Sloan Diary, along with answering questions from validated quality of life scales at regular intervals. When we analyzed the data, we found that while women taking folic acid experienced a mean reduction in their Hot Flush Score, this decrease was not statistically significant compared to those on placebo.
Specifically, the difference in improvement between the folic acid group and the placebo group was marginal, indicating no clear advantage of folic acid in alleviating hot flushes over the study duration. However, some enhancements were noted in emotional and overall quality of life scores among the folic acid group at week 8, suggesting potential benefits that may require further exploration.
Ultimately, this study did not establish folic acid as a proven treatment for reducing hot flushes in postmenopausal women, highlighting the need for more comprehensive research to confirm its effects.
Throughout this period, we asked participants to document the frequency and severity of their hot flushes using a Sloan Diary, along with answering questions from validated quality of life scales at regular intervals. When we analyzed the data, we found that while women taking folic acid experienced a mean reduction in their Hot Flush Score, this decrease was not statistically significant compared to those on placebo.
Specifically, the difference in improvement between the folic acid group and the placebo group was marginal, indicating no clear advantage of folic acid in alleviating hot flushes over the study duration. However, some enhancements were noted in emotional and overall quality of life scores among the folic acid group at week 8, suggesting potential benefits that may require further exploration.
Ultimately, this study did not establish folic acid as a proven treatment for reducing hot flushes in postmenopausal women, highlighting the need for more comprehensive research to confirm its effects.
Read More
9
Vitamin B12 may aid menopause relief
We observed the effects of a nutritional product that combined various ingredients, including vitamin B12, on menopausal symptoms. This study involved 156 menopausal women who took the product daily for 12 weeks and reported their symptoms using a validated scale.
After completing the study, we found significant reductions in various menopause-related issues. This included a substantial 45% decrease in depressive mood and a notable reduction of 48% in hot flashes. It's important to note that while vitamin B12 was included in the treatment, it was part of a broader combination with other beneficial ingredients.
However, we must clarify that the specific impact of vitamin B12 alone cannot be fully determined from this study. The results are promising for the product as a whole, showing effective relief from many menopausal symptoms, but further research is needed to isolate the role of vitamin B12 in managing these symptoms.
After completing the study, we found significant reductions in various menopause-related issues. This included a substantial 45% decrease in depressive mood and a notable reduction of 48% in hot flashes. It's important to note that while vitamin B12 was included in the treatment, it was part of a broader combination with other beneficial ingredients.
However, we must clarify that the specific impact of vitamin B12 alone cannot be fully determined from this study. The results are promising for the product as a whole, showing effective relief from many menopausal symptoms, but further research is needed to isolate the role of vitamin B12 in managing these symptoms.
Read More
Most Useful Reviews
9
Improved mood
1 people found this helpful
On the first day, I chewed two of the lozenges at once, as my B-12 dosage is low; the taste is pleasant. After an hour, I felt quite sleepy. With continued use, I have noticed significant changes over the last three months. My mood has greatly improved despite experiencing menopause, and my sleep quality, energy levels, and optimism have all increased. I feel much happier now. Although my B-12 levels are still not back to normal, they are improving, which has made a considerable difference. I feel as though my efforts have yielded positive results.
Read More
7.5
Mental clarity
It’s alright. A good value for money, essential for the nervous system. I use it during my peri-menopause, and it aids me in clarifying my thoughts.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.2
- All Researches
9
Vitamin B12 may aid menopause relief
We observed the effects of a nutritional product that combined various ingredients, including vitamin B12, on menopausal symptoms. This study involved 156 menopausal women who took the product daily for 12 weeks and reported their symptoms using a validated scale.
After completing the study, we found significant reductions in various menopause-related issues. This included a substantial 45% decrease in depressive mood and a notable reduction of 48% in hot flashes. It's important to note that while vitamin B12 was included in the treatment, it was part of a broader combination with other beneficial ingredients.
However, we must clarify that the specific impact of vitamin B12 alone cannot be fully determined from this study. The results are promising for the product as a whole, showing effective relief from many menopausal symptoms, but further research is needed to isolate the role of vitamin B12 in managing these symptoms.
After completing the study, we found significant reductions in various menopause-related issues. This included a substantial 45% decrease in depressive mood and a notable reduction of 48% in hot flashes. It's important to note that while vitamin B12 was included in the treatment, it was part of a broader combination with other beneficial ingredients.
However, we must clarify that the specific impact of vitamin B12 alone cannot be fully determined from this study. The results are promising for the product as a whole, showing effective relief from many menopausal symptoms, but further research is needed to isolate the role of vitamin B12 in managing these symptoms.
Read More
9
vitamin B12 aids menopause dry eye
We explored the impact of vitamin B12, alongside hyaluronic acid and electrolytes, on menopausal women suffering from moderate dry eye disease. In this study, thirty female participants, aged between 45 to 65, received drops that contained 0.3% sodium hyaluronate, vitamin B12, and other electrolytes for a duration of 30 days.
Throughout this period, we tracked their symptoms and performed several tests to gauge the severity of dry eye, including the Ocular Surface Disease Index (OSDI) questionnaire and tear film assessments. Our findings indicated that the combination of these treatments significantly decreased the symptoms of dry eye disease. Specifically, we noted a substantial improvement in the scores from the OSDI questionnaire and enhancements in both the tear volume and stability.
The results suggest that vitamin B12 plays a supportive role in alleviating dry eye symptoms during menopause, contributing positively when used with other treatments. While it’s hard to isolate the specific benefits of vitamin B12 due to the combination used, its inclusion in the eye drops appears to aid in improving overall eye health for menopausal women dealing with dryness.
Throughout this period, we tracked their symptoms and performed several tests to gauge the severity of dry eye, including the Ocular Surface Disease Index (OSDI) questionnaire and tear film assessments. Our findings indicated that the combination of these treatments significantly decreased the symptoms of dry eye disease. Specifically, we noted a substantial improvement in the scores from the OSDI questionnaire and enhancements in both the tear volume and stability.
The results suggest that vitamin B12 plays a supportive role in alleviating dry eye symptoms during menopause, contributing positively when used with other treatments. While it’s hard to isolate the specific benefits of vitamin B12 due to the combination used, its inclusion in the eye drops appears to aid in improving overall eye health for menopausal women dealing with dryness.
Read More
7
We aimed to understand how folic acid might influence sexual function in postmenopausal women, a group that often experiences sexual dysfunction. For this investigation, we conducted a solid triple-blind randomized controlled trial in Tehran, Iran, involving 100 participants recruited from health centers. Each woman in the study received either 5 mg of folic acid or a placebo daily for eight weeks, always on an empty stomach.
To assess the impact of the treatment, we conducted evaluations using the Female Sexual Function Index at three different times: before the intervention began, then after four weeks, and again at eight weeks. The results indicated that folic acid may have a positive effect on sexual function, suggesting it could be a beneficial option for women navigating postmenopause.
While our findings are promising, they should be interpreted with caution due to the small sample size and relatively short follow-up period. Larger studies will be crucial to confirming these effects and paving the way for broader recommendations about folic acid as a treatment option for sexual health in postmenopausal women.
To assess the impact of the treatment, we conducted evaluations using the Female Sexual Function Index at three different times: before the intervention began, then after four weeks, and again at eight weeks. The results indicated that folic acid may have a positive effect on sexual function, suggesting it could be a beneficial option for women navigating postmenopause.
While our findings are promising, they should be interpreted with caution due to the small sample size and relatively short follow-up period. Larger studies will be crucial to confirming these effects and paving the way for broader recommendations about folic acid as a treatment option for sexual health in postmenopausal women.
Read More
7
Zinc supplementation improves menopause nutrients
In our exploration into the effects of zinc supplementation on postmenopausal women, we examined how it influences key nutrients like folate and homocysteine levels. Within an 8-week study involving 51 women aged 44 to 76, participants were divided into two groups: one received a daily zinc supplement of 50 mg, while the other took a placebo.
After the study period, we observed significant improvements in folate levels among those who received zinc. In fact, this group showed a marked increase in folate compared to their initial levels. Additionally, we noticed a decrease in homocysteine levels when comparing results across both groups, suggesting a positive outcome from the zinc intervention.
Although we found that zinc had a beneficial impact on folate and also influenced homocysteine levels, it’s important to note that the zinc treatment didn’t exclusively affect vitamin B levels, as improvements were observed in both groups equally. While the connection between folate and lower homocysteine levels was strong, further research is necessary to understand the implications fully.
Overall, our findings highlight the potential of zinc supplementation in enhancing nutrient status during menopause, but we recognize the necessity for larger studies with optimized dosages to confirm these outcomes.
After the study period, we observed significant improvements in folate levels among those who received zinc. In fact, this group showed a marked increase in folate compared to their initial levels. Additionally, we noticed a decrease in homocysteine levels when comparing results across both groups, suggesting a positive outcome from the zinc intervention.
Although we found that zinc had a beneficial impact on folate and also influenced homocysteine levels, it’s important to note that the zinc treatment didn’t exclusively affect vitamin B levels, as improvements were observed in both groups equally. While the connection between folate and lower homocysteine levels was strong, further research is necessary to understand the implications fully.
Overall, our findings highlight the potential of zinc supplementation in enhancing nutrient status during menopause, but we recognize the necessity for larger studies with optimized dosages to confirm these outcomes.
Read More
4
We conducted a phase III double-blind, placebo-controlled trial to assess the effects of folic acid supplementation on hot flushes in postmenopausal women. This study, which took place across nine hospitals in England, involved 164 women who reported experiencing at least 50 hot flushes each week. Participants were randomly assigned to take either a daily 5 mg folic acid tablet or a placebo for 12 weeks.
Throughout this period, we asked participants to document the frequency and severity of their hot flushes using a Sloan Diary, along with answering questions from validated quality of life scales at regular intervals. When we analyzed the data, we found that while women taking folic acid experienced a mean reduction in their Hot Flush Score, this decrease was not statistically significant compared to those on placebo.
Specifically, the difference in improvement between the folic acid group and the placebo group was marginal, indicating no clear advantage of folic acid in alleviating hot flushes over the study duration. However, some enhancements were noted in emotional and overall quality of life scores among the folic acid group at week 8, suggesting potential benefits that may require further exploration.
Ultimately, this study did not establish folic acid as a proven treatment for reducing hot flushes in postmenopausal women, highlighting the need for more comprehensive research to confirm its effects.
Throughout this period, we asked participants to document the frequency and severity of their hot flushes using a Sloan Diary, along with answering questions from validated quality of life scales at regular intervals. When we analyzed the data, we found that while women taking folic acid experienced a mean reduction in their Hot Flush Score, this decrease was not statistically significant compared to those on placebo.
Specifically, the difference in improvement between the folic acid group and the placebo group was marginal, indicating no clear advantage of folic acid in alleviating hot flushes over the study duration. However, some enhancements were noted in emotional and overall quality of life scores among the folic acid group at week 8, suggesting potential benefits that may require further exploration.
Ultimately, this study did not establish folic acid as a proven treatment for reducing hot flushes in postmenopausal women, highlighting the need for more comprehensive research to confirm its effects.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved mood
1 people found this helpful
On the first day, I chewed two of the lozenges at once, as my B-12 dosage is low; the taste is pleasant. After an hour, I felt quite sleepy. With continued use, I have noticed significant changes over the last three months. My mood has greatly improved despite experiencing menopause, and my sleep quality, energy levels, and optimism have all increased. I feel much happier now. Although my B-12 levels are still not back to normal, they are improving, which has made a considerable difference. I feel as though my efforts have yielded positive results.
Read More
7.5
Mental clarity
It’s alright. A good value for money, essential for the nervous system. I use it during my peri-menopause, and it aids me in clarifying my thoughts.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Asadi M, Riazi H, Abbasinazari M, Majd HA, Montazeri A. Effect of folic acid on the sexual function of postmenopausal women: a triple-blind randomized controlled trial. J Sex Med. 2023;20:1180. 10.1093/jsxmed/qdad086
- Vázquez-Lorente H, Herrera-Quintana L, Molina-López J, Gamarra Y, Planells E. Effect of zinc supplementation on circulating concentrations of homocysteine, vitamin B, and folate in a postmenopausal population. J Trace Elem Med Biol. 2022;71:126942. 10.1016/j.jtemb.2022.126942
- Ewies A, Ahmed I, Al-Azzawi F, Pitkin J, Gupta P, et al. Folic acid supplementation in postmenopausal women with hot flushes: phase III randomised double-blind placebo-controlled trial. BJOG. 2021;128:2024. 10.1111/1471-0528.16739
- Palacios S, Mustata C, Rizo JM, Regidor PA. Improvement in menopausal symptoms with a nutritional product containing evening primrose oil, hop extract, saffron, tryptophan, vitamins B6, D3, K2, B12, and B9. Eur Rev Med Pharmacol Sci. 2023;27:8180. 10.26355/eurrev_202309_33578
- De-Hita-Cantalejo C, Sánchez-González MC, Silva-Viguera C, GarcĂa-Romera MC, Feria-Mantero R, et al. Efficacy of hyaluronic acid 0.3%, cyanocobalamin, electrolytes, and P-Plus in menopause patients with moderate dry eye disease. Graefes Arch Clin Exp Ophthalmol. 2022;260:529. 10.1007/s00417-021-05415-6
