Overview
SCIENTIFIC SCORE
Questionable
Based on 14 Researches
6.6
USERS' SCORE
Good
Based on 3 Reviews
8.3
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Folate
167 mcg DFE(100 mcg folic acid)
42%
Vitamin B-12 (as Cyanocobalamin)
1 mg (1,000 mcg)
41,667%
Top Medical Research Studies
8
We set out to explore how dietary folate intake might influence severe headaches and migraines. Utilizing data from the National Health and Nutrition Examination Survey (NHANES) collected between 1999 and 2004, we included a substantial sample of 4,107 participants in our analysis.
Our findings revealed that 704 individuals, which represents about 17.14%, reported experiencing severe headaches or migraines. After accounting for various factors, we found a noteworthy association between higher folate intake and reduced occurrences of these conditions. Specifically, the results showed that increasing levels of dietary folate were linked to a lower odds ratio of experiencing migraines—particularly pronounced among those with the highest folate intake.
The data suggested a linear and negative relationship, meaning that as folate intake increased, the likelihood of suffering from migraines decreased. This trend remained consistent across different analysis methods, indicating a robust connection worth noting for those seeking dietary strategies to manage or potentially reduce migraine occurrences.
Our findings revealed that 704 individuals, which represents about 17.14%, reported experiencing severe headaches or migraines. After accounting for various factors, we found a noteworthy association between higher folate intake and reduced occurrences of these conditions. Specifically, the results showed that increasing levels of dietary folate were linked to a lower odds ratio of experiencing migraines—particularly pronounced among those with the highest folate intake.
The data suggested a linear and negative relationship, meaning that as folate intake increased, the likelihood of suffering from migraines decreased. This trend remained consistent across different analysis methods, indicating a robust connection worth noting for those seeking dietary strategies to manage or potentially reduce migraine occurrences.
Read More
8
We investigated the connection between serum folate levels and the occurrence of severe headaches or migraines using a large dataset from the National Health and Nutrition Examination Survey. In total, we analyzed information from 13,351 participants, with 2,742 of them reporting severe headaches or migraines within the last three months.
Our findings indicated that lower serum folate levels were associated with a higher likelihood of experiencing severe headaches or migraines. Specifically, we found that for every increase in serum folate, there was a significant decrease in the odds of having these painful episodes, with an odds ratio of 0.5. This means that individuals with higher folate levels were less likely to suffer from migraines.
The analysis further revealed that this relationship was particularly strong among women, those aged between 20 to 50 years, and non-Hispanic White participants. For instance, women with higher serum folate had an even lower likelihood of experiencing migraines, with an odds ratio of 0.38.
While we established a clear association, it’s important to note that our study didn’t specifically investigate folate treatment effectiveness. Further research is essential to confirm our findings and explore how folate could potentially be incorporated into treatment strategies for migraine sufferers.
Our findings indicated that lower serum folate levels were associated with a higher likelihood of experiencing severe headaches or migraines. Specifically, we found that for every increase in serum folate, there was a significant decrease in the odds of having these painful episodes, with an odds ratio of 0.5. This means that individuals with higher folate levels were less likely to suffer from migraines.
The analysis further revealed that this relationship was particularly strong among women, those aged between 20 to 50 years, and non-Hispanic White participants. For instance, women with higher serum folate had an even lower likelihood of experiencing migraines, with an odds ratio of 0.38.
While we established a clear association, it’s important to note that our study didn’t specifically investigate folate treatment effectiveness. Further research is essential to confirm our findings and explore how folate could potentially be incorporated into treatment strategies for migraine sufferers.
Read More
7
We examined the connection between vitamin B12 serum levels and migraine, both chronic and episodic. In our study, we compared two groups: 90 individuals suffering from migraines and 90 healthy participants. We measured the serum vitamin B12 levels of all subjects using a method known as enzyme-linked immunosorbent assay (ELISA).
Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.
This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.
Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.
This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.
Read More
Most Useful Reviews
9
Reduced attack frequency
Excellent! Following my doctor's advice in treating my migraine, it works exceptionally well when combined with nootropics. I’ve noticed a significant reduction in both the intensity and frequency of my migraine attacks, and the product’s quality is outstanding.
Read More
7.5
Relief from attacks
An excellent vitamin that is essential for the human body! I take it daily, and it effectively relieves my migraine attacks.
Read More
6
Energy boost noted
High-quality B12 lozenges that I take every day after lunch. They significantly help with my migraines and provide a boost of energy. The packaging is convenient, and the overall quality is excellent!
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 14 Researches
6.6
- All Researches
8
We looked into how vitamin B supplementation affects migraines among women and the role of specific gene variants. In a 6-month study involving 206 female migraineurs, we found that daily vitamins B6, B9, and B12 significantly decreased homocysteine levels, headache severity, and migraine-related disabilities. Interestingly, women with specific genetic markers showed an even greater improvement. The benefits of supplements were significant, suggesting they can effectively reduce migraine symptoms by addressing underlying conditions tied to genetics.
Read More
8
We examined how vitamin supplementation could affect migraine symptoms in patients. In a randomized, double-blind trial with 52 participants, daily vitamins, including B12, led to a significant 39% reduction in homocysteine levels.
More importantly, we saw a striking decrease in migraine disability—from 60% to 30%—and a drop in headache frequency and severity. Interestingly, those with the C allele of the MTHFR C677T genotype experienced even greater benefits.
While the results are promising, we need more extensive studies to confirm vitamin therapy's effectiveness in managing migraines.
More importantly, we saw a striking decrease in migraine disability—from 60% to 30%—and a drop in headache frequency and severity. Interestingly, those with the C allele of the MTHFR C677T genotype experienced even greater benefits.
While the results are promising, we need more extensive studies to confirm vitamin therapy's effectiveness in managing migraines.
Read More
8
We explored the connection between genetic factors related to folate metabolism and the occurrence of migraines in children. Our study involved 54 children aged 7 to 18 who experienced migraines, alongside a control group of 115 children without neurological issues.
We focused on specific genetic variations in folate cycle enzyme genes, testing for several polymorphisms and assessing vitamin B levels along with plasma homocysteine levels. Notably, we found that children with migraines had a higher prevalence of the rare homozygous 677TT genotype, which corresponds with elevated plasma homocysteine levels and is often linked to folate deficiency.
In addition to our genetic findings, we administered Cortexin, a treatment aimed at improving patients' symptoms. The results indicated significant improvements, with reported reductions in headaches, fatigue, and emotional instability among the patients involved.
While our study underscores the relationship between genetics and migraine in children, particularly the role of folate metabolism, the specific effects of folate alone on migraine were not fully dissected. Nonetheless, these insights contribute valuable information about potential pathways for understanding and treating migraines in young patients.
We focused on specific genetic variations in folate cycle enzyme genes, testing for several polymorphisms and assessing vitamin B levels along with plasma homocysteine levels. Notably, we found that children with migraines had a higher prevalence of the rare homozygous 677TT genotype, which corresponds with elevated plasma homocysteine levels and is often linked to folate deficiency.
In addition to our genetic findings, we administered Cortexin, a treatment aimed at improving patients' symptoms. The results indicated significant improvements, with reported reductions in headaches, fatigue, and emotional instability among the patients involved.
While our study underscores the relationship between genetics and migraine in children, particularly the role of folate metabolism, the specific effects of folate alone on migraine were not fully dissected. Nonetheless, these insights contribute valuable information about potential pathways for understanding and treating migraines in young patients.
Read More
8
We set out to explore how dietary folate intake might influence severe headaches and migraines. Utilizing data from the National Health and Nutrition Examination Survey (NHANES) collected between 1999 and 2004, we included a substantial sample of 4,107 participants in our analysis.
Our findings revealed that 704 individuals, which represents about 17.14%, reported experiencing severe headaches or migraines. After accounting for various factors, we found a noteworthy association between higher folate intake and reduced occurrences of these conditions. Specifically, the results showed that increasing levels of dietary folate were linked to a lower odds ratio of experiencing migraines—particularly pronounced among those with the highest folate intake.
The data suggested a linear and negative relationship, meaning that as folate intake increased, the likelihood of suffering from migraines decreased. This trend remained consistent across different analysis methods, indicating a robust connection worth noting for those seeking dietary strategies to manage or potentially reduce migraine occurrences.
Our findings revealed that 704 individuals, which represents about 17.14%, reported experiencing severe headaches or migraines. After accounting for various factors, we found a noteworthy association between higher folate intake and reduced occurrences of these conditions. Specifically, the results showed that increasing levels of dietary folate were linked to a lower odds ratio of experiencing migraines—particularly pronounced among those with the highest folate intake.
The data suggested a linear and negative relationship, meaning that as folate intake increased, the likelihood of suffering from migraines decreased. This trend remained consistent across different analysis methods, indicating a robust connection worth noting for those seeking dietary strategies to manage or potentially reduce migraine occurrences.
Read More
8
We investigated the connection between serum folate levels and the occurrence of severe headaches or migraines using a large dataset from the National Health and Nutrition Examination Survey. In total, we analyzed information from 13,351 participants, with 2,742 of them reporting severe headaches or migraines within the last three months.
Our findings indicated that lower serum folate levels were associated with a higher likelihood of experiencing severe headaches or migraines. Specifically, we found that for every increase in serum folate, there was a significant decrease in the odds of having these painful episodes, with an odds ratio of 0.5. This means that individuals with higher folate levels were less likely to suffer from migraines.
The analysis further revealed that this relationship was particularly strong among women, those aged between 20 to 50 years, and non-Hispanic White participants. For instance, women with higher serum folate had an even lower likelihood of experiencing migraines, with an odds ratio of 0.38.
While we established a clear association, it’s important to note that our study didn’t specifically investigate folate treatment effectiveness. Further research is essential to confirm our findings and explore how folate could potentially be incorporated into treatment strategies for migraine sufferers.
Our findings indicated that lower serum folate levels were associated with a higher likelihood of experiencing severe headaches or migraines. Specifically, we found that for every increase in serum folate, there was a significant decrease in the odds of having these painful episodes, with an odds ratio of 0.5. This means that individuals with higher folate levels were less likely to suffer from migraines.
The analysis further revealed that this relationship was particularly strong among women, those aged between 20 to 50 years, and non-Hispanic White participants. For instance, women with higher serum folate had an even lower likelihood of experiencing migraines, with an odds ratio of 0.38.
While we established a clear association, it’s important to note that our study didn’t specifically investigate folate treatment effectiveness. Further research is essential to confirm our findings and explore how folate could potentially be incorporated into treatment strategies for migraine sufferers.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduced attack frequency
Excellent! Following my doctor's advice in treating my migraine, it works exceptionally well when combined with nootropics. I’ve noticed a significant reduction in both the intensity and frequency of my migraine attacks, and the product’s quality is outstanding.
Read More
7.5
Relief from attacks
An excellent vitamin that is essential for the human body! I take it daily, and it effectively relieves my migraine attacks.
Read More
6
Energy boost noted
High-quality B12 lozenges that I take every day after lunch. They significantly help with my migraines and provide a boost of energy. The packaging is convenient, and the overall quality is excellent!
Read More
Frequently Asked Questions
9
Reduced attack frequency
Excellent! Following my doctor's advice in treating my migraine, it works exceptionally well when combined with nootropics. I’ve noticed a significant reduction in both the intensity and frequency of my migraine attacks, and the product’s quality is outstanding.
7.5
Relief from attacks
An excellent vitamin that is essential for the human body! I take it daily, and it effectively relieves my migraine attacks.
6
Energy boost noted
High-quality B12 lozenges that I take every day after lunch. They significantly help with my migraines and provide a boost of energy. The packaging is convenient, and the overall quality is excellent!
7
Vitamin B12 & magnesium aid migraines
This study examined the impact of vitamin B12 and magnesium, combined with high-intensity interval training (HIIT), on women's migraine attacks.
We organized participants into four groups over two months, comparing those on supplements, those doing HIIT, and those using both approaches. We measured serum levels of a specific signaling molecule and assessed migraine severity throughout.
The results highlighted that the combination of B12, magnesium, and exercise appears to reduce migraine pain by targeting inflammation pathways.
We organized participants into four groups over two months, comparing those on supplements, those doing HIIT, and those using both approaches. We measured serum levels of a specific signaling molecule and assessed migraine severity throughout.
The results highlighted that the combination of B12, magnesium, and exercise appears to reduce migraine pain by targeting inflammation pathways.
8
We examined how vitamin supplementation could affect migraine symptoms in patients. In a randomized, double-blind trial with 52 participants, daily vitamins, including B12, led to a significant 39% reduction in homocysteine levels.
More importantly, we saw a striking decrease in migraine disability—from 60% to 30%—and a drop in headache frequency and severity. Interestingly, those with the C allele of the MTHFR C677T genotype experienced even greater benefits.
While the results are promising, we need more extensive studies to confirm vitamin therapy's effectiveness in managing migraines.
More importantly, we saw a striking decrease in migraine disability—from 60% to 30%—and a drop in headache frequency and severity. Interestingly, those with the C allele of the MTHFR C677T genotype experienced even greater benefits.
While the results are promising, we need more extensive studies to confirm vitamin therapy's effectiveness in managing migraines.
4
This study examined the relationship between serum vitamin B12 levels, methylmalonic acid (MMA), and migraines. We found that migraine patients had significantly lower B12 levels and higher MMA compared to healthy individuals.
Essentially, those with higher B12 levels seemed to have a reduced risk of experiencing migraines, while higher MMA levels correlated with increased migraine risk. Despite these findings, there was no connection between vitamin B12 and MMA levels and the characteristics of the migraines themselves.
Overall, our results suggest a notable link between B12 deficiency and the likelihood of migraines.
Essentially, those with higher B12 levels seemed to have a reduced risk of experiencing migraines, while higher MMA levels correlated with increased migraine risk. Despite these findings, there was no connection between vitamin B12 and MMA levels and the characteristics of the migraines themselves.
Overall, our results suggest a notable link between B12 deficiency and the likelihood of migraines.
7
We examined the connection between vitamin B12 serum levels and migraine, both chronic and episodic. In our study, we compared two groups: 90 individuals suffering from migraines and 90 healthy participants. We measured the serum vitamin B12 levels of all subjects using a method known as enzyme-linked immunosorbent assay (ELISA).
Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.
This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.
Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.
This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.
7
We conducted a systematic review to examine the effects of vitamin B6, folate, and B12 on migraine.
Our findings revealed that while these vitamins did not show significant benefits for treating acute migraines, they may help prevent migraines with aura in adults.
Out of five studies, most showed promising results when these vitamins were used together, but folate alone didn’t outperform a placebo.
However, more research is needed, particularly for other types of migraines in both adults and children.
Our findings revealed that while these vitamins did not show significant benefits for treating acute migraines, they may help prevent migraines with aura in adults.
Out of five studies, most showed promising results when these vitamins were used together, but folate alone didn’t outperform a placebo.
However, more research is needed, particularly for other types of migraines in both adults and children.
7
We explored the potential benefits of hydroxocobalamin, a form of vitamin B12, in helping reduce migraine frequency and severity. In a pilot study involving 20 participants with a history of migraines, we administered 1 mg of intranasal hydroxocobalamin daily for three months. Each participant kept a diary detailing their migraine attacks throughout the study.
Our results were promising. About 53% of the patients experienced a significant decrease in their migraine frequency, with a reduction of 50% or more in their attacks. Overall, the average number of migraine attacks per month dropped from 4.7 to 2.7, which is quite a noteworthy change. Additionally, we observed reductions in the total duration of migraine attacks and the number of medication doses used for acute treatment.
While this was the first prospective study indicating the potential of hydroxycobalamin for migraine prophylaxis, we recommend conducting a double-blind study for further validation, especially since a responder rate of over 35-40% may exceed what’s typically expected from a placebo effect. Our findings suggest that vitamin B12 could be a valuable option for individuals struggling with migraines.
Our results were promising. About 53% of the patients experienced a significant decrease in their migraine frequency, with a reduction of 50% or more in their attacks. Overall, the average number of migraine attacks per month dropped from 4.7 to 2.7, which is quite a noteworthy change. Additionally, we observed reductions in the total duration of migraine attacks and the number of medication doses used for acute treatment.
While this was the first prospective study indicating the potential of hydroxycobalamin for migraine prophylaxis, we recommend conducting a double-blind study for further validation, especially since a responder rate of over 35-40% may exceed what’s typically expected from a placebo effect. Our findings suggest that vitamin B12 could be a valuable option for individuals struggling with migraines.
References
- Matin H, Taghian F, Chitsaz A. Artificial intelligence analysis to explore synchronize exercise, cobalamin, and magnesium as new actors to therapeutic of migraine symptoms: a randomized, placebo-controlled trial. Neurol Sci. 2022;43:4413. doi:10.1007/s10072-021-05843-6
- Liampas IN, Siokas V, Aloizou AM, Tsouris Z, Dastamani M, et al. Pyridoxine, folate and cobalamin for migraine: A systematic review. Acta Neurol Scand. 2020;142:108. doi:10.1111/ane.13251
- Togha M, Razeghi Jahromi S, Ghorbani Z, Martami F, Seifishahpar M. Serum Vitamin B12 and Methylmalonic Acid Status in Migraineurs: A Case-Control Study. Headache. 2019;59:1492. doi:10.1111/head.13618
- Menon S, Lea RA, Roy B, Hanna M, Wee S, et al. Genotypes of the MTHFR C677T and MTRR A66G genes act independently to reduce migraine disability in response to vitamin supplementation. Pharmacogenet Genomics. 2012;22:741. doi:10.1097/FPC.0b013e3283576b6b
- Lea R, Colson N, Quinlan S, Macmillan J, Griffiths L. The effects of vitamin supplementation and MTHFR (C677T) genotype on homocysteine-lowering and migraine disability. Pharmacogenet Genomics. 2009;19:422. doi:10.1097/FPC.0b013e32832af5a3
- Strozenko LA, Ponomaryov VS, Sanina OO, Lobanov YF. [The role of genetic polymorphisms in folate metabolism genes in the manifestation of migraine in children]. Zh Nevrol Psikhiatr Im S S Korsakova. 2025;125:47. doi:10.17116/jnevro202512501147
- Zhao D, Long X, Wang J. Association between dietary folate intake and severe headache or migraine in adults: a cross-sectional study of the National Health and Nutrition Examination Survey. Front Nutr. 2024;11:1456502. doi:10.3389/fnut.2024.1456502
- Luwen H, Ping C, Qing-Rong O, Lei X, Linlin L, et al. Association between serum folate levels and migraine or severe headaches: A nationwide cross-sectional study. Medicine (Baltimore). 2024;103:e40458. doi:10.1097/MD.0000000000040458
- Abdelsadek SE, Tahoun SA, Mansour FM, Abdulsalam MF, Ahmed AM. The correlation between vitamin B12 serum levels and migraine: a case-control study. Neurol Res. 2025;47:195. doi:10.1080/01616412.2025.2462735
- Zheng H, Shi YZ, Liang JT, Lu LL, Chen M. Modifiable factors for migraine prophylaxis: A mendelian randomization analysis. Front Pharmacol. 2023;14:1010996. doi:10.3389/fphar.2023.1010996
- Üstün Özek S. A study on the correlation between pain frequency and severity and vitamin B12 levels in episodic and chronic migraine. Arq Neuropsiquiatr. 2022;80:586. doi:10.1590/0004-282X-ANP-2021-0192
- Aydin H, Bucak IH, Geyik M. Vitamin B12 and folic acid levels in pediatric migraine patients. Acta Neurol Belg. 2021;121:1741. doi:10.1007/s13760-020-01491-3
- Menon S, Nasir B, Avgan N, Ghassabian S, Oliver C, et al. The effect of 1 mg folic acid supplementation on clinical outcomes in female migraine with aura patients. J Headache Pain. 2016;17:60. doi:10.1186/s10194-016-0652-7
- van der Kuy PH, Merkus FW, Lohman JJ, ter Berg JW, Hooymans PM. Hydroxocobalamin, a nitric oxide scavenger, in the prophylaxis of migraine: an open, pilot study. Cephalalgia. 2002;22:513.
