5/21/2025
Last update
5/21/2025
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 5 Reviews
8.4
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
MSM (Methylsulfonylmethane)
2 g (2,000 mg)
*
Top Medical Research Studies
8
We investigated how methylsulfonylmethane (MSM) interacts with bone morphogenetic protein 2 (BMP-2) to potentially enhance the differentiation of mesenchymal stem cells (MSCs) into osteoblasts, which are crucial for bone health. The study revealed that both MSM and BMP-2, when combined, lead to increased levels of certain proteins that aid in this process.
Observing changes in cell structure and mineral deposits helped us see the effectiveness of these treatments. The researchers noted that using MSM alongside BMP-2 significantly boosted the differentiation of MSCs into osteoblasts compared to using either treatment on its own.
Moreover, the findings indicated that the combination treatment elevated the expression of genes related to osteoblast differentiation. This suggests that MSM could play a beneficial role in promoting bone formation when used with BMP-2. However, it is essential to consider that the study's focus on the combination makes it challenging to assess MSM's isolated impact on osteoporosis directly.
Observing changes in cell structure and mineral deposits helped us see the effectiveness of these treatments. The researchers noted that using MSM alongside BMP-2 significantly boosted the differentiation of MSCs into osteoblasts compared to using either treatment on its own.
Moreover, the findings indicated that the combination treatment elevated the expression of genes related to osteoblast differentiation. This suggests that MSM could play a beneficial role in promoting bone formation when used with BMP-2. However, it is essential to consider that the study's focus on the combination makes it challenging to assess MSM's isolated impact on osteoporosis directly.
Read More
Most Useful Reviews
9
Pain relief noted
2 people found this helpful
Excellent! My mother is quite elderly and suffers from severe osteoporosis, as well as occasional low back pain following a lower back injury, which caused her to bend over. Due to concerns about side effects from Western medicine, alongside taking Life Extension’s Bone Strength Collagen Formula, I also added MSM for its anti-inflammatory benefits and to strengthen cartilage and connective tissue. After nearly a month, my mother can finally straighten her back and has experienced significant pain relief. This product has been beneficial for her back pain, and I plan to continue purchasing it.
Read More
10
Great effects observed
Amazing... I bought this for my mother who has osteoporosis, and the effects have been remarkable; her pain has vanished.
Read More
7.5
Quick pain relief
1 people found this helpful
I appreciated the composition and quality of this supplement. After reading good reviews regarding its effectiveness for knee issues, I ordered it for my father, with my doctor's advice. The doctor mentioned it's a good supplement for joints and osteoporosis. Although Dad has just started taking it, he claims that the pain is already alleviated. The results appear to be quick, and I am pleased with my purchase. I will update with another review later.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
- All Researches
8
We investigated how methylsulfonylmethane (MSM) interacts with bone morphogenetic protein 2 (BMP-2) to potentially enhance the differentiation of mesenchymal stem cells (MSCs) into osteoblasts, which are crucial for bone health. The study revealed that both MSM and BMP-2, when combined, lead to increased levels of certain proteins that aid in this process.
Observing changes in cell structure and mineral deposits helped us see the effectiveness of these treatments. The researchers noted that using MSM alongside BMP-2 significantly boosted the differentiation of MSCs into osteoblasts compared to using either treatment on its own.
Moreover, the findings indicated that the combination treatment elevated the expression of genes related to osteoblast differentiation. This suggests that MSM could play a beneficial role in promoting bone formation when used with BMP-2. However, it is essential to consider that the study's focus on the combination makes it challenging to assess MSM's isolated impact on osteoporosis directly.
Observing changes in cell structure and mineral deposits helped us see the effectiveness of these treatments. The researchers noted that using MSM alongside BMP-2 significantly boosted the differentiation of MSCs into osteoblasts compared to using either treatment on its own.
Moreover, the findings indicated that the combination treatment elevated the expression of genes related to osteoblast differentiation. This suggests that MSM could play a beneficial role in promoting bone formation when used with BMP-2. However, it is essential to consider that the study's focus on the combination makes it challenging to assess MSM's isolated impact on osteoporosis directly.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Pain relief noted
2 people found this helpful
Excellent! My mother is quite elderly and suffers from severe osteoporosis, as well as occasional low back pain following a lower back injury, which caused her to bend over. Due to concerns about side effects from Western medicine, alongside taking Life Extension’s Bone Strength Collagen Formula, I also added MSM for its anti-inflammatory benefits and to strengthen cartilage and connective tissue. After nearly a month, my mother can finally straighten her back and has experienced significant pain relief. This product has been beneficial for her back pain, and I plan to continue purchasing it.
Read More
10
Great effects observed
Amazing... I bought this for my mother who has osteoporosis, and the effects have been remarkable; her pain has vanished.
Read More
7.5
Quick pain relief
1 people found this helpful
I appreciated the composition and quality of this supplement. After reading good reviews regarding its effectiveness for knee issues, I ordered it for my father, with my doctor's advice. The doctor mentioned it's a good supplement for joints and osteoporosis. Although Dad has just started taking it, he claims that the pain is already alleviated. The results appear to be quick, and I am pleased with my purchase. I will update with another review later.
Read More
7.5
Recommended supplement
This is a good supplement for joint support, especially concerning osteoporosis. The result is that pains diminish when I take this supplement. I highly recommend it!
Read More
7.5
Manageable pain
13 people found this helpful
Recommended by a trusted doctor, I take this for several conditions, including osteoporosis. I avoided opioids due to addiction and found that after taking this for almost three weeks, my pain has become more manageable, and I feel more alert.
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Frequently Asked Questions
9
Pain relief noted
2 people found this helpful
Excellent! My mother is quite elderly and suffers from severe osteoporosis, as well as occasional low back pain following a lower back injury, which caused her to bend over. Due to concerns about side effects from Western medicine, alongside taking Life Extension’s Bone Strength Collagen Formula, I also added MSM for its anti-inflammatory benefits and to strengthen cartilage and connective tissue. After nearly a month, my mother can finally straighten her back and has experienced significant pain relief. This product has been beneficial for her back pain, and I plan to continue purchasing it.
10
Great effects observed
Amazing... I bought this for my mother who has osteoporosis, and the effects have been remarkable; her pain has vanished.
7.5
Quick pain relief
1 people found this helpful
I appreciated the composition and quality of this supplement. After reading good reviews regarding its effectiveness for knee issues, I ordered it for my father, with my doctor's advice. The doctor mentioned it's a good supplement for joints and osteoporosis. Although Dad has just started taking it, he claims that the pain is already alleviated. The results appear to be quick, and I am pleased with my purchase. I will update with another review later.
7.5
Recommended supplement
This is a good supplement for joint support, especially concerning osteoporosis. The result is that pains diminish when I take this supplement. I highly recommend it!
8
We investigated how methylsulfonylmethane (MSM) interacts with bone morphogenetic protein 2 (BMP-2) to potentially enhance the differentiation of mesenchymal stem cells (MSCs) into osteoblasts, which are crucial for bone health. The study revealed that both MSM and BMP-2, when combined, lead to increased levels of certain proteins that aid in this process.
Observing changes in cell structure and mineral deposits helped us see the effectiveness of these treatments. The researchers noted that using MSM alongside BMP-2 significantly boosted the differentiation of MSCs into osteoblasts compared to using either treatment on its own.
Moreover, the findings indicated that the combination treatment elevated the expression of genes related to osteoblast differentiation. This suggests that MSM could play a beneficial role in promoting bone formation when used with BMP-2. However, it is essential to consider that the study's focus on the combination makes it challenging to assess MSM's isolated impact on osteoporosis directly.
Observing changes in cell structure and mineral deposits helped us see the effectiveness of these treatments. The researchers noted that using MSM alongside BMP-2 significantly boosted the differentiation of MSCs into osteoblasts compared to using either treatment on its own.
Moreover, the findings indicated that the combination treatment elevated the expression of genes related to osteoblast differentiation. This suggests that MSM could play a beneficial role in promoting bone formation when used with BMP-2. However, it is essential to consider that the study's focus on the combination makes it challenging to assess MSM's isolated impact on osteoporosis directly.
References
- Kim DN, Joung YH, Darvin P, Kang DY, Sp N, et al. Methylsulfonylmethane enhances BMP‑2‑induced osteoblast differentiation in mesenchymal stem cells. Mol Med Rep. 2016;14:460. 10.3892/mmr.2016.5274
