NOW Supplements Nattokinase

7 people found this helpful

I bought nattokinase for my mother, who previously relied on thromboass. After just a week, she experienced remarkable changes: her blood pressure normalised, and she could now stand on her knees without pain, which she hadn’t been able to do for a long time. She is thrilled with this result, and I’m grateful to iHerb for this incredible product.

22 people found this helpful

Pelvic Pain details

I have a history of very painful periods. Recently, they have been occurring every two weeks along with severe breakouts, which left me quite distressed. After consulting a doctor, I found that I had a cyst on my ovary and "uneven uterine lining," potentially indicating fibroids. Seeking alternatives to taking the pill, I tried nattokinase, serrapeptase, and DIM. Although I experienced some mild cramping, which is common, I have noticed positive changes. It has been a month, and my cycle now arrives at the 27-day mark without any pain, heaviness, or bloating. Furthermore, I feel less exhausted and irritable, with virtually no breakouts. It has been transformative for me so far.

Helps intestinal function

Constipation details

Good medication! I purchase it for my mother, who takes it to thin her blood. I've witnessed the dosage change from four capsules a day to two. Alongside thinning the blood, the medication also improves intestinal function and helps relieve constipation. There is definitely a noticeable benefit from this drug.

Dizziness details

An excellent product! It genuinely works! Merely two days after starting the treatment, my dizziness disappeared, and the ringing in my ears reduced. I suffered this due to thick blood. I have become less sensitive to changing weather. The price is reasonable, and the number of capsules is ample. I shall continue using them!

Athlete’s Foot details

This is the first time I purchased a trial. I usually feel numbness in my feet after using the toilet, as if there’s no blood flow. After taking it, that sensation has disappeared. It seems effective at unblocking my blood vessels. Thank you.

Nattokinase aids cold recovery

Cold details

Nara N, Kurosawa Y, Fuse-Hamaoka S, Kuroiwa M, Endo T, et al. A single dose of oral nattokinase accelerates skin temperature recovery after cold water immersion: A double-blind, placebo-controlled crossover study. Heliyon. 2023;9:e17951. doi:10.1016/j.heliyon.2023.e17951

We conducted a study to explore how a single dose of nattokinase (NK) influences recovery of skin temperature after exposure to cold water. This double-blind, placebo-controlled crossover study involved nine healthy men who took either NK or a placebo before submerging their hands in ice-cold water at 10 °C for one minute.

Our findings showed that participants who took NK experienced a quicker recovery of skin temperature in their middle finger, palm, and back of the hand compared to those who took the placebo. Although cold exposure initially caused a significant drop in skin temperature, the NK appeared to accelerate the warming process afterward.

Interestingly, we did not observe any changes in heart rate, cardiac output, or sympathetic nervous activity as a result of taking NK. This is noteworthy because it suggests that while NK may help with temperature recovery, it does not impact certain cardiovascular responses typically associated with cold exposure.

Overall, our study highlights the potential benefits of nattokinase, especially for individuals who are more sensitive to cold, such as women and the elderly. It could offer a new avenue for managing cold sensitivity and minimizing excessive vasoconstriction during chilly conditions.

Effective immune support

Most Useful Review

Hello everyone! I truly trust this brand's supplements! I've tried various ones, all of excellent quality! Reasonable price, great ingredients, and good formulation. I bought this product as immune support during colds. It fulfils this role perfectly. The packaging is convenient, and the lid closes securely. The capsules are of standard size, making them easy to use.

Updated: Mar 2026

Autoimmune Disorder details

Effectiveness confirmed

Beautiful! Many have expressed no regret over their purchases. They started using it and it significantly helped my husband. I even ordered it for my mother, and it helped her too!

Cancer details

Nattokinase may inhibit liver cancer

Moderately Effective

Based on 4 Researches

Yan Y, Wang Y, Qian J, Wu S, Ji Y, et al. Nattokinase Crude Extract Inhibits Hepatocellular Carcinoma Growth in Mice. J Microbiol Biotechnol. 2019;29:1281. doi:10.4014/jmb.1812.12058

We assessed the impact of nattokinase crude extract (NCE) on liver cancer, specifically hepatocellular carcinoma (HCC), using mouse models.

Mice receiving NCE exhibited a 31% survival rate improvement and reduced tumor sizes, as indicated by imaging and pathology evaluations.

Additionally, NCE led to decreased levels of several cancer markers.

Overall, these findings suggest that nattokinase may positively influence liver cancer outcomes in this model.

7.5

Helps blood cancer

Most Useful Review

12 people found this helpful

Wonderful! We use this instead of aspirin. My husband has a blood cancer that increases the viscosity of his blood, making it thicker, and this is certainly helping.

Updated: Apr 2025

Candidiasis details

Wonderful! Used in the anti-Candidiasis protocol alongside other methods, it truly helps!

Chest Pain details

I take one pill daily on an empty stomach and noticed improvement after just two doses; my chest feels less stuffy. It's great!

7 people found this helpful

Food Poisoning details

I like this product so far; this is the second time I've purchased it. After a TIA, I experienced significant numbness on the right side of my neck and was informed by a doctor that my blood was thick. Since I have been taking Nattokinase, the numbness in my neck has greatly reduced. I still experience slight numbness in my tongue, but that's improved as well. I plan to continue using this product.

Leg Cramps details

After using Nattokinase to counteract the effects of Janine, prescribed for endometriosis, I no longer experience soreness in my legs or heaviness in my veins. I feel content with the results and believe it helps prevent blood clots effectively.

Sinusitis details

It reduces sinusitis and lowers pressure. I've been using it recently.

Sleep Apnea details

Significant improvement

I suffer from severe side effects due to a reaction to the antibiotic Levaquin. One of the most distressing issues is electric shocks in my legs, which rob me of sleep and are excruciating. My doctor recommended Nattokinase, and it has indeed helped. Though I still experience the shocks at times, the improvement is considerable, and I am immensely grateful.

Nattokinase shows promise for heart attacks

Heart Disease details

Shi Y, Liu C, Gui Y, Guo Y, Zhang Y, et al. A Nattokinase-Loaded Nanozyme for Alleviating Acute Myocardial Infarction via Thrombolysis and Antioxidation. Adv Healthc Mater. 2024. doi:10.1002/adhm.202402763

We explored the potential of a novel treatment using nattokinase combined with manganese oxide nanozymes to tackle acute myocardial infarction caused by blood clots. This innovative approach aims to enhance thrombolytic therapy and combat oxidative stress. The study found that injecting this nattokinase-loaded nanozyme significantly restored blood flow and reduced heart damage in mouse models of heart attacks. While the results are promising, suggesting a new avenue for treatment, further research is necessary to establish its effectiveness in humans.

Improves Lyme disease

Most Useful Review

14 people found this helpful

Natto is an excellent blood thinner with no side effects. Nattokinase effectively reduces fibrins and improves blood circulation. My daughter, who has Lyme disease, experienced significant improvements after using it, enhancing the effectiveness of her herbal remedies. Thanks to iHerb for providing this at a fair price!

Updated: Apr 2025

Irritable Bowel Syndrome details

This supplement is essential for maintaining healthy circulation and can aid digestion, making bowel movements smoother when taken after meals.

Oedema reduced noticeably

Swollen Lymph Nodes details

My mother had swollen legs for two years without any identifiable cause from various tests. After using nattokinase, her swelling noticeably diminished and has not returned. She takes it in two-week courses and has found it a reliable herbal remedy, even using it as an alternative to Aspirin after her covid recovery.

Nattokinase identified as allergen

Allergies details

Suzuki K, Nakamura M, Sato N, Futamura K, Matsunaga K, et al. Nattokinase (Bac s 1), a subtilisin family serine protease, is a novel allergen contained in the traditional Japanese fermented food natto. Allergol Int. 2023;72:279. doi:10.1016/j.alit.2022.11.010

We examined the effects of nattokinase, a protease found in natto, on allergies. Our study involved eight individuals who experienced allergic reactions after consuming natto, specifically the sticky substance surrounding the beans. Some participants tested negative for polygamma glutamic acid (PGA), which was previously identified as a potential allergen.

Throughout our investigation, we employed skin prick tests, immunoblotting, and ELISA to assess the reactivity to nattokinase and other components. Notably, we discovered that a subset of patients, particularly those who were negative for PGA, exhibited an allergic response to nattokinase. This finding suggests that nattokinase may act as a distinct allergen in certain individuals.

In the end, we identified nattokinase as a new allergen linked to natto allergy, particularly in those not sensitized to PGA. While our study highlights the allergenic potential of nattokinase, its broader implications for allergy treatment remain to be fully explored.

Effective, subtle impact

Most Useful Review

Excellent product, no allergies or anything like that. The effects are not immediately noticeable, but I believe it works.

Updated: Apr 2025

High Cholesterol details

Nattokinase shows mixed cholesterol benefits

Possibly Effective

Based on 2 Researches

Liu X, Zeng X, Mahe J, Guo K, He P, et al. The Effect of Nattokinase-Monascus Supplements on Dyslipidemia: A Four-Month Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Nutrients. 2023;15. doi:10.3390/nu15194239

This study examined whether nattokinase monascus supplements could effectively lower cholesterol levels in people facing dyslipidemia. In a randomized trial with 113 participants, we noted significant reductions in total cholesterol, LDL cholesterol, and similar lipid markers after 120 days of using the supplements compared to a placebo.

However, we didn't see any notable improvements in triglycerides, HDL cholesterol, or carotid intima-media thickness. Importantly, participants experienced no major side effects from the treatment. Overall, while nattokinase supplements showed promise for some cholesterol levels, they did not deliver significant changes in all examined lipid factors.

Supports heart health

Most Useful Review

30 people found this helpful

Nattokinase is an enzyme derived from fermented soy products and is known to dissolve excess fibrin and improve circulation, reducing clot risks. It also lowers bad LDL cholesterol while raising good HDL cholesterol, improves blood viscosity, and regulates blood pressure. Given the prevalence of cardiovascular diseases after age 55, this supplement is vital. I have been taking it for over four months and it has positively impacted my blood consistency.

Updated: Mar 2026

Bacterial Infection details

Gum bleeding resolved

After having covid, I've found that this supplement works well. Drinking it on an empty stomach helps thin my blood and remove microthrombi. I noticed my gums were bleeding, but taking this supplement managed to resolve that.

Cardiovascular Disease details

Nattokinase shows no cardiovascular benefit

Possibly Effective

Based on 10 Researches

Hodis HN, Mack WJ, Meiselman HJ, Kalra V, Liebman H, et al. Nattokinase atherothrombotic prevention study: A randomized controlled trial. Clin Hemorheol Microcirc. 2021;78:339. doi:10.3233/CH-211147

We examined how nattokinase affects the progression of atherosclerosis and related biomarkers in a double-blind trial involving 265 participants averaging 65 years old, who had no cardiovascular disease. Participants received either nattokinase or a placebo for three years.

Our findings revealed that nattokinase had no significant effect on subclinical atherosclerosis progression, blood pressure, or other laboratory measures. This indicates that nattokinase may not provide the anticipated cardiovascular benefits in healthy individuals at low risk for heart disease.

Strengthens cardiovascular system

Most Useful Review

2 people found this helpful

Very good quality vitamins, kosher product! They significantly bolster the cardiovascular system and the entire body! My husband is pleased! Highly recommend!

Updated: Mar 2026

Chronic Cough details

Helps reduce coughing

It thins the blood and restores blood vessel function, essential after K. It's particularly advantageous for those with cold hands and feet, frequent headaches, and blood pressure increases with weather changes. It also benefits those with a wet cough by aiding in thinning phlegm and individuals with blood vessel issues, cholesterol plaques, and a tendency for thrombosis. Some studies suggest it may help slightly with migraines.

Stroke details

Nattokinase promotes stroke recovery

Moderately Effective

Based on 4 Researches

Wu H, Zhang Q, Xu P, Chen J, Duan L, et al. Nattokinase Promotes Post-stroke Neurogenesis and Cognition Recovery via Increasing Circulating Irisin. J Agric Food Chem. 2023;71:11418. doi:10.1021/acs.jafc.2c08718

We explored how nattokinase, a serine protease derived from the traditional food natto, can benefit individuals who have experienced strokes, particularly focusing on cognitive recovery. Our study specifically aimed to uncover whether nattokinase can act as an anti-post-stroke cognitive impairment (PSCI) agent by influencing blood factors that are crucial for brain health.

The results were telling. We discovered that nattokinase has protective effects against acute ischemic strokes and plays a significant role in promoting neurogenesis, which is the process of generating new brain cells. Through experiments conducted on rat models, we observed that nattokinase notably increases irisin levels in peripheral blood. Irisin is a protein that has emerged as an interesting player in enhancing cognitive functions.

By linking the increased levels of irisin to improved cognitive abilities, our findings suggest that nattokinase could be a promising therapy for those suffering from PSCI, positioning irisin as a potential target for treatment. Overall, our research highlights the exciting possibilities that nattokinase offers in the realm of stroke recovery and brain health.

7.5

Effective for recovery

Most Useful Review

3 people found this helpful

It not only thins the blood but also tackles existing blood clots. It is beneficial for post-stroke recovery and serves as a good preventative measure.

Updated: Mar 2026

Blood Clot details