Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.5
USERS' SCORE
Moderately Good
Based on 10 Reviews
7.8
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Nattokinase (2,000 FU) (enzyme from Natto Extract) (Non-GMO soy derived)
100 mg
**
Top Medical Research Studies
8
We explored how nattokinase, a serine protease derived from the traditional food natto, can benefit individuals who have experienced strokes, particularly focusing on cognitive recovery. Our study specifically aimed to uncover whether nattokinase can act as an anti-post-stroke cognitive impairment (PSCI) agent by influencing blood factors that are crucial for brain health.
The results were telling. We discovered that nattokinase has protective effects against acute ischemic strokes and plays a significant role in promoting neurogenesis, which is the process of generating new brain cells. Through experiments conducted on rat models, we observed that nattokinase notably increases irisin levels in peripheral blood. Irisin is a protein that has emerged as an interesting player in enhancing cognitive functions.
By linking the increased levels of irisin to improved cognitive abilities, our findings suggest that nattokinase could be a promising therapy for those suffering from PSCI, positioning irisin as a potential target for treatment. Overall, our research highlights the exciting possibilities that nattokinase offers in the realm of stroke recovery and brain health.
The results were telling. We discovered that nattokinase has protective effects against acute ischemic strokes and plays a significant role in promoting neurogenesis, which is the process of generating new brain cells. Through experiments conducted on rat models, we observed that nattokinase notably increases irisin levels in peripheral blood. Irisin is a protein that has emerged as an interesting player in enhancing cognitive functions.
By linking the increased levels of irisin to improved cognitive abilities, our findings suggest that nattokinase could be a promising therapy for those suffering from PSCI, positioning irisin as a potential target for treatment. Overall, our research highlights the exciting possibilities that nattokinase offers in the realm of stroke recovery and brain health.
Read More
9
We examined how nattokinase (NK), a powerful enzyme, can benefit patients who suffer from strokes. Our research focused on the effects of NK in a model of transient middle cerebral artery occlusion (tMCAO), which simulates ischemic stroke and its aftermath. By administering different doses of NK to rats before they underwent surgery, we wanted to see if it could reduce brain damage and improve recovery.
Our observations revealed that NK treatment significantly reduced the size of brain injury and enhanced recovery from neurological issues. It also helped lower levels of harmful pro-inflammatory and coagulation substances while reducing oxidative stress markers in the affected brain area. These findings show NK’s potential in protecting the brain from the damaging effects of stroke.
Furthermore, we explored NK's protective properties in laboratory tests simulating neuron injury due to lack of oxygen and glucose. We found that it was effective in countering cell death across these models, working through various biological pathways. However, when we blocked NK's activity with a specific inhibitor, we noticed that its protective effects vanished, demonstrating that NK's enzymatic activity is crucial for its benefits.
Overall, this study highlights the multi-faceted protective role of nattokinase in brain injuries caused by ischemic events, confirming its potential as a therapeutic agent in stroke treatment.
Our observations revealed that NK treatment significantly reduced the size of brain injury and enhanced recovery from neurological issues. It also helped lower levels of harmful pro-inflammatory and coagulation substances while reducing oxidative stress markers in the affected brain area. These findings show NK’s potential in protecting the brain from the damaging effects of stroke.
Furthermore, we explored NK's protective properties in laboratory tests simulating neuron injury due to lack of oxygen and glucose. We found that it was effective in countering cell death across these models, working through various biological pathways. However, when we blocked NK's activity with a specific inhibitor, we noticed that its protective effects vanished, demonstrating that NK's enzymatic activity is crucial for its benefits.
Overall, this study highlights the multi-faceted protective role of nattokinase in brain injuries caused by ischemic events, confirming its potential as a therapeutic agent in stroke treatment.
Read More
8
We conducted a single-blinded randomized controlled trial involving 61 patients recovering from ischemic stroke. We tested Nattospes as a supplement alongside standard treatments such as electroacupuncture.
After 60 days, both the Nattospes and control groups showed significant improvements in physical activities, blood pressure, and quality of life. While Nattospes demonstrated beneficial effects on stroke symptoms, it’s important to note that no adverse effects were reported.
The results suggest that Nattospes can safely support stroke recovery. These findings encourage further research into Nattospes as a potential supplement in cardiovascular disease management.
After 60 days, both the Nattospes and control groups showed significant improvements in physical activities, blood pressure, and quality of life. While Nattospes demonstrated beneficial effects on stroke symptoms, it’s important to note that no adverse effects were reported.
The results suggest that Nattospes can safely support stroke recovery. These findings encourage further research into Nattospes as a potential supplement in cardiovascular disease management.
Read More
Most Useful Reviews
9
Excellent post-stroke alternative
5 people found this helpful
I purchased this for my father, who had a stroke, to replace Aspirin due to its side effects. After two months, his swollen veins improved significantly. Fibrinogen levels dropped from over 500 to 280 in just 20 days. The product quality is unparalleled, delivering numerous benefits.
Read More
7.5
Effective for recovery
3 people found this helpful
It not only thins the blood but also tackles existing blood clots. It is beneficial for post-stroke recovery and serves as a good preventative measure.
Read More
9
Clearer blood vessels
1 people found this helpful
I find the effect very good. After taking it, I underwent a physical examination. I take it every night before bed, and it is said to clear blood vessels and reduce stroke risk!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.5
- All Researches
9
We examined how nattokinase (NK), a powerful enzyme, can benefit patients who suffer from strokes. Our research focused on the effects of NK in a model of transient middle cerebral artery occlusion (tMCAO), which simulates ischemic stroke and its aftermath. By administering different doses of NK to rats before they underwent surgery, we wanted to see if it could reduce brain damage and improve recovery.
Our observations revealed that NK treatment significantly reduced the size of brain injury and enhanced recovery from neurological issues. It also helped lower levels of harmful pro-inflammatory and coagulation substances while reducing oxidative stress markers in the affected brain area. These findings show NK’s potential in protecting the brain from the damaging effects of stroke.
Furthermore, we explored NK's protective properties in laboratory tests simulating neuron injury due to lack of oxygen and glucose. We found that it was effective in countering cell death across these models, working through various biological pathways. However, when we blocked NK's activity with a specific inhibitor, we noticed that its protective effects vanished, demonstrating that NK's enzymatic activity is crucial for its benefits.
Overall, this study highlights the multi-faceted protective role of nattokinase in brain injuries caused by ischemic events, confirming its potential as a therapeutic agent in stroke treatment.
Our observations revealed that NK treatment significantly reduced the size of brain injury and enhanced recovery from neurological issues. It also helped lower levels of harmful pro-inflammatory and coagulation substances while reducing oxidative stress markers in the affected brain area. These findings show NK’s potential in protecting the brain from the damaging effects of stroke.
Furthermore, we explored NK's protective properties in laboratory tests simulating neuron injury due to lack of oxygen and glucose. We found that it was effective in countering cell death across these models, working through various biological pathways. However, when we blocked NK's activity with a specific inhibitor, we noticed that its protective effects vanished, demonstrating that NK's enzymatic activity is crucial for its benefits.
Overall, this study highlights the multi-faceted protective role of nattokinase in brain injuries caused by ischemic events, confirming its potential as a therapeutic agent in stroke treatment.
Read More
9
We investigated how nattokinase, an oral supplement, impacts carotid artery health and lipid levels in patients. Over 26 weeks, participants were randomly assigned to receive either nattokinase or statins. Both groups saw reductions in carotid artery thickness and plaque size, but nattokinase outperformed statins in plaque reduction.
While both treatments lowered cholesterol and triglyceride levels, statins achieved greater reductions. Interestingly, nattokinase raised good cholesterol levels, unlike statins. Our study suggests that nattokinase could be a promising alternative in managing atherosclerosis and reducing stroke risk.
While both treatments lowered cholesterol and triglyceride levels, statins achieved greater reductions. Interestingly, nattokinase raised good cholesterol levels, unlike statins. Our study suggests that nattokinase could be a promising alternative in managing atherosclerosis and reducing stroke risk.
Read More
8
We explored how nattokinase, a serine protease derived from the traditional food natto, can benefit individuals who have experienced strokes, particularly focusing on cognitive recovery. Our study specifically aimed to uncover whether nattokinase can act as an anti-post-stroke cognitive impairment (PSCI) agent by influencing blood factors that are crucial for brain health.
The results were telling. We discovered that nattokinase has protective effects against acute ischemic strokes and plays a significant role in promoting neurogenesis, which is the process of generating new brain cells. Through experiments conducted on rat models, we observed that nattokinase notably increases irisin levels in peripheral blood. Irisin is a protein that has emerged as an interesting player in enhancing cognitive functions.
By linking the increased levels of irisin to improved cognitive abilities, our findings suggest that nattokinase could be a promising therapy for those suffering from PSCI, positioning irisin as a potential target for treatment. Overall, our research highlights the exciting possibilities that nattokinase offers in the realm of stroke recovery and brain health.
The results were telling. We discovered that nattokinase has protective effects against acute ischemic strokes and plays a significant role in promoting neurogenesis, which is the process of generating new brain cells. Through experiments conducted on rat models, we observed that nattokinase notably increases irisin levels in peripheral blood. Irisin is a protein that has emerged as an interesting player in enhancing cognitive functions.
By linking the increased levels of irisin to improved cognitive abilities, our findings suggest that nattokinase could be a promising therapy for those suffering from PSCI, positioning irisin as a potential target for treatment. Overall, our research highlights the exciting possibilities that nattokinase offers in the realm of stroke recovery and brain health.
Read More
8
We conducted a single-blinded randomized controlled trial involving 61 patients recovering from ischemic stroke. We tested Nattospes as a supplement alongside standard treatments such as electroacupuncture.
After 60 days, both the Nattospes and control groups showed significant improvements in physical activities, blood pressure, and quality of life. While Nattospes demonstrated beneficial effects on stroke symptoms, it’s important to note that no adverse effects were reported.
The results suggest that Nattospes can safely support stroke recovery. These findings encourage further research into Nattospes as a potential supplement in cardiovascular disease management.
After 60 days, both the Nattospes and control groups showed significant improvements in physical activities, blood pressure, and quality of life. While Nattospes demonstrated beneficial effects on stroke symptoms, it’s important to note that no adverse effects were reported.
The results suggest that Nattospes can safely support stroke recovery. These findings encourage further research into Nattospes as a potential supplement in cardiovascular disease management.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 10 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Excellent post-stroke alternative
5 people found this helpful
I purchased this for my father, who had a stroke, to replace Aspirin due to its side effects. After two months, his swollen veins improved significantly. Fibrinogen levels dropped from over 500 to 280 in just 20 days. The product quality is unparalleled, delivering numerous benefits.
Read More
7.5
Effective for recovery
3 people found this helpful
It not only thins the blood but also tackles existing blood clots. It is beneficial for post-stroke recovery and serves as a good preventative measure.
Read More
9
Clearer blood vessels
1 people found this helpful
I find the effect very good. After taking it, I underwent a physical examination. I take it every night before bed, and it is said to clear blood vessels and reduce stroke risk!
Read More
7.5
Improved sensation
3 people found this helpful
I have just started using Nattokinase, and it has only been about two weeks. Following a TIA, or mini stroke, the right side of my jaw and tongue often felt thick and slow, raising concerns about a possible recurrence. However, I've noticed an improvement in this sensation for several days now. I will continue using Nattokinase and will be able to provide a more comprehensive review later.
Read More
6
Alternative to aspirin
1 people found this helpful
An excellent blood-thinning agent, this is a great alternative to aspirin. Nattokinase is essential for addressing high cholesterol and blood clots in vessels, significantly reducing stroke risk. I take one capsule daily to maintain normal blood density.
Read More
Frequently Asked Questions
9
Excellent post-stroke alternative
5 people found this helpful
I purchased this for my father, who had a stroke, to replace Aspirin due to its side effects. After two months, his swollen veins improved significantly. Fibrinogen levels dropped from over 500 to 280 in just 20 days. The product quality is unparalleled, delivering numerous benefits.
7.5
Improved sensation
3 people found this helpful
I have just started using Nattokinase, and it has only been about two weeks. Following a TIA, or mini stroke, the right side of my jaw and tongue often felt thick and slow, raising concerns about a possible recurrence. However, I've noticed an improvement in this sensation for several days now. I will continue using Nattokinase and will be able to provide a more comprehensive review later.
6
Alternative to aspirin
1 people found this helpful
An excellent blood-thinning agent, this is a great alternative to aspirin. Nattokinase is essential for addressing high cholesterol and blood clots in vessels, significantly reducing stroke risk. I take one capsule daily to maintain normal blood density.
7
Prevention of thrombosis
This supplement clears blood vessels of clots and promotes healthy blood flow. We use it to prevent stroke and thrombosis.
7.5
Post-stroke use
My husband took this after suffering a stroke, and it effectively removes blood clots.
6
High quality
The manufacturer is commendable! Exceptional quality! iHerb brand offers an excellent blood thinner that reduces the likelihood of a heart attack and stroke.
9
We examined how nattokinase (NK), a powerful enzyme, can benefit patients who suffer from strokes. Our research focused on the effects of NK in a model of transient middle cerebral artery occlusion (tMCAO), which simulates ischemic stroke and its aftermath. By administering different doses of NK to rats before they underwent surgery, we wanted to see if it could reduce brain damage and improve recovery.
Our observations revealed that NK treatment significantly reduced the size of brain injury and enhanced recovery from neurological issues. It also helped lower levels of harmful pro-inflammatory and coagulation substances while reducing oxidative stress markers in the affected brain area. These findings show NK’s potential in protecting the brain from the damaging effects of stroke.
Furthermore, we explored NK's protective properties in laboratory tests simulating neuron injury due to lack of oxygen and glucose. We found that it was effective in countering cell death across these models, working through various biological pathways. However, when we blocked NK's activity with a specific inhibitor, we noticed that its protective effects vanished, demonstrating that NK's enzymatic activity is crucial for its benefits.
Overall, this study highlights the multi-faceted protective role of nattokinase in brain injuries caused by ischemic events, confirming its potential as a therapeutic agent in stroke treatment.
Our observations revealed that NK treatment significantly reduced the size of brain injury and enhanced recovery from neurological issues. It also helped lower levels of harmful pro-inflammatory and coagulation substances while reducing oxidative stress markers in the affected brain area. These findings show NK’s potential in protecting the brain from the damaging effects of stroke.
Furthermore, we explored NK's protective properties in laboratory tests simulating neuron injury due to lack of oxygen and glucose. We found that it was effective in countering cell death across these models, working through various biological pathways. However, when we blocked NK's activity with a specific inhibitor, we noticed that its protective effects vanished, demonstrating that NK's enzymatic activity is crucial for its benefits.
Overall, this study highlights the multi-faceted protective role of nattokinase in brain injuries caused by ischemic events, confirming its potential as a therapeutic agent in stroke treatment.
8
We explored how nattokinase, a serine protease derived from the traditional food natto, can benefit individuals who have experienced strokes, particularly focusing on cognitive recovery. Our study specifically aimed to uncover whether nattokinase can act as an anti-post-stroke cognitive impairment (PSCI) agent by influencing blood factors that are crucial for brain health.
The results were telling. We discovered that nattokinase has protective effects against acute ischemic strokes and plays a significant role in promoting neurogenesis, which is the process of generating new brain cells. Through experiments conducted on rat models, we observed that nattokinase notably increases irisin levels in peripheral blood. Irisin is a protein that has emerged as an interesting player in enhancing cognitive functions.
By linking the increased levels of irisin to improved cognitive abilities, our findings suggest that nattokinase could be a promising therapy for those suffering from PSCI, positioning irisin as a potential target for treatment. Overall, our research highlights the exciting possibilities that nattokinase offers in the realm of stroke recovery and brain health.
The results were telling. We discovered that nattokinase has protective effects against acute ischemic strokes and plays a significant role in promoting neurogenesis, which is the process of generating new brain cells. Through experiments conducted on rat models, we observed that nattokinase notably increases irisin levels in peripheral blood. Irisin is a protein that has emerged as an interesting player in enhancing cognitive functions.
By linking the increased levels of irisin to improved cognitive abilities, our findings suggest that nattokinase could be a promising therapy for those suffering from PSCI, positioning irisin as a potential target for treatment. Overall, our research highlights the exciting possibilities that nattokinase offers in the realm of stroke recovery and brain health.
8
We conducted a single-blinded randomized controlled trial involving 61 patients recovering from ischemic stroke. We tested Nattospes as a supplement alongside standard treatments such as electroacupuncture.
After 60 days, both the Nattospes and control groups showed significant improvements in physical activities, blood pressure, and quality of life. While Nattospes demonstrated beneficial effects on stroke symptoms, it’s important to note that no adverse effects were reported.
The results suggest that Nattospes can safely support stroke recovery. These findings encourage further research into Nattospes as a potential supplement in cardiovascular disease management.
After 60 days, both the Nattospes and control groups showed significant improvements in physical activities, blood pressure, and quality of life. While Nattospes demonstrated beneficial effects on stroke symptoms, it’s important to note that no adverse effects were reported.
The results suggest that Nattospes can safely support stroke recovery. These findings encourage further research into Nattospes as a potential supplement in cardiovascular disease management.
References
- Yang XY, Wang SL, Xue WC, Zhang YP, Li LL, et al. Nattokinase's Neuroprotective Mechanisms in Ischemic Stroke: Targeting Inflammation, Oxidative Stress, and Coagulation. Antioxid Redox Signal. 2025;42:228. 10.1089/ars.2023.0527
- Wu H, Zhang Q, Xu P, Chen J, Duan L, et al. Nattokinase Promotes Post-stroke Neurogenesis and Cognition Recovery via Increasing Circulating Irisin. J Agric Food Chem. 2023;71:11418. 10.1021/acs.jafc.2c08718
- Pham PT, Han B, Hoang BX. Nattospes as Effective and Safe Functional Supplements in Management of Stroke. J Med Food. 2020;23:879. 10.1089/jmf.2019.0183
- Ren NN, Chen HJ, Li Y, Mcgowan GW, Lin YG. [A clinical study on the effect of nattokinase on carotid artery atherosclerosis and hyperlipidaemia]. Zhonghua Yi Xue Za Zhi. 2017;97:2038. 10.3760/cma.j.issn.0376-2491.2017.26.005
