Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.3
USERS' SCORE
Good
Based on 9 Reviews
8.3
Supplement Facts
Serving Size: 2 Softgels
Amount Per Serving
%DV
Calories
20
Total Fat
2 g
3%**
Saturated Fat
0.5 g
3%**
Polyunsaturated Fat
1 g
†
Monounsaturated Fat
0.5 g
†
Fish Oil Concentrate
2 g (2,000 mg)
†
Eicosapentaenoic Acid (EPA)
360 mg
†
Docosahexaenoic Acid (DHA)
240 mg
†
Top Medical Research Studies
9
We set out to explore how hypothyroidism affects cognitive functions in adult male rats and whether omega-3 supplementation could help. In our study, we divided thirty rats into three groups: a control group, one with induced hypothyroidism, and another that received omega-3 treatment.
The findings revealed that the rats with hypothyroidism faced significant challenges with memory tasks, such as recalling and recognizing objects and navigating mazes. Notably, their brain structure showed damage, including vacuolar degeneration and distorted brain cells.
Interestingly, the hypothyroid rats also had decreased levels of antioxidants, serotonin, and GABA in their brains, all of which are crucial for healthy mental functions. However, when we supplemented the hypothyroid rats with omega-3, we observed a remarkable reversal in their memory deficits. The omega-3-treated rats showed improved cognitive performance, increased antioxidant levels, and reduced brain damage, alongside a decrease in a particular protein associated with cellular stress.
Our findings suggest that omega-3 can serve as a protective agent against cognitive impairment linked to hypothyroidism. It points towards a potential therapeutic option for enhancing brain health in individuals facing this condition.
The findings revealed that the rats with hypothyroidism faced significant challenges with memory tasks, such as recalling and recognizing objects and navigating mazes. Notably, their brain structure showed damage, including vacuolar degeneration and distorted brain cells.
Interestingly, the hypothyroid rats also had decreased levels of antioxidants, serotonin, and GABA in their brains, all of which are crucial for healthy mental functions. However, when we supplemented the hypothyroid rats with omega-3, we observed a remarkable reversal in their memory deficits. The omega-3-treated rats showed improved cognitive performance, increased antioxidant levels, and reduced brain damage, alongside a decrease in a particular protein associated with cellular stress.
Our findings suggest that omega-3 can serve as a protective agent against cognitive impairment linked to hypothyroidism. It points towards a potential therapeutic option for enhancing brain health in individuals facing this condition.
Read More
8
Fish oil benefits hypothyroid function
We set out to understand how fish oil, specifically eicosapentaenoic acid ethyl ester (EPA-E), might affect thyroid function in individuals with hypothyroidism. Previous observations noted that while plasma free fatty acid (FFA) levels are typically normal in people with hypothyroidism, some patients exhibited higher levels. Surprisingly, those with elevated FFA levels reported milder symptoms compared to those with lower concentrations.
To investigate this further, we utilized an animal model involving rats that had been induced with hypothyroidism using a substance known as 1-methyl-2-imidazolethiol (MMI). By orally administering EPA-E, we aimed to see if it could counteract the hormonal disruptions caused by the MMI treatment. Our findings revealed that EPA-E played a positive role in maintaining thyroid hormone levels and preserving the structure of thyroid follicles.
Overall, our study suggests that higher levels of FFAs might influence thyroid function positively, and that EPA-E could potentially help mitigate some of the adverse effects of hypothyroidism. These insights could pave the way for exploring fish oil as a beneficial treatment option for those affected by thyroid dysfunction.
To investigate this further, we utilized an animal model involving rats that had been induced with hypothyroidism using a substance known as 1-methyl-2-imidazolethiol (MMI). By orally administering EPA-E, we aimed to see if it could counteract the hormonal disruptions caused by the MMI treatment. Our findings revealed that EPA-E played a positive role in maintaining thyroid hormone levels and preserving the structure of thyroid follicles.
Overall, our study suggests that higher levels of FFAs might influence thyroid function positively, and that EPA-E could potentially help mitigate some of the adverse effects of hypothyroidism. These insights could pave the way for exploring fish oil as a beneficial treatment option for those affected by thyroid dysfunction.
Read More
7
Fish oil improves mitochondrial function
We explored how fish oil, specifically omega-3 fatty acids, impacts mitochondrial function in hypothyroid rats compared to normal thyroid function. By examining mitochondrial proton leak—essentially how efficiently energy is used in cells—we found that hypothyroid rats had lower proton leak rates than those with normal thyroid function.
Interestingly, when hypothyroid rats were fed a diet with 5% omega-3 fatty acids, their proton leak rates dropped even further. We also noted this same trend in euthyroid rats that consumed the higher omega-3 diet, suggesting that increasing dietary omega-3 content can improve mitochondrial efficiency, regardless of thyroid status.
Our findings pointed to significant changes in the membranes of mitochondria, specifically with levels of omega-3 fatty acids being higher. This change corresponds with a favorable shift in the balance between omega-6 and omega-3 fatty acids, across several important phospholipid categories. Overall, it appears that both the hypothyroid state and the omega-3 dietary influence seem to work through similar biological pathways.
While the study clearly demonstrates how fish oil can affect mitochondrial function in thyroid-related conditions, it does highlight the complex interactions between diet and hormone status. Therefore, while fish oil shows promise, it operates within a broader context that includes both dietary and hormonal factors.
Interestingly, when hypothyroid rats were fed a diet with 5% omega-3 fatty acids, their proton leak rates dropped even further. We also noted this same trend in euthyroid rats that consumed the higher omega-3 diet, suggesting that increasing dietary omega-3 content can improve mitochondrial efficiency, regardless of thyroid status.
Our findings pointed to significant changes in the membranes of mitochondria, specifically with levels of omega-3 fatty acids being higher. This change corresponds with a favorable shift in the balance between omega-6 and omega-3 fatty acids, across several important phospholipid categories. Overall, it appears that both the hypothyroid state and the omega-3 dietary influence seem to work through similar biological pathways.
While the study clearly demonstrates how fish oil can affect mitochondrial function in thyroid-related conditions, it does highlight the complex interactions between diet and hormone status. Therefore, while fish oil shows promise, it operates within a broader context that includes both dietary and hormonal factors.
Read More
Most Useful Reviews
9
Improved well-being
Chewable tablets are delightful! I have hypothyroidism and high homocysteine. I take this B12 alongside other supplements, and after a month, I feel fantastic! The dosage is optimal, replenishing my deficiency while reducing homocysteine. I regularly remember to take it because they taste good, and B12 is better absorbed sublingually through the oral mucosa. A great addition!
Read More
9
Enhanced vitality
I began taking Omega in November-December and started again in February. The first course had an especially noticeable effect. Despite having AIT and hypothyroidism, my husband and I felt more energetic and overall better. If taken after meals, there are no fish oil burps. We're very pleased with this product and will continue using it regularly.
Read More
9
Multiple benefits
I highly recommend Omega 3, which offers numerous benefits. It improves hair and skin, has anti-inflammatory properties, and is crucial for individuals with PCOS and hypothyroidism. It has a slight fishy smell and flavour.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.3
- All Researches
9
We set out to explore how hypothyroidism affects cognitive functions in adult male rats and whether omega-3 supplementation could help. In our study, we divided thirty rats into three groups: a control group, one with induced hypothyroidism, and another that received omega-3 treatment.
The findings revealed that the rats with hypothyroidism faced significant challenges with memory tasks, such as recalling and recognizing objects and navigating mazes. Notably, their brain structure showed damage, including vacuolar degeneration and distorted brain cells.
Interestingly, the hypothyroid rats also had decreased levels of antioxidants, serotonin, and GABA in their brains, all of which are crucial for healthy mental functions. However, when we supplemented the hypothyroid rats with omega-3, we observed a remarkable reversal in their memory deficits. The omega-3-treated rats showed improved cognitive performance, increased antioxidant levels, and reduced brain damage, alongside a decrease in a particular protein associated with cellular stress.
Our findings suggest that omega-3 can serve as a protective agent against cognitive impairment linked to hypothyroidism. It points towards a potential therapeutic option for enhancing brain health in individuals facing this condition.
The findings revealed that the rats with hypothyroidism faced significant challenges with memory tasks, such as recalling and recognizing objects and navigating mazes. Notably, their brain structure showed damage, including vacuolar degeneration and distorted brain cells.
Interestingly, the hypothyroid rats also had decreased levels of antioxidants, serotonin, and GABA in their brains, all of which are crucial for healthy mental functions. However, when we supplemented the hypothyroid rats with omega-3, we observed a remarkable reversal in their memory deficits. The omega-3-treated rats showed improved cognitive performance, increased antioxidant levels, and reduced brain damage, alongside a decrease in a particular protein associated with cellular stress.
Our findings suggest that omega-3 can serve as a protective agent against cognitive impairment linked to hypothyroidism. It points towards a potential therapeutic option for enhancing brain health in individuals facing this condition.
Read More
9
We investigated how omega-3 fatty acids, found in fish oil, could influence brain development in a rat model with hypothyroidism. Our focus was on understanding whether these fatty acids could help prevent neuronal apoptosis—a type of programmed cell death that can be harmful during brain development.
To study this, we supplemented pregnant and nursing rats with a mix of two important omega-3 fatty acids, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). Meanwhile, we induced hypothyroidism in these rats using a medication known as methimazole. We then examined the cerebellums of their offspring at a specific age, looking for indicators of neuronal health and apoptosis.
Our findings showed that the supplement significantly reduced DNA fragmentation and the activation of caspase-3, another indicator of apoptosis, in the developing brains of hypothyroid pups. Additionally, omega-3 fatty acids helped to increase levels of protective proteins that fight apoptosis, such as Bcl-2 and Bcl-x(L). They also reinstated normal levels of signaling molecules affected by hypothyroid conditions.
Overall, this suggests that omega-3 fatty acids could play a protective role in brain development, especially under stress conditions like hypothyroidism. Through this research, we gained valuable insights into how fish oil might help support neuronal health in challenging developmental situations.
To study this, we supplemented pregnant and nursing rats with a mix of two important omega-3 fatty acids, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). Meanwhile, we induced hypothyroidism in these rats using a medication known as methimazole. We then examined the cerebellums of their offspring at a specific age, looking for indicators of neuronal health and apoptosis.
Our findings showed that the supplement significantly reduced DNA fragmentation and the activation of caspase-3, another indicator of apoptosis, in the developing brains of hypothyroid pups. Additionally, omega-3 fatty acids helped to increase levels of protective proteins that fight apoptosis, such as Bcl-2 and Bcl-x(L). They also reinstated normal levels of signaling molecules affected by hypothyroid conditions.
Overall, this suggests that omega-3 fatty acids could play a protective role in brain development, especially under stress conditions like hypothyroidism. Through this research, we gained valuable insights into how fish oil might help support neuronal health in challenging developmental situations.
Read More
8
We observed the effects of Omega 3 fatty acids (O3FA) on hypothyroidism caused by the endocrine-disrupting chemical Bisphenol F (BPF) in a controlled study with male Wistar rats. The rats were divided into four groups: a control group, a BPF-only group, and two intervention groups receiving different doses of O3FA alongside BPF.
Our findings revealed that both low and high doses of O3FA significantly improved sperm quality, hormonal levels, and antioxidant defenses, which were adversely affected by BPF. Notably, the treatment with O3FA restored important enzymes and prevented harmful increases in certain inflammatory markers, showing its protective role against testicular dysfunction linked to thyroid issues.
Overall, this study indicates that incorporating Omega 3 fatty acids could be an effective strategy to counteract the negative impacts of BPF-induced hypothyroidism and support male reproductive health.
Our findings revealed that both low and high doses of O3FA significantly improved sperm quality, hormonal levels, and antioxidant defenses, which were adversely affected by BPF. Notably, the treatment with O3FA restored important enzymes and prevented harmful increases in certain inflammatory markers, showing its protective role against testicular dysfunction linked to thyroid issues.
Overall, this study indicates that incorporating Omega 3 fatty acids could be an effective strategy to counteract the negative impacts of BPF-induced hypothyroidism and support male reproductive health.
Read More
8
Fish oil benefits hypothyroid function
We set out to understand how fish oil, specifically eicosapentaenoic acid ethyl ester (EPA-E), might affect thyroid function in individuals with hypothyroidism. Previous observations noted that while plasma free fatty acid (FFA) levels are typically normal in people with hypothyroidism, some patients exhibited higher levels. Surprisingly, those with elevated FFA levels reported milder symptoms compared to those with lower concentrations.
To investigate this further, we utilized an animal model involving rats that had been induced with hypothyroidism using a substance known as 1-methyl-2-imidazolethiol (MMI). By orally administering EPA-E, we aimed to see if it could counteract the hormonal disruptions caused by the MMI treatment. Our findings revealed that EPA-E played a positive role in maintaining thyroid hormone levels and preserving the structure of thyroid follicles.
Overall, our study suggests that higher levels of FFAs might influence thyroid function positively, and that EPA-E could potentially help mitigate some of the adverse effects of hypothyroidism. These insights could pave the way for exploring fish oil as a beneficial treatment option for those affected by thyroid dysfunction.
To investigate this further, we utilized an animal model involving rats that had been induced with hypothyroidism using a substance known as 1-methyl-2-imidazolethiol (MMI). By orally administering EPA-E, we aimed to see if it could counteract the hormonal disruptions caused by the MMI treatment. Our findings revealed that EPA-E played a positive role in maintaining thyroid hormone levels and preserving the structure of thyroid follicles.
Overall, our study suggests that higher levels of FFAs might influence thyroid function positively, and that EPA-E could potentially help mitigate some of the adverse effects of hypothyroidism. These insights could pave the way for exploring fish oil as a beneficial treatment option for those affected by thyroid dysfunction.
Read More
7
Fish oil improves mitochondrial function
We explored how fish oil, specifically omega-3 fatty acids, impacts mitochondrial function in hypothyroid rats compared to normal thyroid function. By examining mitochondrial proton leak—essentially how efficiently energy is used in cells—we found that hypothyroid rats had lower proton leak rates than those with normal thyroid function.
Interestingly, when hypothyroid rats were fed a diet with 5% omega-3 fatty acids, their proton leak rates dropped even further. We also noted this same trend in euthyroid rats that consumed the higher omega-3 diet, suggesting that increasing dietary omega-3 content can improve mitochondrial efficiency, regardless of thyroid status.
Our findings pointed to significant changes in the membranes of mitochondria, specifically with levels of omega-3 fatty acids being higher. This change corresponds with a favorable shift in the balance between omega-6 and omega-3 fatty acids, across several important phospholipid categories. Overall, it appears that both the hypothyroid state and the omega-3 dietary influence seem to work through similar biological pathways.
While the study clearly demonstrates how fish oil can affect mitochondrial function in thyroid-related conditions, it does highlight the complex interactions between diet and hormone status. Therefore, while fish oil shows promise, it operates within a broader context that includes both dietary and hormonal factors.
Interestingly, when hypothyroid rats were fed a diet with 5% omega-3 fatty acids, their proton leak rates dropped even further. We also noted this same trend in euthyroid rats that consumed the higher omega-3 diet, suggesting that increasing dietary omega-3 content can improve mitochondrial efficiency, regardless of thyroid status.
Our findings pointed to significant changes in the membranes of mitochondria, specifically with levels of omega-3 fatty acids being higher. This change corresponds with a favorable shift in the balance between omega-6 and omega-3 fatty acids, across several important phospholipid categories. Overall, it appears that both the hypothyroid state and the omega-3 dietary influence seem to work through similar biological pathways.
While the study clearly demonstrates how fish oil can affect mitochondrial function in thyroid-related conditions, it does highlight the complex interactions between diet and hormone status. Therefore, while fish oil shows promise, it operates within a broader context that includes both dietary and hormonal factors.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved well-being
Chewable tablets are delightful! I have hypothyroidism and high homocysteine. I take this B12 alongside other supplements, and after a month, I feel fantastic! The dosage is optimal, replenishing my deficiency while reducing homocysteine. I regularly remember to take it because they taste good, and B12 is better absorbed sublingually through the oral mucosa. A great addition!
Read More
9
Enhanced vitality
I began taking Omega in November-December and started again in February. The first course had an especially noticeable effect. Despite having AIT and hypothyroidism, my husband and I felt more energetic and overall better. If taken after meals, there are no fish oil burps. We're very pleased with this product and will continue using it regularly.
Read More
9
Multiple benefits
I highly recommend Omega 3, which offers numerous benefits. It improves hair and skin, has anti-inflammatory properties, and is crucial for individuals with PCOS and hypothyroidism. It has a slight fishy smell and flavour.
Read More
7.5
Increased energy
I buy Omega for myself due to my hypothyroidism, as prescribed by my endocrinologist. I take it with D3 and feel excellent with increased energy. The quality is good.
Read More
7.5
Skin quality improved
The quality of my skin has significantly improved after two weeks of taking this product. I have hypothyroidism, and my skin has been very dry, but the dryness has disappeared. I wholeheartedly recommend it!
Read More
Frequently Asked Questions
9
Improved well-being
Chewable tablets are delightful! I have hypothyroidism and high homocysteine. I take this B12 alongside other supplements, and after a month, I feel fantastic! The dosage is optimal, replenishing my deficiency while reducing homocysteine. I regularly remember to take it because they taste good, and B12 is better absorbed sublingually through the oral mucosa. A great addition!
7.5
Skin quality improved
The quality of my skin has significantly improved after two weeks of taking this product. I have hypothyroidism, and my skin has been very dry, but the dryness has disappeared. I wholeheartedly recommend it!
9
Enhanced vitality
I began taking Omega in November-December and started again in February. The first course had an especially noticeable effect. Despite having AIT and hypothyroidism, my husband and I felt more energetic and overall better. If taken after meals, there are no fish oil burps. We're very pleased with this product and will continue using it regularly.
7.5
Faster recovery
I was satisfied with this product I bought for the first time. One can lasted a month and a half for both me and my teenage daughter. There were no side effects. After a month, I noticed bruises healed faster, and my skin (hypothyroidism, hyperkeratosis) peeled less. The composition and dosage were optimal for us. I’ll reorder.
7.5
Increased energy
I buy Omega for myself due to my hypothyroidism, as prescribed by my endocrinologist. I take it with D3 and feel excellent with increased energy. The quality is good.
7.5
Consistent use essential
Omega 3 must be taken consistently and is particularly beneficial for hypothyroidism.
9
We set out to explore how hypothyroidism affects cognitive functions in adult male rats and whether omega-3 supplementation could help. In our study, we divided thirty rats into three groups: a control group, one with induced hypothyroidism, and another that received omega-3 treatment.
The findings revealed that the rats with hypothyroidism faced significant challenges with memory tasks, such as recalling and recognizing objects and navigating mazes. Notably, their brain structure showed damage, including vacuolar degeneration and distorted brain cells.
Interestingly, the hypothyroid rats also had decreased levels of antioxidants, serotonin, and GABA in their brains, all of which are crucial for healthy mental functions. However, when we supplemented the hypothyroid rats with omega-3, we observed a remarkable reversal in their memory deficits. The omega-3-treated rats showed improved cognitive performance, increased antioxidant levels, and reduced brain damage, alongside a decrease in a particular protein associated with cellular stress.
Our findings suggest that omega-3 can serve as a protective agent against cognitive impairment linked to hypothyroidism. It points towards a potential therapeutic option for enhancing brain health in individuals facing this condition.
The findings revealed that the rats with hypothyroidism faced significant challenges with memory tasks, such as recalling and recognizing objects and navigating mazes. Notably, their brain structure showed damage, including vacuolar degeneration and distorted brain cells.
Interestingly, the hypothyroid rats also had decreased levels of antioxidants, serotonin, and GABA in their brains, all of which are crucial for healthy mental functions. However, when we supplemented the hypothyroid rats with omega-3, we observed a remarkable reversal in their memory deficits. The omega-3-treated rats showed improved cognitive performance, increased antioxidant levels, and reduced brain damage, alongside a decrease in a particular protein associated with cellular stress.
Our findings suggest that omega-3 can serve as a protective agent against cognitive impairment linked to hypothyroidism. It points towards a potential therapeutic option for enhancing brain health in individuals facing this condition.
8
Fish oil benefits hypothyroid function
We set out to understand how fish oil, specifically eicosapentaenoic acid ethyl ester (EPA-E), might affect thyroid function in individuals with hypothyroidism. Previous observations noted that while plasma free fatty acid (FFA) levels are typically normal in people with hypothyroidism, some patients exhibited higher levels. Surprisingly, those with elevated FFA levels reported milder symptoms compared to those with lower concentrations.
To investigate this further, we utilized an animal model involving rats that had been induced with hypothyroidism using a substance known as 1-methyl-2-imidazolethiol (MMI). By orally administering EPA-E, we aimed to see if it could counteract the hormonal disruptions caused by the MMI treatment. Our findings revealed that EPA-E played a positive role in maintaining thyroid hormone levels and preserving the structure of thyroid follicles.
Overall, our study suggests that higher levels of FFAs might influence thyroid function positively, and that EPA-E could potentially help mitigate some of the adverse effects of hypothyroidism. These insights could pave the way for exploring fish oil as a beneficial treatment option for those affected by thyroid dysfunction.
To investigate this further, we utilized an animal model involving rats that had been induced with hypothyroidism using a substance known as 1-methyl-2-imidazolethiol (MMI). By orally administering EPA-E, we aimed to see if it could counteract the hormonal disruptions caused by the MMI treatment. Our findings revealed that EPA-E played a positive role in maintaining thyroid hormone levels and preserving the structure of thyroid follicles.
Overall, our study suggests that higher levels of FFAs might influence thyroid function positively, and that EPA-E could potentially help mitigate some of the adverse effects of hypothyroidism. These insights could pave the way for exploring fish oil as a beneficial treatment option for those affected by thyroid dysfunction.
4
Fish oil's thyroid interaction effects
We investigated the effects of fish oil, particularly its n-3 polyunsaturated fatty acids (n-3 PUFA), on lipid metabolism in the context of thyroid health. Our study involved comparing the results in euthyroid (normal thyroid function) and hypothyroid (reduced thyroid function) rats that were treated with fish oil or a control soybean oil.
In the euthyroid group, we observed that fish oil significantly lowered serum triglycerides and cholesterol levels, reduced body fat, and even increased the protein content of the animals. These positive changes were accompanied by higher levels of a thyroid hormone receptor called TRβ1 and enhanced mitochondrial enzyme mGPD in the liver.
However, the results were less impressive in the hypothyroid rats. While fish oil treatment still reduced cholesterol levels and increased body protein content, it failed to lower triglycerides or body fat, and did not boost TRβ1 or mGPD expression. Interestingly, hypothyroid conditions led to an increase in liver levels of a nuclear receptor known as PPARα, but this did not significantly change TRβ1 or TRα expressions.
Overall, our findings suggest that fish oil’s benefits on lipid metabolism could depend significantly on thyroid hormone signaling, indicating complex interactions between these fatty acids and thyroid hormones in liver metabolism. While there were some positive effects of fish oil in hypothyroidism, the potential benefits were not as robust compared to euthyroid conditions.
In the euthyroid group, we observed that fish oil significantly lowered serum triglycerides and cholesterol levels, reduced body fat, and even increased the protein content of the animals. These positive changes were accompanied by higher levels of a thyroid hormone receptor called TRβ1 and enhanced mitochondrial enzyme mGPD in the liver.
However, the results were less impressive in the hypothyroid rats. While fish oil treatment still reduced cholesterol levels and increased body protein content, it failed to lower triglycerides or body fat, and did not boost TRβ1 or mGPD expression. Interestingly, hypothyroid conditions led to an increase in liver levels of a nuclear receptor known as PPARα, but this did not significantly change TRβ1 or TRα expressions.
Overall, our findings suggest that fish oil’s benefits on lipid metabolism could depend significantly on thyroid hormone signaling, indicating complex interactions between these fatty acids and thyroid hormones in liver metabolism. While there were some positive effects of fish oil in hypothyroidism, the potential benefits were not as robust compared to euthyroid conditions.
7
In this study, we evaluated how fish oil affects cholesterol levels in rats with hypothyroidism and its relationship with thyroid hormone treatment. Methimazole was used to create a hypothyroid state in the rats, which were then fed different diets including low-fat chow, corn oil, or fish oil. We closely monitored changes in their serum, liver, and bile lipids before and after administering thyroid hormone.
Interestingly, we found that the fish oil diet only led to increased cholesterol secretion into bile after the rats received thyroid hormone treatment. This demonstrates a complementary effect between fish oil and thyroid hormone, suggesting that the presence of thyroid hormone is crucial for fish oil to exert its influence on cholesterol levels.
Furthermore, the rats on a fish oil diet showed lower serum cholesterol, aligning with the increase in cholesterol secretion into bile and a decrease in cholesterol content in the liver. However, despite these findings, we didn’t see a clear link between fatty acid composition in liver or bile phospholipids and the bile cholesterol secretion. A notable observation was that higher bile cholesterol secretion corresponded with a lower percentage of linoleic acid in the liver and bile.
Overall, our findings indicate that the effectiveness of fish oil in inducing changes in cholesterol metabolism in hypothyroid rats is significantly dependent on the presence of thyroid hormone.
Interestingly, we found that the fish oil diet only led to increased cholesterol secretion into bile after the rats received thyroid hormone treatment. This demonstrates a complementary effect between fish oil and thyroid hormone, suggesting that the presence of thyroid hormone is crucial for fish oil to exert its influence on cholesterol levels.
Furthermore, the rats on a fish oil diet showed lower serum cholesterol, aligning with the increase in cholesterol secretion into bile and a decrease in cholesterol content in the liver. However, despite these findings, we didn’t see a clear link between fatty acid composition in liver or bile phospholipids and the bile cholesterol secretion. A notable observation was that higher bile cholesterol secretion corresponded with a lower percentage of linoleic acid in the liver and bile.
Overall, our findings indicate that the effectiveness of fish oil in inducing changes in cholesterol metabolism in hypothyroid rats is significantly dependent on the presence of thyroid hormone.
References
- Odetayo AF, Olayaki LA. Omega 3 fatty acids preserve testicular function by ameliorating BPF-induced dysthyroidism: role of p53/Bcl-2 signaling and proton pump activities. JBRA Assist Reprod. 2024;28:471. doi:10.5935/1518-0557.20240033
- Abd Allah ES, Gomaa AM, Sayed MM. The effect of omega-3 on cognition in hypothyroid adult male rats. Acta Physiol Hung. 2014;101:362. doi:10.1556/APhysiol.101.2014.3.11
- Souza LL, Cordeiro A, Oliveira LS, de Paula GS, Faustino LC, et al. Thyroid hormone contributes to the hypolipidemic effect of polyunsaturated fatty acids from fish oil: in vivo evidence for cross talking mechanisms. J Endocrinol. 2011;211:65. doi:10.1530/JOE-11-0142
- Sinha RA, Khare P, Rai A, Maurya SK, Pathak A, et al. Anti-apoptotic role of omega-3-fatty acids in developing brain: perinatal hypothyroid rat cerebellum as apoptotic model. Int J Dev Neurosci. 2009;27:377. doi:10.1016/j.ijdevneu.2009.02.003
- Makino M, Oda N, Miura N, Imamura S, Yamamoto K, et al. Effect of eicosapentaenoic acid ethyl ester on hypothyroid function. J Endocrinol. 2001;171:259.
- Pehowich DJ. Thyroid hormone status and membrane n-3 fatty acid content influence mitochondrial proton leak. Biochim Biophys Acta. 1999;1411:192.
- Prigge WF, Gebhard RL. Oral acetylsalicylic acid induces biliary cholesterol secretion in the rat. Lipids. 1997;32:753.
- Prigge WF, Ketover SR, Gebhard RL. Thyroid hormone is required for dietary fish oil to induce hypersecretion of biliary cholesterol in the rat. Lipids. 1995;30:833.
- Simonides WS, van Hardeveld C. Effects of hypothyroidism on the distribution and fatty acyl composition of phospholipids in sarcoplasmic reticulum of fast skeletal muscle of the rat. Biochim Biophys Acta. 1987;924:204.
