Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.6
USERS' SCORE
Moderately Good
Based on 5 Reviews
7.3
Supplement Facts
Serving Size: 2 Softgels
Amount Per Serving
%DV
Calories
20
Total Fat
2 g
3%**
Saturated Fat
0.5 g
3%**
Polyunsaturated Fat
1 g
†
Monounsaturated Fat
0.5 g
†
Fish Oil Concentrate
2 g (2,000 mg)
†
Eicosapentaenoic Acid (EPA)
360 mg
†
Docosahexaenoic Acid (DHA)
240 mg
†
Top Medical Research Studies
9
Eicosapentaenoic acid aids pancreatic health
We investigated the effects of eicosapentaenoic acid (EPA) on pancreatic injury, particularly in the context of conditions that mimic pancreatitis. Our study began by creating a mouse model with a deficiency in n-3 polyunsaturated fatty acids (PUFAs) to evaluate how this lack impacts pancreatic function and injury.
The findings were quite striking. In the absence of n-3 PUFAs, the mice experienced significant pancreatic impairment, including reduced insulin levels and decreased health of pancreatic islets. However, when we introduced dietary EPA and DHA—both forms of n-3 PUFAs—prior to inflicting pancreatic damage, we observed remarkable protective effects. Specifically, the treatment with EPA led to notable increases in insulin production and improved overall islet function.
Additionally, our research highlighted that these protective effects of EPA may stem from its ability to modulate inflammation, oxidative stress, and apoptosis in pancreatic tissues. This suggests that dietary adjustments, especially increasing n-3 PUFAs like EPA, could be a beneficial strategy to support pancreatic health and combat injuries associated with conditions like pancreatitis.
The findings were quite striking. In the absence of n-3 PUFAs, the mice experienced significant pancreatic impairment, including reduced insulin levels and decreased health of pancreatic islets. However, when we introduced dietary EPA and DHA—both forms of n-3 PUFAs—prior to inflicting pancreatic damage, we observed remarkable protective effects. Specifically, the treatment with EPA led to notable increases in insulin production and improved overall islet function.
Additionally, our research highlighted that these protective effects of EPA may stem from its ability to modulate inflammation, oxidative stress, and apoptosis in pancreatic tissues. This suggests that dietary adjustments, especially increasing n-3 PUFAs like EPA, could be a beneficial strategy to support pancreatic health and combat injuries associated with conditions like pancreatitis.
Read More
9
We explored the impact of docosahexaenoic acid (DHA) found in algal oil on pancreatitis, specifically looking at how it influences the health of pancreatic acinar cells. The study involved rat pancreatic acinar AR42J cells, which were pretreated with varying concentrations of DHA before being exposed to sodium taurocholate (STC), a compound that induces pancreatitis.
Our findings revealed that when these cells were treated with DHA before STC exposure, they experienced significant benefits. We observed a notable reduction in the harmful effects associated with pancreatitis, such as excessive intracellular calcium levels, oxidative stress, and the activation of inflammatory markers like tumor necrosis factor-α and interleukin-6. These factors are typically elevated during pancreatitis and can lead to further cell damage.
Moreover, cells that received higher doses of DHA showed improved mitochondrial function and less oxidative damage. This was evidenced by a healthier mitochondrial membrane potential and lower levels of lipid peroxidation compared to untreated cells. Importantly, DHA also appeared to dampen the activation of NF-κB, a key player in the inflammation process.
In summary, our study suggests that DHA from algal oil can help protect pancreatic acinar cells from damage and may offer a promising avenue for treating pancreatitis by addressing both calcium overload and oxidative stress.
Our findings revealed that when these cells were treated with DHA before STC exposure, they experienced significant benefits. We observed a notable reduction in the harmful effects associated with pancreatitis, such as excessive intracellular calcium levels, oxidative stress, and the activation of inflammatory markers like tumor necrosis factor-α and interleukin-6. These factors are typically elevated during pancreatitis and can lead to further cell damage.
Moreover, cells that received higher doses of DHA showed improved mitochondrial function and less oxidative damage. This was evidenced by a healthier mitochondrial membrane potential and lower levels of lipid peroxidation compared to untreated cells. Importantly, DHA also appeared to dampen the activation of NF-κB, a key player in the inflammation process.
In summary, our study suggests that DHA from algal oil can help protect pancreatic acinar cells from damage and may offer a promising avenue for treating pancreatitis by addressing both calcium overload and oxidative stress.
Read More
9
We explored how docosahexaenoic acid (DHA) can influence inflammation in pancreatic stellate cells (PSCs), which are key players in the progression of chronic pancreatitis. The study specifically looked at whether DHA could help suppress the expression of certain cytokines activated by inflammatory signals, such as TNF-α and viral mimic polyinosinic-polycytidylic acid (poly (I:C)).
By pre-treating PSCs with either DHA or an antioxidant called N-acetylcysteine (NAC), we observed significant changes when the cells were stimulated with TNF-α or poly (I:C). Notably, we saw that DHA treatment reduced the production of molecules related to inflammation, such as monocyte chemoattractant protein 1 (MCP-1) and chemokine C-X3-C motif ligand 1 (CX3CL1).
Additionally, DHA helped lower levels of reactive oxygen species (ROS)—chemicals that can cause cell damage and are often increased during inflammation. This reduction in ROS levels led to a decline in the activation of NF-κB, a protein that further drives inflammatory processes. Essentially, DHA acted as a protective barrier, helping to maintain mitochondrial stability and lessening the impact of inflammatory cytokines.
The findings suggest that consuming DHA-rich foods could be an effective strategy for potentially preventing or alleviating the effects of chronic pancreatitis by dampening inflammatory responses in PSCs.
By pre-treating PSCs with either DHA or an antioxidant called N-acetylcysteine (NAC), we observed significant changes when the cells were stimulated with TNF-α or poly (I:C). Notably, we saw that DHA treatment reduced the production of molecules related to inflammation, such as monocyte chemoattractant protein 1 (MCP-1) and chemokine C-X3-C motif ligand 1 (CX3CL1).
Additionally, DHA helped lower levels of reactive oxygen species (ROS)—chemicals that can cause cell damage and are often increased during inflammation. This reduction in ROS levels led to a decline in the activation of NF-κB, a protein that further drives inflammatory processes. Essentially, DHA acted as a protective barrier, helping to maintain mitochondrial stability and lessening the impact of inflammatory cytokines.
The findings suggest that consuming DHA-rich foods could be an effective strategy for potentially preventing or alleviating the effects of chronic pancreatitis by dampening inflammatory responses in PSCs.
Read More
Most Useful Reviews
9
No exacerbations
Good omega, but should be taken with caution in pancreatitis. I took 1 capsule after meals and had no issues or exacerbations.
Read More
9
Weight loss
I’ve finished two cans and regret not starting sooner. With chronic pancreatitis, I can’t eat much fish, but this has helped me become more stress-resistant and shed about 4 kg. I will continue to order it and recommend it.
Read More
4
Improved condition
Good Omega-3! I trust this brand and have taken it several times. There’s no fish smell or taste. My son takes two capsules twice daily as advised by an endocrinologist and has seen improvements. I had some discomfort, but overall it was beneficial for him.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.6
- All Researches
9
Eicosapentaenoic acid aids pancreatic health
We investigated the effects of eicosapentaenoic acid (EPA) on pancreatic injury, particularly in the context of conditions that mimic pancreatitis. Our study began by creating a mouse model with a deficiency in n-3 polyunsaturated fatty acids (PUFAs) to evaluate how this lack impacts pancreatic function and injury.
The findings were quite striking. In the absence of n-3 PUFAs, the mice experienced significant pancreatic impairment, including reduced insulin levels and decreased health of pancreatic islets. However, when we introduced dietary EPA and DHA—both forms of n-3 PUFAs—prior to inflicting pancreatic damage, we observed remarkable protective effects. Specifically, the treatment with EPA led to notable increases in insulin production and improved overall islet function.
Additionally, our research highlighted that these protective effects of EPA may stem from its ability to modulate inflammation, oxidative stress, and apoptosis in pancreatic tissues. This suggests that dietary adjustments, especially increasing n-3 PUFAs like EPA, could be a beneficial strategy to support pancreatic health and combat injuries associated with conditions like pancreatitis.
The findings were quite striking. In the absence of n-3 PUFAs, the mice experienced significant pancreatic impairment, including reduced insulin levels and decreased health of pancreatic islets. However, when we introduced dietary EPA and DHA—both forms of n-3 PUFAs—prior to inflicting pancreatic damage, we observed remarkable protective effects. Specifically, the treatment with EPA led to notable increases in insulin production and improved overall islet function.
Additionally, our research highlighted that these protective effects of EPA may stem from its ability to modulate inflammation, oxidative stress, and apoptosis in pancreatic tissues. This suggests that dietary adjustments, especially increasing n-3 PUFAs like EPA, could be a beneficial strategy to support pancreatic health and combat injuries associated with conditions like pancreatitis.
Read More
9
We explored the impact of docosahexaenoic acid (DHA) found in algal oil on pancreatitis, specifically looking at how it influences the health of pancreatic acinar cells. The study involved rat pancreatic acinar AR42J cells, which were pretreated with varying concentrations of DHA before being exposed to sodium taurocholate (STC), a compound that induces pancreatitis.
Our findings revealed that when these cells were treated with DHA before STC exposure, they experienced significant benefits. We observed a notable reduction in the harmful effects associated with pancreatitis, such as excessive intracellular calcium levels, oxidative stress, and the activation of inflammatory markers like tumor necrosis factor-α and interleukin-6. These factors are typically elevated during pancreatitis and can lead to further cell damage.
Moreover, cells that received higher doses of DHA showed improved mitochondrial function and less oxidative damage. This was evidenced by a healthier mitochondrial membrane potential and lower levels of lipid peroxidation compared to untreated cells. Importantly, DHA also appeared to dampen the activation of NF-κB, a key player in the inflammation process.
In summary, our study suggests that DHA from algal oil can help protect pancreatic acinar cells from damage and may offer a promising avenue for treating pancreatitis by addressing both calcium overload and oxidative stress.
Our findings revealed that when these cells were treated with DHA before STC exposure, they experienced significant benefits. We observed a notable reduction in the harmful effects associated with pancreatitis, such as excessive intracellular calcium levels, oxidative stress, and the activation of inflammatory markers like tumor necrosis factor-α and interleukin-6. These factors are typically elevated during pancreatitis and can lead to further cell damage.
Moreover, cells that received higher doses of DHA showed improved mitochondrial function and less oxidative damage. This was evidenced by a healthier mitochondrial membrane potential and lower levels of lipid peroxidation compared to untreated cells. Importantly, DHA also appeared to dampen the activation of NF-κB, a key player in the inflammation process.
In summary, our study suggests that DHA from algal oil can help protect pancreatic acinar cells from damage and may offer a promising avenue for treating pancreatitis by addressing both calcium overload and oxidative stress.
Read More
9
We explored how docosahexaenoic acid (DHA) can influence inflammation in pancreatic stellate cells (PSCs), which are key players in the progression of chronic pancreatitis. The study specifically looked at whether DHA could help suppress the expression of certain cytokines activated by inflammatory signals, such as TNF-α and viral mimic polyinosinic-polycytidylic acid (poly (I:C)).
By pre-treating PSCs with either DHA or an antioxidant called N-acetylcysteine (NAC), we observed significant changes when the cells were stimulated with TNF-α or poly (I:C). Notably, we saw that DHA treatment reduced the production of molecules related to inflammation, such as monocyte chemoattractant protein 1 (MCP-1) and chemokine C-X3-C motif ligand 1 (CX3CL1).
Additionally, DHA helped lower levels of reactive oxygen species (ROS)—chemicals that can cause cell damage and are often increased during inflammation. This reduction in ROS levels led to a decline in the activation of NF-κB, a protein that further drives inflammatory processes. Essentially, DHA acted as a protective barrier, helping to maintain mitochondrial stability and lessening the impact of inflammatory cytokines.
The findings suggest that consuming DHA-rich foods could be an effective strategy for potentially preventing or alleviating the effects of chronic pancreatitis by dampening inflammatory responses in PSCs.
By pre-treating PSCs with either DHA or an antioxidant called N-acetylcysteine (NAC), we observed significant changes when the cells were stimulated with TNF-α or poly (I:C). Notably, we saw that DHA treatment reduced the production of molecules related to inflammation, such as monocyte chemoattractant protein 1 (MCP-1) and chemokine C-X3-C motif ligand 1 (CX3CL1).
Additionally, DHA helped lower levels of reactive oxygen species (ROS)—chemicals that can cause cell damage and are often increased during inflammation. This reduction in ROS levels led to a decline in the activation of NF-κB, a protein that further drives inflammatory processes. Essentially, DHA acted as a protective barrier, helping to maintain mitochondrial stability and lessening the impact of inflammatory cytokines.
The findings suggest that consuming DHA-rich foods could be an effective strategy for potentially preventing or alleviating the effects of chronic pancreatitis by dampening inflammatory responses in PSCs.
Read More
9
We investigated how protectin D1, a compound derived from docosahexaenoic acid (DHA), affects pancreatitis, a condition marked by inflammation in the pancreas. Our research utilized three different models of acute pancreatitis in male mice, where we introduced the inflammatory condition using caerulein, L-arginine, and pancreatic duct ligation.
Through these models, we discovered that treatement with protectin D1 helped decrease the severity of the condition. Specifically, we observed reduced levels of key enzymes in the blood that are indicators of pancreatic damage, alongside lower concentrations of inflammatory cytokines. Moreover, protectin D1 appeared to protect the pancreas from structural damage, potentially extending survival in more severe cases.
Notably, we found that the treatment decreased the early infiltration of harmful neutrophils and the formation of neutrophil extracellular traps, which usually exacerbate inflammation. Furthermore, in laboratory settings, protectin D1 reduced markers associated with neutrophil activity. However, when we used a specific inhibitor to block the cells' activation, the protective benefits of protectin D1 were diminished, indicating its effectiveness may rely on a specific immune response.
Our findings suggest that protectin D1 from DHA could play an important role in managing acute pancreatitis, providing a potential therapeutic avenue to explore further.
Through these models, we discovered that treatement with protectin D1 helped decrease the severity of the condition. Specifically, we observed reduced levels of key enzymes in the blood that are indicators of pancreatic damage, alongside lower concentrations of inflammatory cytokines. Moreover, protectin D1 appeared to protect the pancreas from structural damage, potentially extending survival in more severe cases.
Notably, we found that the treatment decreased the early infiltration of harmful neutrophils and the formation of neutrophil extracellular traps, which usually exacerbate inflammation. Furthermore, in laboratory settings, protectin D1 reduced markers associated with neutrophil activity. However, when we used a specific inhibitor to block the cells' activation, the protective benefits of protectin D1 were diminished, indicating its effectiveness may rely on a specific immune response.
Our findings suggest that protectin D1 from DHA could play an important role in managing acute pancreatitis, providing a potential therapeutic avenue to explore further.
Read More
8
Eicosapentaenoic acid and pancreatitis
We observed that hypertriglyceridemia, a condition characterized by high triglyceride levels, can lead to serious health issues such as cardiovascular disease and pancreatitis. One of the treatments explored for lowering triglyceride levels is eicosapentaenoic acid (EPA), which is a type of omega-3 fatty acid.
A significant study showed that daily doses of 4 grams of EPA can effectively lower triglyceride levels in high-risk patients, potentially decreasing their chances of pancreatitis. However, though there is evidence of its effectiveness for triglyceride reduction, the research did not specifically isolate its direct impact on pancreatitis. Hence, while we recognize its role in managing triglycerides, the direct benefit of EPA on preventing or treating pancreatitis remains unclear.
Overall, lifestyle changes such as diet modification, weight management, and blood sugar control are crucial for addressing hypertriglyceridemia, and these should be the primary focus before considering specific drug treatments like EPA.
A significant study showed that daily doses of 4 grams of EPA can effectively lower triglyceride levels in high-risk patients, potentially decreasing their chances of pancreatitis. However, though there is evidence of its effectiveness for triglyceride reduction, the research did not specifically isolate its direct impact on pancreatitis. Hence, while we recognize its role in managing triglycerides, the direct benefit of EPA on preventing or treating pancreatitis remains unclear.
Overall, lifestyle changes such as diet modification, weight management, and blood sugar control are crucial for addressing hypertriglyceridemia, and these should be the primary focus before considering specific drug treatments like EPA.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 5 Reviews
7.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
No exacerbations
Good omega, but should be taken with caution in pancreatitis. I took 1 capsule after meals and had no issues or exacerbations.
Read More
9
Weight loss
I’ve finished two cans and regret not starting sooner. With chronic pancreatitis, I can’t eat much fish, but this has helped me become more stress-resistant and shed about 4 kg. I will continue to order it and recommend it.
Read More
4
Improved condition
Good Omega-3! I trust this brand and have taken it several times. There’s no fish smell or taste. My son takes two capsules twice daily as advised by an endocrinologist and has seen improvements. I had some discomfort, but overall it was beneficial for him.
Read More
4
No exacerbation
I’ve taken this omega before and like it. I consume it with food twice daily. My chronic gastritis hasn't worsened. However, those with gastrointestinal issues should consult their doctor before trying, as fish oil can exacerbate pancreatitis and gastritis.
Read More
0
Care needed
1 people found this helpful
After having two children, I felt weak, and my hair fell out. I tried omega, but it made me feel nauseous, particularly in the morning. It aggravated my pancreatitis, so I plan to continue but with caution—perhaps just one capsule a day.
Read More
Frequently Asked Questions
9
Weight loss
I’ve finished two cans and regret not starting sooner. With chronic pancreatitis, I can’t eat much fish, but this has helped me become more stress-resistant and shed about 4 kg. I will continue to order it and recommend it.
0
Care needed
1 people found this helpful
After having two children, I felt weak, and my hair fell out. I tried omega, but it made me feel nauseous, particularly in the morning. It aggravated my pancreatitis, so I plan to continue but with caution—perhaps just one capsule a day.
4
No exacerbation
I’ve taken this omega before and like it. I consume it with food twice daily. My chronic gastritis hasn't worsened. However, those with gastrointestinal issues should consult their doctor before trying, as fish oil can exacerbate pancreatitis and gastritis.
9
No exacerbations
Good omega, but should be taken with caution in pancreatitis. I took 1 capsule after meals and had no issues or exacerbations.
4
Improved condition
Good Omega-3! I trust this brand and have taken it several times. There’s no fish smell or taste. My son takes two capsules twice daily as advised by an endocrinologist and has seen improvements. I had some discomfort, but overall it was beneficial for him.
9
Eicosapentaenoic acid aids pancreatic health
We investigated the effects of eicosapentaenoic acid (EPA) on pancreatic injury, particularly in the context of conditions that mimic pancreatitis. Our study began by creating a mouse model with a deficiency in n-3 polyunsaturated fatty acids (PUFAs) to evaluate how this lack impacts pancreatic function and injury.
The findings were quite striking. In the absence of n-3 PUFAs, the mice experienced significant pancreatic impairment, including reduced insulin levels and decreased health of pancreatic islets. However, when we introduced dietary EPA and DHA—both forms of n-3 PUFAs—prior to inflicting pancreatic damage, we observed remarkable protective effects. Specifically, the treatment with EPA led to notable increases in insulin production and improved overall islet function.
Additionally, our research highlighted that these protective effects of EPA may stem from its ability to modulate inflammation, oxidative stress, and apoptosis in pancreatic tissues. This suggests that dietary adjustments, especially increasing n-3 PUFAs like EPA, could be a beneficial strategy to support pancreatic health and combat injuries associated with conditions like pancreatitis.
The findings were quite striking. In the absence of n-3 PUFAs, the mice experienced significant pancreatic impairment, including reduced insulin levels and decreased health of pancreatic islets. However, when we introduced dietary EPA and DHA—both forms of n-3 PUFAs—prior to inflicting pancreatic damage, we observed remarkable protective effects. Specifically, the treatment with EPA led to notable increases in insulin production and improved overall islet function.
Additionally, our research highlighted that these protective effects of EPA may stem from its ability to modulate inflammation, oxidative stress, and apoptosis in pancreatic tissues. This suggests that dietary adjustments, especially increasing n-3 PUFAs like EPA, could be a beneficial strategy to support pancreatic health and combat injuries associated with conditions like pancreatitis.
4
Assessing EPA's effectiveness in pancreatitis
We explored the impact of eicosapentaenoic acid (EPA) as part of a treatment regimen for a patient experiencing hypertriglyceridemia-induced acute pancreatitis during pregnancy. In this case, we learned that although EPA was included in the treatment alongside other medications, the isolated effect of this fatty acid on the patient's condition remains unclear due to its combination with multiple therapies.
The patient, a 28-year-old woman at 29 weeks of gestation, faced severe abdominal pain and was diagnosed with acute pancreatitis. Throughout the management, which included insulin and bowel rest, eicosapentaenoic acid was one of several treatments aimed at lowering triglyceride levels.
While EPA is known for potential benefits in managing triglyceride levels, the complexity of the treatment makes it challenging to determine its direct effectiveness in this patient's pancreatitis. Given the serious risks associated with this condition during pregnancy, each treatment's contribution to overall recovery is crucial; however, we cannot definitively conclude that EPA alone provided significant benefits.
This case highlights the complexities involved in treating pancreatitis, especially in pregnant patients, and the need for more focused studies to evaluate the specific roles of individual therapies like eicosapentaenoic acid.
The patient, a 28-year-old woman at 29 weeks of gestation, faced severe abdominal pain and was diagnosed with acute pancreatitis. Throughout the management, which included insulin and bowel rest, eicosapentaenoic acid was one of several treatments aimed at lowering triglyceride levels.
While EPA is known for potential benefits in managing triglyceride levels, the complexity of the treatment makes it challenging to determine its direct effectiveness in this patient's pancreatitis. Given the serious risks associated with this condition during pregnancy, each treatment's contribution to overall recovery is crucial; however, we cannot definitively conclude that EPA alone provided significant benefits.
This case highlights the complexities involved in treating pancreatitis, especially in pregnant patients, and the need for more focused studies to evaluate the specific roles of individual therapies like eicosapentaenoic acid.
8
Eicosapentaenoic acid and pancreatitis
We observed that hypertriglyceridemia, a condition characterized by high triglyceride levels, can lead to serious health issues such as cardiovascular disease and pancreatitis. One of the treatments explored for lowering triglyceride levels is eicosapentaenoic acid (EPA), which is a type of omega-3 fatty acid.
A significant study showed that daily doses of 4 grams of EPA can effectively lower triglyceride levels in high-risk patients, potentially decreasing their chances of pancreatitis. However, though there is evidence of its effectiveness for triglyceride reduction, the research did not specifically isolate its direct impact on pancreatitis. Hence, while we recognize its role in managing triglycerides, the direct benefit of EPA on preventing or treating pancreatitis remains unclear.
Overall, lifestyle changes such as diet modification, weight management, and blood sugar control are crucial for addressing hypertriglyceridemia, and these should be the primary focus before considering specific drug treatments like EPA.
A significant study showed that daily doses of 4 grams of EPA can effectively lower triglyceride levels in high-risk patients, potentially decreasing their chances of pancreatitis. However, though there is evidence of its effectiveness for triglyceride reduction, the research did not specifically isolate its direct impact on pancreatitis. Hence, while we recognize its role in managing triglycerides, the direct benefit of EPA on preventing or treating pancreatitis remains unclear.
Overall, lifestyle changes such as diet modification, weight management, and blood sugar control are crucial for addressing hypertriglyceridemia, and these should be the primary focus before considering specific drug treatments like EPA.
5
Studying omega-3 fatty acids' effects
We conducted an exploratory study to understand how eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, impacts individuals with a history of acute pancreatitis caused by severe hypertriglyceridemia. In this study, 15 participants were randomly assigned to take either omega-3 carboxylic acids (OM3-CA) or omega-3 ethyl esters (OM3-EE) for four weeks, all while following a low-fat diet.
During the study, we measured the levels of EPA and docosahexaenoic acid (DHA) in the participants' blood after taking a dose with a low-fat meal. We found that there was a greater 24-hour exposure of OM3-CA compared to OM3-EE. However, despite this initial observation, the long-term effects showed that both treatments led to similar increases in fasting plasma levels of EPA and DHA, and the overall differences were not statistically significant.
This suggests that while we saw some benefits of OM3-CA in terms of short-term exposure, these did not translate into a meaningful advantage over time. Therefore, we cannot conclusively say that eicosapentaenoic acid offers significant benefits for preventing pancreatitis in patients with a history of high triglycerides.
During the study, we measured the levels of EPA and docosahexaenoic acid (DHA) in the participants' blood after taking a dose with a low-fat meal. We found that there was a greater 24-hour exposure of OM3-CA compared to OM3-EE. However, despite this initial observation, the long-term effects showed that both treatments led to similar increases in fasting plasma levels of EPA and DHA, and the overall differences were not statistically significant.
This suggests that while we saw some benefits of OM3-CA in terms of short-term exposure, these did not translate into a meaningful advantage over time. Therefore, we cannot conclusively say that eicosapentaenoic acid offers significant benefits for preventing pancreatitis in patients with a history of high triglycerides.
References
- Zou HY, Zhang HJ, Zhao YC, Li XY, Wang YM, et al. N-3 PUFA Deficiency Aggravates Streptozotocin-Induced Pancreatic Injury in Mice but Dietary Supplementation with DHA/EPA Protects the Pancreas via Suppressing Inflammation, Oxidative Stress and Apoptosis. Mar Drugs. 2023;21. doi:10.3390/md21010039
- Keller D, Hardin EM, Nagula SV, Royek A. Hypertriglyceridemia-Induced Acute Pancreatitis During Pregnancy: A Case Report. Cureus. 2022;14:e28273. doi:10.7759/cureus.28273
- Dunbar RL, Gaudet D, Davidson M, Rensfeldt M, Yang H, et al. Omega-3 fatty acid exposure with a low-fat diet in patients with past hypertriglyceridemia-induced acute pancreatitis; an exploratory, randomized, open-label crossover study. Lipids Health Dis. 2020;19:117. doi:10.1186/s12944-020-01295-7
- Parhofer KG, Laufs U. The Diagnosis and Treatment of Hypertriglyceridemia. Dtsch Arztebl Int. 2019;116:825. doi:10.3238/arztebl.2019.0825
- Fang Y, Lin SY, Chen CH, Lo HC. Algal Oil Mitigates Sodium Taurocholate-Induced Pancreatitis by Alleviating Calcium Overload, Oxidative Stress, and NF-κB Activation in Pancreatic Acinar Cells. Curr Issues Mol Biol. 2024;46:4403. doi:10.3390/cimb46050267
- Chung SA, Lim JW, Kim H. Docosahexaenoic Acid Inhibits Cytokine Expression by Reducing Reactive Oxygen Species in Pancreatic Stellate Cells. J Cancer Prev. 2021;26:195. doi:10.15430/JCP.2021.26.3.195
- Wu Z, Lu G, Zhang L, Ke L, Yuan C, et al. Protectin D1 decreases pancreatitis severity in mice by inhibiting neutrophil extracellular trap formation. Int Immunopharmacol. 2021;94:107486. doi:10.1016/j.intimp.2021.107486
