Overview

SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8.5
USERS' SCORE
Medium or Average
Based on 5 Reviews
6.8
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Oregano Oil (Origanum vulgare) min. 55% Carvacrol)
0.2 ml / 181 mg
**
Ginger Oil (Zingiber officinale)
0.02 ml / 17.6 mg
**
Fennel Oil (Foeniculum vulgare)
0.02 ml / 19.3 mg
**

Top Medical Research Studies

9
Marjoram shows promise against ulcers
Our study focused on understanding the effects of marjoram, scientifically known as Origanum majorana, in treating ulcers. We assessed its antiulcerogenic activity using various models of gastric mucosal injury in rats, including stress-induced and chemically induced ulcers.

We discovered that administering the ethanol extract of marjoram at doses of 250 and 500 mg/kg significantly reduced the incidence of ulcers, as well as the overall gastric acid secretion. Interestingly, the marjoram extract not only aided in healing but also replenished the gastric wall mucus and nonprotein sulfhydryls, which were depleted due to ethanol exposure.

Additionally, we noted a decrease in malondialdehyde levels, a marker of lipid damage, highlighting the protective effects of marjoram. These findings were further confirmed by histopathological evaluations, supporting marjoram's role as a potential natural remedy for ulcers. Importantly, an acute toxicity assessment indicated a favorable safety profile for this extract in mice.
Read More
We explored the effects of carvacrol, a compound found in oregano oil, on inflammation and ulcers in scientific studies. The research analyzed how carvacrol performed against various agents that induce swelling and gastric ulcers. In these experiments, carvacrol showed promising results in reducing swelling, particularly in models triggered by substances like dextran and histamine.

Carvacrol was especially effective at higher doses, significantly decreasing swelling and ear edema caused by two different irritants. When it came to ulcers, we observed remarkable healing effects, with carvacrol showing up to 91% effectiveness at specific dosages after 14 days of treatment. This suggests that carvacrol may help tackle the issues with gastric lesions that many people experience.

Overall, the findings indicate that carvacrol has the potential to positively influence the healing of ulcers, likely by affecting inflammatory responses in the body. This makes carvacrol, and by extension oregano, an exciting area for further exploration concerning natural treatments for gastric issues.
Read More
9
Oregano oil shows ulcer healing
We explored how Origanum onites, commonly known as oregano, may help treat ulceration caused by colitis in an experiment using rats. In the study, we tested two different methods of applying oregano essential oil: intra-rectally and intra-peritoneally. This provided us with a clear picture of how effective oregano oil can be compared to a traditional treatment, dexamethasone.

Our results showed that oregano oil significantly improved several markers of colonic injury, such as ulceration and inflammation, especially at a higher dosage. For instance, when we applied 1 mg/kg of oregano oil rectally, we noted major improvements in ulceration and reduced inflammatory cell infiltration compared to the control group that received no treatment.

Interestingly, while dexamethasone has been a standard treatment for this condition, it did not show a significant benefit over the control group in our analysis. This emphasizes the potential of oregano oil as a promising alternative treatment option for colitis-related ulcers, allowing us to think about natural remedies alongside conventional medicines.

Overall, our findings suggest that both intra-rectal and intra-peritoneal applications of oregano essential oil can offer significant protective effects against colonic injuries related to ulceration and inflammation. This study opens the door for further exploration into the practical use of oregano oil in similar health issues.
Read More

Most Useful Reviews

9
Good nutritional supplement
The high-quality oregano capsules are beneficial for treating stomach ailments and ulcers, making them an excellent nutritional supplement.
Read More
0
Painful reaction; improved.
23 people found this helpful
Upon reading lower review stars, I wanted to share my experience. I had tremendous stabbing gastro-intestinal pain despite taking it with food when I bought the Now Oregano Oil supplement in 2014. After taking it a few times, I realised I may have had an ulcer. I am now taking it again and have not experienced the same response. I've added Glutamine, fats, and probiotics to my diet, which I believe have helped alleviate the pain. I'm thankful for the improvement.
Read More
6
Non-antibiotic treatment.
19 people found this helpful
I have had stomach issues (ulcers, poor digestion) for several years. Despite trying various remedies, nothing was fully successful until now. I started taking these along with black cumin seed oil and can now confidently ask for "another serving please." Even though my doctors hesitate to diagnose SIBO, these are known to provide effective non-antibiotic treatment for me.
Read More

Medical Researches

SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8.5
  • All Researches
9.5
Oregano oil enhances diabetic wound healing
We investigated the effectiveness of a special gel, enriched with oregano essential oil, in promoting healing for diabetic foot ulcers. This healing patch was designed using natural polymers such as chitosan and gelatin, combined with a unique nanoemulsion technique to enhance the properties of oregano oil.

To gauge its effectiveness, we assessed the physical properties of the gel and its ability to support cell growth and migration. Our findings revealed that when combined with low-level laser therapy, this duo improved wound healing significantly, achieving up to 100% closure within 48 hours in cell studies.

More impressively, tests on diabetic rats with foot ulcers showed that this combined approach resulted in a 97.5% healing rate, minimal scarring, and faster recovery compared to treatments using only one method. The oregano oil nanoemulsion within the gel played a key role in enhancing healing, demonstrating promising results for managing diabetic ulcers effectively.

Overall, our study suggests that integrating oregano essential oil with advanced therapeutic techniques can be a beneficial strategy for diabetic wound care.
Read More
We explored the effects of carvacrol, a compound found in oregano oil, on inflammation and ulcers in scientific studies. The research analyzed how carvacrol performed against various agents that induce swelling and gastric ulcers. In these experiments, carvacrol showed promising results in reducing swelling, particularly in models triggered by substances like dextran and histamine.

Carvacrol was especially effective at higher doses, significantly decreasing swelling and ear edema caused by two different irritants. When it came to ulcers, we observed remarkable healing effects, with carvacrol showing up to 91% effectiveness at specific dosages after 14 days of treatment. This suggests that carvacrol may help tackle the issues with gastric lesions that many people experience.

Overall, the findings indicate that carvacrol has the potential to positively influence the healing of ulcers, likely by affecting inflammatory responses in the body. This makes carvacrol, and by extension oregano, an exciting area for further exploration concerning natural treatments for gastric issues.
Read More
We investigated the potential of oregano extract in helping heal pressure ulcers by integrating it with collagen hydrogel. In our study, we used 44 mice, dividing them into four distinct groups. These included a control group with no treatment, one group receiving plain collagen hydrogel, and two groups receiving collagen hydrogel with either 1% green propolis extract or 1% oregano extract.

Pressure ulcers were induced on the mice’s backs, and then we evaluated the healing process over a period of 14 days. During this time, we measured various factors such as the area of the wounds, their contraction, and re-epithelialization, as well as the density of dermal collagen and levels of reactive oxygen species and nitrite.

The results were promising and indicated that both oregano and propolis extracts significantly boosted the healing of these ulcers, with oregano being particularly effective in promoting wound contraction. Importantly, these treatments not only helped with the physical aspects of healing, but also led to improvements in skin layer organization and reduction of harmful substances.

Overall, we found that incorporating oregano extract into collagen hydrogels holds significant therapeutic promise for treating pressure ulcers.
Read More
9
Oregano benefits gut health
We examined how Herba Origani, derived from the oregano plant, can help with ulcerative colitis, a type of gut inflammation. By focusing on its effects on mice with colitis induced by dextran sodium sulfate (DSS), we observed several key benefits from oregano treatment.

The results indicated that oregano helped reduce inflammation and damage in the colon while also enhancing the functioning of the intestinal barrier. Additionally, we found that oregano worked to restore the balance of the gut microbiota, increasing the diversity and abundance of beneficial bacteria. This is crucial for maintaining a healthy gut environment.

Importantly, oregano treatment also appeared to influence the metabolism of bile acids and short-chain fatty acids, which are essential for gut health. By regulating these metabolic processes, oregano may promote better immune function within the intestines.

Overall, our findings suggest that oregano could be a valuable ally in addressing inflammatory gut issues. However, it's important to note that this study primarily focused on the broader condition of ulcerative colitis rather than ulcers alone.
Read More
9
Marjoram shows promise against ulcers
Our study focused on understanding the effects of marjoram, scientifically known as Origanum majorana, in treating ulcers. We assessed its antiulcerogenic activity using various models of gastric mucosal injury in rats, including stress-induced and chemically induced ulcers.

We discovered that administering the ethanol extract of marjoram at doses of 250 and 500 mg/kg significantly reduced the incidence of ulcers, as well as the overall gastric acid secretion. Interestingly, the marjoram extract not only aided in healing but also replenished the gastric wall mucus and nonprotein sulfhydryls, which were depleted due to ethanol exposure.

Additionally, we noted a decrease in malondialdehyde levels, a marker of lipid damage, highlighting the protective effects of marjoram. These findings were further confirmed by histopathological evaluations, supporting marjoram's role as a potential natural remedy for ulcers. Importantly, an acute toxicity assessment indicated a favorable safety profile for this extract in mice.
Read More

User Reviews

USERS' SCORE
Medium or Average
Based on 5 Reviews
6.8
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Good nutritional supplement
The high-quality oregano capsules are beneficial for treating stomach ailments and ulcers, making them an excellent nutritional supplement.
Read More
0
Painful reaction; improved.
23 people found this helpful
Upon reading lower review stars, I wanted to share my experience. I had tremendous stabbing gastro-intestinal pain despite taking it with food when I bought the Now Oregano Oil supplement in 2014. After taking it a few times, I realised I may have had an ulcer. I am now taking it again and have not experienced the same response. I've added Glutamine, fats, and probiotics to my diet, which I believe have helped alleviate the pain. I'm thankful for the improvement.
Read More
6
Non-antibiotic treatment.
19 people found this helpful
I have had stomach issues (ulcers, poor digestion) for several years. Despite trying various remedies, nothing was fully successful until now. I started taking these along with black cumin seed oil and can now confidently ask for "another serving please." Even though my doctors hesitate to diagnose SIBO, these are known to provide effective non-antibiotic treatment for me.
Read More
7.5
Helps with inflammation
1 people found this helpful
If you have a compromised immune system, such as from mouth ulcers, I recommend taking it. The inflammation subsides remarkably.
Read More
0
Not for ulcer issues
1 people found this helpful
I experienced significant burning in my upper stomach after taking this for three days. The pain escalated at night, prompting me to search for other supplements for possible culprits. It appears the oregano oil was the issue, as other users reported similar reactions. This product might be more suitable for someone without ulcer issues, but it isn't right for me. Oregano oil has benefits, but this was my experience with it.
Read More

Frequently Asked Questions

7.5
Helps with inflammation
1 people found this helpful
If you have a compromised immune system, such as from mouth ulcers, I recommend taking it. The inflammation subsides remarkably.
0
Not for ulcer issues
1 people found this helpful
I experienced significant burning in my upper stomach after taking this for three days. The pain escalated at night, prompting me to search for other supplements for possible culprits. It appears the oregano oil was the issue, as other users reported similar reactions. This product might be more suitable for someone without ulcer issues, but it isn't right for me. Oregano oil has benefits, but this was my experience with it.
9
Good nutritional supplement
The high-quality oregano capsules are beneficial for treating stomach ailments and ulcers, making them an excellent nutritional supplement.
8
Oregano extract alleviates ulcerative colitis
We explored the potential of oregano, specifically Origanum majorana L., for addressing ulcerative colitis, a painful inflammatory condition of the colon. Our study involved 32 male rats divided into groups that received either the oregano extract, a medication known as sulfasalazine, or a control treatment.

Through our research, we identified 15 different components in the oregano extracts using gas chromatography/mass spectrometry. These components played critical roles in improving the health of the rats with induced ulcerative colitis. We observed that both oregano extract and sulfasalazine significantly improved the rats’ overall health and reduced the signs of inflammation in their colons.

One of the remarkable findings was how oregano extract and sulfasalazine reduced oxidative stress in the colon, leading to lower levels of harmful substances while boosting the body's antioxidant defenses. Furthermore, these treatments appeared to calm down inflammatory pathways in the colon, which is essential for managing ulcerative colitis effectively. Importantly, we noticed a reduction in some markers associated with inflammatory responses, including Th17 cells, which are known to exacerbate conditions like colitis.

Overall, our work suggests that oregano may have protective qualities that could help manage ulcerative colitis. The antioxidant and anti-inflammatory properties of oregano extract could pave the way for further research into its therapeutic potential.
8
Oregano honey's therapeutic potential
We examined the potential benefits of oregano honey on bacteria associated with gastric ulcers and gastritis. In our study, we tested 14 strains of bacteria—six isolated from gastric ulcer patients and eight from those with clinical gastritis. We used different concentrations of oregano honey, employing the agar well method to observe inhibition zones around each well.

The results revealed that while the bacteria from gastric ulcers had a wide range of resistance (inhibition zones from 0 to 34 mm), the strains from gastritis cases showed more susceptibility, with inhibition zones reaching up to 58 mm. Initially, we noticed that the bacteria from ulcers tended to resist treatment more than their gastritis counterparts, similar to their response to standard antibiotics.

We prepared extracts from the honey using various organic solvents and discovered that hexane and chloroform extracts exhibited the strongest antibacterial effects. Additionally, both pure oregano honey and its diethyl ether extracts effectively inhibited urease production by the bacteria. Overall, we found that oregano honey appears to possess multiple modes of action against the ulcer-related bacteria, supporting its traditional use in folk medicine for treating gastric issues.
We explored the effects of carvacrol, a compound found in oregano oil, on inflammation and ulcers in scientific studies. The research analyzed how carvacrol performed against various agents that induce swelling and gastric ulcers. In these experiments, carvacrol showed promising results in reducing swelling, particularly in models triggered by substances like dextran and histamine.

Carvacrol was especially effective at higher doses, significantly decreasing swelling and ear edema caused by two different irritants. When it came to ulcers, we observed remarkable healing effects, with carvacrol showing up to 91% effectiveness at specific dosages after 14 days of treatment. This suggests that carvacrol may help tackle the issues with gastric lesions that many people experience.

Overall, the findings indicate that carvacrol has the potential to positively influence the healing of ulcers, likely by affecting inflammatory responses in the body. This makes carvacrol, and by extension oregano, an exciting area for further exploration concerning natural treatments for gastric issues.
We focused on exploring the potential impact of oregano, specifically Origanum dictamnus, on treating ulcers. This plant, known for its traditional use in medicine since ancient times, has garnered attention for its possible benefits against various health issues, including gastric ulcers.

Our investigation revealed that recent studies have identified a range of beneficial compounds in oregano, such as flavonoids and terpenoids. Notably, substances like carvacrol and thymol have demonstrated antimicrobial, antioxidant, and anti-ulcer properties. These findings align well with the traditional uses of the plant, especially for ailments like sore throats and coughing.

However, it's crucial to acknowledge that while some studies support the effectiveness of oregano against ulcers, it’s often in conjunction with other treatments. This means we cannot always determine the isolated benefits of oregano alone. Therefore, while the evidence is promising, it warrants further research to establish its role as a standalone herbal remedy for ulcers.

References

  1. Luiz Silva J, de Melo EM, Borges Sales AA, Maria Ferreira T, Mazzon Pontes L, et al. Therapeutic potential of Brazilian green propolis and oregano () extracts in collagen hydrogel for pressure ulcer repair: an experimental study in an animal model. Nat Prod Res. 2025. doi:10.1080/14786419.2025.2469320
  2. Taha M, Elazab ST, Abdelbagi O, Saati AA, Babateen O, et al. Phytochemical analysis of Origanum majorana L. extract and investigation of its antioxidant, anti-inflammatory and immunomodulatory effects against experimentally induced colitis downregulating Th17 cells. J Ethnopharmacol. 2023;317:116826. doi:10.1016/j.jep.2023.116826
  3. Yu Z, Li D, Sun H. Herba Origani alleviated DSS-induced ulcerative colitis in mice through remolding gut microbiota to regulate bile acid and short-chain fatty acid metabolisms. Biomed Pharmacother. 2023;161:114409. doi:10.1016/j.biopha.2023.114409
  4. Razack SA, Lee Y, Shin H, Duraiarasan S, Chun BS, et al. Cellulose nanofibrils reinforced chitosan-gelatin based hydrogel loaded with nanoemulsion of oregano essential oil for diabetic wound healing assisted by low level laser therapy. Int J Biol Macromol. 2023;226:220. doi:10.1016/j.ijbiomac.2022.12.003
  5. Voidarou CC, Rozos G, Alexopoulos A, Plessas S, Mantzourani I, et al. In Vitro Screening Potential Antibacterial Properties of the Greek Oregano Honey against Clinical Isolates of . Foods. 2021;10. doi:10.3390/foods10071568
  6. Zengin G, Ferrante C, Orlando G, Zheleva-Dimitrova D, Gevrenova R, et al. Chemical profiling and pharmaco-toxicological activity of Origanum sipyleum extracts: Exploring for novel sources for potential therapeutic agents. J Food Biochem. 2019;43:e13003. doi:10.1111/jfbc.13003
  7. Silva FV, Guimarães AG, Silva ER, Sousa-Neto BP, Machado FD, et al. Anti-inflammatory and anti-ulcer activities of carvacrol, a monoterpene present in the essential oil of oregano. J Med Food. 2012;15:984. doi:10.1089/jmf.2012.0102
  8. Liolios CC, Graikou K, Skaltsa E, Chinou I. Dittany of Crete: a botanical and ethnopharmacological review. J Ethnopharmacol. 2010;131:229. doi:10.1016/j.jep.2010.06.005
  9. Al-Howiriny T, Alsheikh A, Alqasoumi S, Al-Yahya M, ElTahir K, et al. Protective Effect of Origanum majorana L. 'Marjoram' on various models of gastric mucosal injury in rats. Am J Chin Med. 2009;37:531.
  10. Dundar E, Olgun EG, Isiksoy S, Kurkcuoglu M, Baser KH, et al. The effects of intra-rectal and intra-peritoneal application of Origanum onites L. essential oil on 2,4,6-trinitrobenzenesulfonic acid-induced colitis in the rat. Exp Toxicol Pathol. 2008;59:399. doi:10.1016/j.etp.2007.11.009
  11. Lin YT, Kwon YI, Labbe RG, Shetty K. Inhibition of Helicobacter pylori and associated urease by oregano and cranberry phytochemical synergies. Appl Environ Microbiol. 2005;71:8558.
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