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NOW Supplements P-5-P
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.2
USERS' SCORE
Good
Based on 3 Reviews
8.3
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Vitamin B-6 [from 50 mg Coenzyme Pyridoxal-5-Phosphate (P-5-P) Monohydrate]
33 mg
1941%
Magnesium (from Magnesium Bisglycinate) (TRAACS®)
25 mg
6%

Top Medical Research Studies

7
Vitamin B6 may influence IBS symptoms
Low intake of vitamin B6 is associated with irritable bowel syndrome symptoms.
Significant link found with IBS
We explored the relationship between vitamin B6 intake and the severity of symptoms in individuals with irritable bowel syndrome (IBS). Through a study involving 17 participants diagnosed with IBS according to the Rome II criteria, we gathered daily symptom reports and food intake logs over a week.

Our findings indicated that the only significant dietary component linked to symptom severity was vitamin B6. Participants generally consumed less than the recommended daily intake of vitamin B6, averaging just 0.9 mg per day, compared to the suggested amounts of 1.6 mg for men and 1.2 mg for women. Notably, a higher symptom score correlated with lower vitamin B6 consumption.

This suggests that individuals with IBS may benefit from increasing their vitamin B6 intake. Although this study has limitations—being small in scale and cross-sectional—it highlights a potential dietary factor that may impact the management of IBS symptoms.
Read More
9.5
Vitamin B6 may improve IBS
Effects of Bifidobacterium longum BB536 and Lactobacillus rhamnosus HN001 in IBS patients.
Investigates B6's role in IBS
In our exploration of how vitamin B6 influences irritable bowel syndrome (IBS), we conducted a controlled, double-blind study involving 25 IBS patients who met the Rome IV criteria. These individuals were randomly assigned to receive either a novel formulation combining Bifidobacterium longum BB536, Lactobacillus rhamnosus HN001, and vitamin B6, or a placebo for one month before switching treatments.

We observed significant improvements in several IBS symptoms when patients were treated with the vitamin B6 probiotic combination compared to the placebo. Specifically, abdominal pain showed a notable decrease of nearly 49%, and bloating symptoms dropped by over 36%. Furthermore, the overall severity of the disease lessened substantially, suggesting that vitamin B6 in conjunction with these probiotics may play an essential role in managing IBS.

The trial also revealed improvements in intestinal permeability, which is a key factor in gut health. We noted an increase in beneficial gut bacteria, which indicates a revitalization of the intestinal microbiota during treatment. While the study's findings support the benefits of the B6 probiotic blend in alleviating IBS symptoms, it is important to recognize that these symptoms could be related to the probiotics themselves rather than the vitamin B6 alone.
Read More
8
Vitamin B6 in IBS-C treatment
[Dry jelly concentrate with vitamins and dietary fiber in patients with IBS with constipation: a comparative controlled study].
Combination product complicates results
We conducted a study to assess the effectiveness of a dry jelly concentrate containing vitamin B6, along with inulin and curcumin, on patients with irritable bowel syndrome (IBS) with constipation (IBS-C). Fifty patients who met the criteria for IBS-C were divided into two groups. One group received the jelly drinks alongside a standard diet for two weeks, while the control group followed the standard diet only.

Throughout the study, we carefully monitored changes in abdominal pain, bloating, stool frequency, and overall quality of life. The results showed that those who consumed the jelly concentrate experienced significant improvements in several gastrointestinal parameters. For instance, stool frequency increased, abdominal pain decreased, and there was a notable enhancement in quality of life ratings.

It's worth mentioning that while vitamin B6 was part of the jelly formulation, the specific benefits attributed solely to vitamin B6 are difficult to isolate. The improvements in the jelly group indicate that the combination of ingredients worked well together to alleviate symptoms of IBS-C. However, the control group did show some improvement in pain and bloating, which suggests that dietary factors alone can also play a role.

Overall, the inclusion of this jelly concentrate could be a beneficial addition for patients suffering from IBS-C, particularly due to its positive effects on stool parameters and quality of life. The study did not report any significant adverse effects, making this product a potentially safe option for those looking to manage their symptoms.
Read More

Most Useful Reviews

8
Eases irritability
Very good! All vitamins have inactive forms that need to be converted in the body for absorption. Pyridoxal five phosphate is the most active form of vitamin B6, which the body absorbs effectively, unlike pyridoxine, and it includes magnesium as a cofactor. If you often feel irritable and anxious, this supplement might help address your problem. Please like, kind person 🙏🏻
Read More
8.8
Better sleep pattern
Excellent! This good magnesium B6 comes with plenty of capsules. I take one daily, and it seems I've started sleeping better and have become less irritable.
Read More
5
No noticeable impact
I have been taking this type of vitamin B6 for about a year on a specialist's recommendation to counteract deficiency and improve magnesium absorption. However, I didn’t notice any significant changes in how I felt. Interestingly, my child becomes more irritable after consuming P-5-P.
Read More

Medical Researches

SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.2
  • All Researches
9.5
Vitamin B6 may improve IBS
Effects of Bifidobacterium longum BB536 and Lactobacillus rhamnosus HN001 in IBS patients.
Investigates B6's role in IBS
In our exploration of how vitamin B6 influences irritable bowel syndrome (IBS), we conducted a controlled, double-blind study involving 25 IBS patients who met the Rome IV criteria. These individuals were randomly assigned to receive either a novel formulation combining Bifidobacterium longum BB536, Lactobacillus rhamnosus HN001, and vitamin B6, or a placebo for one month before switching treatments.

We observed significant improvements in several IBS symptoms when patients were treated with the vitamin B6 probiotic combination compared to the placebo. Specifically, abdominal pain showed a notable decrease of nearly 49%, and bloating symptoms dropped by over 36%. Furthermore, the overall severity of the disease lessened substantially, suggesting that vitamin B6 in conjunction with these probiotics may play an essential role in managing IBS.

The trial also revealed improvements in intestinal permeability, which is a key factor in gut health. We noted an increase in beneficial gut bacteria, which indicates a revitalization of the intestinal microbiota during treatment. While the study's findings support the benefits of the B6 probiotic blend in alleviating IBS symptoms, it is important to recognize that these symptoms could be related to the probiotics themselves rather than the vitamin B6 alone.
Read More
8
Vitamin B6 in IBS-C treatment
[Dry jelly concentrate with vitamins and dietary fiber in patients with IBS with constipation: a comparative controlled study].
Combination product complicates results
We conducted a study to assess the effectiveness of a dry jelly concentrate containing vitamin B6, along with inulin and curcumin, on patients with irritable bowel syndrome (IBS) with constipation (IBS-C). Fifty patients who met the criteria for IBS-C were divided into two groups. One group received the jelly drinks alongside a standard diet for two weeks, while the control group followed the standard diet only.

Throughout the study, we carefully monitored changes in abdominal pain, bloating, stool frequency, and overall quality of life. The results showed that those who consumed the jelly concentrate experienced significant improvements in several gastrointestinal parameters. For instance, stool frequency increased, abdominal pain decreased, and there was a notable enhancement in quality of life ratings.

It's worth mentioning that while vitamin B6 was part of the jelly formulation, the specific benefits attributed solely to vitamin B6 are difficult to isolate. The improvements in the jelly group indicate that the combination of ingredients worked well together to alleviate symptoms of IBS-C. However, the control group did show some improvement in pain and bloating, which suggests that dietary factors alone can also play a role.

Overall, the inclusion of this jelly concentrate could be a beneficial addition for patients suffering from IBS-C, particularly due to its positive effects on stool parameters and quality of life. The study did not report any significant adverse effects, making this product a potentially safe option for those looking to manage their symptoms.
Read More
7
Vitamin B6 may influence IBS symptoms
Low intake of vitamin B6 is associated with irritable bowel syndrome symptoms.
Significant link found with IBS
We explored the relationship between vitamin B6 intake and the severity of symptoms in individuals with irritable bowel syndrome (IBS). Through a study involving 17 participants diagnosed with IBS according to the Rome II criteria, we gathered daily symptom reports and food intake logs over a week.

Our findings indicated that the only significant dietary component linked to symptom severity was vitamin B6. Participants generally consumed less than the recommended daily intake of vitamin B6, averaging just 0.9 mg per day, compared to the suggested amounts of 1.6 mg for men and 1.2 mg for women. Notably, a higher symptom score correlated with lower vitamin B6 consumption.

This suggests that individuals with IBS may benefit from increasing their vitamin B6 intake. Although this study has limitations—being small in scale and cross-sectional—it highlights a potential dietary factor that may impact the management of IBS symptoms.
Read More

User Reviews

USERS' SCORE
Good
Based on 3 Reviews
8.3
  • All Reviews
  • Positive Reviews
  • Negative Reviews
8
Eases irritability
Very good! All vitamins have inactive forms that need to be converted in the body for absorption. Pyridoxal five phosphate is the most active form of vitamin B6, which the body absorbs effectively, unlike pyridoxine, and it includes magnesium as a cofactor. If you often feel irritable and anxious, this supplement might help address your problem. Please like, kind person 🙏🏻
Read More
8.8
Better sleep pattern
Excellent! This good magnesium B6 comes with plenty of capsules. I take one daily, and it seems I've started sleeping better and have become less irritable.
5
No noticeable impact
I have been taking this type of vitamin B6 for about a year on a specialist's recommendation to counteract deficiency and improve magnesium absorption. However, I didn’t notice any significant changes in how I felt. Interestingly, my child becomes more irritable after consuming P-5-P.
Read More
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