Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.4
USERS' SCORE
Good
Based on 3 Reviews
8.5
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Potassium (from 310 mg Potassium Citrate)
99 mg
2%
Top Medical Research Studies
9.5
Potassium channels induce migraines
We explored the question of whether levcromakalim, a potassium channel opener, can induce migraine attacks in individuals already treated with erenumab, a CGRP receptor antibody. In a double-blind, placebo-controlled study, participants received injections of both levcromakalim and placebo to compare their effects on migraine frequency.
Our findings revealed that levcromakalim led to significantly more migraine attacks within 12 hours compared to placebo, with 88% of participants experiencing attacks after the potassium infusion. This suggests that potassium channels can trigger migraines independently of CGRP activation.
Our findings revealed that levcromakalim led to significantly more migraine attacks within 12 hours compared to placebo, with 88% of participants experiencing attacks after the potassium infusion. This suggests that potassium channels can trigger migraines independently of CGRP activation.
Read More
8
We conducted a thorough investigation into whether levcromakalim, a potassium channel opener, can trigger migraine-like headaches in individuals suffering from persistent post-traumatic headaches.
In our randomized, double-blind study with a placebo group, we found that 57% of participants experienced such headaches after receiving levcromakalim, compared to only 14% after the placebo.
This suggests that potassium channels may play a significant role in the nature of these headaches and indicates that K channel blockers could be a promising area for future treatments.
In our randomized, double-blind study with a placebo group, we found that 57% of participants experienced such headaches after receiving levcromakalim, compared to only 14% after the placebo.
This suggests that potassium channels may play a significant role in the nature of these headaches and indicates that K channel blockers could be a promising area for future treatments.
Read More
7
We investigated whether the drug MaxiPost, which opens large conductance calcium-activated potassium channels, can trigger migraine-like headaches in adults with persistent post-traumatic headache (PPTH) after mild brain injuries.
In a randomized double-blind trial, participants received either MaxiPost or a placebo, with sessions spaced a week apart to prevent bias.
Our findings suggest that activating these potassium channels can indeed induce migraine-like symptoms, paving the way for potential new treatments. However, further research is needed for solid conclusions about using BK channel blockers for PPTH.
In a randomized double-blind trial, participants received either MaxiPost or a placebo, with sessions spaced a week apart to prevent bias.
Our findings suggest that activating these potassium channels can indeed induce migraine-like symptoms, paving the way for potential new treatments. However, further research is needed for solid conclusions about using BK channel blockers for PPTH.
Read More
Most Useful Reviews
9
Migraines improved
1 people found this helpful
I bought this product to balance my magnesium for migraines with potassium. Since using it, I’ve seen improvement in the numbness in my feet and fluid retention. I had no shipping issues to Australia.
Read More
9
Migraine frequency reduced
This product helps normalise sleep with regular intake. It improves my migraines, allowing me to manage them more easily. Since taking magnesium regularly, my PMS and menstrual pain have also significantly improved, and chronic nasopharyngeal pain is less severe. I’ve noticed benefits from taking collagen too. Overall, no allergies or stomach issues occurred; the quality is excellent.
Read More
7.5
Helps migraine relief
1 people found this helpful
Very useful for those who suffer from constipation and muscle tremors. Most importantly, it alleviates headaches for migraine sufferers.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.4
- All Researches
9.5
Potassium channels induce migraines
We explored the question of whether levcromakalim, a potassium channel opener, can induce migraine attacks in individuals already treated with erenumab, a CGRP receptor antibody. In a double-blind, placebo-controlled study, participants received injections of both levcromakalim and placebo to compare their effects on migraine frequency.
Our findings revealed that levcromakalim led to significantly more migraine attacks within 12 hours compared to placebo, with 88% of participants experiencing attacks after the potassium infusion. This suggests that potassium channels can trigger migraines independently of CGRP activation.
Our findings revealed that levcromakalim led to significantly more migraine attacks within 12 hours compared to placebo, with 88% of participants experiencing attacks after the potassium infusion. This suggests that potassium channels can trigger migraines independently of CGRP activation.
Read More
9
Exploring TRESK's impact on migraine
We examined how TRESK potassium channels could play a role in managing migraine pain. Using both in-vivo and ex-vivo rat models, we tested different activation methods and found that cloxyquin, a TRESK activator, significantly reduced pain and the associated chemical markers linked to migraines.
Although combining it with sumatriptan showed promising results in lab settings, this didn't translate to the animal models. Our findings suggest that targeting TRESK channels might be a viable method for alleviating migraine symptoms.
Although combining it with sumatriptan showed promising results in lab settings, this didn't translate to the animal models. Our findings suggest that targeting TRESK channels might be a viable method for alleviating migraine symptoms.
Read More
8
We conducted a thorough investigation into whether levcromakalim, a potassium channel opener, can trigger migraine-like headaches in individuals suffering from persistent post-traumatic headaches.
In our randomized, double-blind study with a placebo group, we found that 57% of participants experienced such headaches after receiving levcromakalim, compared to only 14% after the placebo.
This suggests that potassium channels may play a significant role in the nature of these headaches and indicates that K channel blockers could be a promising area for future treatments.
In our randomized, double-blind study with a placebo group, we found that 57% of participants experienced such headaches after receiving levcromakalim, compared to only 14% after the placebo.
This suggests that potassium channels may play a significant role in the nature of these headaches and indicates that K channel blockers could be a promising area for future treatments.
Read More
7
We investigated whether the drug MaxiPost, which opens large conductance calcium-activated potassium channels, can trigger migraine-like headaches in adults with persistent post-traumatic headache (PPTH) after mild brain injuries.
In a randomized double-blind trial, participants received either MaxiPost or a placebo, with sessions spaced a week apart to prevent bias.
Our findings suggest that activating these potassium channels can indeed induce migraine-like symptoms, paving the way for potential new treatments. However, further research is needed for solid conclusions about using BK channel blockers for PPTH.
In a randomized double-blind trial, participants received either MaxiPost or a placebo, with sessions spaced a week apart to prevent bias.
Our findings suggest that activating these potassium channels can indeed induce migraine-like symptoms, paving the way for potential new treatments. However, further research is needed for solid conclusions about using BK channel blockers for PPTH.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Migraines improved
1 people found this helpful
I bought this product to balance my magnesium for migraines with potassium. Since using it, I’ve seen improvement in the numbness in my feet and fluid retention. I had no shipping issues to Australia.
Read More
9
Migraine frequency reduced
This product helps normalise sleep with regular intake. It improves my migraines, allowing me to manage them more easily. Since taking magnesium regularly, my PMS and menstrual pain have also significantly improved, and chronic nasopharyngeal pain is less severe. I’ve noticed benefits from taking collagen too. Overall, no allergies or stomach issues occurred; the quality is excellent.
Read More
7.5
Helps migraine relief
1 people found this helpful
Very useful for those who suffer from constipation and muscle tremors. Most importantly, it alleviates headaches for migraine sufferers.
Read More
Frequently Asked Questions
9
Migraine frequency reduced
This product helps normalise sleep with regular intake. It improves my migraines, allowing me to manage them more easily. Since taking magnesium regularly, my PMS and menstrual pain have also significantly improved, and chronic nasopharyngeal pain is less severe. I’ve noticed benefits from taking collagen too. Overall, no allergies or stomach issues occurred; the quality is excellent.
7.5
Helps migraine relief
1 people found this helpful
Very useful for those who suffer from constipation and muscle tremors. Most importantly, it alleviates headaches for migraine sufferers.
9
Migraines improved
1 people found this helpful
I bought this product to balance my magnesium for migraines with potassium. Since using it, I’ve seen improvement in the numbness in my feet and fluid retention. I had no shipping issues to Australia.
References
- Torun IE, Kilinc YB, Kilinc E, Töre F. TRESK channel activation ameliorates migraine-like pain via modulation of CGRP release from the trigeminovascular system and meningeal mast cells in experimental migraine models. Life Sci. 2024;357:123091. 10.1016/j.lfs.2024.123091
- Al-Khazali HM, Christensen RH, Dodick DW, Chaudhry BA, Melchior AG, et al. Hypersensitivity to BK channel opening in persistent post-traumatic headache. J Headache Pain. 2024;25:102. 10.1186/s10194-024-01808-0
- Raffaelli B, Do TP, Chaudhry BA, Amin FM, Ashina H, et al. Activation of ATP-sensitive potassium channels triggers migraine attacks independent of calcitonin gene-related peptide receptors: a randomized placebo-controlled trial. Cephalalgia. 2024;44:3331024231222916. 10.1177/03331024231222916
- Al-Khazali HM, Christensen RH, Dodick DW, Chaudhry BA, Burstein R, et al. Hypersensitivity to opening of ATP-sensitive potassium channels in post-traumatic headache. Cephalalgia. 2023;43:3331024231210930. 10.1177/03331024231210930
