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SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.5
USERS' SCORE
Good
Based on 46 Reviews
8.6
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Quercetin
800 mg
**
Bromelain (2,400 GDU/g)
165 mg
**
Top Medical Research Studies
9
Quercetin's role against colorectal cancer
Structure-activity relationship analysis of mono-methylated quercetins by comprehensive MS/MS analysis and anti-proliferative efficacy in human colorectal cancer cells.
Direct effects on colorectal cancer
We aimed to understand how quercetin and its derivatives, especially mono-methylated quercetins (MQs), might help in treating colorectal cancer. Using advanced techniques like tandem mass spectrometry, we identified specific structural features of these flavonoids that could enhance their anti-cancer activities.
Our findings showed that methylation at specific positions on the quercetin molecule significantly improved its ability to fight cancer cells. Notably, 3-O-methylquercetin and 4'-O-methylquercetin were particularly effective. These compounds caused cancer cells to stop dividing and triggered programmed cell death, also known as apoptosis.
We observed that these MQs worked through several mechanisms, such as inducing oxidative stress, disrupting mitochondrial function, and inactivating cancer-related signaling pathways—all while being non-toxic to normal human colon cells. This makes them promising candidates for cancer therapy, especially for patients with colorectal cancer.
Ultimately, our research revealed that small modifications in flavonoid structures could lead to significant improvements in their anti-cancer effectiveness, providing a path for developing targeted treatments for colorectal cancer.
Our findings showed that methylation at specific positions on the quercetin molecule significantly improved its ability to fight cancer cells. Notably, 3-O-methylquercetin and 4'-O-methylquercetin were particularly effective. These compounds caused cancer cells to stop dividing and triggered programmed cell death, also known as apoptosis.
We observed that these MQs worked through several mechanisms, such as inducing oxidative stress, disrupting mitochondrial function, and inactivating cancer-related signaling pathways—all while being non-toxic to normal human colon cells. This makes them promising candidates for cancer therapy, especially for patients with colorectal cancer.
Ultimately, our research revealed that small modifications in flavonoid structures could lead to significant improvements in their anti-cancer effectiveness, providing a path for developing targeted treatments for colorectal cancer.
Read More
9
Quercetin induces cancer cell death
Quercetin triggers cell apoptosis-associated ROS-mediated cell death and induces S and G2/M-phase cell cycle arrest in KON oral cancer cells.
Direct focus on oral cancer
We explored the effects of quercetin, a plant flavonoid, on KON oral cancer cells. Our aim was to understand how quercetin could potentially fight cancer by assessing its anti-growth, anti-migrative, and anti-invasive properties. Using various assays, we treated KON cells with quercetin and observed its impact on their viability compared to normal fibroblast cells.
After treatment, we noticed that quercetin significantly induced cell death and apoptosis. It did this by raising reactive oxygen species (ROS) levels, leading to the disruption of normal mitochondrial function. We also found that quercetin caused the cancer cells to halt their growth in both the S and G2/M phases of the cell cycle, which is a crucial factor in cancer progression.
Beyond its direct effects on cell viability, quercetin exhibited promising anti-metastatic properties. Our investigation also included detailed assessments of key markers associated with apoptosis and metastasis, which clarified the underlying mechanisms at play. This discovery presents exciting opportunities for quercetin as a potential treatment option for oral cancer, paving the way for further research and clinical trials.
After treatment, we noticed that quercetin significantly induced cell death and apoptosis. It did this by raising reactive oxygen species (ROS) levels, leading to the disruption of normal mitochondrial function. We also found that quercetin caused the cancer cells to halt their growth in both the S and G2/M phases of the cell cycle, which is a crucial factor in cancer progression.
Beyond its direct effects on cell viability, quercetin exhibited promising anti-metastatic properties. Our investigation also included detailed assessments of key markers associated with apoptosis and metastasis, which clarified the underlying mechanisms at play. This discovery presents exciting opportunities for quercetin as a potential treatment option for oral cancer, paving the way for further research and clinical trials.
Read More
8
Quercetin reduces oral cancer cell viability
Therapeutic effects of quercetin in oral cancer therapy: a systematic review of preclinical evidence focused on oxidative damage, apoptosis and anti-metastasis.
Direct investigation of quercetin's effects
We explored the effects of quercetin, a natural flavonoid, on oral cancer during a systematic review of existing studies. Our investigation included a thorough screening process, where we analyzed 193 articles and selected 18 that met our inclusion criteria.
Through this review, we observed that quercetin significantly reduced cancer cell proliferation and overall viability. It also appeared to decrease tumor volume, invasion, and metastasis, all of which are critical factors in cancer progression. Notably, quercetin seems to work by inducing oxidative stress and triggering apoptosis, the process of programmed cell death, in cancer cells.
However, while the findings are promising, we must exercise caution in suggesting quercetin as a standalone treatment for oral cancer. Its effectiveness is tempered by poor absorption rates in the body, and we still have much to uncover about the precise molecular mechanisms behind its anti-cancer properties. Therefore, further clinical studies are essential to determine how best to utilize quercetin in cancer therapy.
Through this review, we observed that quercetin significantly reduced cancer cell proliferation and overall viability. It also appeared to decrease tumor volume, invasion, and metastasis, all of which are critical factors in cancer progression. Notably, quercetin seems to work by inducing oxidative stress and triggering apoptosis, the process of programmed cell death, in cancer cells.
However, while the findings are promising, we must exercise caution in suggesting quercetin as a standalone treatment for oral cancer. Its effectiveness is tempered by poor absorption rates in the body, and we still have much to uncover about the precise molecular mechanisms behind its anti-cancer properties. Therefore, further clinical studies are essential to determine how best to utilize quercetin in cancer therapy.
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Most Useful Reviews
8.8
Improved wellbeing
I have multiple sclerosis, but this supplement has been stunningly effective. At 52, my health has improved significantly. Quercetin, a powerful antioxidant, along with bromelain, is helping my treatment against cancer. I only relied on these supplements and avoided antibiotics throughout my recovery. I consistently take them for ongoing health and quality of life.
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8.8
Allergy relief
After taking this supplement for two weeks, my chronic allergies and rhinitis improved remarkably. Quercetin effectively reduced blood viscosity and strengthened my immune system, while bromelain enhanced its properties. I am more resistant to infections, allowing me to focus more on my overall health and cancer prevention.
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9.5
Cancer treatment
I take this supplement as part of an anti-cancer regime, along with curcumin. Although it is challenging to digest with food, the anti-cancer properties of quercetin have proven effective. The bromelain significantly aids absorption. I believe this combination will help combat cancer cells over time.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.5
9.5
Quercetin enhances cancer treatment efficacy
Active tumor targeting by core-shell PDMS-HA nanoparticles with sequential delivery of doxorubicin and quercetin to overcome P-glycoprotein efflux pump.
Combines quercetin and doxorubicin
We explored the impact of quercetin when used alongside doxorubicin in treating breast cancer. In our study, we delivered these two compounds using specialized polydimethylsiloxane nanoparticles, which were designed to enhance their effectiveness in targeting cancer cells.
Quercetin plays a crucial role by blocking the P-glycoprotein efflux pump. This action helps increase the intracellular levels of doxorubicin, leading to better cell death and more effective treatment outcomes. The combination of these two agents helps to tackle the problem of cancer cell resistance to drugs, making it easier for treatment to work.
Our research demonstrated that the sequential delivery of doxorubicin followed by quercetin significantly reduced tumor size in experimental models compared to using either treatment alone. We observed noticeable cell death and inhibited tumor growth in the tested breast cancer cells.
Overall, the findings suggest that quercetin can effectively support chemotherapy by reversing drug resistance and enhancing the anticancer effects of doxorubicin when they are delivered together. The approach not only shows promise in bolstering treatment efficacy but also indicates minimal toxicity to normal tissues.
Quercetin plays a crucial role by blocking the P-glycoprotein efflux pump. This action helps increase the intracellular levels of doxorubicin, leading to better cell death and more effective treatment outcomes. The combination of these two agents helps to tackle the problem of cancer cell resistance to drugs, making it easier for treatment to work.
Our research demonstrated that the sequential delivery of doxorubicin followed by quercetin significantly reduced tumor size in experimental models compared to using either treatment alone. We observed noticeable cell death and inhibited tumor growth in the tested breast cancer cells.
Overall, the findings suggest that quercetin can effectively support chemotherapy by reversing drug resistance and enhancing the anticancer effects of doxorubicin when they are delivered together. The approach not only shows promise in bolstering treatment efficacy but also indicates minimal toxicity to normal tissues.
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9
Quercetin promotes cancer cell death
Activation of SIRT3/AMPK/mTOR-mediated autophagy promotes quercetin-induced ferroptosis in oral squamous cell carcinoma.
Strong evidence for quercetin's effect
We explored how quercetin, a natural compound, affects cancer cells, particularly in the context of oral squamous cell carcinoma (OSCC). This study focused on understanding the role of sirtuin 3 (SIRT3) and a specific form of cell death known as ferroptosis, as well as how quercetin influences these processes.
Using specially engineered SCC15 cell lines, we treated the cells with quercetin and observed significant changes. Our experiments revealed that overexpressing SIRT3 led to increased levels of harmful substances like malondialdehyde (MDA) and reactive oxygen species (ROS), which diminished cell viability and promoted ferroptosis. In contrast, knocking out SIRT3 produced the opposite effect, supporting the idea that SIRT3 plays a pivotal role in this process.
Notably, we found that quercetin treatment enhanced SIRT3 levels and other relevant markers, indicating its potential as a therapeutic agent. It actively triggered autophagy, particularly through a pathway involving AMPK and mTOR, thereby fostering ferroptosis. Our findings suggest that not only does quercetin have a direct impact on OSCC cells, but it enhances the cell death process that can be beneficial in cancer treatment.
Overall, our research highlights quercetin as a promising candidate for further investigation in the battle against oral squamous cell carcinoma.
Using specially engineered SCC15 cell lines, we treated the cells with quercetin and observed significant changes. Our experiments revealed that overexpressing SIRT3 led to increased levels of harmful substances like malondialdehyde (MDA) and reactive oxygen species (ROS), which diminished cell viability and promoted ferroptosis. In contrast, knocking out SIRT3 produced the opposite effect, supporting the idea that SIRT3 plays a pivotal role in this process.
Notably, we found that quercetin treatment enhanced SIRT3 levels and other relevant markers, indicating its potential as a therapeutic agent. It actively triggered autophagy, particularly through a pathway involving AMPK and mTOR, thereby fostering ferroptosis. Our findings suggest that not only does quercetin have a direct impact on OSCC cells, but it enhances the cell death process that can be beneficial in cancer treatment.
Overall, our research highlights quercetin as a promising candidate for further investigation in the battle against oral squamous cell carcinoma.
Read More
9
Quercetin's role against colorectal cancer
Structure-activity relationship analysis of mono-methylated quercetins by comprehensive MS/MS analysis and anti-proliferative efficacy in human colorectal cancer cells.
Direct effects on colorectal cancer
We aimed to understand how quercetin and its derivatives, especially mono-methylated quercetins (MQs), might help in treating colorectal cancer. Using advanced techniques like tandem mass spectrometry, we identified specific structural features of these flavonoids that could enhance their anti-cancer activities.
Our findings showed that methylation at specific positions on the quercetin molecule significantly improved its ability to fight cancer cells. Notably, 3-O-methylquercetin and 4'-O-methylquercetin were particularly effective. These compounds caused cancer cells to stop dividing and triggered programmed cell death, also known as apoptosis.
We observed that these MQs worked through several mechanisms, such as inducing oxidative stress, disrupting mitochondrial function, and inactivating cancer-related signaling pathways—all while being non-toxic to normal human colon cells. This makes them promising candidates for cancer therapy, especially for patients with colorectal cancer.
Ultimately, our research revealed that small modifications in flavonoid structures could lead to significant improvements in their anti-cancer effectiveness, providing a path for developing targeted treatments for colorectal cancer.
Our findings showed that methylation at specific positions on the quercetin molecule significantly improved its ability to fight cancer cells. Notably, 3-O-methylquercetin and 4'-O-methylquercetin were particularly effective. These compounds caused cancer cells to stop dividing and triggered programmed cell death, also known as apoptosis.
We observed that these MQs worked through several mechanisms, such as inducing oxidative stress, disrupting mitochondrial function, and inactivating cancer-related signaling pathways—all while being non-toxic to normal human colon cells. This makes them promising candidates for cancer therapy, especially for patients with colorectal cancer.
Ultimately, our research revealed that small modifications in flavonoid structures could lead to significant improvements in their anti-cancer effectiveness, providing a path for developing targeted treatments for colorectal cancer.
Read More
9
Quercetin combats cancer drug resistance
Jian Pi Hua Tan Fang Reverses Trastuzumab Resistance of HER2-Positive Gastric Cancer Through PI3K/AKT/mTOR Pathway: Integrating Network Pharmacology, Molecular Docking and Experimental Validation.
Relevant insights on cancer treatment
We explored the potential of quercetin, a natural compound found in various fruits and vegetables, in combating resistance to the cancer drug trastuzumab, particularly in patients with HER2-positive gastric cancer. Our study investigated how quercetin, as part of a mixture known as Jian Pi Hua Tan Fang (JPHTF), could enhance the effectiveness of this treatment.
Through a combination of network pharmacology and molecular docking techniques, we identified key targets and pathways linked to quercetin's action. Notably, the study revealed that quercetin might target vital proteins in the PI3K/AKT/mTOR pathway, which is crucial for cell growth and survival in cancer.
We validated our findings using laboratory models of gastric cancer cells, where JPHTF containing quercetin demonstrated the ability to reverse trastuzumab resistance effectively. The results indicated that quercetin not only helped in reducing cell proliferation but also promoted cell death in resistant cancer cells.
Overall, our findings suggest that integrating quercetin with trastuzumab could be a promising strategy for enhancing treatment outcomes in patients dealing with HER2-positive gastric cancer.
Through a combination of network pharmacology and molecular docking techniques, we identified key targets and pathways linked to quercetin's action. Notably, the study revealed that quercetin might target vital proteins in the PI3K/AKT/mTOR pathway, which is crucial for cell growth and survival in cancer.
We validated our findings using laboratory models of gastric cancer cells, where JPHTF containing quercetin demonstrated the ability to reverse trastuzumab resistance effectively. The results indicated that quercetin not only helped in reducing cell proliferation but also promoted cell death in resistant cancer cells.
Overall, our findings suggest that integrating quercetin with trastuzumab could be a promising strategy for enhancing treatment outcomes in patients dealing with HER2-positive gastric cancer.
Read More
9
Quercetin disrupts liver cancer metabolism
Crippled Hepatocarcinogenesis Inhibition of Quercetin in Glycolysis Pathway with Hepatic Farnesoid X Receptor Deficiency.
Relevant and focused study
Our research delved into the effects of quercetin, a flavonoid commonly found in plants, on hepatocellular carcinoma (HCC), a prevalent form of liver cancer. We focused on the role of the Farnesoid X receptor (FXR), which is crucial for maintaining liver health and metabolism. By investigating how quercetin influences the glycolysis pathway through FXR signaling, we sought to uncover its anti-cancer properties.
Utilizing various methods like RNA sequencing, molecular docking, and cell proliferation assays, we found that quercetin significantly impacted several genes associated with HCC and glycolysis. Our analysis revealed that quercetin inhibits the growth of liver cancer cells by triggering an accumulation of these cells in the S-phase of the cell cycle.
Furthermore, quercetin reduced the expression of key glycolysis-related enzymes and regulated metabolite levels. This suggests that quercetin can effectively disrupt the cancer-promoting processes in the liver by altering energy metabolism. Overall, our findings illustrate quercetin's potential as an anti-cancer agent specifically targeting the glycolysis pathway in liver cancer.
Utilizing various methods like RNA sequencing, molecular docking, and cell proliferation assays, we found that quercetin significantly impacted several genes associated with HCC and glycolysis. Our analysis revealed that quercetin inhibits the growth of liver cancer cells by triggering an accumulation of these cells in the S-phase of the cell cycle.
Furthermore, quercetin reduced the expression of key glycolysis-related enzymes and regulated metabolite levels. This suggests that quercetin can effectively disrupt the cancer-promoting processes in the liver by altering energy metabolism. Overall, our findings illustrate quercetin's potential as an anti-cancer agent specifically targeting the glycolysis pathway in liver cancer.
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User Reviews
USERS' SCORE
Good
Based on 46 Reviews
8.6
9.5
Cancer treatment
I take this supplement as part of an anti-cancer regime, along with curcumin. Although it is challenging to digest with food, the anti-cancer properties of quercetin have proven effective. The bromelain significantly aids absorption. I believe this combination will help combat cancer cells over time.
Read More
9.5
Prostate cancer
I chose this quercetin supplement due to its popularity, and it's helping me manage my advanced prostate cancer. I'm experiencing less pain in my legs and feet. Despite my oncologist's grim prognosis, I am finding relief and am pleased with the effects of this product.
9.5
Disease management
This versatile supplement contains an antioxidant and immunomodulator. The quercetin and bromelain combination is reducing inflammation and enhancing my immune response. It is also aiding in my battle against cancer while improving cholesterol levels and mitigating varicose vein issues I have suffered from for years.
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9.5
Irritation soothing
Initially prescribed to reduce inflammation after my cancer diagnosis, I stopped taking quercetin. However, upon experiencing throat irritation, I resumed it, and within three days, my coughing subsided. This has greatly relieved my anxiety about recurring cancer symptoms.
9.5
Overall health benefits
Quercetin is a powerful supplement I take regularly. With strong antioxidant, anti-inflammatory, and anti-cancer effects, I find it essential for my health. I take two tablets twice daily, firmly believing in its capability to support my overall wellbeing and resist chronic conditions, including cancer.
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