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SCIENTIFIC SCORE
Moderately Effective
Based on 14 Researches
8.2
USERS' SCORE
Good
Based on 10 Reviews
8.6
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Quercetin
800 mg
**
Bromelain (2,400 GDU/g)
165 mg
**
Top Medical Research Studies
8
Quercetin aids diabetic heart health
Role of Quercetin in Diabetic Cardiomyopathy.
Highly relevant to diabetic cardiomyopathy
We explored the emerging role of quercetin in managing diabetic cardiomyopathy, a serious complication linked to diabetes. The study highlights how quercetin, a natural compound found in many fruits and vegetables, shows promise in addressing various issues associated with this condition.
Through research, we uncovered that quercetin may aid in improving insulin signaling and reducing oxidative stress, both of which play significant roles in the progression of heart problems related to diabetes. Additionally, it appears to help combat inflammation and fibrosis, which are key factors in heart dysfunction.
We also noted that quercetin affects cellular processes like apoptosis and mitochondrial health, which are crucial for maintaining heart cell function. This multifaceted approach might be beneficial in preventing severe heart complications as diabetes progresses.
Overall, this review positions quercetin as a potential star in diabetes management, particularly for heart health, inviting further research and consideration for future therapeutic strategies.
Through research, we uncovered that quercetin may aid in improving insulin signaling and reducing oxidative stress, both of which play significant roles in the progression of heart problems related to diabetes. Additionally, it appears to help combat inflammation and fibrosis, which are key factors in heart dysfunction.
We also noted that quercetin affects cellular processes like apoptosis and mitochondrial health, which are crucial for maintaining heart cell function. This multifaceted approach might be beneficial in preventing severe heart complications as diabetes progresses.
Overall, this review positions quercetin as a potential star in diabetes management, particularly for heart health, inviting further research and consideration for future therapeutic strategies.
Read More
9
Quercetin improves diabetic wound healing
Dual ROS/Glucose-Responsive Quercetin-Loaded Supramolecular Hydrogel for Diabetic Wound Healing.
Highly relevant quercetin study results
We set out to evaluate how quercetin, a natural compound, could aid in healing wounds, particularly in the context of diabetes. Our research introduced a novel hydrogel infused with quercetin, designed to respond to both reactive oxygen species (ROS) and glucose. By doing so, we aimed to release quercetin in a controlled manner, addressing some challenges of the diabetic wound environment.
Throughout the study, we demonstrated that this quercetin-loaded hydrogel showed impressive antibacterial and antioxidant properties, which are crucial for managing inflammation in diabetic wounds. Notably, in tests using diabetic rats, we found that our hydrogel significantly sped up wound healing compared to other treatments.
It improved crucial healing aspects such as re-epithelialization and collagen deposition. Furthermore, our observations indicated a boost in blood vessel formation, which is essential for delivering nutrients and oxygen to healing tissues. Overall, this study suggests that quercetin could be a valuable addition to diabetic wound care, enhancing healing processes while combating common complications.
Throughout the study, we demonstrated that this quercetin-loaded hydrogel showed impressive antibacterial and antioxidant properties, which are crucial for managing inflammation in diabetic wounds. Notably, in tests using diabetic rats, we found that our hydrogel significantly sped up wound healing compared to other treatments.
It improved crucial healing aspects such as re-epithelialization and collagen deposition. Furthermore, our observations indicated a boost in blood vessel formation, which is essential for delivering nutrients and oxygen to healing tissues. Overall, this study suggests that quercetin could be a valuable addition to diabetic wound care, enhancing healing processes while combating common complications.
Read More
9
Quercetin shows promise in diabetes
Antidiabetic Effects of Quercetin and Silk Sericin in Attenuating Dysregulation of Hepatic Gluconeogenesis in Diabetic Rats Through Potential Modulation of PI3K/Akt/FOXO1 Signaling: In Vivo and In Silico Studies.
Strongly relevant to study topic
We sought to understand how quercetin (QCT) and silk sericin (SS) can aid in managing diabetes, particularly focusing on their effects on liver glucose production. In our investigation, diabetic male albino rats were treated with QCT and SS to see how these substances influence several metabolic markers and overall glucose metabolism.
Following treatment, we observed that both QCT and SS significantly improved levels of glucose, insulin, and important liver enzymes. These substances also enhanced the functioning of liver carbohydrate-metabolizing enzymes. Notably, the administration of QCT and SS helped reduce markers of oxidative stress and inflammation, suggesting they may protect liver cells from damage.
We particularly noted that QCT led to increased expression of key signaling proteins in the liver, which are crucial in controlling blood sugar levels. Moreover, our immunohistochemical analysis showed a decrease in markers for cell death among the treated rats, highlighting the protective effects of QCT and SS.
Our results demonstrate that QCT and SS could effectively mitigate the complications of diabetes related to liver function. Importantly, quercetin showcased stronger interactions at the molecular level than silk sericin, pointing to its potential as a more effective therapeutic agent for managing diabetes.
Following treatment, we observed that both QCT and SS significantly improved levels of glucose, insulin, and important liver enzymes. These substances also enhanced the functioning of liver carbohydrate-metabolizing enzymes. Notably, the administration of QCT and SS helped reduce markers of oxidative stress and inflammation, suggesting they may protect liver cells from damage.
We particularly noted that QCT led to increased expression of key signaling proteins in the liver, which are crucial in controlling blood sugar levels. Moreover, our immunohistochemical analysis showed a decrease in markers for cell death among the treated rats, highlighting the protective effects of QCT and SS.
Our results demonstrate that QCT and SS could effectively mitigate the complications of diabetes related to liver function. Importantly, quercetin showcased stronger interactions at the molecular level than silk sericin, pointing to its potential as a more effective therapeutic agent for managing diabetes.
Read More
Most Useful Reviews
9.5
Improved eyesight
As a diabetic, my eyesight began to blur, and my optometrist advised me that nothing could be done due to dilated blood vessels at the back of my eye. However, I read that Quercetin might assist with this issue by improving blood vessel function. Not wanting to lose my driving licence, I took a chance on some pills. It worked wonders! My doctor can't believe the difference; my eyesight is now 20/20, despite my diabetes and other conditions! Give it a go if your vision is blurry!
Read More
7.5
Pain reduction
I appreciate that Quercetin and bromelain can be taken together. Quercetin possesses anti-inflammatory, antioxidant, and blood pressure regulating qualities, which I find beneficial. The combination helps with pain and inflammation, especially for diabetic conditions.
Read More
8.8
Improved kidney function
Quercetin is a life-prolonging supplement I adore, particularly for its benefits in improving kidney function and supporting heart health. It rejuvenates the immune system and maintains muscle condition. Along with bromelain, it effectively reduces joint inflammation. I regularly use it, especially for older family members, and the results have been remarkable.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 14 Researches
8.2
9
Quercetin improves diabetic wound healing
Dual ROS/Glucose-Responsive Quercetin-Loaded Supramolecular Hydrogel for Diabetic Wound Healing.
Highly relevant quercetin study results
We set out to evaluate how quercetin, a natural compound, could aid in healing wounds, particularly in the context of diabetes. Our research introduced a novel hydrogel infused with quercetin, designed to respond to both reactive oxygen species (ROS) and glucose. By doing so, we aimed to release quercetin in a controlled manner, addressing some challenges of the diabetic wound environment.
Throughout the study, we demonstrated that this quercetin-loaded hydrogel showed impressive antibacterial and antioxidant properties, which are crucial for managing inflammation in diabetic wounds. Notably, in tests using diabetic rats, we found that our hydrogel significantly sped up wound healing compared to other treatments.
It improved crucial healing aspects such as re-epithelialization and collagen deposition. Furthermore, our observations indicated a boost in blood vessel formation, which is essential for delivering nutrients and oxygen to healing tissues. Overall, this study suggests that quercetin could be a valuable addition to diabetic wound care, enhancing healing processes while combating common complications.
Throughout the study, we demonstrated that this quercetin-loaded hydrogel showed impressive antibacterial and antioxidant properties, which are crucial for managing inflammation in diabetic wounds. Notably, in tests using diabetic rats, we found that our hydrogel significantly sped up wound healing compared to other treatments.
It improved crucial healing aspects such as re-epithelialization and collagen deposition. Furthermore, our observations indicated a boost in blood vessel formation, which is essential for delivering nutrients and oxygen to healing tissues. Overall, this study suggests that quercetin could be a valuable addition to diabetic wound care, enhancing healing processes while combating common complications.
Read More
9
Quercetin's effectiveness in diabetes
α-Glucosidase Inhibitory Activities of Polyphenols From Mesua ferrea L. Leaves.
Study evaluates combined effects
We aimed to uncover how certain compounds from Mesua ferrea leaves, particularly quercetin, can aid in managing diabetes. Using a precise extraction process, we identified several polyphenols, notably quercetin 3-O-(3″,4″-di-E-p-coumaroyl)-α-l-rhamnoside (referred to as compound 8) and mammea A/AA cyclo D (compound 6), which displayed impressive α-glucosidase inhibitory activity.
The results were striking: compound 8 exhibited an IC value of just 1.81 µM—this shows it’s very effective at inhibiting the enzyme that contributes to diabetes. This was even more impressive than the more commonly known quercetin, which had an IC value of 7.82 µM. This hints that our compounds could be key players in diabetes treatment.
Additionally, we observed that compounds 3 and 4 not only inhibited α-glucosidase but also promoted glucose uptake in fat cells. This dual action opens the door to new, multi-targeted treatments for diabetes, showcasing the potential of M. ferrea leaves as a promising source for innovative anti-diabetic agents.
The results were striking: compound 8 exhibited an IC value of just 1.81 µM—this shows it’s very effective at inhibiting the enzyme that contributes to diabetes. This was even more impressive than the more commonly known quercetin, which had an IC value of 7.82 µM. This hints that our compounds could be key players in diabetes treatment.
Additionally, we observed that compounds 3 and 4 not only inhibited α-glucosidase but also promoted glucose uptake in fat cells. This dual action opens the door to new, multi-targeted treatments for diabetes, showcasing the potential of M. ferrea leaves as a promising source for innovative anti-diabetic agents.
Read More
9
Quercetin shows promise in diabetes
Antidiabetic Effects of Quercetin and Silk Sericin in Attenuating Dysregulation of Hepatic Gluconeogenesis in Diabetic Rats Through Potential Modulation of PI3K/Akt/FOXO1 Signaling: In Vivo and In Silico Studies.
Strongly relevant to study topic
We sought to understand how quercetin (QCT) and silk sericin (SS) can aid in managing diabetes, particularly focusing on their effects on liver glucose production. In our investigation, diabetic male albino rats were treated with QCT and SS to see how these substances influence several metabolic markers and overall glucose metabolism.
Following treatment, we observed that both QCT and SS significantly improved levels of glucose, insulin, and important liver enzymes. These substances also enhanced the functioning of liver carbohydrate-metabolizing enzymes. Notably, the administration of QCT and SS helped reduce markers of oxidative stress and inflammation, suggesting they may protect liver cells from damage.
We particularly noted that QCT led to increased expression of key signaling proteins in the liver, which are crucial in controlling blood sugar levels. Moreover, our immunohistochemical analysis showed a decrease in markers for cell death among the treated rats, highlighting the protective effects of QCT and SS.
Our results demonstrate that QCT and SS could effectively mitigate the complications of diabetes related to liver function. Importantly, quercetin showcased stronger interactions at the molecular level than silk sericin, pointing to its potential as a more effective therapeutic agent for managing diabetes.
Following treatment, we observed that both QCT and SS significantly improved levels of glucose, insulin, and important liver enzymes. These substances also enhanced the functioning of liver carbohydrate-metabolizing enzymes. Notably, the administration of QCT and SS helped reduce markers of oxidative stress and inflammation, suggesting they may protect liver cells from damage.
We particularly noted that QCT led to increased expression of key signaling proteins in the liver, which are crucial in controlling blood sugar levels. Moreover, our immunohistochemical analysis showed a decrease in markers for cell death among the treated rats, highlighting the protective effects of QCT and SS.
Our results demonstrate that QCT and SS could effectively mitigate the complications of diabetes related to liver function. Importantly, quercetin showcased stronger interactions at the molecular level than silk sericin, pointing to its potential as a more effective therapeutic agent for managing diabetes.
Read More
9
Quercetin improves wound healing
Collagen-based hydrogel derived from amniotic membrane loaded with quercetin accelerates wound healing by improving stereological parameters and reducing inflammation in a diabetic rat model.
Combined effects evaluated, limited isolation
We explored the impact of collagen-based hydrogel derived from amniotic membrane, loaded with quercetin, on wound healing in diabetic rats. The experiment involved sixty rats divided into four groups: a control group, one receiving the hydrogel alone, another with quercetin, and a final group that received both treatments.
Over a period of eight days, we observed significant improvements in wound healing for the groups treated with the hydrogel and quercetin compared to the control. Notably, the combined treatment of CHAM and quercetin showed the greatest benefits, enhancing the rates of wound contraction and promoting the formation of new skin layers, blood vessels, and collagen.
Furthermore, we found that inflammatory markers in the combined treatment group significantly decreased, indicating less inflammation. However, while the study highlighted the positive effects of quercetin within the context of the hydrogel, it is essential to note that it does not provide clear insights into the isolated effects of quercetin on diabetes itself.
Overall, we concluded that the combination of CHAM and quercetin brings promising improvements to wound healing in diabetic conditions but further investigation would be needed to separate quercetin's specific contributions to diabetes management.
Over a period of eight days, we observed significant improvements in wound healing for the groups treated with the hydrogel and quercetin compared to the control. Notably, the combined treatment of CHAM and quercetin showed the greatest benefits, enhancing the rates of wound contraction and promoting the formation of new skin layers, blood vessels, and collagen.
Furthermore, we found that inflammatory markers in the combined treatment group significantly decreased, indicating less inflammation. However, while the study highlighted the positive effects of quercetin within the context of the hydrogel, it is essential to note that it does not provide clear insights into the isolated effects of quercetin on diabetes itself.
Overall, we concluded that the combination of CHAM and quercetin brings promising improvements to wound healing in diabetic conditions but further investigation would be needed to separate quercetin's specific contributions to diabetes management.
Read More
8
Quercetin inhibits glucose-regulating enzymes
Inhibitory effects of phenolic compounds from blueberry leaf on α-amylase and α-glucosidase: kinetics, mode of action, and molecular interactions.
Significant diabetes-related findings
We analyzed how quercetin, a key component of blueberry leaf polyphenols, influences diabetes by examining its effects on enzymes that regulate glucose levels. Our study utilized various techniques to understand the interactions between these compounds and the digestive enzymes α-amylase and α-glucosidase, both of which play significant roles in carbohydrate digestion.
During our research, we found that quercetin exhibited the most potent inhibitory effects on these enzymes. Specifically, it showed stronger action against α-glucosidase than α-amylase, which means it could potentially be more beneficial in managing blood sugar levels. Furthermore, we discovered that blueberry leaf polyphenols acted as mixed-type inhibitors, indicating that they hinder enzyme activity in multiple ways.
By evaluating the binding characteristics and the stability of the complexes formed between quercetin and the enzymes, we uncovered that α-glucosidase has a greater affinity for blueberry leaf compounds than α-amylase does. These molecular interactions suggest that quercetin might be a valuable addition to diabetes management strategies, particularly through its effects on glucose metabolism.
Overall, this research sheds light on how quercetin, derived from blueberry leaves, may help in controlling diabetes by effectively inhibiting key digestive enzymes.
During our research, we found that quercetin exhibited the most potent inhibitory effects on these enzymes. Specifically, it showed stronger action against α-glucosidase than α-amylase, which means it could potentially be more beneficial in managing blood sugar levels. Furthermore, we discovered that blueberry leaf polyphenols acted as mixed-type inhibitors, indicating that they hinder enzyme activity in multiple ways.
By evaluating the binding characteristics and the stability of the complexes formed between quercetin and the enzymes, we uncovered that α-glucosidase has a greater affinity for blueberry leaf compounds than α-amylase does. These molecular interactions suggest that quercetin might be a valuable addition to diabetes management strategies, particularly through its effects on glucose metabolism.
Overall, this research sheds light on how quercetin, derived from blueberry leaves, may help in controlling diabetes by effectively inhibiting key digestive enzymes.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.6
9.5
Improved eyesight
As a diabetic, my eyesight began to blur, and my optometrist advised me that nothing could be done due to dilated blood vessels at the back of my eye. However, I read that Quercetin might assist with this issue by improving blood vessel function. Not wanting to lose my driving licence, I took a chance on some pills. It worked wonders! My doctor can't believe the difference; my eyesight is now 20/20, despite my diabetes and other conditions! Give it a go if your vision is blurry!
Read More
8.8
Improved kidney function
Quercetin is a life-prolonging supplement I adore, particularly for its benefits in improving kidney function and supporting heart health. It rejuvenates the immune system and maintains muscle condition. Along with bromelain, it effectively reduces joint inflammation. I regularly use it, especially for older family members, and the results have been remarkable.
Read More
8.8
Blood sugar reduction
I began taking Quercetin based on recommendations from naturopaths for its ability to inhibit an enzyme linked to diabetic issues. I noticed a slight decrease in my blood sugar levels, which was unexpected. For me, this has become an essential supplement, and I plan to continue using this particular brand.
Read More
8.8
Supports immunity
This Quercetin supplement is easy to swallow and provides energy without any aftertaste. I’ve found the quality to be excellent, and it appears to benefit my diabetes and immunity.
8.8
Positive reviews
Knowing that Quercetin has demonstrated increased insulin secretion in diabetic mice, I’ve given it to my mother, who is undergoing treatment. I am hopeful for positive results based on the good reviews it has received.
