Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 27 Researches
8.2
USERS' SCORE
Good
Based on 10 Reviews
8.3
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Quercetin
800 mg
**
Bromelain (2,400 GDU/g)
165 mg
**
Top Medical Research Studies
8
Quercetin aids diabetic heart health
We explored the emerging role of quercetin in managing diabetic cardiomyopathy, a serious complication linked to diabetes. The study highlights how quercetin, a natural compound found in many fruits and vegetables, shows promise in addressing various issues associated with this condition.
Through research, we uncovered that quercetin may aid in improving insulin signaling and reducing oxidative stress, both of which play significant roles in the progression of heart problems related to diabetes. Additionally, it appears to help combat inflammation and fibrosis, which are key factors in heart dysfunction.
We also noted that quercetin affects cellular processes like apoptosis and mitochondrial health, which are crucial for maintaining heart cell function. This multifaceted approach might be beneficial in preventing severe heart complications as diabetes progresses.
Overall, this review positions quercetin as a potential star in diabetes management, particularly for heart health, inviting further research and consideration for future therapeutic strategies.
Through research, we uncovered that quercetin may aid in improving insulin signaling and reducing oxidative stress, both of which play significant roles in the progression of heart problems related to diabetes. Additionally, it appears to help combat inflammation and fibrosis, which are key factors in heart dysfunction.
We also noted that quercetin affects cellular processes like apoptosis and mitochondrial health, which are crucial for maintaining heart cell function. This multifaceted approach might be beneficial in preventing severe heart complications as diabetes progresses.
Overall, this review positions quercetin as a potential star in diabetes management, particularly for heart health, inviting further research and consideration for future therapeutic strategies.
Read More
9
We set out to evaluate how quercetin, a natural compound, could aid in healing wounds, particularly in the context of diabetes. Our research introduced a novel hydrogel infused with quercetin, designed to respond to both reactive oxygen species (ROS) and glucose. By doing so, we aimed to release quercetin in a controlled manner, addressing some challenges of the diabetic wound environment.
Throughout the study, we demonstrated that this quercetin-loaded hydrogel showed impressive antibacterial and antioxidant properties, which are crucial for managing inflammation in diabetic wounds. Notably, in tests using diabetic rats, we found that our hydrogel significantly sped up wound healing compared to other treatments.
It improved crucial healing aspects such as re-epithelialization and collagen deposition. Furthermore, our observations indicated a boost in blood vessel formation, which is essential for delivering nutrients and oxygen to healing tissues. Overall, this study suggests that quercetin could be a valuable addition to diabetic wound care, enhancing healing processes while combating common complications.
Throughout the study, we demonstrated that this quercetin-loaded hydrogel showed impressive antibacterial and antioxidant properties, which are crucial for managing inflammation in diabetic wounds. Notably, in tests using diabetic rats, we found that our hydrogel significantly sped up wound healing compared to other treatments.
It improved crucial healing aspects such as re-epithelialization and collagen deposition. Furthermore, our observations indicated a boost in blood vessel formation, which is essential for delivering nutrients and oxygen to healing tissues. Overall, this study suggests that quercetin could be a valuable addition to diabetic wound care, enhancing healing processes while combating common complications.
Read More
9
Quercetin shows promise in diabetes
We sought to understand how quercetin (QCT) and silk sericin (SS) can aid in managing diabetes, particularly focusing on their effects on liver glucose production. In our investigation, diabetic male albino rats were treated with QCT and SS to see how these substances influence several metabolic markers and overall glucose metabolism.
Following treatment, we observed that both QCT and SS significantly improved levels of glucose, insulin, and important liver enzymes. These substances also enhanced the functioning of liver carbohydrate-metabolizing enzymes. Notably, the administration of QCT and SS helped reduce markers of oxidative stress and inflammation, suggesting they may protect liver cells from damage.
We particularly noted that QCT led to increased expression of key signaling proteins in the liver, which are crucial in controlling blood sugar levels. Moreover, our immunohistochemical analysis showed a decrease in markers for cell death among the treated rats, highlighting the protective effects of QCT and SS.
Our results demonstrate that QCT and SS could effectively mitigate the complications of diabetes related to liver function. Importantly, quercetin showcased stronger interactions at the molecular level than silk sericin, pointing to its potential as a more effective therapeutic agent for managing diabetes.
Following treatment, we observed that both QCT and SS significantly improved levels of glucose, insulin, and important liver enzymes. These substances also enhanced the functioning of liver carbohydrate-metabolizing enzymes. Notably, the administration of QCT and SS helped reduce markers of oxidative stress and inflammation, suggesting they may protect liver cells from damage.
We particularly noted that QCT led to increased expression of key signaling proteins in the liver, which are crucial in controlling blood sugar levels. Moreover, our immunohistochemical analysis showed a decrease in markers for cell death among the treated rats, highlighting the protective effects of QCT and SS.
Our results demonstrate that QCT and SS could effectively mitigate the complications of diabetes related to liver function. Importantly, quercetin showcased stronger interactions at the molecular level than silk sericin, pointing to its potential as a more effective therapeutic agent for managing diabetes.
Read More
Most Useful Reviews
9
Improved eyesight
59 people found this helpful
As a diabetic, my eyesight began to blur, and my optometrist advised me that nothing could be done due to dilated blood vessels at the back of my eye. However, I read that Quercetin might assist with this issue by improving blood vessel function. Not wanting to lose my driving licence, I took a chance on some pills. It worked wonders! My doctor can't believe the difference; my eyesight is now 20/20, despite my diabetes and other conditions! Give it a go if your vision is blurry!
Read More
7.5
Pain reduction
14 people found this helpful
I appreciate that Quercetin and bromelain can be taken together. Quercetin possesses anti-inflammatory, antioxidant, and blood pressure regulating qualities, which I find beneficial. The combination helps with pain and inflammation, especially for diabetic conditions.
Read More
7.5
Improved kidney function
2 people found this helpful
Quercetin is a life-prolonging supplement I adore, particularly for its benefits in improving kidney function and supporting heart health. It rejuvenates the immune system and maintains muscle condition. Along with bromelain, it effectively reduces joint inflammation. I regularly use it, especially for older family members, and the results have been remarkable.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 27 Researches
8.2
- All Researches
9.5
Microneedles accelerate diabetic wound healing
We developed a cutting-edge microneedle system that combines quercetin with growth factors and a unique polymer for treating diabetic ulcers. This method allows for deeper delivery of the treatment, effectively targeting infections while reducing inflammation and promoting new blood vessel growth.
In our experiments, we observed impressive wound healing rates in diabetic rats, with nearly 97% improvement after 14 days of treatment, compared to just over 40% in untreated controls. These results highlight the potential of our microneedle approach in tackling the serious challenges posed by diabetic wounds.
In our experiments, we observed impressive wound healing rates in diabetic rats, with nearly 97% improvement after 14 days of treatment, compared to just over 40% in untreated controls. These results highlight the potential of our microneedle approach in tackling the serious challenges posed by diabetic wounds.
Read More
9
We set out to evaluate how quercetin, a natural compound, could aid in healing wounds, particularly in the context of diabetes. Our research introduced a novel hydrogel infused with quercetin, designed to respond to both reactive oxygen species (ROS) and glucose. By doing so, we aimed to release quercetin in a controlled manner, addressing some challenges of the diabetic wound environment.
Throughout the study, we demonstrated that this quercetin-loaded hydrogel showed impressive antibacterial and antioxidant properties, which are crucial for managing inflammation in diabetic wounds. Notably, in tests using diabetic rats, we found that our hydrogel significantly sped up wound healing compared to other treatments.
It improved crucial healing aspects such as re-epithelialization and collagen deposition. Furthermore, our observations indicated a boost in blood vessel formation, which is essential for delivering nutrients and oxygen to healing tissues. Overall, this study suggests that quercetin could be a valuable addition to diabetic wound care, enhancing healing processes while combating common complications.
Throughout the study, we demonstrated that this quercetin-loaded hydrogel showed impressive antibacterial and antioxidant properties, which are crucial for managing inflammation in diabetic wounds. Notably, in tests using diabetic rats, we found that our hydrogel significantly sped up wound healing compared to other treatments.
It improved crucial healing aspects such as re-epithelialization and collagen deposition. Furthermore, our observations indicated a boost in blood vessel formation, which is essential for delivering nutrients and oxygen to healing tissues. Overall, this study suggests that quercetin could be a valuable addition to diabetic wound care, enhancing healing processes while combating common complications.
Read More
9
We aimed to uncover how certain compounds from Mesua ferrea leaves, particularly quercetin, can aid in managing diabetes. Using a precise extraction process, we identified several polyphenols, notably quercetin 3-O-(3″,4″-di-E-p-coumaroyl)-α-l-rhamnoside (referred to as compound 8) and mammea A/AA cyclo D (compound 6), which displayed impressive α-glucosidase inhibitory activity.
The results were striking: compound 8 exhibited an IC value of just 1.81 µM—this shows it’s very effective at inhibiting the enzyme that contributes to diabetes. This was even more impressive than the more commonly known quercetin, which had an IC value of 7.82 µM. This hints that our compounds could be key players in diabetes treatment.
Additionally, we observed that compounds 3 and 4 not only inhibited α-glucosidase but also promoted glucose uptake in fat cells. This dual action opens the door to new, multi-targeted treatments for diabetes, showcasing the potential of M. ferrea leaves as a promising source for innovative anti-diabetic agents.
The results were striking: compound 8 exhibited an IC value of just 1.81 µM—this shows it’s very effective at inhibiting the enzyme that contributes to diabetes. This was even more impressive than the more commonly known quercetin, which had an IC value of 7.82 µM. This hints that our compounds could be key players in diabetes treatment.
Additionally, we observed that compounds 3 and 4 not only inhibited α-glucosidase but also promoted glucose uptake in fat cells. This dual action opens the door to new, multi-targeted treatments for diabetes, showcasing the potential of M. ferrea leaves as a promising source for innovative anti-diabetic agents.
Read More
9
Quercetin shows promise in diabetes
We sought to understand how quercetin (QCT) and silk sericin (SS) can aid in managing diabetes, particularly focusing on their effects on liver glucose production. In our investigation, diabetic male albino rats were treated with QCT and SS to see how these substances influence several metabolic markers and overall glucose metabolism.
Following treatment, we observed that both QCT and SS significantly improved levels of glucose, insulin, and important liver enzymes. These substances also enhanced the functioning of liver carbohydrate-metabolizing enzymes. Notably, the administration of QCT and SS helped reduce markers of oxidative stress and inflammation, suggesting they may protect liver cells from damage.
We particularly noted that QCT led to increased expression of key signaling proteins in the liver, which are crucial in controlling blood sugar levels. Moreover, our immunohistochemical analysis showed a decrease in markers for cell death among the treated rats, highlighting the protective effects of QCT and SS.
Our results demonstrate that QCT and SS could effectively mitigate the complications of diabetes related to liver function. Importantly, quercetin showcased stronger interactions at the molecular level than silk sericin, pointing to its potential as a more effective therapeutic agent for managing diabetes.
Following treatment, we observed that both QCT and SS significantly improved levels of glucose, insulin, and important liver enzymes. These substances also enhanced the functioning of liver carbohydrate-metabolizing enzymes. Notably, the administration of QCT and SS helped reduce markers of oxidative stress and inflammation, suggesting they may protect liver cells from damage.
We particularly noted that QCT led to increased expression of key signaling proteins in the liver, which are crucial in controlling blood sugar levels. Moreover, our immunohistochemical analysis showed a decrease in markers for cell death among the treated rats, highlighting the protective effects of QCT and SS.
Our results demonstrate that QCT and SS could effectively mitigate the complications of diabetes related to liver function. Importantly, quercetin showcased stronger interactions at the molecular level than silk sericin, pointing to its potential as a more effective therapeutic agent for managing diabetes.
Read More
9
Quercetin improves wound healing
We explored the impact of collagen-based hydrogel derived from amniotic membrane, loaded with quercetin, on wound healing in diabetic rats. The experiment involved sixty rats divided into four groups: a control group, one receiving the hydrogel alone, another with quercetin, and a final group that received both treatments.
Over a period of eight days, we observed significant improvements in wound healing for the groups treated with the hydrogel and quercetin compared to the control. Notably, the combined treatment of CHAM and quercetin showed the greatest benefits, enhancing the rates of wound contraction and promoting the formation of new skin layers, blood vessels, and collagen.
Furthermore, we found that inflammatory markers in the combined treatment group significantly decreased, indicating less inflammation. However, while the study highlighted the positive effects of quercetin within the context of the hydrogel, it is essential to note that it does not provide clear insights into the isolated effects of quercetin on diabetes itself.
Overall, we concluded that the combination of CHAM and quercetin brings promising improvements to wound healing in diabetic conditions but further investigation would be needed to separate quercetin's specific contributions to diabetes management.
Over a period of eight days, we observed significant improvements in wound healing for the groups treated with the hydrogel and quercetin compared to the control. Notably, the combined treatment of CHAM and quercetin showed the greatest benefits, enhancing the rates of wound contraction and promoting the formation of new skin layers, blood vessels, and collagen.
Furthermore, we found that inflammatory markers in the combined treatment group significantly decreased, indicating less inflammation. However, while the study highlighted the positive effects of quercetin within the context of the hydrogel, it is essential to note that it does not provide clear insights into the isolated effects of quercetin on diabetes itself.
Overall, we concluded that the combination of CHAM and quercetin brings promising improvements to wound healing in diabetic conditions but further investigation would be needed to separate quercetin's specific contributions to diabetes management.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved eyesight
59 people found this helpful
As a diabetic, my eyesight began to blur, and my optometrist advised me that nothing could be done due to dilated blood vessels at the back of my eye. However, I read that Quercetin might assist with this issue by improving blood vessel function. Not wanting to lose my driving licence, I took a chance on some pills. It worked wonders! My doctor can't believe the difference; my eyesight is now 20/20, despite my diabetes and other conditions! Give it a go if your vision is blurry!
Read More
7.5
Pain reduction
14 people found this helpful
I appreciate that Quercetin and bromelain can be taken together. Quercetin possesses anti-inflammatory, antioxidant, and blood pressure regulating qualities, which I find beneficial. The combination helps with pain and inflammation, especially for diabetic conditions.
Read More
7.5
Improved kidney function
2 people found this helpful
Quercetin is a life-prolonging supplement I adore, particularly for its benefits in improving kidney function and supporting heart health. It rejuvenates the immune system and maintains muscle condition. Along with bromelain, it effectively reduces joint inflammation. I regularly use it, especially for older family members, and the results have been remarkable.
Read More
7.5
Blood sugar reduction
1 people found this helpful
I began taking Quercetin based on recommendations from naturopaths for its ability to inhibit an enzyme linked to diabetic issues. I noticed a slight decrease in my blood sugar levels, which was unexpected. For me, this has become an essential supplement, and I plan to continue using this particular brand.
Read More
7.5
Supports immunity
This Quercetin supplement is easy to swallow and provides energy without any aftertaste. I’ve found the quality to be excellent, and it appears to benefit my diabetes and immunity.
Read More
Frequently Asked Questions
7.5
Blood sugar reduction
1 people found this helpful
I began taking Quercetin based on recommendations from naturopaths for its ability to inhibit an enzyme linked to diabetic issues. I noticed a slight decrease in my blood sugar levels, which was unexpected. For me, this has become an essential supplement, and I plan to continue using this particular brand.
7.5
Supports immunity
This Quercetin supplement is easy to swallow and provides energy without any aftertaste. I’ve found the quality to be excellent, and it appears to benefit my diabetes and immunity.
7.5
Pain reduction
14 people found this helpful
I appreciate that Quercetin and bromelain can be taken together. Quercetin possesses anti-inflammatory, antioxidant, and blood pressure regulating qualities, which I find beneficial. The combination helps with pain and inflammation, especially for diabetic conditions.
7.5
Improved kidney function
2 people found this helpful
Quercetin is a life-prolonging supplement I adore, particularly for its benefits in improving kidney function and supporting heart health. It rejuvenates the immune system and maintains muscle condition. Along with bromelain, it effectively reduces joint inflammation. I regularly use it, especially for older family members, and the results have been remarkable.
7.5
Positive reviews
Knowing that Quercetin has demonstrated increased insulin secretion in diabetic mice, I’ve given it to my mother, who is undergoing treatment. I am hopeful for positive results based on the good reviews it has received.
6
Detoxifying agent
9 people found this helpful
Quercetin, found in common vegetables like onions and broccoli, offers antioxidant, anti-inflammatory, and antihypertensive effects, serving as a detoxifying agent for the body. It has been advantageous for some individuals with diabetes.
7.5
Helps absorption
3 people found this helpful
I consume quercetin, an onion component, due to its benefits for diabetes and hyperlipidemia. The addition of bromelain is advantageous for better absorption of quercetin.
8
We analyzed how quercetin, a key component of blueberry leaf polyphenols, influences diabetes by examining its effects on enzymes that regulate glucose levels. Our study utilized various techniques to understand the interactions between these compounds and the digestive enzymes α-amylase and α-glucosidase, both of which play significant roles in carbohydrate digestion.
During our research, we found that quercetin exhibited the most potent inhibitory effects on these enzymes. Specifically, it showed stronger action against α-glucosidase than α-amylase, which means it could potentially be more beneficial in managing blood sugar levels. Furthermore, we discovered that blueberry leaf polyphenols acted as mixed-type inhibitors, indicating that they hinder enzyme activity in multiple ways.
By evaluating the binding characteristics and the stability of the complexes formed between quercetin and the enzymes, we uncovered that α-glucosidase has a greater affinity for blueberry leaf compounds than α-amylase does. These molecular interactions suggest that quercetin might be a valuable addition to diabetes management strategies, particularly through its effects on glucose metabolism.
Overall, this research sheds light on how quercetin, derived from blueberry leaves, may help in controlling diabetes by effectively inhibiting key digestive enzymes.
During our research, we found that quercetin exhibited the most potent inhibitory effects on these enzymes. Specifically, it showed stronger action against α-glucosidase than α-amylase, which means it could potentially be more beneficial in managing blood sugar levels. Furthermore, we discovered that blueberry leaf polyphenols acted as mixed-type inhibitors, indicating that they hinder enzyme activity in multiple ways.
By evaluating the binding characteristics and the stability of the complexes formed between quercetin and the enzymes, we uncovered that α-glucosidase has a greater affinity for blueberry leaf compounds than α-amylase does. These molecular interactions suggest that quercetin might be a valuable addition to diabetes management strategies, particularly through its effects on glucose metabolism.
Overall, this research sheds light on how quercetin, derived from blueberry leaves, may help in controlling diabetes by effectively inhibiting key digestive enzymes.
8
Quercetin aids diabetes protection
We examined how quercetin (QCT), a natural plant-based antioxidant, can influence diabetes and liver health in leptin-deficient mice. The study involved 30 mice divided into different groups, including a control group and groups that received either QCT, catechin (CAT), or both treatments over seven days.
Observations revealed that mice treated with QCT and CAT showed marked improvements. Specifically, we found significant reductions in key health indicators like fasting blood sugar and harmful liver enzymes. Additionally, there were notable increases in beneficial factors such as high-density lipoprotein (HDL) and important antioxidants in the liver. This suggests that both QCT and CAT could help manage diabetes and protect the liver from damage.
However, remember that while QCT appears to contribute positively, the combined effects with CAT make it hard to pinpoint its benefits on its own. Nevertheless, these findings suggest potential pathways for using quercetin and catechin as protective agents against diabetes and liver toxicity in future treatments.
Observations revealed that mice treated with QCT and CAT showed marked improvements. Specifically, we found significant reductions in key health indicators like fasting blood sugar and harmful liver enzymes. Additionally, there were notable increases in beneficial factors such as high-density lipoprotein (HDL) and important antioxidants in the liver. This suggests that both QCT and CAT could help manage diabetes and protect the liver from damage.
However, remember that while QCT appears to contribute positively, the combined effects with CAT make it hard to pinpoint its benefits on its own. Nevertheless, these findings suggest potential pathways for using quercetin and catechin as protective agents against diabetes and liver toxicity in future treatments.
8
Quercetin's potential in diabetes management
We explored the impact of quercetin, a well-known flavonoid, on diabetes and its complications through various studies. The research reviewed includes laboratory experiments, animal models, and clinical trials. We found that quercetin has several beneficial effects, such as reducing inflammation, lowering blood sugar levels, and improving insulin sensitivity.
Specifically, quercetin appears to influence the expression of important signaling molecules like TNF-α and NF-κB, which are involved in inflammation. Additionally, we observed that quercetin increases the body’s ability to take up glucose, helping to combat insulin resistance—an important aspect of diabetes management. Furthermore, it seems to stimulate insulin secretion and contribute to healthier metabolism through various mechanisms in muscle tissues.
Importantly, quercetin's protective effects extend to complications arising from diabetes, including polycystic ovary syndrome, obesity linked to high-fat diets, and damages to the liver and kidneys. Overall, our findings suggest that quercetin could be a valuable supplement in managing not just diabetes itself but also its associated health issues.
Specifically, quercetin appears to influence the expression of important signaling molecules like TNF-α and NF-κB, which are involved in inflammation. Additionally, we observed that quercetin increases the body’s ability to take up glucose, helping to combat insulin resistance—an important aspect of diabetes management. Furthermore, it seems to stimulate insulin secretion and contribute to healthier metabolism through various mechanisms in muscle tissues.
Importantly, quercetin's protective effects extend to complications arising from diabetes, including polycystic ovary syndrome, obesity linked to high-fat diets, and damages to the liver and kidneys. Overall, our findings suggest that quercetin could be a valuable supplement in managing not just diabetes itself but also its associated health issues.
9
We set out to evaluate how quercetin, a natural compound, could aid in healing wounds, particularly in the context of diabetes. Our research introduced a novel hydrogel infused with quercetin, designed to respond to both reactive oxygen species (ROS) and glucose. By doing so, we aimed to release quercetin in a controlled manner, addressing some challenges of the diabetic wound environment.
Throughout the study, we demonstrated that this quercetin-loaded hydrogel showed impressive antibacterial and antioxidant properties, which are crucial for managing inflammation in diabetic wounds. Notably, in tests using diabetic rats, we found that our hydrogel significantly sped up wound healing compared to other treatments.
It improved crucial healing aspects such as re-epithelialization and collagen deposition. Furthermore, our observations indicated a boost in blood vessel formation, which is essential for delivering nutrients and oxygen to healing tissues. Overall, this study suggests that quercetin could be a valuable addition to diabetic wound care, enhancing healing processes while combating common complications.
Throughout the study, we demonstrated that this quercetin-loaded hydrogel showed impressive antibacterial and antioxidant properties, which are crucial for managing inflammation in diabetic wounds. Notably, in tests using diabetic rats, we found that our hydrogel significantly sped up wound healing compared to other treatments.
It improved crucial healing aspects such as re-epithelialization and collagen deposition. Furthermore, our observations indicated a boost in blood vessel formation, which is essential for delivering nutrients and oxygen to healing tissues. Overall, this study suggests that quercetin could be a valuable addition to diabetic wound care, enhancing healing processes while combating common complications.
References
- Wu H, Liu X, Xie S, Zhou J, Corradini MG, et al. Inhibitory effects of phenolic compounds from blueberry leaf on α-amylase and α-glucosidase: kinetics, mode of action, and molecular interactions. J Sci Food Agric. 2025. doi:10.1002/jsfa.14187
- Badiee MS, Vadizadeh A, Salehcheh M, Moosavi M, Shirani M, et al. Quercetin and Catechin Protects Leptin-Deficient Lep Mice Against Alloxan-Induced Diabetes and Hepatotoxicity via Suppression of Oxidative Stress and Inflammation. Rep Biochem Mol Biol. 2024;13:184. doi:10.61186/rbmb.13.2.184
- Basaldúa-Maciel V, Guzmán-Flores JM, Reyes-Chaparro A, Martínez-Esquivias F. Therapeutic Potential of Quercetin in Type 2 Diabetes Based on a Network Pharmacology Study. Curr Top Med Chem. 2025. doi:10.2174/0115680266361598250212030220
- Liu H, Sun Z, Yin M, Ru J, Liu X, et al. Polyphenol-Modified Mg-Zn Layered Hydroxide-Contained Microneedle Patch Enhance Mucosal Repair by Remolding Diabetic Oral Microenvironment. Adv Healthc Mater. 2025. doi:10.1002/adhm.202403883
- Liu H, Ai R, Liu B, He L. Dual ROS/Glucose-Responsive Quercetin-Loaded Supramolecular Hydrogel for Diabetic Wound Healing. Biomacromolecules. 2025. doi:10.1021/acs.biomac.4c01331
- Farhadi F, Sharififar F, Jafari M, Rahimi VB, Askari N, et al. Hallmarks of Quercetin Benefits as a Functional Supplementary in the Management of Diabetes Mellitus-Related Maladies: From Basic to Clinical Applications. Curr Drug Metab. 2025. doi:10.2174/0113892002339410250108031621
- Zhang DD, Wang YH, Panya A, Pandith H, Inta A, et al. α-Glucosidase Inhibitory Activities of Polyphenols From Mesua ferrea L. Leaves. Chem Biodivers. 2025. doi:10.1002/cbdv.202402330
- Abdou HM, Elmageed GMA, Hussein HK, Yamari I, Chtita S, et al. Antidiabetic Effects of Quercetin and Silk Sericin in Attenuating Dysregulation of Hepatic Gluconeogenesis in Diabetic Rats Through Potential Modulation of PI3K/Akt/FOXO1 Signaling: In Vivo and In Silico Studies. J Xenobiot. 2025;15. doi:10.3390/jox15010016
- Xiang X, Peng W, Lu Q, Ma S, Wang J, et al. Collagen-based hydrogel derived from amniotic membrane loaded with quercetin accelerates wound healing by improving stereological parameters and reducing inflammation in a diabetic rat model. Tissue Cell. 2025;93:102743. doi:10.1016/j.tice.2025.102743
- Shybyray Y, Liu L, Zhao H, Li J, Aisa HA. Flavonoid glycosides in Lepidium sativum seeds and their bioactivities. Phytochemistry. 2025;233:114410. doi:10.1016/j.phytochem.2025.114410
- Khajehlandi M, Bolboli L. The Role of Quercetin and Exercise in Modulating Apoptosis and Cardiomyopathy via PI3K/AKT/FOXO3 Pathways in Diabetic Obese Rats. Cell J. 2025;26:559. doi:10.22074/cellj.2024.2042044.1682
- Pan Y, Li Y, Zhou X, Luo J, Ding Q, et al. Extracellular Matrix-Mimicking Hydrogel with Angiogenic and Immunomodulatory Properties Accelerates Healing of Diabetic Wounds by Promoting Autophagy. ACS Appl Mater Interfaces. 2025;17:4608. doi:10.1021/acsami.4c18945
- Mustafa NH, Siti HN, Kamisah Y. Role of Quercetin in Diabetic Cardiomyopathy. Plants (Basel). 2024;14. doi:10.3390/plants14010025
- Latif S, Sameeullah M, Abbasi HQ, Masood Z, Demiral Sert T, et al. Broccoli () leaves exhibit significant antidiabetic potential in alloxan-induced diabetic rats: the putative role of ABC vacuolar transporter for accumulation of Quercetin and Kaempferol. Front Pharmacol. 2024;15:1421131. doi:10.3389/fphar.2024.1421131
- Sun H, Lu G, Fu C, Xu M, Zhu X, et al. [Quercetin ameliorates myocardial injury in diabetic rats by regulating L-type calcium channels]. Nan Fang Yi Ke Da Xue Xue Bao. 2025;45:531. doi:10.12122/j.issn.1673-4254.2025.03.11
- Zubaidi SN, Wong PL, Qadi WSM, Dawoud EAD, Hamezah HS, et al. Deciphering the mechanism of Annona muricata leaf extract in alloxan-nicotinamide-induced diabetic rat model with H-NMR-based metabolomics approach. J Pharm Biomed Anal. 2025;260:116806. doi:10.1016/j.jpba.2025.116806
- Zhang W, Yi C, Song Z, Yu B, Jiang X, et al. Reshaping the gut microbiota: Tangliping decoction and its core blood-absorbed component quercetin improve diabetic cognitive impairment. Phytomedicine. 2025;140:156560. doi:10.1016/j.phymed.2025.156560
- Tylishchak Z, Pryshliak O, Boichuk O, Fedorov S, Protsyk A, et al. Effectiveness of the quercetin use in patients with COVID-19 with concomitant type 2 diabetes mellitus. Wiad Lek. 2024;77:1962. doi:10.36740/WLek/191875
- Wu S, Zhou Z, Li Y, Wu R, Jiang J. Pretreatment of Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes with Quercetin Enhances the Healing of Diabetic Skin Wounds by Modulating Host-Microbiota Interactions. Int J Nanomedicine. 2024;19:12557. doi:10.2147/IJN.S491471
- Zhao X, Wang S, He X, Wei W, Huang K. Quercetin prevents the USP22-Snail1 signaling pathway to ameliorate diabetic tubulointerstitial fibrosis. Food Funct. 2024;15:11990. doi:10.1039/d4fo03564j
- Solfaine R, Hamid IS, Desiandura K. Therapeutic potential of extract: Modulating IL-35, TNF-α, and hematology profile in streptozotocin-induced rat model. Open Vet J. 2024;14:2250. doi:10.5455/OVJ.2024.v14.i9.12
- Jiang Y, Li X, Geng J, Chen Y, Tang B, et al. [Quercetin ameliorates diabetic kidney injury in rats by inhibiting the HMGB1/RAGE/NF-κB signaling pathway]. Nan Fang Yi Ke Da Xue Xue Bao. 2024;44:1769. doi:10.12122/j.issn.1673-4254.2024.09.17
- Wu Z, Hu J, Li Y, Yao X, Ouyang S, et al. Assessment of renal pathophysiological processes and protective effect of quercetin on contrast-induced acute kidney injury in type 1 diabetic mice using diffusion tensor imaging. Redox Rep. 2024;29:2398380. doi:10.1080/13510002.2024.2398380
- Wang A, Ruan X, Wang X, Ren Y, Shen C, et al. A one-stop integrated natural antimicrobial microneedles with anti-inflammatory, pro-angiogenic and long-term moisturizing properties to accelerate diabetic wound healing. Eur J Pharm Biopharm. 2024;203:114448. doi:10.1016/j.ejpb.2024.114448
- Khadrawy SM, Altoom NG, Alotaibi AG, Othman SI. Hepatoprotective potential of taxifolin in type 2 diabetic rats: modulation of oxidative stress and Bcl2/Bax/Caspase-3 signaling pathway. Mol Biol Rep. 2024;51:897. doi:10.1007/s11033-024-09805-x
- Wang J, Cui W, Dou X, Yin B, Niu Y, et al. [Euonymus alatus delays progression of diabetic kidney disease in mice by regulating EGFR tyrosine kinase inhibitor resistance signaling pathway]. Nan Fang Yi Ke Da Xue Xue Bao. 2024;44:1243. doi:10.12122/j.issn.1673-4254.2024.07.04
- Liu Z, Shang Q, Zuo H, Li H, Fang D, et al. Cynomorium songaricum: UHPLC/ESI-LTQ-Orbitrap-MS analysis and mechanistic study on insulin sensitivity of a flavonoid-enriched fraction. Phytomedicine. 2024;132:155862. doi:10.1016/j.phymed.2024.155862
