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SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.9
USERS' SCORE
Good
Based on 2 Reviews
8.6
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Quercetin
800 mg
**
Bromelain (2,400 GDU/g)
165 mg
**
Top Medical Research Studies
9
Quercetin reverses hyperthyroid damage
Quercetin alleviates hyperthyroidism-induced liver damage via Nrf2 Signaling pathway.
High relevance for hypothyroidism context.
We examined the effects of quercetin, a plant-derived flavonoid known for its antioxidant properties, in treating hyperthyroidism induced by L-thyroxine (LT4) in rats. Through a carefully designed study, we administered quercetin at different doses over two weeks to observe its impact on thyroid dysfunction.
The findings were striking. We noted that LT4 injections raised thyroid hormone levels while simultaneously increasing oxidative stress markers and decreasing antioxidant activity. However, when quercetin was introduced, it effectively reversed these adverse effects. Specifically, we saw improvements in liver function and oxidative stress markers, which suggests that quercetin held protective properties against the liver damage associated with hyperthyroidism.
Moreover, it became clear that these beneficial effects were tied to a specific signaling pathway known as Nrf2. When Nrf2 was inhibited in certain experimental rats, the positive impact of quercetin diminished, reinforcing the significance of this pathway in quercetin's action. Therefore, while our focus was on hyperthyroidism, the results imply that quercetin may hold potential therapeutic value in related conditions like hypothyroidism as well.
The findings were striking. We noted that LT4 injections raised thyroid hormone levels while simultaneously increasing oxidative stress markers and decreasing antioxidant activity. However, when quercetin was introduced, it effectively reversed these adverse effects. Specifically, we saw improvements in liver function and oxidative stress markers, which suggests that quercetin held protective properties against the liver damage associated with hyperthyroidism.
Moreover, it became clear that these beneficial effects were tied to a specific signaling pathway known as Nrf2. When Nrf2 was inhibited in certain experimental rats, the positive impact of quercetin diminished, reinforcing the significance of this pathway in quercetin's action. Therefore, while our focus was on hyperthyroidism, the results imply that quercetin may hold potential therapeutic value in related conditions like hypothyroidism as well.
Read More
8
Quercetin modulates hypothyroidism effects
Quercetin changes purinergic enzyme activities and oxidative profile in platelets of rats with hypothyroidism.
Study uniquely explores quercetin
We aimed to explore how quercetin, a plant flavonoid known for its potential health benefits, impacts rats with hypothyroidism caused by methimazole treatment. Over a period of 90 days, rats were given methimazole to induce hypothyroidism, and starting from the second month, they received quercetin at two different doses for 60 days.
Our observations revealed that hypothyroidism led to a notable decrease in certain enzyme activities in the platelets. Specifically, ecto-5’-nucleotidase activity dropped significantly in the untreated rats. Interestingly, treatment with the higher quercetin dosage decreased the activities of enzymes related to purine metabolism, such as NTPDase and adenosine deaminase.
Additionally, we noticed that platelets from hypothyroid rats showed increased aggregation and signs of oxidative stress indicated by higher lipid peroxidation levels, along with reduced antioxidant enzyme activities like superoxide dismutase and catalase. However, quercetin seemed to reverse these negative changes and also reduced platelet aggregation.
Overall, this suggests that quercetin is capable of modulating platelet function and oxidative stress in the context of hypothyroidism, potentially contributing to the prevention of related complications.
Our observations revealed that hypothyroidism led to a notable decrease in certain enzyme activities in the platelets. Specifically, ecto-5’-nucleotidase activity dropped significantly in the untreated rats. Interestingly, treatment with the higher quercetin dosage decreased the activities of enzymes related to purine metabolism, such as NTPDase and adenosine deaminase.
Additionally, we noticed that platelets from hypothyroid rats showed increased aggregation and signs of oxidative stress indicated by higher lipid peroxidation levels, along with reduced antioxidant enzyme activities like superoxide dismutase and catalase. However, quercetin seemed to reverse these negative changes and also reduced platelet aggregation.
Overall, this suggests that quercetin is capable of modulating platelet function and oxidative stress in the context of hypothyroidism, potentially contributing to the prevention of related complications.
Read More
8
Quercetin reduces oxidative stress
Effects of quercetin on oxidative stress biomarkers in methimazole - induced hypothyroid rats.
Direct effects on hypothyroidism >9
We conducted a study to explore how quercetin, a natural antioxidant, affects oxidative stress in rats with hypothyroidism induced by methimazole. The research involved 60 male Wistar rats divided into six groups, including controls and those treated with different doses of quercetin for eight weeks after being made hypothyroid.
During our observations, we noted that hypothyroid rats displayed significantly increased levels of oxidative stress markers in their liver, kidneys, and even in the brain. However, when we administered quercetin, we found that it effectively lowered these harmful oxidative markers, suggesting it helps restore balance in oxidative stress levels.
Notably, quercetin treatment also improved overall antioxidant capacity in both liver and kidney tissues. This means quercetin shows promise in mitigating some of the negative effects caused by hypothyroidism. Overall, our findings suggest that quercetin could be a beneficial addition to managing oxidative stress associated with hypothyroid conditions.
During our observations, we noted that hypothyroid rats displayed significantly increased levels of oxidative stress markers in their liver, kidneys, and even in the brain. However, when we administered quercetin, we found that it effectively lowered these harmful oxidative markers, suggesting it helps restore balance in oxidative stress levels.
Notably, quercetin treatment also improved overall antioxidant capacity in both liver and kidney tissues. This means quercetin shows promise in mitigating some of the negative effects caused by hypothyroidism. Overall, our findings suggest that quercetin could be a beneficial addition to managing oxidative stress associated with hypothyroid conditions.
Read More
Most Useful Reviews
9.5
Improved energy levels
I started taking this quercetin for my hypothyroidism after experiencing severe fatigue and a racing heart, yet my thyroid hormones were normal. I added magnesium and vitamin D to my regimen. Within a week, I began feeling more energetic and cheerful, and I stopped needing daytime naps. The magnesium course didn't help previously, but now I feel completely different. The combination of supplements may have made a difference. I'm pleased with the outcome and plan to keep taking it!
Read More
8.8
Lower cholesterol levels
I purchased this because the large size was out of stock. Although it is costly and somewhat painful, the results are remarkable. I have hypothyroidism and my bad cholesterol level once surged, but with daily use, it stabilised at about 170. Thanks to its bromelain content, my sensitive stomach tolerates it well. Typically, I take 2 tablets in the morning and evening, but recently just after dinner. It also has anti-inflammatory benefits that help with joint pain. I intend to continue using quercetin alone.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.9
9
Quercetin reverses hyperthyroid damage
Quercetin alleviates hyperthyroidism-induced liver damage via Nrf2 Signaling pathway.
High relevance for hypothyroidism context.
We examined the effects of quercetin, a plant-derived flavonoid known for its antioxidant properties, in treating hyperthyroidism induced by L-thyroxine (LT4) in rats. Through a carefully designed study, we administered quercetin at different doses over two weeks to observe its impact on thyroid dysfunction.
The findings were striking. We noted that LT4 injections raised thyroid hormone levels while simultaneously increasing oxidative stress markers and decreasing antioxidant activity. However, when quercetin was introduced, it effectively reversed these adverse effects. Specifically, we saw improvements in liver function and oxidative stress markers, which suggests that quercetin held protective properties against the liver damage associated with hyperthyroidism.
Moreover, it became clear that these beneficial effects were tied to a specific signaling pathway known as Nrf2. When Nrf2 was inhibited in certain experimental rats, the positive impact of quercetin diminished, reinforcing the significance of this pathway in quercetin's action. Therefore, while our focus was on hyperthyroidism, the results imply that quercetin may hold potential therapeutic value in related conditions like hypothyroidism as well.
The findings were striking. We noted that LT4 injections raised thyroid hormone levels while simultaneously increasing oxidative stress markers and decreasing antioxidant activity. However, when quercetin was introduced, it effectively reversed these adverse effects. Specifically, we saw improvements in liver function and oxidative stress markers, which suggests that quercetin held protective properties against the liver damage associated with hyperthyroidism.
Moreover, it became clear that these beneficial effects were tied to a specific signaling pathway known as Nrf2. When Nrf2 was inhibited in certain experimental rats, the positive impact of quercetin diminished, reinforcing the significance of this pathway in quercetin's action. Therefore, while our focus was on hyperthyroidism, the results imply that quercetin may hold potential therapeutic value in related conditions like hypothyroidism as well.
Read More
8
Quercetin's role in brain development
β-Sitosterol & quercetin enhances brain development in iodine deficient rat models.
Combining treatments complicates quercetin's effect
We explored how the combination of β-sitosterol and quercetin impacts brain development in rats affected by iodine deficiency. This study involved young adult female Wistar rats that were made hypothyroid through iodine deficiency. They were then mated, and the resulting pregnant females received treatment with β-sitosterol and quercetin during their pregnancy.
Our findings revealed positive effects on the brain development of their offspring, analyzed through genetic and histological studies. The results indicated that both β-sitosterol and quercetin, especially when combined, could support normal brain growth in infants born to iodine-deficient mothers. This suggests potential therapeutic applications in cases of iodine deficiency.
However, it's important to note that while quercetin was part of the treatment, its specific effects on hypothyroidism could not be isolated from those of β-sitosterol, making it challenging to determine its unique benefits. Overall, the study provides insights into the possible enhancements quercetin may offer when used alongside other compounds.
Our findings revealed positive effects on the brain development of their offspring, analyzed through genetic and histological studies. The results indicated that both β-sitosterol and quercetin, especially when combined, could support normal brain growth in infants born to iodine-deficient mothers. This suggests potential therapeutic applications in cases of iodine deficiency.
However, it's important to note that while quercetin was part of the treatment, its specific effects on hypothyroidism could not be isolated from those of β-sitosterol, making it challenging to determine its unique benefits. Overall, the study provides insights into the possible enhancements quercetin may offer when used alongside other compounds.
Read More
8
Quercetin aids cadmium-related hypothyroidism
Protective effects of quercetin supplementation against short-term toxicity of cadmium-induced hematological impairment, hypothyroidism, and testicular disturbances in albino rats.
Study shows mixed effectiveness
We examined how quercetin might protect against thyroid problems caused by cadmium exposure in a recent study with albino rats. The rats were given cadmium chloride, which led to increased cadmium levels in their blood and thyroid glands, resulting in noticeable thyroid hormone suppression. This decline in hormones negatively impacted their overall health and reproductive functions.
After four weeks, we found that not only did cadmium lower hormone levels, but it also harmed the rats’ ability to produce healthy sperm. Fortunately, when we introduced quercetin alongside cadmium, we observed significant improvements. Quercetin seemed to help restore the normal production of thyroid hormones and reduce various toxic effects associated with cadmium.
Overall, our findings suggest that quercetin may have the potential to reverse some of the damage caused by cadmium, particularly in relation to hypothyroidism and reproductive health. This could be beneficial for those looking for dietary ways to support thyroid function amid environmental toxins.
After four weeks, we found that not only did cadmium lower hormone levels, but it also harmed the rats’ ability to produce healthy sperm. Fortunately, when we introduced quercetin alongside cadmium, we observed significant improvements. Quercetin seemed to help restore the normal production of thyroid hormones and reduce various toxic effects associated with cadmium.
Overall, our findings suggest that quercetin may have the potential to reverse some of the damage caused by cadmium, particularly in relation to hypothyroidism and reproductive health. This could be beneficial for those looking for dietary ways to support thyroid function amid environmental toxins.
Read More
8
Quercetin modulates hypothyroidism effects
Quercetin changes purinergic enzyme activities and oxidative profile in platelets of rats with hypothyroidism.
Study uniquely explores quercetin
We aimed to explore how quercetin, a plant flavonoid known for its potential health benefits, impacts rats with hypothyroidism caused by methimazole treatment. Over a period of 90 days, rats were given methimazole to induce hypothyroidism, and starting from the second month, they received quercetin at two different doses for 60 days.
Our observations revealed that hypothyroidism led to a notable decrease in certain enzyme activities in the platelets. Specifically, ecto-5’-nucleotidase activity dropped significantly in the untreated rats. Interestingly, treatment with the higher quercetin dosage decreased the activities of enzymes related to purine metabolism, such as NTPDase and adenosine deaminase.
Additionally, we noticed that platelets from hypothyroid rats showed increased aggregation and signs of oxidative stress indicated by higher lipid peroxidation levels, along with reduced antioxidant enzyme activities like superoxide dismutase and catalase. However, quercetin seemed to reverse these negative changes and also reduced platelet aggregation.
Overall, this suggests that quercetin is capable of modulating platelet function and oxidative stress in the context of hypothyroidism, potentially contributing to the prevention of related complications.
Our observations revealed that hypothyroidism led to a notable decrease in certain enzyme activities in the platelets. Specifically, ecto-5’-nucleotidase activity dropped significantly in the untreated rats. Interestingly, treatment with the higher quercetin dosage decreased the activities of enzymes related to purine metabolism, such as NTPDase and adenosine deaminase.
Additionally, we noticed that platelets from hypothyroid rats showed increased aggregation and signs of oxidative stress indicated by higher lipid peroxidation levels, along with reduced antioxidant enzyme activities like superoxide dismutase and catalase. However, quercetin seemed to reverse these negative changes and also reduced platelet aggregation.
Overall, this suggests that quercetin is capable of modulating platelet function and oxidative stress in the context of hypothyroidism, potentially contributing to the prevention of related complications.
Read More
8
Quercetin reduces oxidative stress
Effects of quercetin on oxidative stress biomarkers in methimazole - induced hypothyroid rats.
Direct effects on hypothyroidism >9
We conducted a study to explore how quercetin, a natural antioxidant, affects oxidative stress in rats with hypothyroidism induced by methimazole. The research involved 60 male Wistar rats divided into six groups, including controls and those treated with different doses of quercetin for eight weeks after being made hypothyroid.
During our observations, we noted that hypothyroid rats displayed significantly increased levels of oxidative stress markers in their liver, kidneys, and even in the brain. However, when we administered quercetin, we found that it effectively lowered these harmful oxidative markers, suggesting it helps restore balance in oxidative stress levels.
Notably, quercetin treatment also improved overall antioxidant capacity in both liver and kidney tissues. This means quercetin shows promise in mitigating some of the negative effects caused by hypothyroidism. Overall, our findings suggest that quercetin could be a beneficial addition to managing oxidative stress associated with hypothyroid conditions.
During our observations, we noted that hypothyroid rats displayed significantly increased levels of oxidative stress markers in their liver, kidneys, and even in the brain. However, when we administered quercetin, we found that it effectively lowered these harmful oxidative markers, suggesting it helps restore balance in oxidative stress levels.
Notably, quercetin treatment also improved overall antioxidant capacity in both liver and kidney tissues. This means quercetin shows promise in mitigating some of the negative effects caused by hypothyroidism. Overall, our findings suggest that quercetin could be a beneficial addition to managing oxidative stress associated with hypothyroid conditions.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.6
9.5
Improved energy levels
I started taking this quercetin for my hypothyroidism after experiencing severe fatigue and a racing heart, yet my thyroid hormones were normal. I added magnesium and vitamin D to my regimen. Within a week, I began feeling more energetic and cheerful, and I stopped needing daytime naps. The magnesium course didn't help previously, but now I feel completely different. The combination of supplements may have made a difference. I'm pleased with the outcome and plan to keep taking it!
Read More
8.8
Lower cholesterol levels
I purchased this because the large size was out of stock. Although it is costly and somewhat painful, the results are remarkable. I have hypothyroidism and my bad cholesterol level once surged, but with daily use, it stabilised at about 170. Thanks to its bromelain content, my sensitive stomach tolerates it well. Typically, I take 2 tablets in the morning and evening, but recently just after dinner. It also has anti-inflammatory benefits that help with joint pain. I intend to continue using quercetin alone.
Read More
