Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.5
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Quercetin
800 mg
**
Bromelain (2,400 GDU/g)
165 mg
**
Top Medical Research Studies
8
Quercetin shows neuroprotective potential
We investigated the effects of quercetin on brain cells after strokes caused by middle cerebral artery occlusion (MCAO) in male rats. The study involved fifty-six rats divided into groups receiving different treatments, including a control group.
Quercetin, a natural compound known for its anti-inflammatory properties, showed promise in protecting CA1 neurons in the hippocampus—an area particularly vulnerable during a stroke. The results indicated that rats treated with lower doses of quercetin (5 and 10 mg/kg) had better neurological functions, improved motor skills, and showed remarkable preservation of brain tissue.
Additionally, quercetin treatment led to favorable changes in inflammation markers, specifically, a reduction in interleukin-1β (IL-1β) levels and an increase in interleukin-10 (IL-10) levels. However, the highest dosage of 20 mg/kg did not produce significant results compared to the control groups.
Overall, our findings suggest that quercetin may play a crucial role in neuroprotection following strokes, highlighting its potential as a therapeutic agent to mitigate brain injury.
Quercetin, a natural compound known for its anti-inflammatory properties, showed promise in protecting CA1 neurons in the hippocampus—an area particularly vulnerable during a stroke. The results indicated that rats treated with lower doses of quercetin (5 and 10 mg/kg) had better neurological functions, improved motor skills, and showed remarkable preservation of brain tissue.
Additionally, quercetin treatment led to favorable changes in inflammation markers, specifically, a reduction in interleukin-1β (IL-1β) levels and an increase in interleukin-10 (IL-10) levels. However, the highest dosage of 20 mg/kg did not produce significant results compared to the control groups.
Overall, our findings suggest that quercetin may play a crucial role in neuroprotection following strokes, highlighting its potential as a therapeutic agent to mitigate brain injury.
Read More
9
We explored how quercetin, an active ingredient in Polygonum cuspidatum, could impact ischemic stroke (IS). The research combined advanced techniques like ultra-high-performance liquid chromatography and network pharmacology to reveal how quercetin interacts with other compounds in Polygonum cuspidatum and affects IS.
We found 43 active components in Polygonum cuspidatum and identified 142 associated targets related to stroke. Notably, the study suggested that quercetin works through the PI3K/Akt signaling pathway, which seems crucial in regulating inflammation and cell survival during stroke.
Further investigations, including both lab tests and animal studies, showed that quercetin helped reduce inflammation and promote healing in stroke models. However, it’s worth noting that while quercetin helps when part of Polygonum cuspidatum, the study emphasizes its effects in a collective context rather than isolating its impact specifically on stroke.
Overall, this research highlights the potential role of quercetin, but we must consider it as part of a broader therapeutic strategy involving multiple compounds.
We found 43 active components in Polygonum cuspidatum and identified 142 associated targets related to stroke. Notably, the study suggested that quercetin works through the PI3K/Akt signaling pathway, which seems crucial in regulating inflammation and cell survival during stroke.
Further investigations, including both lab tests and animal studies, showed that quercetin helped reduce inflammation and promote healing in stroke models. However, it’s worth noting that while quercetin helps when part of Polygonum cuspidatum, the study emphasizes its effects in a collective context rather than isolating its impact specifically on stroke.
Overall, this research highlights the potential role of quercetin, but we must consider it as part of a broader therapeutic strategy involving multiple compounds.
Read More
9
We examined how a water extract from the Oliv. bark could potentially affect stroke recovery, particularly focusing on a compound called quercetin found within it. In a mouse model simulating a stroke—specifically, the middle cerebral artery occlusion (MCAO)—we observed that this extract significantly decreased brain damage and improved overall neurological function.
The study highlighted quercetin alongside other beneficial compounds present in the water extract. We noticed that after administering the extract, the activation of microglia—key players in inflammation in the brain—was considerably reduced. This led to lower levels of inflammatory substances, which are often associated with stroke damage.
Importantly, we discovered that the extract works by inhibiting certain inflammatory pathways, including the TLR4/p38 MAPK and NF-ÎşB pathways. This suggests that quercetin and its peers in the extract might play an essential role in mitigating neuroinflammation after a stroke. Our findings indicate the potential of using Oliv. bark extract as a promising avenue for supporting brain health post-stroke, emphasizing the value of quercetin's presence in this context.
The study highlighted quercetin alongside other beneficial compounds present in the water extract. We noticed that after administering the extract, the activation of microglia—key players in inflammation in the brain—was considerably reduced. This led to lower levels of inflammatory substances, which are often associated with stroke damage.
Importantly, we discovered that the extract works by inhibiting certain inflammatory pathways, including the TLR4/p38 MAPK and NF-ÎşB pathways. This suggests that quercetin and its peers in the extract might play an essential role in mitigating neuroinflammation after a stroke. Our findings indicate the potential of using Oliv. bark extract as a promising avenue for supporting brain health post-stroke, emphasizing the value of quercetin's presence in this context.
Read More
Most Useful Reviews
9
Effective for recovery
A wonderful drug; my husband took it after a stroke. I recommend it for thinning the blood. The price and quality are satisfactory, and it's easy to take.
Read More
7.5
Good for elderly
I bought this for Covid, but my grandmother took it after her stroke. Overall, it’s a good thing, and I plan to order more.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.5
- All Researches
9
We examined how a water extract from the Oliv. bark could potentially affect stroke recovery, particularly focusing on a compound called quercetin found within it. In a mouse model simulating a stroke—specifically, the middle cerebral artery occlusion (MCAO)—we observed that this extract significantly decreased brain damage and improved overall neurological function.
The study highlighted quercetin alongside other beneficial compounds present in the water extract. We noticed that after administering the extract, the activation of microglia—key players in inflammation in the brain—was considerably reduced. This led to lower levels of inflammatory substances, which are often associated with stroke damage.
Importantly, we discovered that the extract works by inhibiting certain inflammatory pathways, including the TLR4/p38 MAPK and NF-ÎşB pathways. This suggests that quercetin and its peers in the extract might play an essential role in mitigating neuroinflammation after a stroke. Our findings indicate the potential of using Oliv. bark extract as a promising avenue for supporting brain health post-stroke, emphasizing the value of quercetin's presence in this context.
The study highlighted quercetin alongside other beneficial compounds present in the water extract. We noticed that after administering the extract, the activation of microglia—key players in inflammation in the brain—was considerably reduced. This led to lower levels of inflammatory substances, which are often associated with stroke damage.
Importantly, we discovered that the extract works by inhibiting certain inflammatory pathways, including the TLR4/p38 MAPK and NF-ÎşB pathways. This suggests that quercetin and its peers in the extract might play an essential role in mitigating neuroinflammation after a stroke. Our findings indicate the potential of using Oliv. bark extract as a promising avenue for supporting brain health post-stroke, emphasizing the value of quercetin's presence in this context.
Read More
9
We explored how quercetin, an active ingredient in Polygonum cuspidatum, could impact ischemic stroke (IS). The research combined advanced techniques like ultra-high-performance liquid chromatography and network pharmacology to reveal how quercetin interacts with other compounds in Polygonum cuspidatum and affects IS.
We found 43 active components in Polygonum cuspidatum and identified 142 associated targets related to stroke. Notably, the study suggested that quercetin works through the PI3K/Akt signaling pathway, which seems crucial in regulating inflammation and cell survival during stroke.
Further investigations, including both lab tests and animal studies, showed that quercetin helped reduce inflammation and promote healing in stroke models. However, it’s worth noting that while quercetin helps when part of Polygonum cuspidatum, the study emphasizes its effects in a collective context rather than isolating its impact specifically on stroke.
Overall, this research highlights the potential role of quercetin, but we must consider it as part of a broader therapeutic strategy involving multiple compounds.
We found 43 active components in Polygonum cuspidatum and identified 142 associated targets related to stroke. Notably, the study suggested that quercetin works through the PI3K/Akt signaling pathway, which seems crucial in regulating inflammation and cell survival during stroke.
Further investigations, including both lab tests and animal studies, showed that quercetin helped reduce inflammation and promote healing in stroke models. However, it’s worth noting that while quercetin helps when part of Polygonum cuspidatum, the study emphasizes its effects in a collective context rather than isolating its impact specifically on stroke.
Overall, this research highlights the potential role of quercetin, but we must consider it as part of a broader therapeutic strategy involving multiple compounds.
Read More
8
Quercetin shows neuroprotective potential
We investigated the effects of quercetin on brain cells after strokes caused by middle cerebral artery occlusion (MCAO) in male rats. The study involved fifty-six rats divided into groups receiving different treatments, including a control group.
Quercetin, a natural compound known for its anti-inflammatory properties, showed promise in protecting CA1 neurons in the hippocampus—an area particularly vulnerable during a stroke. The results indicated that rats treated with lower doses of quercetin (5 and 10 mg/kg) had better neurological functions, improved motor skills, and showed remarkable preservation of brain tissue.
Additionally, quercetin treatment led to favorable changes in inflammation markers, specifically, a reduction in interleukin-1β (IL-1β) levels and an increase in interleukin-10 (IL-10) levels. However, the highest dosage of 20 mg/kg did not produce significant results compared to the control groups.
Overall, our findings suggest that quercetin may play a crucial role in neuroprotection following strokes, highlighting its potential as a therapeutic agent to mitigate brain injury.
Quercetin, a natural compound known for its anti-inflammatory properties, showed promise in protecting CA1 neurons in the hippocampus—an area particularly vulnerable during a stroke. The results indicated that rats treated with lower doses of quercetin (5 and 10 mg/kg) had better neurological functions, improved motor skills, and showed remarkable preservation of brain tissue.
Additionally, quercetin treatment led to favorable changes in inflammation markers, specifically, a reduction in interleukin-1β (IL-1β) levels and an increase in interleukin-10 (IL-10) levels. However, the highest dosage of 20 mg/kg did not produce significant results compared to the control groups.
Overall, our findings suggest that quercetin may play a crucial role in neuroprotection following strokes, highlighting its potential as a therapeutic agent to mitigate brain injury.
Read More
4
Combination therapy shows promise
We set out to understand how quercetin, along with other treatments, influences recovery from stroke in a rat model of cerebral ischemia/reperfusion injury. Utilizing a combination of Edaravone and Ginaton injection, we found that this multifaceted approach helped reduce brain damage significantly.
Although our focus included quercetin, its effect was explored primarily as part of the combination therapy rather than on its own. We observed that this combined treatment not only lessened the size of brain infarcts but also improved neurological functions and curbed neuronal damage more effectively than either treatment alone.
With our analysis, we discovered that quercetin, along with other compounds, benefited from extended circulation time in the bloodstream when administered together. Importantly, we used advanced techniques like matrix-assisted laser desorption/ionization mass spectrometry imaging to track changes in amine metabolites within the brain's affected regions. Here, the combination treatment showed a remarkable ability to adjust the disrupted metabolic pathways, spotlighting its potential as a meaningful strategy against stroke-related damage.
Although our focus included quercetin, its effect was explored primarily as part of the combination therapy rather than on its own. We observed that this combined treatment not only lessened the size of brain infarcts but also improved neurological functions and curbed neuronal damage more effectively than either treatment alone.
With our analysis, we discovered that quercetin, along with other compounds, benefited from extended circulation time in the bloodstream when administered together. Importantly, we used advanced techniques like matrix-assisted laser desorption/ionization mass spectrometry imaging to track changes in amine metabolites within the brain's affected regions. Here, the combination treatment showed a remarkable ability to adjust the disrupted metabolic pathways, spotlighting its potential as a meaningful strategy against stroke-related damage.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective for recovery
A wonderful drug; my husband took it after a stroke. I recommend it for thinning the blood. The price and quality are satisfactory, and it's easy to take.
Read More
7.5
Good for elderly
I bought this for Covid, but my grandmother took it after her stroke. Overall, it’s a good thing, and I plan to order more.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Pan J, Chai X, Li C, Wu Y, Ma Y, et al. Oliv. Bark Extracts Alleviate MCAO/Reperfusion-Induced Neurological Dysfunction by Suppressing Microglial Inflammation in the Gray Matter. Int J Mol Sci. 2025;26. doi:10.3390/ijms26041572
- Cao X, Zhang S, Mao M, Zhang Q, Guo Y. Exploring the mechanism of Polygonum Cuspidatum in the treatment of ischemic stroke by network pharmacology analysis and experimental validation. Fitoterapia. 2025;182:106414. doi:10.1016/j.fitote.2025.106414
- Li K, Wang S, Tang W, Chen Y, Li B. MALDI MSI-based spatial amine metabolomics revealing the protective effect of combination therapy against cerebral ischemia/reperfusion-induced brain injury in rats. J Pharm Biomed Anal. 2025;257:116715. doi:10.1016/j.jpba.2025.116715
- Mahyar M, Ghadirzadeh E, Nezhadnaderi P, Moayedi Z, Maboud P, et al. Neuroprotective effects of quercetin on hippocampal CA1 neurons following middle cerebral artery ischemia‒reperfusion in male rats: a behavioral, biochemical, and histological study. BMC Neurol. 2025;25:9. doi:10.1186/s12883-024-04017-z
