Last update
5/26/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.1
USERS' SCORE
Good
Based on 2 Reviews
8.2
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Calories
5
Total Carbohydrate
1 g
<1%**
Milk Thistle Extract (Silybum marianum)(Fruit/Seeds) (Standardized to 240 mg Silymarin Flavonoids - equivalent 80%)
300 mg
†
Turmeric (Curcuma longa) (Root)
700 mg
†
Top Medical Research Studies
9
Silibinin reduces depression in mice
We investigated the impact of silibinin, a natural compound from Silybum marianum, on depression and anxiety in mice with Parkinson's disease. Through various behavioral tests, we found that silibinin significantly reduced depressive and anxious behaviors caused by MPTP, a chemical used to induce these symptoms.
Additionally, silibinin helped repair neuronal damage in the hippocampus and restored levels of important mood-regulating neurotransmitters. It also reduced markers of neuroinflammation linked to depression, suggesting silibinin may hold promise as a treatment for these conditions in Parkinson's.
Additionally, silibinin helped repair neuronal damage in the hippocampus and restored levels of important mood-regulating neurotransmitters. It also reduced markers of neuroinflammation linked to depression, suggesting silibinin may hold promise as a treatment for these conditions in Parkinson's.
Read More
9
We explored the impact of silymarin, a compound from the Silybum marianum plant, on depression-like behaviors in mice exposed to chronic stress over four weeks. By administering different doses of silymarin alongside fluoxetine, we observed behavioral and biochemical changes in the mice. The results showed that silymarin reversed several negative effects caused by stress, including decreased serotonin and dopamine levels, and improved neurobiological markers like BDNF. This suggests that silymarin could play a beneficial role in alleviating depression by enhancing critical neurochemical pathways.
Read More
9
We investigated whether silymarin, derived from milk thistle, has antidepressant-like effects in male mice. Administered in varying doses before tests, silymarin significantly reduced immobility times, indicating potential antidepressant activity.
Notably, the study found that nitric oxide may play a role in this effect, as inhibiting nitric oxide synthesis reversed silymarin’s impact. However, it’s important to note that this study only involved animal models, and results may not directly translate to humans.
Notably, the study found that nitric oxide may play a role in this effect, as inhibiting nitric oxide synthesis reversed silymarin’s impact. However, it’s important to note that this study only involved animal models, and results may not directly translate to humans.
Read More
Most Useful Reviews
7.5
Aiding depression treatment
This excellent product is vital for maintaining our liver’s health, acting as a filter against harmful substances. It aids in the repair of damaged cells, reduces fat oxidation, and normalises lipid metabolism. Additionally, it helps manage depression and the effects of stress, while improving biochemical parameters and regulating cellular fluid transport. It also neutralises and removes hepatotoxic substances. I trust my review is useful to you.
Read More
6
Restoring mood effectively
The liver serves as our primary cleansing organ and is crucial for maintaining overall health. Historically, both European and Chinese healers have recognised that liver issues can lead to depression, irritability, and resentment. Milk thistle has been utilised for centuries to enhance liver function, mood, and vitality. It contains silymarin, which supports liver detoxification, stimulates new cell formation, and strengthens cell membranes. As a result, the liver's secretory functions improve, and digestion becomes more efficient. However, caution is advised for diabetics, as milk thistle may significantly lower blood sugar levels.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.1
- All Researches
9
Silibinin reduces depression in mice
We investigated the impact of silibinin, a natural compound from Silybum marianum, on depression and anxiety in mice with Parkinson's disease. Through various behavioral tests, we found that silibinin significantly reduced depressive and anxious behaviors caused by MPTP, a chemical used to induce these symptoms.
Additionally, silibinin helped repair neuronal damage in the hippocampus and restored levels of important mood-regulating neurotransmitters. It also reduced markers of neuroinflammation linked to depression, suggesting silibinin may hold promise as a treatment for these conditions in Parkinson's.
Additionally, silibinin helped repair neuronal damage in the hippocampus and restored levels of important mood-regulating neurotransmitters. It also reduced markers of neuroinflammation linked to depression, suggesting silibinin may hold promise as a treatment for these conditions in Parkinson's.
Read More
9
We explored the impact of silymarin, a compound from the Silybum marianum plant, on depression-like behaviors in mice exposed to chronic stress over four weeks. By administering different doses of silymarin alongside fluoxetine, we observed behavioral and biochemical changes in the mice. The results showed that silymarin reversed several negative effects caused by stress, including decreased serotonin and dopamine levels, and improved neurobiological markers like BDNF. This suggests that silymarin could play a beneficial role in alleviating depression by enhancing critical neurochemical pathways.
Read More
9
We investigated whether silymarin, derived from milk thistle, has antidepressant-like effects in male mice. Administered in varying doses before tests, silymarin significantly reduced immobility times, indicating potential antidepressant activity.
Notably, the study found that nitric oxide may play a role in this effect, as inhibiting nitric oxide synthesis reversed silymarin’s impact. However, it’s important to note that this study only involved animal models, and results may not directly translate to humans.
Notably, the study found that nitric oxide may play a role in this effect, as inhibiting nitric oxide synthesis reversed silymarin’s impact. However, it’s important to note that this study only involved animal models, and results may not directly translate to humans.
Read More
8
We explored the potential antidepressant effects of silibinin, a compound from Silybum marianum, by looking into how it impacts brain health in depression. Supporting our study, we found that silibinin improved behaviors in mice showing depressive symptoms.
Our findings connected its positive effects to increased growth of neural stem cells and better signaling in the BDNF/TrkB pathway, which is crucial for brain function. These results suggest that silibinin could be a valuable supplement for enhancing neurogenesis in those struggling with depression.
Our findings connected its positive effects to increased growth of neural stem cells and better signaling in the BDNF/TrkB pathway, which is crucial for brain function. These results suggest that silibinin could be a valuable supplement for enhancing neurogenesis in those struggling with depression.
Read More
8
Silibinin shows potential in depression
We investigated whether silibinin, a compound extracted from milk thistle, could alleviate anxiety and depression-like behaviors in rats exposed to amyloid β. Our findings showed that silibinin significantly reduced these negative behaviors as indicated by multiple tests.
Additionally, it helped protect against cellular damage in the hippocampus, revealing its potential to enhance important neurological pathways. While promising, these results are based on animal studies, highlighting the need for further research to determine silibinin's effectiveness in humans.
Additionally, it helped protect against cellular damage in the hippocampus, revealing its potential to enhance important neurological pathways. While promising, these results are based on animal studies, highlighting the need for further research to determine silibinin's effectiveness in humans.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Aiding depression treatment
This excellent product is vital for maintaining our liver’s health, acting as a filter against harmful substances. It aids in the repair of damaged cells, reduces fat oxidation, and normalises lipid metabolism. Additionally, it helps manage depression and the effects of stress, while improving biochemical parameters and regulating cellular fluid transport. It also neutralises and removes hepatotoxic substances. I trust my review is useful to you.
Read More
6
Restoring mood effectively
The liver serves as our primary cleansing organ and is crucial for maintaining overall health. Historically, both European and Chinese healers have recognised that liver issues can lead to depression, irritability, and resentment. Milk thistle has been utilised for centuries to enhance liver function, mood, and vitality. It contains silymarin, which supports liver detoxification, stimulates new cell formation, and strengthens cell membranes. As a result, the liver's secretory functions improve, and digestion becomes more efficient. However, caution is advised for diabetics, as milk thistle may significantly lower blood sugar levels.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Turlier V, Froliger M, Ribet V, Mengeaud V, Reygagne P. A Well-Tolerated Hair Serum Containing New Natural Active Ingredients Reduced Hair Loss and Improved Quality of Life in Women With Chronic Telogen Effluvium: A 16-Week Controlled Study. J Cosmet Dermatol. 2024;23 Suppl 5:12. 10.1111/jocd.16656
- Liu P, Chen W, Kang Y, Wang C, Wang X, et al. Silibinin ameliorates STING-mediated neuroinflammation via downregulation of ferroptotic damage in a sporadic Alzheimer's disease model. Arch Biochem Biophys. 2023;744:109691. 10.1016/j.abb.2023.109691
- Liu X, Chen W, Wang C, Liu W, Hayashi T, et al. Silibinin ameliorates depression/anxiety-like behaviors of Parkinson's disease mouse model and is associated with attenuated STING-IRF3-IFN-β pathway activation and neuroinflammation. Physiol Behav. 2021;241:113593. 10.1016/j.physbeh.2021.113593
- Li YJ, Li YJ, Yang LD, Zhang K, Zheng KY, et al. Silibinin exerts antidepressant effects by improving neurogenesis through BDNF/TrkB pathway. Behav Brain Res. 2018;348:184. 10.1016/j.bbr.2018.04.025
- Thakare VN, Patil RR, Oswal RJ, Dhakane VD, Aswar MK, et al. Therapeutic potential of silymarin in chronic unpredictable mild stress induced depressive-like behavior in mice. J Psychopharmacol. 2018;32:223. 10.1177/0269881117742666
- Song X, Liu B, Cui L, Zhou B, Liu W, et al. Silibinin ameliorates anxiety/depression-like behaviors in amyloid β-treated rats by upregulating BDNF/TrkB pathway and attenuating autophagy in hippocampus. Physiol Behav. 2017;179:487. 10.1016/j.physbeh.2017.07.023
- Thakare VN, Aswar MK, Kulkarni YP, Patil RR, Patel BM. Silymarin ameliorates experimentally induced depressive like behavior in rats: Involvement of hippocampal BDNF signaling, inflammatory cytokines and oxidative stress response. Physiol Behav. 2017;179:401. 10.1016/j.physbeh.2017.07.010
- Khoshnoodi M, Fakhraei N, Dehpour AR. Possible involvement of nitric oxide in antidepressant-like effect of silymarin in male mice. Pharm Biol. 2015;53:739. 10.3109/13880209.2014.942787
