Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.1
USERS' SCORE
Good
Based on 7 Reviews
8.2
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Calories
5
Total Carbohydrate
1 g
<1%**
Milk Thistle Extract (Silybum marianum)(Fruit/Seeds) (Standardized to 240 mg Silymarin Flavonoids - equivalent 80%)
300 mg
†
Turmeric (Curcuma longa) (Root)
700 mg
†
Top Medical Research Studies
9
Silibinin shows potential for diabetes
We explored the effects of silibinin, a key component from milk thistle, on diabetes through various studies. The systematic review covered data from multiple databases and highlighted that silibinin can help lower blood glucose levels, reduce insulin resistance, and improve inflammatory responses.
It also showed promise in tackling diabetes complications like liver damage and neuropathy. Despite these encouraging results, it's important to note that further well-structured studies are needed to fully understand how silibinin works in managing diabetes effectively.
It also showed promise in tackling diabetes complications like liver damage and neuropathy. Despite these encouraging results, it's important to note that further well-structured studies are needed to fully understand how silibinin works in managing diabetes effectively.
9
Effective silymarin delivery improves diabetes
We investigated how silymarin, derived from Silybum marianum, can potentially help manage type 2 diabetes. By using nanostructured lipid carriers (NLCs), we aimed to enhance silymarin's absorption since it usually has poor bioavailability.
Our study revealed that animals treated with NLCs showed significant reductions in blood glucose and triglyceride levels compared to those administered free silymarin. Additionally, there were notable protective effects on the liver and a reduction in nerve pain. Overall, these findings indicate that enhanced delivery methods could make silymarin a more effective treatment in diabetes management.
Our study revealed that animals treated with NLCs showed significant reductions in blood glucose and triglyceride levels compared to those administered free silymarin. Additionally, there were notable protective effects on the liver and a reduction in nerve pain. Overall, these findings indicate that enhanced delivery methods could make silymarin a more effective treatment in diabetes management.
8
We explored the effects of silibinin, an active compound from milk thistle, on type 2 diabetes in rats. Using a controlled study design, diabetic rats were treated with silibinin after exposure to diesel exhaust particles.
The results showed that silibinin positively influenced key insulin-related genes and reduced inflammation and oxidative stress. This suggests that silibinin may help regulate blood sugar levels and counteract some harmful effects of diabetes.
However, while promising, these findings require further investigation before we can fully endorse silibinin as a treatment option.
The results showed that silibinin positively influenced key insulin-related genes and reduced inflammation and oxidative stress. This suggests that silibinin may help regulate blood sugar levels and counteract some harmful effects of diabetes.
However, while promising, these findings require further investigation before we can fully endorse silibinin as a treatment option.
Most Useful Reviews
7.5
Supports borderline diabetes
1 people found this helpful
I have been using this product for many years and have noticed it is a great complement to the other products I take for my borderline diabetes. It has benefitted my liver and overall health, which is why I sometimes feel a slight twitch in the liver area after taking it.
9
Effective detox solution
This product is excellent for liver health, detoxification, and diabetes management. Now Foods ensures that it is a clean supplement.
7.5
Good for liver issues
A lovely product at a decent price! It assists with liver problems and diabetes.
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.1
- All Researches
9
Silibinin shows potential for diabetes
We explored the effects of silibinin, a key component from milk thistle, on diabetes through various studies. The systematic review covered data from multiple databases and highlighted that silibinin can help lower blood glucose levels, reduce insulin resistance, and improve inflammatory responses.
It also showed promise in tackling diabetes complications like liver damage and neuropathy. Despite these encouraging results, it's important to note that further well-structured studies are needed to fully understand how silibinin works in managing diabetes effectively.
It also showed promise in tackling diabetes complications like liver damage and neuropathy. Despite these encouraging results, it's important to note that further well-structured studies are needed to fully understand how silibinin works in managing diabetes effectively.
9
We observed significant improvements in blood sugar and lipid levels in diabetic rats treated with a polyherbal formulation named F6-SMONSECCE. This blend, made from various plant extracts, was tested against a known diabetic agent.
The results indicated substantial reductions in glucose and harmful cholesterol levels, alongside enhancements in insulin and beneficial HDL levels. Notably, there was also evidence of tissue healing in the pancreas and kidneys.
This suggests that F6-SMONSECCE could serve as a supportive treatment for diabetes, enhancing overall health alongside conventional medicines.
The results indicated substantial reductions in glucose and harmful cholesterol levels, alongside enhancements in insulin and beneficial HDL levels. Notably, there was also evidence of tissue healing in the pancreas and kidneys.
This suggests that F6-SMONSECCE could serve as a supportive treatment for diabetes, enhancing overall health alongside conventional medicines.
9
Effective silymarin delivery improves diabetes
We investigated how silymarin, derived from Silybum marianum, can potentially help manage type 2 diabetes. By using nanostructured lipid carriers (NLCs), we aimed to enhance silymarin's absorption since it usually has poor bioavailability.
Our study revealed that animals treated with NLCs showed significant reductions in blood glucose and triglyceride levels compared to those administered free silymarin. Additionally, there were notable protective effects on the liver and a reduction in nerve pain. Overall, these findings indicate that enhanced delivery methods could make silymarin a more effective treatment in diabetes management.
Our study revealed that animals treated with NLCs showed significant reductions in blood glucose and triglyceride levels compared to those administered free silymarin. Additionally, there were notable protective effects on the liver and a reduction in nerve pain. Overall, these findings indicate that enhanced delivery methods could make silymarin a more effective treatment in diabetes management.
8
We explored the effects of silibinin, an active compound from milk thistle, on type 2 diabetes in rats. Using a controlled study design, diabetic rats were treated with silibinin after exposure to diesel exhaust particles.
The results showed that silibinin positively influenced key insulin-related genes and reduced inflammation and oxidative stress. This suggests that silibinin may help regulate blood sugar levels and counteract some harmful effects of diabetes.
However, while promising, these findings require further investigation before we can fully endorse silibinin as a treatment option.
The results showed that silibinin positively influenced key insulin-related genes and reduced inflammation and oxidative stress. This suggests that silibinin may help regulate blood sugar levels and counteract some harmful effects of diabetes.
However, while promising, these findings require further investigation before we can fully endorse silibinin as a treatment option.
8
We investigated the effects of silibinin, a flavonoid from milk thistle, on diabetes in an animal model. Using healthy and diabetic rats, we examined how silibinin influenced insulin secretion, anxiety, and memory over 21 days.
Our findings showed that silibinin helped preserve insulin levels and decreased blood sugar. Additionally, it improved learning abilities in the rats. However, we did not evaluate the long-term effects or human applicability of these results. Overall, silibinin appears promising for diabetes management but needs further exploration.
Our findings showed that silibinin helped preserve insulin levels and decreased blood sugar. Additionally, it improved learning abilities in the rats. However, we did not evaluate the long-term effects or human applicability of these results. Overall, silibinin appears promising for diabetes management but needs further exploration.
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Supports borderline diabetes
1 people found this helpful
I have been using this product for many years and have noticed it is a great complement to the other products I take for my borderline diabetes. It has benefitted my liver and overall health, which is why I sometimes feel a slight twitch in the liver area after taking it.
9
Effective detox solution
This product is excellent for liver health, detoxification, and diabetes management. Now Foods ensures that it is a clean supplement.
7.5
Good for liver issues
A lovely product at a decent price! It assists with liver problems and diabetes.
7.5
Rebuilds liver support
This is my go-to for liver support and protection. I personally use it and also buy it for my mother, who has diabetes, to help rebuild and support her liver. It is soothing to the stomach lining and an excellent source of antioxidants.
7.5
Liver detoxification benefits
2 people found this helpful
A must for the body! Milk thistle has been renowned for its numerous advantages, acting as a liver detoxifier and regenerator, and providing assistance with diabetes, candida, and several other issues. I take it with NAC during body detox protocols.
Frequently Asked Questions
7.5
Supports borderline diabetes
1 people found this helpful
I have been using this product for many years and have noticed it is a great complement to the other products I take for my borderline diabetes. It has benefitted my liver and overall health, which is why I sometimes feel a slight twitch in the liver area after taking it.
7.5
Helpful for fatty liver
Taking milk thistle extract has significantly improved my liver function indicators, including platelets and leukocytes. It is also beneficial for fatty liver and diabetes linked to obesity as well as metabolic syndrome.
9
Effective detox solution
This product is excellent for liver health, detoxification, and diabetes management. Now Foods ensures that it is a clean supplement.
7.5
Rebuilds liver support
This is my go-to for liver support and protection. I personally use it and also buy it for my mother, who has diabetes, to help rebuild and support her liver. It is soothing to the stomach lining and an excellent source of antioxidants.
7.5
Liver detoxification benefits
2 people found this helpful
A must for the body! Milk thistle has been renowned for its numerous advantages, acting as a liver detoxifier and regenerator, and providing assistance with diabetes, candida, and several other issues. I take it with NAC during body detox protocols.
4
We reviewed several studies to understand how silymarin, a natural supplement, affects insulin resistance and sensitivity in individuals with diabetes. Our analysis showed that while silymarin can improve HOMA-IR levels slightly in type 2 diabetes patients, it did not significantly alter fasting insulin levels.
Interestingly, those with alcoholic cirrhosis experienced some benefits, but individuals with non-alcoholic fatty liver disease saw none. Overall, it appears that silymarin’s effects are limited, indicating a need for more robust research in this area.
Interestingly, those with alcoholic cirrhosis experienced some benefits, but individuals with non-alcoholic fatty liver disease saw none. Overall, it appears that silymarin’s effects are limited, indicating a need for more robust research in this area.
9
Silibinin shows potential for diabetes
We explored the effects of silibinin, a key component from milk thistle, on diabetes through various studies. The systematic review covered data from multiple databases and highlighted that silibinin can help lower blood glucose levels, reduce insulin resistance, and improve inflammatory responses.
It also showed promise in tackling diabetes complications like liver damage and neuropathy. Despite these encouraging results, it's important to note that further well-structured studies are needed to fully understand how silibinin works in managing diabetes effectively.
It also showed promise in tackling diabetes complications like liver damage and neuropathy. Despite these encouraging results, it's important to note that further well-structured studies are needed to fully understand how silibinin works in managing diabetes effectively.
8
Natural supplement aids diabetes management
We explored how a new blend of natural ingredients, including silymarin, affects metabolic balance in a diabetes model. In our study involving male mice on a high-fat diet, we observed that those given the new nutraceutical showed significant improvements.
Over four weeks, this group had lower fasting blood sugar, reduced insulin levels, and improved overall metabolic health compared to others. Notably, liver health improved, indicating promise for managing diabetes-related issues.
However, the results mainly highlight the benefits of the entire supplement rather than isolating silymarin’s specific effects.
Over four weeks, this group had lower fasting blood sugar, reduced insulin levels, and improved overall metabolic health compared to others. Notably, liver health improved, indicating promise for managing diabetes-related issues.
However, the results mainly highlight the benefits of the entire supplement rather than isolating silymarin’s specific effects.
References
- Yin S, Zhu F, Liu Y, Chen Q. Effects of silymarin on insulin resistance and sensitivity: A systematic review and meta-analysis of randomized controlled trials. Diabetes Res Clin Pract. 2025;220:112008. doi:10.1016/j.diabres.2025.112008
- Awolaja OO. Protective potentials of extracted compound SILIBININ from milk thistle on type-2 diabetes mellitus and diesel exhaust particle (DEP) toxicity in experimental rats. J Nutr Biochem. 2025;137:109836. doi:10.1016/j.jnutbio.2024.109836
- Zare Mehrjerdi P, Asadi S, Ehsani E, Askari VR, Baradaran Rahimi V. Silibinin as a major component of milk thistle seed provides promising influences against diabetes and its complications: a systematic review. Naunyn Schmiedebergs Arch Pharmacol. 2024;397:7531. doi:10.1007/s00210-024-03172-x
- Dagli Gul AS, Boyuk Ozcan G, Arihan O. Silibinin as a promising treatment for diabetes: Insights into behavioral and metabolic changes in an animal model. Food Sci Nutr. 2024;12:3336. doi:10.1002/fsn3.3999
- Awla NJ, Naqishbandi AM, Baqi Y. Preventive and Therapeutic Effects of Seed Extract Rich in Silydianin and Silychristin in a Rat Model of Metabolic Syndrome. ACS Pharmacol Transl Sci. 2023;6:1715. doi:10.1021/acsptsci.3c00171
- Akhtar MT, Almas T, Safdar S, Saadia M, Qadir R, et al. Antioxidant, Hypoglycemic, Antilipidemic, and Protective Effect of Polyherbal Emulsion (F6-SMONSECCE) on Alloxan-Induced Diabetic Rats. ACS Omega. 2023;8:21642. doi:10.1021/acsomega.3c01027
- Borymska W, Zych M, Dudek S, Kaczmarczyk-Sedlak I. Silymarin from Milk Thistle Fruits Counteracts Selected Pathological Changes in the Lenses of Type 1 Diabetic Rats. Nutrients. 2022;14. doi:10.3390/nu14071450
- Santamarina AB, Moraes RCM, Nehmi Filho V, Murata GM, de Freitas JA, et al. The Symbiotic Effect of a New Nutraceutical with Yeast β-Glucan, Prebiotics, Minerals, and (Silymarin) for Recovering Metabolic Homeostasis via , , and Gene Expression in a Type-2 Diabetes Obesity Model. Antioxidants (Basel). 2022;11. doi:10.3390/antiox11030447
- Doostkam A, Fathalipour M, Anbardar MH, Purkhosrow A, Mirkhani H. Therapeutic Effects of Milk Thistle ( L.) and Artichoke ( L.) on Nonalcoholic Fatty Liver Disease in Type 2 Diabetic Rats. Can J Gastroenterol Hepatol. 2022;2022:2868904. doi:10.1155/2022/2868904
- Colletta C, Colletta A, Placentino G. Lifestyle and silymarin: a fight against liver damage in NAFLD associated - prediabetic disease. J Diabetes Metab Disord. 2020;19:883. doi:10.1007/s40200-020-00576-3
- Miranda LMO, Agostini LDC, Lima WG, Camini FC, Costa DC. Silymarin Attenuates Hepatic and Pancreatic Redox Imbalance Independent of Glycemic Regulation in the Alloxan-induced Diabetic Rat Model. Biomed Environ Sci. 2020;33:690. doi:10.3967/bes2020.090
- Shen HH, Alex R, Bellner L, Raffaele M, Licari M, et al. Milk thistle seed cold press oil attenuates markers of the metabolic syndrome in a mouse model of dietary-induced obesity. J Food Biochem. 2020;44:e13522. doi:10.1111/jfbc.13522
- Shah M, Nawaz S, Jan H, Uddin N, Ali A, et al. Synthesis of bio-mediated silver nanoparticles from Silybum marianum and their biological and clinical activities. Mater Sci Eng C Mater Biol Appl. 2020;112:110889. doi:10.1016/j.msec.2020.110889
- Mehrzadi S, Mirzaei R, Heydari M, Sasani M, Yaqoobvand B, et al. Efficacy and Safety of a Traditional Herbal Combination in Patients with Type II Diabetes Mellitus: A Randomized Controlled Trial. J Diet Suppl. 2021;18:31. doi:10.1080/19390211.2020.1727076
- Piazzini V, Micheli L, Luceri C, D'Ambrosio M, Cinci L, et al. Nanostructured lipid carriers for oral delivery of silymarin: Improving its absorption and in vivo efficacy in type 2 diabetes and metabolic syndrome model. Int J Pharm. 2019;572:118838. doi:10.1016/j.ijpharm.2019.118838
- Sun Y, Yang J, Liu W, Yao G, Xu F, et al. Attenuating effect of silibinin on palmitic acid-induced apoptosis and mitochondrial dysfunction in pancreatic β-cells is mediated by estrogen receptor alpha. Mol Cell Biochem. 2019;460:81. doi:10.1007/s11010-019-03572-1
