5/26/2025
Last update
5/26/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 19 Reviews
8.2
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
5-HTP (5-hydroxytryptophan) (from Griffonia simplicifolia Extract) (Seed)
100 mg
*
Top Medical Research Studies
7
Cord blood metabolites and ADHD
We examined how levels of 5-hydroxytryptophan (5-HTP) in cord blood relate to the risk of developing ADHD and other developmental disorders. This study followed nearly 1,000 children from birth, looking for connections between cord plasma metabolites and diagnoses later on.
Interestingly, while higher levels of certain metabolites like 5-methoxytryptophol were linked to a reduced risk of ADHD, higher levels of 5-HTP actually correlated with an increased risk. It seems that not all tryptophan-related metabolites act the same way when it comes to ADHD.
Interestingly, while higher levels of certain metabolites like 5-methoxytryptophol were linked to a reduced risk of ADHD, higher levels of 5-HTP actually correlated with an increased risk. It seems that not all tryptophan-related metabolites act the same way when it comes to ADHD.
Read More
Most Useful Reviews
9
Enhanced positive thinking
31 people found this helpful
5-HTP has remarkably changed my life. Living with six subtypes of ADHD, it greatly aids in alleviating negative thought patterns and mental stress. I can confidently say that my thinking has turned more positive, allowing me to process my thoughts effortlessly. The obsessiveness associated with ADHD has significantly decreased. Thank you, IHERB!
Read More
9
Family user satisfaction
1 people found this helpful
I discovered 5-HTP from my endocrinologist for overcoming seasonal blues and bought it here due to better pricing. I noticed vivid dreams, deeper sleep, and reduced emotionality at work. My mother uses it as well and has experienced positive changes in sleep and irritability. We've recently started giving it to my ADHD-affected 12-year-old, and the results are striking—concentration improved significantly within just two days, although appetite decreased.
Read More
9
Aids ADHD treatment
Excellent! I take a lot of 5-HTP, a precursor of serotonin, which elevates my mood and aids in weight loss. It significantly alleviates my ADHD symptoms. I recommend trying it instead of serious pharmaceuticals and divide the doses for children.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
- All Researches
7
Cord blood metabolites and ADHD
We examined how levels of 5-hydroxytryptophan (5-HTP) in cord blood relate to the risk of developing ADHD and other developmental disorders. This study followed nearly 1,000 children from birth, looking for connections between cord plasma metabolites and diagnoses later on.
Interestingly, while higher levels of certain metabolites like 5-methoxytryptophol were linked to a reduced risk of ADHD, higher levels of 5-HTP actually correlated with an increased risk. It seems that not all tryptophan-related metabolites act the same way when it comes to ADHD.
Interestingly, while higher levels of certain metabolites like 5-methoxytryptophol were linked to a reduced risk of ADHD, higher levels of 5-HTP actually correlated with an increased risk. It seems that not all tryptophan-related metabolites act the same way when it comes to ADHD.
Read More
User Reviews
USERS' SCORE
Good
Based on 19 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Enhanced positive thinking
31 people found this helpful
5-HTP has remarkably changed my life. Living with six subtypes of ADHD, it greatly aids in alleviating negative thought patterns and mental stress. I can confidently say that my thinking has turned more positive, allowing me to process my thoughts effortlessly. The obsessiveness associated with ADHD has significantly decreased. Thank you, IHERB!
Read More
9
Family user satisfaction
1 people found this helpful
I discovered 5-HTP from my endocrinologist for overcoming seasonal blues and bought it here due to better pricing. I noticed vivid dreams, deeper sleep, and reduced emotionality at work. My mother uses it as well and has experienced positive changes in sleep and irritability. We've recently started giving it to my ADHD-affected 12-year-old, and the results are striking—concentration improved significantly within just two days, although appetite decreased.
Read More
9
Aids ADHD treatment
Excellent! I take a lot of 5-HTP, a precursor of serotonin, which elevates my mood and aids in weight loss. It significantly alleviates my ADHD symptoms. I recommend trying it instead of serious pharmaceuticals and divide the doses for children.
Read More
9
Improved sleep quality
I have ADHD, which caused sleep problems and frequent awakenings. After starting this supplement last autumn, I experienced substantial improvements; I could finally sleep longer than two hours at a time. I now take 100mg each evening without side effects. The quality of sleep is markedly better, and I wake feeling refreshed. My mood has improved as well, and I am highly satisfied with this product and will continue to repurchase it.
Read More
9
Mood improvement
Excellent! I have ADHD, and 5HTP significantly impacts me; I feel more down when I stop taking it. Of all the supplements I've tried, this is the best quality!
Read More
Frequently Asked Questions
9
Family user satisfaction
1 people found this helpful
I discovered 5-HTP from my endocrinologist for overcoming seasonal blues and bought it here due to better pricing. I noticed vivid dreams, deeper sleep, and reduced emotionality at work. My mother uses it as well and has experienced positive changes in sleep and irritability. We've recently started giving it to my ADHD-affected 12-year-old, and the results are striking—concentration improved significantly within just two days, although appetite decreased.
9
Improved sleep quality
I have ADHD, which caused sleep problems and frequent awakenings. After starting this supplement last autumn, I experienced substantial improvements; I could finally sleep longer than two hours at a time. I now take 100mg each evening without side effects. The quality of sleep is markedly better, and I wake feeling refreshed. My mood has improved as well, and I am highly satisfied with this product and will continue to repurchase it.
9
Calmness achieved
I absolutely love it! It truly aids my mood. Having ADHD, I've always experienced quick mood changes and irritability, but since starting this, I feel much calmer and nicer overall.
9
Enhanced positive thinking
31 people found this helpful
5-HTP has remarkably changed my life. Living with six subtypes of ADHD, it greatly aids in alleviating negative thought patterns and mental stress. I can confidently say that my thinking has turned more positive, allowing me to process my thoughts effortlessly. The obsessiveness associated with ADHD has significantly decreased. Thank you, IHERB!
7
Behaviour regulation
Great product; it helped me regulate some behaviours and my overall mood, alleviating some of my ADHD issues. However, it may induce nausea when taken on an empty stomach.
7.5
Sleep enhancement
I started using this product every night before bed, and I've noticed a significant improvement in my sleep. I take L-tyrosine during the day, and I believe these products together help with my ADHD symptoms.
7.5
Reduced anxiety levels
I have ADHD and have been taking 5-HTP for several years. Whenever I ran out, I noticed a significant decline in my overall well-being; my sleep was disturbed, and I felt anxious and unfocused. Resuming the supplement has markedly improved my sleep and reduced anxiety, making me feel much calmer and enhancing my concentration. While I also took L-theanine alongside, I can confidently recommend this supplement for those experiencing similar ADHD symptoms.
9
Enhanced quality
Amazing! I've been taking these with saffron for my ADHD at night. The dosage is great, and they help my husband too; he enjoys the quality.
6
Limited impact observed
This is for my daughter with ADHD. It seems to help her sleep somewhat, but I haven't noticed much change in her overall mood. She takes one pill before bed along with Zoloft in the morning. We'll continue to monitor her progress for more noticeable results.
4
Concentration aid
POWERFUL! Being on the spectrum of ADD/ADHD as an adult, I take these when I struggle to concentrate. Taking them daily doesn’t always help; they might make me hyper. I think a lower dose would help my symptoms more regularly. For now, I find taking these occasionally is a good reboot!
7
Cord blood metabolites and ADHD
We examined how levels of 5-hydroxytryptophan (5-HTP) in cord blood relate to the risk of developing ADHD and other developmental disorders. This study followed nearly 1,000 children from birth, looking for connections between cord plasma metabolites and diagnoses later on.
Interestingly, while higher levels of certain metabolites like 5-methoxytryptophol were linked to a reduced risk of ADHD, higher levels of 5-HTP actually correlated with an increased risk. It seems that not all tryptophan-related metabolites act the same way when it comes to ADHD.
Interestingly, while higher levels of certain metabolites like 5-methoxytryptophol were linked to a reduced risk of ADHD, higher levels of 5-HTP actually correlated with an increased risk. It seems that not all tryptophan-related metabolites act the same way when it comes to ADHD.
References
- Raghavan R, Anand NS, Wang G, Hong X, Pearson C, et al. Association between cord blood metabolites in tryptophan pathway and childhood risk of autism spectrum disorder and attention-deficit hyperactivity disorder. Transl Psychiatry. 2022;12:270. 10.1038/s41398-022-01992-0
