Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
USERS' SCORE
Good
Based on 64 Reviews
8.3
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
5-HTP (5-hydroxytryptophan) (from Griffonia simplicifolia Extract) (Seed)
100 mg
*
Top Medical Research Studies
8
5-HTP nanoparticles improve sleep
We investigated how a new composite nanoparticle system can enhance the sleep-promoting effects of 5-hydroxytryptophan (5-HTP).
By encapsulating 5-HTP in nanoparticles made from β-cyclodextrin and corn starch, we aimed to improve its sustained release and effectiveness.
Our findings showed that these nanoparticles significantly alleviated sleep-related issues in mice, helping to stabilize circadian rhythms and reduce symptoms caused by sleep deprivation.
This approach offers a promising avenue for efficiently using 5-HTP in sleep improvement products.
By encapsulating 5-HTP in nanoparticles made from β-cyclodextrin and corn starch, we aimed to improve its sustained release and effectiveness.
Our findings showed that these nanoparticles significantly alleviated sleep-related issues in mice, helping to stabilize circadian rhythms and reduce symptoms caused by sleep deprivation.
This approach offers a promising avenue for efficiently using 5-HTP in sleep improvement products.
Read More
8
We investigated how 5-hydroxytryptophan (5HTP) affects insomnia caused by parachlorophenylalanine (PCPA). In our research, we found that while one variant of 5HTP had no impact, another effectively suppressed insomnia and restored sleep phases, specifically slow-wave sleep (SWS) and paradoxical sleep (PS), albeit after some delay. When administered through different methods, 5HTP resulted in physiological sleep, yet its effect on PS was inconsistent, particularly when certain suppressants were introduced. In brief, 5HTP appears to play a role in sleep restoration, but responses can vary.
Read More
7
We explored the impact of L-5-Hydroxytryptophan (5-HTP) on insomnia caused by para-chlorophenylalanine, a compound that blocks serotonin production. This investigation revealed that microinjection of 5-HTP into the hypothalamus helped restore slow and paradoxical sleep, though insomnia returned afterward. Despite the initial improvement, the insomnia remained persistent, with no significant suppression of the abnormal brain activity linked to the treated condition. Overall, while 5-HTP showed some potential benefits, its effectiveness in creating lasting relief for insomnia was limited.
Read More
Most Useful Reviews
10
Quickly aids sleep
465 people found this helpful
I’ve been taking this nightly for over two years and love it. I have insomnia and take 1 or 2 at bedtime, and within minutes I’m asleep. It alleviates my anxiety for the next day. Previously, I was prescribed medications that dulled my senses. This, however, makes me feel like myself again. I truly appreciate it.
Read More
7.5
Quick results noted
205 people found this helpful
I noticed the effects of this supplement by the second day of use, addressing irritation and insomnia. I would recommend it to everyone facing similar challenges!
Read More
10
Insomnia relief
98 people found this helpful
Insomnia ceased to bother me.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
- All Researches
8
5-HTP nanoparticles improve sleep
We investigated how a new composite nanoparticle system can enhance the sleep-promoting effects of 5-hydroxytryptophan (5-HTP).
By encapsulating 5-HTP in nanoparticles made from β-cyclodextrin and corn starch, we aimed to improve its sustained release and effectiveness.
Our findings showed that these nanoparticles significantly alleviated sleep-related issues in mice, helping to stabilize circadian rhythms and reduce symptoms caused by sleep deprivation.
This approach offers a promising avenue for efficiently using 5-HTP in sleep improvement products.
By encapsulating 5-HTP in nanoparticles made from β-cyclodextrin and corn starch, we aimed to improve its sustained release and effectiveness.
Our findings showed that these nanoparticles significantly alleviated sleep-related issues in mice, helping to stabilize circadian rhythms and reduce symptoms caused by sleep deprivation.
This approach offers a promising avenue for efficiently using 5-HTP in sleep improvement products.
Read More
8
We investigated how 5-hydroxytryptophan (5HTP) affects insomnia caused by parachlorophenylalanine (PCPA). In our research, we found that while one variant of 5HTP had no impact, another effectively suppressed insomnia and restored sleep phases, specifically slow-wave sleep (SWS) and paradoxical sleep (PS), albeit after some delay. When administered through different methods, 5HTP resulted in physiological sleep, yet its effect on PS was inconsistent, particularly when certain suppressants were introduced. In brief, 5HTP appears to play a role in sleep restoration, but responses can vary.
Read More
7
We explored the impact of L-5-Hydroxytryptophan (5-HTP) on insomnia caused by para-chlorophenylalanine, a compound that blocks serotonin production. This investigation revealed that microinjection of 5-HTP into the hypothalamus helped restore slow and paradoxical sleep, though insomnia returned afterward. Despite the initial improvement, the insomnia remained persistent, with no significant suppression of the abnormal brain activity linked to the treated condition. Overall, while 5-HTP showed some potential benefits, its effectiveness in creating lasting relief for insomnia was limited.
Read More
User Reviews
USERS' SCORE
Good
Based on 64 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
10
Quickly aids sleep
465 people found this helpful
I’ve been taking this nightly for over two years and love it. I have insomnia and take 1 or 2 at bedtime, and within minutes I’m asleep. It alleviates my anxiety for the next day. Previously, I was prescribed medications that dulled my senses. This, however, makes me feel like myself again. I truly appreciate it.
Read More
7.5
Quick results noted
205 people found this helpful
I noticed the effects of this supplement by the second day of use, addressing irritation and insomnia. I would recommend it to everyone facing similar challenges!
Read More
10
Insomnia relief
98 people found this helpful
Insomnia ceased to bother me.
Read More
9
Natural sleep aid
10 people found this helpful
After using prescription sleep medications for years, I needed to stop due to their harmful side effects. My research led me to 5-HTP, which I've used for a month now. It helps with my insomnia just as effectively as the prescription meds did, but without the adverse effects.
Read More
9
Insomnia relief
7 people found this helpful
No more headaches. I used to suffer from weekly migraines, which sometimes necessitated an ER visit. Being an insomniac, I stumbled upon this recommendation on the Joe Rogan Podcast for sleep and mood. My migraines have completely disappeared, and my mood has improved significantly, along with the persistent headaches. I'm now headache-free! A note of caution: avoid certain medications to prevent "serotonin syndrome", but overall, my headaches are gone!
Read More
Frequently Asked Questions
7.5
Quick results noted
205 people found this helpful
I noticed the effects of this supplement by the second day of use, addressing irritation and insomnia. I would recommend it to everyone facing similar challenges!
7.5
Seeing results already
1 people found this helpful
I purchased this to aid with my insomnia, and after a week of use, I have already noticed positive results!
10
Insomnia relief
98 people found this helpful
Insomnia ceased to bother me.
7.5
Faster sleep onset
6 people found this helpful
Initially, I sought a serotonin boost but discovered it helped me fall asleep faster. Taking this alone an hour before bed or alongside melatonin allows me to sleep soundly until morning. Within moments of lying down, I feel comfy and sleepy, and it has significantly improved my insomnia.
9
Normalised sleep and stress
5 people found this helpful
This is the best remedy for stress! After two months of taking one capsule at night with GABA, my sleep and nerves have fully normalised. I recommend it to everyone!
8
Stress reduction
1 people found this helpful
A saviour for insomniacs, 5-HTP reduces stress and insomnia, allowing me to wake up feeling positive and relaxed. 5-HTP positively affects serotonin, enhancing relaxation.
9
Life-changing remedy
I've stocked up on this, as there’s no certainty about future availability. It genuinely assists me in tackling depressive episodes, anxiety, and insomnia. I’ve tried various brands, and all have worked in conjunction with GABA, theanine, and B vitamins. It has transformed my life!
0
Increased insomnia
1 people found this helpful
I didn't experience the declared effect. Rather, insomnia developed when taking this remedy. I haven't felt any improvement over the past month.
8
5-HTP nanoparticles improve sleep
We investigated how a new composite nanoparticle system can enhance the sleep-promoting effects of 5-hydroxytryptophan (5-HTP).
By encapsulating 5-HTP in nanoparticles made from β-cyclodextrin and corn starch, we aimed to improve its sustained release and effectiveness.
Our findings showed that these nanoparticles significantly alleviated sleep-related issues in mice, helping to stabilize circadian rhythms and reduce symptoms caused by sleep deprivation.
This approach offers a promising avenue for efficiently using 5-HTP in sleep improvement products.
By encapsulating 5-HTP in nanoparticles made from β-cyclodextrin and corn starch, we aimed to improve its sustained release and effectiveness.
Our findings showed that these nanoparticles significantly alleviated sleep-related issues in mice, helping to stabilize circadian rhythms and reduce symptoms caused by sleep deprivation.
This approach offers a promising avenue for efficiently using 5-HTP in sleep improvement products.
7
We explored the impact of L-5-Hydroxytryptophan (5-HTP) on insomnia caused by para-chlorophenylalanine, a compound that blocks serotonin production. This investigation revealed that microinjection of 5-HTP into the hypothalamus helped restore slow and paradoxical sleep, though insomnia returned afterward. Despite the initial improvement, the insomnia remained persistent, with no significant suppression of the abnormal brain activity linked to the treated condition. Overall, while 5-HTP showed some potential benefits, its effectiveness in creating lasting relief for insomnia was limited.
8
We investigated how 5-hydroxytryptophan (5HTP) affects insomnia caused by parachlorophenylalanine (PCPA). In our research, we found that while one variant of 5HTP had no impact, another effectively suppressed insomnia and restored sleep phases, specifically slow-wave sleep (SWS) and paradoxical sleep (PS), albeit after some delay. When administered through different methods, 5HTP resulted in physiological sleep, yet its effect on PS was inconsistent, particularly when certain suppressants were introduced. In brief, 5HTP appears to play a role in sleep restoration, but responses can vary.
References
- Gao L, Gu L, Li W, Wang G, Zhao J, et al. Construction of composite nanoparticles of β-cyclodextrin and corn starch encapsulating 5-hydroxytryptophan for sustained release and sleep improvement in vivo. Int J Biol Macromol. 2025;303:140831. doi:10.1016/j.ijbiomac.2025.140831
- Denoyer M, Sallanon M, Kitahama K, Aubert C, Jouvet M. Reversibility of para-chlorophenylalanine-induced insomnia by intrahypothalamic microinjection of L-5-hydroxytryptophan. Neuroscience. 1989;28:83.
- Petitjean F, Buda C, Janin M, Sallanon M, Jouvet M. [Insomnia caused by administration of para-chlorophenylalanine: reversibility by peripheral or central injection of 5-hydroxytryptophan and serotonin]. Sleep. 1985;8:56.
