Association between cord blood metabolites in tryptophan pathway and childhood risk of autism spectrum disorder and attention-deficit hyperactivity disorder.
We examined how levels of 5-hydroxytryptophan (5-HTP) in cord blood relate to the risk of developing ADHD and other developmental disorders. This study followed nearly 1,000 children from birth, looking for connections between cord plasma metabolites and diagnoses later on.
Interestingly, while higher levels of certain metabolites like 5-methoxytryptophol were linked to a reduced risk of ADHD, higher levels of 5-HTP actually correlated with an increased risk. It seems that not all tryptophan-related metabolites act the same way when it comes to ADHD.
Read More
Most Useful Reviews
9
Success with mood regulation
5 people found this helpful
5-HTP (5-Hydroxytryptophan) is an active form of L-Tryptophan and serves as a precursor to serotonin and melatonin, essential for alertness, mood elevation, and memory. I use it for my son, who has Non-Verbal ASD with ADHD. Please conduct your own research, as we find that 5-HTP works well at night with L-Tyrosine in the morning. These neurotransmitter precursors are vital for maintaining dopamine levels. We've had great success in regulating his mood!
Read More
9
Steady energy boost
1 people found this helpful
Major improvements! I visited the doctor last week for anxiety, depression, and ADHD. While awaiting my psychiatry appointment, I decided to try this supplement. Within a week, I've experienced steadier energy levels and less anxiety. I feel happier without worrying as much. Normally, I'd face PMS symptoms like low energy and mood swings, but not this month. Even during a stressful week at work, where I'd typically struggle with procrastination and anxiety attacks, I’ve managed to remain calm and perform well under pressure.
Read More
9
Mental clarity boost
1 people found this helpful
Fantastic for ADHD, especially when combined with a vitamin B complex. For the first time, I truly feel like I have a handful of brain cells.
Association between cord blood metabolites in tryptophan pathway and childhood risk of autism spectrum disorder and attention-deficit hyperactivity disorder.
We examined how levels of 5-hydroxytryptophan (5-HTP) in cord blood relate to the risk of developing ADHD and other developmental disorders. This study followed nearly 1,000 children from birth, looking for connections between cord plasma metabolites and diagnoses later on.
Interestingly, while higher levels of certain metabolites like 5-methoxytryptophol were linked to a reduced risk of ADHD, higher levels of 5-HTP actually correlated with an increased risk. It seems that not all tryptophan-related metabolites act the same way when it comes to ADHD.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.2
All Reviews
Positive Reviews
Negative Reviews
9
Success with mood regulation
5 people found this helpful
5-HTP (5-Hydroxytryptophan) is an active form of L-Tryptophan and serves as a precursor to serotonin and melatonin, essential for alertness, mood elevation, and memory. I use it for my son, who has Non-Verbal ASD with ADHD. Please conduct your own research, as we find that 5-HTP works well at night with L-Tyrosine in the morning. These neurotransmitter precursors are vital for maintaining dopamine levels. We've had great success in regulating his mood!
Read More
9
Steady energy boost
1 people found this helpful
Major improvements! I visited the doctor last week for anxiety, depression, and ADHD. While awaiting my psychiatry appointment, I decided to try this supplement. Within a week, I've experienced steadier energy levels and less anxiety. I feel happier without worrying as much. Normally, I'd face PMS symptoms like low energy and mood swings, but not this month. Even during a stressful week at work, where I'd typically struggle with procrastination and anxiety attacks, I’ve managed to remain calm and perform well under pressure.
Read More
9
Mental clarity boost
1 people found this helpful
Fantastic for ADHD, especially when combined with a vitamin B complex. For the first time, I truly feel like I have a handful of brain cells.
Read More
7.5
Improved sleep quality
4 people found this helpful
So much better than expected! I have ADHD and struggle with sleeping, often waking multiple times during the night. I decided to try this new supplement this autumn. Surprisingly, after my first dose, I slept well for the first time in about three months, no longer just in two-hour increments. I woke up a bit dizzy, likely due to my low blood pressure or calorie deficit, but this passed quickly. It didn't upset my sensitive stomach, and I find the dosage manageable as long as I drink plenty of water with it. Overall, I'm very pleased so far and hope it continues to positively impact my health.
Read More
7.5
Significant mood improvement
2 people found this helpful
A great quality product! The small capsules are easy to swallow and perfectly tailored for individual dosing, which is crucial with 5-HTP. We noticed significant improvements in sleep and stress reduction over time. This has led to improved mood and helped enhance focus and concentration at school while decreasing agitation.
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental condition characterized by a persistent pattern of inattention and/or hyperactivity-impulsivity that interferes with functioning or development. The symptoms typically present in early childhood and can continue into adolescence and adulthood. Individuals with ADHD may find it challenging to focus, organize tasks, follow through on instructions, and regulate their emotions. Hyperactivity can manifest as excessive fidgeting or an inability to remain seated in structured environments, while impulsivity may lead to hasty actions without considering the consequences.
Diagnosis of ADHD involves comprehensive assessments, often including behavioral evaluations and standardized rating scales, to determine how symptoms impact the individual’s daily life. Treatment can vary widely and may include behavioral therapy, psychoeducation, and medications such as stimulants or non-stimulants, aimed at improving attention span and impulse control. Understanding ADHD is crucial, not only for effective management but also for reducing stigma and promoting awareness. As our understanding of neurodiversity expands, more resources and support systems are becoming available to help those with ADHD thrive in both academic and social settings.
5-Hydroxytryptophan (5-HTP) is a naturally occurring amino acid and chemical precursor to serotonin, a neurotransmitter that plays a crucial role in regulating mood, sleep, and appetite. It is derived from the seeds of the griffonia simplicifolia plant and is often used as a dietary supplement to help improve mood, reduce anxiety, and aid in sleep. Many people turn to 5-HTP to support their mental health, particularly those struggling with conditions like depression or insomnia, as it is thought to help increase serotonin levels in the brain.
While some studies suggest that 5-HTP may be effective for these purposes, it’s essential to approach it with caution. The effectiveness can vary from person to person, and it's not a substitute for professional medical advice or treatment. If you're considering incorporating 5-HTP supplements into your routine, it's wise to consult with a healthcare provider, especially if you're taking other medications or have underlying health conditions. Remember, while natural supplements can be beneficial, they are not without potential side effects and interactions.
Based on user reviews, the time it takes to see results from using this supplement for ADHD can vary. Users report experiencing noticeable improvements in as little as one week. For instance, one user mentioned achieving steadier energy levels and reduced anxiety within just a week after starting the supplement Read Review. Meanwhile, others have noted significant benefits in focus, mood regulation, and cognitive functions after several weeks of consistent use Read Review, Read Review.
Thus, while some users may feel initial effects quite quickly, most see more substantial and stable improvements over a period of weeks. It's important to maintain consistency and monitor how your body responds to the supplement during this time. This aligns with feedback from various users who found the long-term use of the supplement beneficial for managing ADHD symptoms Read Review.
The supplement 5-hydroxytryptophan (5-HTP) shows some connection to ADHD, but the research indicates a complex relationship rather than clear support for its use. A study that followed nearly 1,000 children from birth found that while certain metabolites associated with tryptophan may help reduce the risk of ADHD, higher levels of 5-HTP actually correlated with an increased risk of developing the disorder [1]. This suggests that while 5-HTP is often touted for its potential benefits in mood and focus, its impact on ADHD may not be positive.
In summary, the data points to caution when considering 5-HTP as a supplement for ADHD. While metabolites related to tryptophan have various roles, higher levels of 5-HTP may contribute to an increased risk rather than offering therapeutic benefits. Therefore, it’s recommended that individuals explore alternative therapies and consult healthcare professionals before starting any new supplement regimen targeting ADHD.
Users have reported a range of improvements in symptoms associated with ADHD, anxiety, and mood regulation after using this supplement. Many have found noticeable changes in energy levels, calmness, and anxiety reduction within just a week of starting. For example, one user experienced steadier energy and reduced anxiety, enabling improved performance during stressful situations Read Review. Another mentioned a significant improvement in sleep quality, going from fragmented sleep to more restful nights, which positively affected their overall mood and focus Read Review.
Longer-term users have also reported considerable benefits, including enhanced cognitive functions, better concentration, and overall mood elevation. One user noted improvements in mood and stress reduction after several weeks, leading to better focus at school Read Review. Additionally, some have specifically highlighted the supplement's efficacy in managing ADHD symptoms in children, citing better balance and improved morning wakefulness Read Review. Overall, while individual results may vary, the anecdotal experiences of users suggest that this supplement can be a valuable component in managing ADHD and related emotional symptoms.
Users have reported a variety of positive responses when combining this supplement with other supplements for managing ADHD. For instance, one reviewer stated that 5-HTP works well when paired with L-Tyrosine in the morning, as these neurotransmitter precursors are essential for maintaining dopamine levels, greatly aiding in mood regulation for their son with ADHD Read Review. Additionally, another user highlighted that the supplement worked effectively alongside a vitamin B complex, helping them feel more mentally alert and focused, which is particularly beneficial for those grappling with ADHD symptoms Read Review.
The anecdotal evidence suggests that combining this supplement with other natural products may enhance its effects on mood and concentration. Many users have noted improvements in focus, mood stabilization, and reduced agitation when using it alongside various other supplements. This synergistic approach appears to offer a holistic strategy for managing ADHD, bringing together the benefits of multiple formulations to address both cognitive and emotional symptoms effectively Read Review. Overall, integrating this supplement with complementary items in a tailored regimen seems to yield favorable outcomes for improving ADHD symptoms.
Based on user reviews, individuals treating ADHD with 5-HTP report varying experiences regarding the ideal dosage for effectiveness. Many users emphasize the importance of personalized dosing, suggesting that 5-HTP can greatly improve mood, cognitive function, and sleep quality when tailored to individual needs. For instance, one parent noted that their son with ADHD benefits from combining 5-HTP at night with L-Tyrosine in the morning, advocating for experimentation with dosages to achieve the desired effect Read Review. Another user mentioned feeling improvements in attention and reduction of agitation, suggesting that gradual increases may be beneficial Read Review.
Overall, users generally agree that starting with a manageable dose, while monitoring changes in symptoms, is key. One user highlighted benefits after first use, correlating dosage with enhanced sleep and mood stability, indicating the significance of hydration and overall health conditions in determining efficacy Read Review. Ultimately, while there are positive anecdotal experiences, users are encouraged to consult healthcare professionals to tailor the dosage to their specific situations.
9
Steady energy boost
1 people found this helpful
Major improvements! I visited the doctor last week for anxiety, depression, and ADHD. While awaiting my psychiatry appointment, I decided to try this supplement. Within a week, I've experienced steadier energy levels and less anxiety. I feel happier without worrying as much. Normally, I'd face PMS symptoms like low energy and mood swings, but not this month. Even during a stressful week at work, where I'd typically struggle with procrastination and anxiety attacks, I’ve managed to remain calm and perform well under pressure.
7.5
Mood and sleep enhancement
An effective supplement for improving mood and sleep quality. 5-HTP is a precursor to serotonin that helps regulate these areas. After several weeks of use, I noticed enhancements in my mood and a reduction in anxiety. The vegetable capsules are easy to swallow, lacking side effects, making it an excellent natural solution for emotional health and sleep.
7.5
Significant mood improvement
2 people found this helpful
A great quality product! The small capsules are easy to swallow and perfectly tailored for individual dosing, which is crucial with 5-HTP. We noticed significant improvements in sleep and stress reduction over time. This has led to improved mood and helped enhance focus and concentration at school while decreasing agitation.
7.5
Cognitive function improvement
I used it for a teenager with ADHD. Regular use improved his sleep, morning awakening, cognitive functions, and balance. It's worth trying if nervous disorders are present.
7.5
Improved sleep quality
4 people found this helpful
So much better than expected! I have ADHD and struggle with sleeping, often waking multiple times during the night. I decided to try this new supplement this autumn. Surprisingly, after my first dose, I slept well for the first time in about three months, no longer just in two-hour increments. I woke up a bit dizzy, likely due to my low blood pressure or calorie deficit, but this passed quickly. It didn't upset my sensitive stomach, and I find the dosage manageable as long as I drink plenty of water with it. Overall, I'm very pleased so far and hope it continues to positively impact my health.
9
Success with mood regulation
5 people found this helpful
5-HTP (5-Hydroxytryptophan) is an active form of L-Tryptophan and serves as a precursor to serotonin and melatonin, essential for alertness, mood elevation, and memory. I use it for my son, who has Non-Verbal ASD with ADHD. Please conduct your own research, as we find that 5-HTP works well at night with L-Tyrosine in the morning. These neurotransmitter precursors are vital for maintaining dopamine levels. We've had great success in regulating his mood!
9
Mental clarity boost
1 people found this helpful
Fantastic for ADHD, especially when combined with a vitamin B complex. For the first time, I truly feel like I have a handful of brain cells.
7
Cord blood metabolites and ADHD
Association between cord blood metabolites in tryptophan pathway and childhood risk of autism spectrum disorder and attention-deficit hyperactivity disorder.
We examined how levels of 5-hydroxytryptophan (5-HTP) in cord blood relate to the risk of developing ADHD and other developmental disorders. This study followed nearly 1,000 children from birth, looking for connections between cord plasma metabolites and diagnoses later on.
Interestingly, while higher levels of certain metabolites like 5-methoxytryptophol were linked to a reduced risk of ADHD, higher levels of 5-HTP actually correlated with an increased risk. It seems that not all tryptophan-related metabolites act the same way when it comes to ADHD.
References
Raghavan R, Anand NS, Wang G, Hong X, Pearson C, et al. Association between cord blood metabolites in tryptophan pathway and childhood risk of autism spectrum disorder and attention-deficit hyperactivity disorder. Transl Psychiatry. 2022;12:270. doi:10.1038/s41398-022-01992-0