Last update
5/5/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 9 Reviews
8.1
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
5-HTP (5-hydroxytryptophan) (from Griffonia simplicifolia Extract) (seed)
50 mg
*
Top Medical Research Studies
7
Cord blood metabolites and ADHD
We examined how levels of 5-hydroxytryptophan (5-HTP) in cord blood relate to the risk of developing ADHD and other developmental disorders. This study followed nearly 1,000 children from birth, looking for connections between cord plasma metabolites and diagnoses later on.
Interestingly, while higher levels of certain metabolites like 5-methoxytryptophol were linked to a reduced risk of ADHD, higher levels of 5-HTP actually correlated with an increased risk. It seems that not all tryptophan-related metabolites act the same way when it comes to ADHD.
Interestingly, while higher levels of certain metabolites like 5-methoxytryptophol were linked to a reduced risk of ADHD, higher levels of 5-HTP actually correlated with an increased risk. It seems that not all tryptophan-related metabolites act the same way when it comes to ADHD.
Read More
Most Useful Reviews
9
Success with mood regulation
5 people found this helpful
5-HTP (5-Hydroxytryptophan) is an active form of L-Tryptophan and serves as a precursor to serotonin and melatonin, essential for alertness, mood elevation, and memory. I use it for my son, who has Non-Verbal ASD with ADHD. Please conduct your own research, as we find that 5-HTP works well at night with L-Tyrosine in the morning. These neurotransmitter precursors are vital for maintaining dopamine levels. We've had great success in regulating his mood!
Read More
9
Mental clarity boost
1 people found this helpful
Fantastic for ADHD, especially when combined with a vitamin B complex. For the first time, I truly feel like I have a handful of brain cells.
Read More
7.5
Improved sleep quality
4 people found this helpful
So much better than expected! I have ADHD and struggle with sleeping, often waking multiple times during the night. I decided to try this new supplement this autumn. Surprisingly, after my first dose, I slept well for the first time in about three months, no longer just in two-hour increments. I woke up a bit dizzy, likely due to my low blood pressure or calorie deficit, but this passed quickly. It didn't upset my sensitive stomach, and I find the dosage manageable as long as I drink plenty of water with it. Overall, I'm very pleased so far and hope it continues to positively impact my health.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
- All Researches
7
Cord blood metabolites and ADHD
We examined how levels of 5-hydroxytryptophan (5-HTP) in cord blood relate to the risk of developing ADHD and other developmental disorders. This study followed nearly 1,000 children from birth, looking for connections between cord plasma metabolites and diagnoses later on.
Interestingly, while higher levels of certain metabolites like 5-methoxytryptophol were linked to a reduced risk of ADHD, higher levels of 5-HTP actually correlated with an increased risk. It seems that not all tryptophan-related metabolites act the same way when it comes to ADHD.
Interestingly, while higher levels of certain metabolites like 5-methoxytryptophol were linked to a reduced risk of ADHD, higher levels of 5-HTP actually correlated with an increased risk. It seems that not all tryptophan-related metabolites act the same way when it comes to ADHD.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Success with mood regulation
5 people found this helpful
5-HTP (5-Hydroxytryptophan) is an active form of L-Tryptophan and serves as a precursor to serotonin and melatonin, essential for alertness, mood elevation, and memory. I use it for my son, who has Non-Verbal ASD with ADHD. Please conduct your own research, as we find that 5-HTP works well at night with L-Tyrosine in the morning. These neurotransmitter precursors are vital for maintaining dopamine levels. We've had great success in regulating his mood!
Read More
9
Mental clarity boost
1 people found this helpful
Fantastic for ADHD, especially when combined with a vitamin B complex. For the first time, I truly feel like I have a handful of brain cells.
Read More
7.5
Improved sleep quality
4 people found this helpful
So much better than expected! I have ADHD and struggle with sleeping, often waking multiple times during the night. I decided to try this new supplement this autumn. Surprisingly, after my first dose, I slept well for the first time in about three months, no longer just in two-hour increments. I woke up a bit dizzy, likely due to my low blood pressure or calorie deficit, but this passed quickly. It didn't upset my sensitive stomach, and I find the dosage manageable as long as I drink plenty of water with it. Overall, I'm very pleased so far and hope it continues to positively impact my health.
Read More
7.5
Significant mood improvement
2 people found this helpful
A great quality product! The small capsules are easy to swallow and perfectly tailored for individual dosing, which is crucial with 5-HTP. We noticed significant improvements in sleep and stress reduction over time. This has led to improved mood and helped enhance focus and concentration at school while decreasing agitation.
Read More
7.5
Mood and sleep enhancement
An effective supplement for improving mood and sleep quality. 5-HTP is a precursor to serotonin that helps regulate these areas. After several weeks of use, I noticed enhancements in my mood and a reduction in anxiety. The vegetable capsules are easy to swallow, lacking side effects, making it an excellent natural solution for emotional health and sleep.
Read More
Frequently Asked Questions
7.5
Mood and sleep enhancement
An effective supplement for improving mood and sleep quality. 5-HTP is a precursor to serotonin that helps regulate these areas. After several weeks of use, I noticed enhancements in my mood and a reduction in anxiety. The vegetable capsules are easy to swallow, lacking side effects, making it an excellent natural solution for emotional health and sleep.
7.5
Significant mood improvement
2 people found this helpful
A great quality product! The small capsules are easy to swallow and perfectly tailored for individual dosing, which is crucial with 5-HTP. We noticed significant improvements in sleep and stress reduction over time. This has led to improved mood and helped enhance focus and concentration at school while decreasing agitation.
7.5
Cognitive function improvement
I used it for a teenager with ADHD. Regular use improved his sleep, morning awakening, cognitive functions, and balance. It's worth trying if nervous disorders are present.
7.5
Improved sleep quality
4 people found this helpful
So much better than expected! I have ADHD and struggle with sleeping, often waking multiple times during the night. I decided to try this new supplement this autumn. Surprisingly, after my first dose, I slept well for the first time in about three months, no longer just in two-hour increments. I woke up a bit dizzy, likely due to my low blood pressure or calorie deficit, but this passed quickly. It didn't upset my sensitive stomach, and I find the dosage manageable as long as I drink plenty of water with it. Overall, I'm very pleased so far and hope it continues to positively impact my health.
9
Success with mood regulation
5 people found this helpful
5-HTP (5-Hydroxytryptophan) is an active form of L-Tryptophan and serves as a precursor to serotonin and melatonin, essential for alertness, mood elevation, and memory. I use it for my son, who has Non-Verbal ASD with ADHD. Please conduct your own research, as we find that 5-HTP works well at night with L-Tyrosine in the morning. These neurotransmitter precursors are vital for maintaining dopamine levels. We've had great success in regulating his mood!
9
Mental clarity boost
1 people found this helpful
Fantastic for ADHD, especially when combined with a vitamin B complex. For the first time, I truly feel like I have a handful of brain cells.
7
Cord blood metabolites and ADHD
We examined how levels of 5-hydroxytryptophan (5-HTP) in cord blood relate to the risk of developing ADHD and other developmental disorders. This study followed nearly 1,000 children from birth, looking for connections between cord plasma metabolites and diagnoses later on.
Interestingly, while higher levels of certain metabolites like 5-methoxytryptophol were linked to a reduced risk of ADHD, higher levels of 5-HTP actually correlated with an increased risk. It seems that not all tryptophan-related metabolites act the same way when it comes to ADHD.
Interestingly, while higher levels of certain metabolites like 5-methoxytryptophol were linked to a reduced risk of ADHD, higher levels of 5-HTP actually correlated with an increased risk. It seems that not all tryptophan-related metabolites act the same way when it comes to ADHD.
References
- Raghavan R, Anand NS, Wang G, Hong X, Pearson C, et al. Association between cord blood metabolites in tryptophan pathway and childhood risk of autism spectrum disorder and attention-deficit hyperactivity disorder. Transl Psychiatry. 2022;12:270. 10.1038/s41398-022-01992-0
