Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
USERS' SCORE
Moderately Good
Based on 20 Reviews
7.5
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
5-HTP (5-hydroxytryptophan) (from Griffonia simplicifolia Extract) (seed)
50 mg
*
Top Medical Research Studies
8
5-HTP nanoparticles improve sleep
We investigated how a new composite nanoparticle system can enhance the sleep-promoting effects of 5-hydroxytryptophan (5-HTP).
By encapsulating 5-HTP in nanoparticles made from β-cyclodextrin and corn starch, we aimed to improve its sustained release and effectiveness.
Our findings showed that these nanoparticles significantly alleviated sleep-related issues in mice, helping to stabilize circadian rhythms and reduce symptoms caused by sleep deprivation.
This approach offers a promising avenue for efficiently using 5-HTP in sleep improvement products.
By encapsulating 5-HTP in nanoparticles made from β-cyclodextrin and corn starch, we aimed to improve its sustained release and effectiveness.
Our findings showed that these nanoparticles significantly alleviated sleep-related issues in mice, helping to stabilize circadian rhythms and reduce symptoms caused by sleep deprivation.
This approach offers a promising avenue for efficiently using 5-HTP in sleep improvement products.
Read More
8
We investigated how 5-hydroxytryptophan (5HTP) affects insomnia caused by parachlorophenylalanine (PCPA). In our research, we found that while one variant of 5HTP had no impact, another effectively suppressed insomnia and restored sleep phases, specifically slow-wave sleep (SWS) and paradoxical sleep (PS), albeit after some delay. When administered through different methods, 5HTP resulted in physiological sleep, yet its effect on PS was inconsistent, particularly when certain suppressants were introduced. In brief, 5HTP appears to play a role in sleep restoration, but responses can vary.
Read More
7
We explored the impact of L-5-Hydroxytryptophan (5-HTP) on insomnia caused by para-chlorophenylalanine, a compound that blocks serotonin production. This investigation revealed that microinjection of 5-HTP into the hypothalamus helped restore slow and paradoxical sleep, though insomnia returned afterward. Despite the initial improvement, the insomnia remained persistent, with no significant suppression of the abnormal brain activity linked to the treated condition. Overall, while 5-HTP showed some potential benefits, its effectiveness in creating lasting relief for insomnia was limited.
Read More
Most Useful Reviews
9
Quick relief
1 people found this helpful
I find 5-HTP remarkably effective for stress-induced insomnia. A mere 50 mg before bed helps me feel relaxed and sleep well without lethargy during the day. It's a perfect remedy for when I face insomnia.
Read More
9
Highly recommended
I recommend this for anyone suffering from insomnia. It's effective!
Read More
9
Helpful remedy
It helps with my insomnia.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
- All Researches
8
5-HTP nanoparticles improve sleep
We investigated how a new composite nanoparticle system can enhance the sleep-promoting effects of 5-hydroxytryptophan (5-HTP).
By encapsulating 5-HTP in nanoparticles made from β-cyclodextrin and corn starch, we aimed to improve its sustained release and effectiveness.
Our findings showed that these nanoparticles significantly alleviated sleep-related issues in mice, helping to stabilize circadian rhythms and reduce symptoms caused by sleep deprivation.
This approach offers a promising avenue for efficiently using 5-HTP in sleep improvement products.
By encapsulating 5-HTP in nanoparticles made from β-cyclodextrin and corn starch, we aimed to improve its sustained release and effectiveness.
Our findings showed that these nanoparticles significantly alleviated sleep-related issues in mice, helping to stabilize circadian rhythms and reduce symptoms caused by sleep deprivation.
This approach offers a promising avenue for efficiently using 5-HTP in sleep improvement products.
Read More
8
We investigated how 5-hydroxytryptophan (5HTP) affects insomnia caused by parachlorophenylalanine (PCPA). In our research, we found that while one variant of 5HTP had no impact, another effectively suppressed insomnia and restored sleep phases, specifically slow-wave sleep (SWS) and paradoxical sleep (PS), albeit after some delay. When administered through different methods, 5HTP resulted in physiological sleep, yet its effect on PS was inconsistent, particularly when certain suppressants were introduced. In brief, 5HTP appears to play a role in sleep restoration, but responses can vary.
Read More
7
We explored the impact of L-5-Hydroxytryptophan (5-HTP) on insomnia caused by para-chlorophenylalanine, a compound that blocks serotonin production. This investigation revealed that microinjection of 5-HTP into the hypothalamus helped restore slow and paradoxical sleep, though insomnia returned afterward. Despite the initial improvement, the insomnia remained persistent, with no significant suppression of the abnormal brain activity linked to the treated condition. Overall, while 5-HTP showed some potential benefits, its effectiveness in creating lasting relief for insomnia was limited.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 20 Reviews
7.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Quick relief
1 people found this helpful
I find 5-HTP remarkably effective for stress-induced insomnia. A mere 50 mg before bed helps me feel relaxed and sleep well without lethargy during the day. It's a perfect remedy for when I face insomnia.
Read More
9
Highly recommended
I recommend this for anyone suffering from insomnia. It's effective!
Read More
9
Helpful remedy
It helps with my insomnia.
Read More
9
Helpful for insomnia
It helps me a lot with insomnia. I rarely manage to fall asleep at night, but this product assists me greatly.
Read More
7.5
Regular sleep schedule
7 people found this helpful
5-HTP was suggested by a naturopath to aid sleep without relying on prescriptions. It helps induce sleep by converting Tryptophan to Serotonin. I have a challenging relationship with carbs and coffee, which disrupt my sleep. I take 5-HTP twice daily and notice it starts working when I yawn at 8 PM. I highly recommend it for insomnia, especially when combined with melatonin.
Read More
Frequently Asked Questions
9
Quick relief
1 people found this helpful
I find 5-HTP remarkably effective for stress-induced insomnia. A mere 50 mg before bed helps me feel relaxed and sleep well without lethargy during the day. It's a perfect remedy for when I face insomnia.
2
No effect after initial dreams
Initially, I had very vivid dreams for the first five days, but after that, there was no effect. At times, insomnia set in, indicating this medication may not suit everyone.
0
No benefits noted
I used it to help me sleep and relieve insomnia, but honestly, I did not notice any benefit, either in improving my mood or in helping me fall asleep quickly.
10
Immediate effects
1 people found this helpful
I happily rate this product a 5. My mother-in-law, who suffers from insomnia, is pleased. After relying on melatonin for some time, its efficacy waned. This product helped me quickly fall asleep and wake up refreshed.
7.5
Effective but mood swings
Not for me. I wanted to give this another try. I bought it for insomnia and stress. It works great for insomnia, but the next morning, I had horrible mood swings and felt irritated and sleepy all day.
2
No relief
1 people found this helpful
It didn't help at all and did not resolve my insomnia issue.
7.5
Effective relaxation
5-HTP is a natural amino acid that influences the body's serotonin production, the so-called happy hormone. It's beneficial for those prone to depression or anxiety. Although I appear calm, my internal stress causes me insomnia at night. My routine includes taking vitamin B12 in the morning and melatonin with 5-HTP in the evening. B12 keeps me energetic during the day, while the combination promotes relaxation and good sleep at night. I haven't slept this well in ages. Highly recommended!
7.5
Partial relief
2 people found this helpful
The quality is good, and it moderately alleviates insomnia when taken at night. However, if anxiety is more prominent, the effects may be less noticeable. It might be beneficial to increase the dosage for better results.
0
Not effective
It made me feel jittery, wired, and strange, causing insomnia. It seems it doesn't suit everyone.
8
We investigated how 5-hydroxytryptophan (5HTP) affects insomnia caused by parachlorophenylalanine (PCPA). In our research, we found that while one variant of 5HTP had no impact, another effectively suppressed insomnia and restored sleep phases, specifically slow-wave sleep (SWS) and paradoxical sleep (PS), albeit after some delay. When administered through different methods, 5HTP resulted in physiological sleep, yet its effect on PS was inconsistent, particularly when certain suppressants were introduced. In brief, 5HTP appears to play a role in sleep restoration, but responses can vary.
7
We explored the impact of L-5-Hydroxytryptophan (5-HTP) on insomnia caused by para-chlorophenylalanine, a compound that blocks serotonin production. This investigation revealed that microinjection of 5-HTP into the hypothalamus helped restore slow and paradoxical sleep, though insomnia returned afterward. Despite the initial improvement, the insomnia remained persistent, with no significant suppression of the abnormal brain activity linked to the treated condition. Overall, while 5-HTP showed some potential benefits, its effectiveness in creating lasting relief for insomnia was limited.
8
5-HTP nanoparticles improve sleep
We investigated how a new composite nanoparticle system can enhance the sleep-promoting effects of 5-hydroxytryptophan (5-HTP).
By encapsulating 5-HTP in nanoparticles made from β-cyclodextrin and corn starch, we aimed to improve its sustained release and effectiveness.
Our findings showed that these nanoparticles significantly alleviated sleep-related issues in mice, helping to stabilize circadian rhythms and reduce symptoms caused by sleep deprivation.
This approach offers a promising avenue for efficiently using 5-HTP in sleep improvement products.
By encapsulating 5-HTP in nanoparticles made from β-cyclodextrin and corn starch, we aimed to improve its sustained release and effectiveness.
Our findings showed that these nanoparticles significantly alleviated sleep-related issues in mice, helping to stabilize circadian rhythms and reduce symptoms caused by sleep deprivation.
This approach offers a promising avenue for efficiently using 5-HTP in sleep improvement products.
References
- Gao L, Gu L, Li W, Wang G, Zhao J, et al. Construction of composite nanoparticles of β-cyclodextrin and corn starch encapsulating 5-hydroxytryptophan for sustained release and sleep improvement in vivo. Int J Biol Macromol. 2025;303:140831. 10.1016/j.ijbiomac.2025.140831
- Denoyer M, Sallanon M, Kitahama K, Aubert C, Jouvet M. Reversibility of para-chlorophenylalanine-induced insomnia by intrahypothalamic microinjection of L-5-hydroxytryptophan. Neuroscience. 1989;28:83.
- Petitjean F, Buda C, Janin M, Sallanon M, Jouvet M. [Insomnia caused by administration of para-chlorophenylalanine: reversibility by peripheral or central injection of 5-hydroxytryptophan and serotonin]. Sleep. 1985;8:56.
