We explored the effects of vitamin C on chest pain in chronic smokers experiencing endothelial dysfunction. In our study, 31 patients, who were undergoing diagnostic catheterization without significant coronary artery issues, participated in a controlled trial. They were given either an IV infusion of 3 grams of ascorbic acid (vitamin C) or a placebo saline solution before undergoing a cold pressor test to assess their coronary artery response.
The results were telling. Smokers typically showed a decrease in luminal area—an indicator of blood flow—during the cold pressor test. However, after infusing vitamin C, this response shifted positively, demonstrating improved blood flow through a vasodilation effect. On the other hand, those who received the placebo did not experience significant changes.
This means that for chronic smokers, acute administration of vitamin C appears to enhance the function of the endothelium, which is vital for proper blood vessel health and managing chest pain. Ultimately, we observed that vitamin C may help prevent the inactivation of nitric oxide, a compound that supports healthy blood flow, and this effect could be crucial for managing cardiovascular health in smokers.
We examined the relationship between vitamin C levels and previously undiagnosed angina, a type of chest pain, in women aged 45 to 74 years. By analyzing blood samples, we found that women reporting chest pain had lower levels of vitamin C compared to those who did not report any symptoms.
Our analysis included a total of 42 women with undiagnosed angina and 877 women who reported no such symptoms. We noted that the average plasma vitamin C levels were significantly lower in the angina group, indicating a potential connection between low vitamin C levels and the presence of chest pain.
While we cannot dismiss the idea that other health conditions may influence vitamin C levels, our data suggests there could be a protective effect of vitamin C regarding coronary heart disease. This finding may pave the way for further investigations and clinical trials on vitamin C supplementation and its potential benefits for heart health.
Read More
8
Vitamin C aids nitrate therapy
Metabolomics-Driven Elucidation of Cellular Nitrate Tolerance Reveals Ascorbic Acid Prevents Nitroglycerin-Induced Inactivation of Xanthine Oxidase.
We explored the relationship between vitamin C, commonly known as ascorbic acid, and nitrate tolerance in patients using nitroglycerin for angina pectoris, a condition that causes chest pain due to insufficient blood flow to the heart. In our study, we created a cell culture model to understand how the body becomes tolerant to nitroglycerin, which is a medication that works by turning into nitric oxide to help expand blood vessels.
Our findings showed that nitroglycerin reduces the activity of xanthine oxidase, an enzyme crucial for converting nitroglycerin into the beneficial nitric oxide. This reduction can limit how effective nitroglycerin is over time, leading to what is called "nitrate tolerance." However, when we introduced vitamin C into the model, it was able to protect xanthine oxidase from being inactivated, which helped increase nitric oxide production.
This means that vitamin C might play a vital role in preventing the body from developing tolerance to nitroglycerin, which could be beneficial for patients who rely on this medication to alleviate chest pain over the long term. Our study sheds light on why incorporating vitamin C into treatment regimens may enhance the effectiveness of nitrate therapy and support heart health.
Read More
Most Useful Reviews
9
Improves chest symptoms
3 people found this helpful
The capsules are large and taste sour. I took them after breakfast with some water to avoid pain, unlike when I took them on an empty stomach. The quantity is excellent, and they wonderfully alleviate my chest pain. After I received the Covid vaccine and felt unwell, this product helped with the fatigue lasting only one day. Additionally, my skin improved significantly, with red acne spots beginning to fade. I recommend it; just remember to keep it in the fridge.
Read More
9
Excellent for pain relief
2 people found this helpful
During the epidemic, I avoided the dentist. When I had gum bleeding and sores, I took high doses of Vitamin C every 1-2 hours, resulting in no pain in just a day or two. I've taken about 7 capsules daily for over three years, maintaining good health without flu or other medicines.
Read More
9
No stomach pain
1 people found this helpful
This Vitamin C didn't cause any stomach pain, which is great for my acid reflux. I took 1g during the pandemic and found it very helpful.
We investigated the role of vitamin C in treating symptoms, including chest pain, among South Sudanese refugee young men living in Kakuma Refugee Camp, Kenya. Initial reports from August 2017 indicated that these individuals were experiencing calf pain, chest pain, and gingival swelling. Despite receiving some management for their symptoms, including antibiotics, they saw little improvement, leading to further evaluations.
Following an alert to the United Nations High Commissioner for Refugees in January 2018, we noticed a pattern of symptoms suggesting a possible vitamin C deficiency, or scurvy. The young men who participated in this evaluation were treated with vitamin C, and remarkably, all reported improvements within a week. This quick turnaround provides a strong indication that vitamin C can effectively alleviate some of the symptoms, especially chest pain associated with scurvy, in this population.
While the immediate effects of the vitamin treatment were promising, we also found that food and cash assistance provided to these refugees were not sufficient for a balanced diet rich in fresh fruits and vegetables. Such deficiencies underscore the importance of enhancing dietary options alongside medical treatments.
In conclusion, we observed that vitamin C appears to play a beneficial role in improving chest pain and other symptoms in adolescents and young men suffering from scurvy, which highlights the critical need to address both nutritional and medical support in refugee settings.
Read More
9
Scurvy linked to chest pain
Haemorrhagic Pericardial Effusion as the Presenting Symptom of Scurvy.
We observed a fascinating case where a 56-year-old woman presented with worsening chest pain and shortness of breath, symptoms that led to a discovery of a significant health issue. Upon examination, she displayed a range of alarming signs, including rapid heart rate, low blood pressure, and swollen neck veins. The clinical team performed an emergency procedure that revealed a large haemorrhagic pericardial effusion, which drew attention to the possibility of vitamin C deficiency, or scurvy.
Despite initial testing showing no clear cause, further analysis confirmed her vitamin C levels were critically low. Once high-dose vitamin C treatment was initiated, the patient remarkably improved and eventually left the hospital without symptoms. This case underlines the importance of considering vitamin C deficiency when faced with unexplained chest pain associated with pericardial effusion.
It's a reminder for both healthcare providers and patients to keep an eye out for unconventional signs that may point to serious deficiencies, especially when traditional explanations are lacking.
Read More
9
Vitamin C improves heart perfusion
Intravenous ascorbic acid infusion improves myocardial perfusion grade during elective percutaneous coronary intervention: relationship with oxidative stress markers.
We explored how vitamin C infusion might affect microcirculation and related chest pain during elective percutaneous coronary intervention (PCI) for stable angina. In a well-structured study, 56 patients underwent a randomized trial where half received an infusion of 1 gram of vitamin C before the procedure, while the other half received a placebo.
Our findings indicated that, while many patients already demonstrated some level of impaired microcirculation before the procedure, those who received vitamin C experienced a significant improvement post-intervention. Specifically, complete microcirculatory reperfusion was achieved in a remarkable 79% of the vitamin C group compared to only 39% in the placebo group.
Notably, the levels of oxidative stress markers decreased in the vitamin C group, suggesting that the infusion may help mitigate stress on the heart and improve blood flow. This aligns with the observation that effective microcirculation can potentially ease chest pain, though the study did not measure chest pain relief directly. Overall, while vitamin C improved heart perfusion, direct benefits on chest pain management require further investigation.
Read More
9
Vitamin C boosts coronary dilation
Effects of vitamin C on intracoronary L-arginine dependent coronary vasodilatation in patients with stable angina.
We explored the effects of vitamin C on chest pain through a study that involved 28 patients with stable angina and coronary artery disease. Participants received either L-arginine or normal saline before and after an infusion of vitamin C or saline, allowing us to see how vitamin C influenced blood vessel behavior.
Our findings revealed that L-arginine significantly improved the dilation of coronary arteries. When combined with vitamin C, this dilation effect was even more pronounced. Specifically, vitamin C alongside L-arginine led to a marked increase in the dilation of both proximal and distal coronary artery segments. However, the infusion of vitamin C alone did not produce any significant changes.
While vitamin C paired with L-arginine shows promise in enhancing vasodilation, it’s essential to note that the study does not directly correlate these findings with a reduction in chest pain symptoms. Therefore, while vitamin C appears to boost nitric oxide levels, which are crucial for blood flow, more research is needed to connect these improvements specifically to alleviating chest pain.
Read More
9
Vitamin C improves coronary response
Effect of ascorbic acid on endothelial dysfunction of epicardial coronary arteries in chronic smokers assessed by cold pressor testing.
We explored the effects of vitamin C on chest pain in chronic smokers experiencing endothelial dysfunction. In our study, 31 patients, who were undergoing diagnostic catheterization without significant coronary artery issues, participated in a controlled trial. They were given either an IV infusion of 3 grams of ascorbic acid (vitamin C) or a placebo saline solution before undergoing a cold pressor test to assess their coronary artery response.
The results were telling. Smokers typically showed a decrease in luminal area—an indicator of blood flow—during the cold pressor test. However, after infusing vitamin C, this response shifted positively, demonstrating improved blood flow through a vasodilation effect. On the other hand, those who received the placebo did not experience significant changes.
This means that for chronic smokers, acute administration of vitamin C appears to enhance the function of the endothelium, which is vital for proper blood vessel health and managing chest pain. Ultimately, we observed that vitamin C may help prevent the inactivation of nitric oxide, a compound that supports healthy blood flow, and this effect could be crucial for managing cardiovascular health in smokers.
The capsules are large and taste sour. I took them after breakfast with some water to avoid pain, unlike when I took them on an empty stomach. The quantity is excellent, and they wonderfully alleviate my chest pain. After I received the Covid vaccine and felt unwell, this product helped with the fatigue lasting only one day. Additionally, my skin improved significantly, with red acne spots beginning to fade. I recommend it; just remember to keep it in the fridge.
Read More
9
Excellent for pain relief
2 people found this helpful
During the epidemic, I avoided the dentist. When I had gum bleeding and sores, I took high doses of Vitamin C every 1-2 hours, resulting in no pain in just a day or two. I've taken about 7 capsules daily for over three years, maintaining good health without flu or other medicines.
Read More
9
No stomach pain
1 people found this helpful
This Vitamin C didn't cause any stomach pain, which is great for my acid reflux. I took 1g during the pandemic and found it very helpful.
Read More
0
Side effects noted
11 people found this helpful
I take 6-10 grams of Vitamin C daily. This brand's product is in capsule form and contains cytisinicline, which can be toxic. After consuming about 10 grams, I experienced severe tongue pain and fatigue. I urge the manufacturer to avoid adding such ingredients.
Read More
7.5
Effective during illness
2 people found this helpful
The vitamins work! I'm very pleased with the speedy delivery to Ukraine. I take Vitamin C-1000 once daily in the morning before meals. After three days, I felt a sore throat and doubled my intake that day, drinking it morning and evening. By morning, the pain had vanished! If you need Vitamin C, I recommend this product.
Chest pain is a broad term that refers to discomfort or pain felt in the chest area, and it can arise from a variety of causes. It can range from a sharp, stabbing sensation to a dull ache or pressure. Some common causes of chest pain include heart-related issues, such as angina or heart attacks, as well as non-cardiac conditions like acid reflux, musculoskeletal problems, or anxiety. Since chest pain can represent a serious condition, especially if it is sudden and severe, it's crucial to pay attention to accompanying symptoms such as shortness of breath, sweating, or nausea, which may warrant immediate medical attention.
If you're experiencing chest pain, it's essential to consult a healthcare professional for an accurate diagnosis. They may perform tests such as an electrocardiogram (ECG), blood tests, or imaging studies to determine the underlying cause. Early identification of heart-related issues can be life-saving, while non-cardiac causes, though often less serious, still require appropriate assessment and treatment. Understanding the context and quality of the pain can help guide that conversation with your doctor, ensuring you receive the best care possible.
Vitamin C, also known as ascorbic acid, is a water-soluble vitamin that plays a critical role in numerous bodily functions. As an essential nutrient, it contributes to the growth and repair of tissues in the body, and it is vital for the production of collagen, an important protein that helps maintain skin, cartilage, tendons, ligaments, and blood vessels. Additionally, Vitamin C acts as a powerful antioxidant, which means it helps combat free radicals—unstable molecules that can cause oxidative stress and contribute to various chronic diseases.
Moreover, Vitamin C enhances iron absorption from plant-based foods, making it a vital component for those following vegetarian or vegan diets. While many people get sufficient Vitamin C from a well-balanced diet that includes fruits and vegetables like oranges, strawberries, kiwi, broccoli, and bell peppers, some individuals might require supplementation. It's generally recommended to stay within the daily intake guidelines, as excessive consumption can lead to gastrointestinal disturbances. Overall, Vitamin C is not just a skincare celebrity—it's a fundamental part of maintaining overall health and well-being.
Based on user reviews, the timeframe for seeing results from this supplement can vary. Several users reported experiencing relief from symptoms such as chest pain within a matter of days. For instance, one individual noted that they felt a sore throat and after increasing their Vitamin C intake, the pain vanished by the next morning, which suggests prompt effectiveness Read Review. Meanwhile, another user mentioned that taking high doses for just one to two days alleviated their gum pain, implying that swift results can be common with this supplement Read Review.
However, it's important to note that individual experiences may vary. Some users reported discomfort or the need to stop use due to stomach irritation after a few days, which could delay any potential benefits Read Review. Overall, while many users experienced rapid relief, others faced challenges that could impact how quickly one might feel the intended benefits.
Vitamin C is emerging as a potential aid for chest pain relief based on a variety of studies. For example, a study observed that vitamin C treatment significantly improved symptoms, including chest pain, in South Sudanese refugees experiencing scurvy [3]. Moreover, another investigation highlighted that vitamin C may enhance the effectiveness of nitroglycerin treatment, which is commonly used for angina pectoris, by preventing the body from developing nitrate tolerance [4]. These findings suggest that vitamin C could play a role in managing chest pain, particularly in specific populations or contexts.
Additionally, multiple studies indicate a correlation between low vitamin C levels and chest pain, especially in women with undiagnosed angina [13]. Another trial found that vitamin C infusion improved endothelial function in chronic smokers with chest pain, hinting at its potential cardiovascular benefits [10]. While direct measures of chest pain relief are not always taken in these studies, the collected evidence points toward vitamin C's potential utility in addressing chest pain related to various underlying causes. However, further research is needed to solidify these findings and elucidate the mechanism by which vitamin C might alleviate chest pain.
Based on user reviews, many individuals have reported significant improvements in various symptoms after taking Vitamin C supplements. One user emphasized the effectiveness in alleviating chest pain, stating that after receiving the Covid vaccine, the supplement helped alleviate their fatigue and also contributed to the fading of red acne spots on their skin Read Review. Another reviewer who experienced gum bleeding and sores found rapid relief by taking high doses, noting that their pain disappeared in just a day or two Read Review.
However, experiences can vary greatly among users. Some individuals have mentioned adverse reactions, such as digestive discomfort or new pains, indicating that not everyone may benefit from the same formulation of Vitamin C Read Review. In contrast, others appreciated that this particular product did not irritate their stomach, unlike previous supplements they had tried, showcasing a potential for use among those with sensitivity Read Review
Based on user reviews, some individuals have reported positive experiences when combining Vitamin C supplements with other supplements for managing chest pain. One user noted that after receiving the Covid vaccine, the Vitamin C helped alleviate their chest pain and fatigue significantly, suggesting that it may work well in conjunction with other recovery strategies Read Review. Similarly, another reviewer who took high doses for gum pain found rapid relief, indicating that a higher intake during distressful times could be beneficial, likely paralleling other concurrent treatments Read Review.
However, there are also cautionary tales among users who faced adverse reactions. One user reported severe tongue pain and fatigue after taking large doses, advising others to be mindful of potential toxic ingredients in some formulations Read Review. Another noted that the introduction of a new Vitamin C product correlated with unexplained lymphatic pain, raising concerns about compatibility with existing health regimens Read Review. Overall, while Vitamin C may offer relief alongside other treatments, users are advised to monitor their responses closely and consult with healthcare providers when considering combinations with other supplements.
Based on user reviews, the appropriate dosage of Vitamin C for treating chest pain appears to vary among individuals, with some reporting relief at different levels. For instance, one user reported taking 1 gram of Vitamin C and found it to be very helpful for their chest pain during the pandemic Read Review. Another user frequently consumes 6 to 10 grams daily, though they also experienced adverse effects at the higher end of that range Read Review. Overall, the consensus among those who found success with Vitamin C suggests starting with lower doses, such as 1,000 mg, and adjusting as needed, keeping in mind personal tolerance levels to avoid gastrointestinal discomfort Read Review.
However, it is important for users to listen to their bodies and consult healthcare professionals when determining the right dosage, especially if experiencing any negative side effects. Some users praised the effects of Vitamin C in alleviating symptoms, while others reported stomach issues or other complications with certain products Read Review. Therefore, a tailored approach, starting at lower doses, while observing any adverse reactions, is advised for those considering Vitamin C for chest pain relief.
7.5
Effective during illness
2 people found this helpful
The vitamins work! I'm very pleased with the speedy delivery to Ukraine. I take Vitamin C-1000 once daily in the morning before meals. After three days, I felt a sore throat and doubled my intake that day, drinking it morning and evening. By morning, the pain had vanished! If you need Vitamin C, I recommend this product.
9
Excellent for pain relief
2 people found this helpful
During the epidemic, I avoided the dentist. When I had gum bleeding and sores, I took high doses of Vitamin C every 1-2 hours, resulting in no pain in just a day or two. I've taken about 7 capsules daily for over three years, maintaining good health without flu or other medicines.
0
Caused stomach pain
This vitamin C didn't suit me. I usually take Solaray's Vitamin C 1000mg, but this one caused stomach pain after a few days, which I initially attributed to stress. Upon stopping it, the pain subsided in 2-3 days.
9
Improves chest symptoms
3 people found this helpful
The capsules are large and taste sour. I took them after breakfast with some water to avoid pain, unlike when I took them on an empty stomach. The quantity is excellent, and they wonderfully alleviate my chest pain. After I received the Covid vaccine and felt unwell, this product helped with the fatigue lasting only one day. Additionally, my skin improved significantly, with red acne spots beginning to fade. I recommend it; just remember to keep it in the fridge.
0
Not suitable supplement
I cannot recommend this supplement. After taking it for several weeks, I experienced unexplained lymphatic pain, which coincided with its use. I've never had this issue with any other vitamin C supplement.
7.5
No more irritation
Previously, Vitamin C would irritate my stomach, but since switching to this product, I haven't experienced any pain. Thank you for this supplement!
0
Side effects noted
11 people found this helpful
I take 6-10 grams of Vitamin C daily. This brand's product is in capsule form and contains cytisinicline, which can be toxic. After consuming about 10 grams, I experienced severe tongue pain and fatigue. I urge the manufacturer to avoid adding such ingredients.
9
No stomach pain
1 people found this helpful
This Vitamin C didn't cause any stomach pain, which is great for my acid reflux. I took 1g during the pandemic and found it very helpful.
9.5
Vitamin C improves chest pain
Scurvy Outbreak Among South Sudanese Adolescents and Young Men - Kakuma Refugee Camp, Kenya, 2017-2018.
We investigated the role of vitamin C in treating symptoms, including chest pain, among South Sudanese refugee young men living in Kakuma Refugee Camp, Kenya. Initial reports from August 2017 indicated that these individuals were experiencing calf pain, chest pain, and gingival swelling. Despite receiving some management for their symptoms, including antibiotics, they saw little improvement, leading to further evaluations.
Following an alert to the United Nations High Commissioner for Refugees in January 2018, we noticed a pattern of symptoms suggesting a possible vitamin C deficiency, or scurvy. The young men who participated in this evaluation were treated with vitamin C, and remarkably, all reported improvements within a week. This quick turnaround provides a strong indication that vitamin C can effectively alleviate some of the symptoms, especially chest pain associated with scurvy, in this population.
While the immediate effects of the vitamin treatment were promising, we also found that food and cash assistance provided to these refugees were not sufficient for a balanced diet rich in fresh fruits and vegetables. Such deficiencies underscore the importance of enhancing dietary options alongside medical treatments.
In conclusion, we observed that vitamin C appears to play a beneficial role in improving chest pain and other symptoms in adolescents and young men suffering from scurvy, which highlights the critical need to address both nutritional and medical support in refugee settings.
8
Vitamin C aids nitrate therapy
Metabolomics-Driven Elucidation of Cellular Nitrate Tolerance Reveals Ascorbic Acid Prevents Nitroglycerin-Induced Inactivation of Xanthine Oxidase.
We explored the relationship between vitamin C, commonly known as ascorbic acid, and nitrate tolerance in patients using nitroglycerin for angina pectoris, a condition that causes chest pain due to insufficient blood flow to the heart. In our study, we created a cell culture model to understand how the body becomes tolerant to nitroglycerin, which is a medication that works by turning into nitric oxide to help expand blood vessels.
Our findings showed that nitroglycerin reduces the activity of xanthine oxidase, an enzyme crucial for converting nitroglycerin into the beneficial nitric oxide. This reduction can limit how effective nitroglycerin is over time, leading to what is called "nitrate tolerance." However, when we introduced vitamin C into the model, it was able to protect xanthine oxidase from being inactivated, which helped increase nitric oxide production.
This means that vitamin C might play a vital role in preventing the body from developing tolerance to nitroglycerin, which could be beneficial for patients who rely on this medication to alleviate chest pain over the long term. Our study sheds light on why incorporating vitamin C into treatment regimens may enhance the effectiveness of nitrate therapy and support heart health.
We examined the relationship between vitamin C levels and previously undiagnosed angina, a type of chest pain, in women aged 45 to 74 years. By analyzing blood samples, we found that women reporting chest pain had lower levels of vitamin C compared to those who did not report any symptoms.
Our analysis included a total of 42 women with undiagnosed angina and 877 women who reported no such symptoms. We noted that the average plasma vitamin C levels were significantly lower in the angina group, indicating a potential connection between low vitamin C levels and the presence of chest pain.
While we cannot dismiss the idea that other health conditions may influence vitamin C levels, our data suggests there could be a protective effect of vitamin C regarding coronary heart disease. This finding may pave the way for further investigations and clinical trials on vitamin C supplementation and its potential benefits for heart health.
9
Vitamin C improves coronary response
Effect of ascorbic acid on endothelial dysfunction of epicardial coronary arteries in chronic smokers assessed by cold pressor testing.
We explored the effects of vitamin C on chest pain in chronic smokers experiencing endothelial dysfunction. In our study, 31 patients, who were undergoing diagnostic catheterization without significant coronary artery issues, participated in a controlled trial. They were given either an IV infusion of 3 grams of ascorbic acid (vitamin C) or a placebo saline solution before undergoing a cold pressor test to assess their coronary artery response.
The results were telling. Smokers typically showed a decrease in luminal area—an indicator of blood flow—during the cold pressor test. However, after infusing vitamin C, this response shifted positively, demonstrating improved blood flow through a vasodilation effect. On the other hand, those who received the placebo did not experience significant changes.
This means that for chronic smokers, acute administration of vitamin C appears to enhance the function of the endothelium, which is vital for proper blood vessel health and managing chest pain. Ultimately, we observed that vitamin C may help prevent the inactivation of nitric oxide, a compound that supports healthy blood flow, and this effect could be crucial for managing cardiovascular health in smokers.
References
Joulal H, Yousfi J, Benjilali L, Zahlane M, Essaadouni L. Haemorrhagic Pericardial Effusion as the Presenting Symptom of Scurvy. Eur J Case Rep Intern Med. 2023;10:004026. doi:10.12890/2023_004026
Li J, Wang XZ, Wang RC, Yang J, Hao HL, et al. Pulmonary tuberculosis presenting as henoch-schönlein purpura: Case report and literature review. Medicine (Baltimore). 2020;99:e22583. doi:10.1097/MD.0000000000022583
Ververs M, Muriithi JW, Burton A, Burton JW, Lawi AO. Scurvy Outbreak Among South Sudanese Adolescents and Young Men - Kakuma Refugee Camp, Kenya, 2017-2018. MMWR Morb Mortal Wkly Rep. 2019;68:72. doi:10.15585/mmwr.mm6803a4
Axton ER, Cristobal E, Choi J, Miranda CL, Stevens JF. Metabolomics-Driven Elucidation of Cellular Nitrate Tolerance Reveals Ascorbic Acid Prevents Nitroglycerin-Induced Inactivation of Xanthine Oxidase. Front Pharmacol. 2018;9:1085. doi:10.3389/fphar.2018.01085
Ran L, Zhao W, Wang J, Wang H, Zhao Y, et al. Extra Dose of Vitamin C Based on a Daily Supplementation Shortens the Common Cold: A Meta-Analysis of 9 Randomized Controlled Trials. Biomed Res Int. 2018;2018:1837634. doi:10.1155/2018/1837634
Wang ZJ, Hu WK, Liu YY, Shi DM, Cheng WJ, et al. The effect of intravenous vitamin C infusion on periprocedural myocardial injury for patients undergoing elective percutaneous coronary intervention. Can J Cardiol. 2014;30:96. doi:10.1016/j.cjca.2013.08.018
Basili S, Tanzilli G, Mangieri E, Raparelli V, Di Santo S, et al. Intravenous ascorbic acid infusion improves myocardial perfusion grade during elective percutaneous coronary intervention: relationship with oxidative stress markers. JACC Cardiovasc Interv. 2010;3:221. doi:10.1016/j.jcin.2009.10.025
Tousoulis D, Xenakis C, Tentolouris C, Davies G, Antoniades C, et al. Effects of vitamin C on intracoronary L-arginine dependent coronary vasodilatation in patients with stable angina. Heart. 2005;91:1319.
Boev SS. [Changes in the blood content of some vitamins in patients with ischemic heart disease]. Lik Sprava. 2003.
Schindler TH, Magosaki N, Jeserich M, Olschewski M, Nitzsche E, et al. Effect of ascorbic acid on endothelial dysfunction of epicardial coronary arteries in chronic smokers assessed by cold pressor testing. Cardiology. 2000;94:239.
Hirashima O, Kawano H, Motoyama T, Hirai N, Ohgushi M, et al. Improvement of endothelial function and insulin sensitivity with vitamin C in patients with coronary spastic angina: possible role of reactive oxygen species. J Am Coll Cardiol. 2000;35:1860.
Kugiyama K, Motoyama T, Hirashima O, Ohgushi M, Soejima H, et al. Vitamin C attenuates abnormal vasomotor reactivity in spasm coronary arteries in patients with coronary spastic angina. J Am Coll Cardiol. 1998;32:103.
Ness AR, Khaw KT, Bingham S, Day NE. Vitamin c status and undiagnosed angina. J Cardiovasc Risk. 1996;3:373.