Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 20 Researches
8.2
USERS' SCORE
Good
Based on 30 Reviews
8
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
15
Total Fat
1.5 g
2%**
Fish Oil Concentrate
1.3 g (1,300 mg)
†
Docosahexaenoic Acid (DHA)
1 g (1,000 mg)
†
Top Medical Research Studies
8
We explored the potential of dihydroartemisinin (DHA), a compound derived from an antimalarial drug, to impact glioma stem cells (GSCs). In our study, we found that DHA effectively halted the growth of GSCs and triggered their programmed cell death.
We discovered that DHA influenced the activation of specific proteins that control these processes. In particular, it reduced the activity of p-AKT while boosting Cleaved Caspase-3 levels.
These findings suggest that DHA could offer a promising new method for treating challenging brain tumors like gliomas.
We discovered that DHA influenced the activation of specific proteins that control these processes. In particular, it reduced the activity of p-AKT while boosting Cleaved Caspase-3 levels.
These findings suggest that DHA could offer a promising new method for treating challenging brain tumors like gliomas.
Read More
9
We explored the potential of docosahexaenoic acid (DHA), an omega-3 fatty acid, in fighting glioblastoma, the most aggressive brain tumor. Our study examined various glioblastoma cell lines, discovering that DHA successfully induced cell death through mechanisms like apoptosis and autophagy. Additionally, findings from animal models suggested that DHA reduced tumor size through similar processes. This indicates that DHA could be a promising candidate for future therapies against glioblastoma, potentially improving treatment options for this challenging cancer type.
Read More
8
We explored the effectiveness of docosahexaenoic acid (DHA) liposomes for treating glioblastoma, a tough brain tumor to manage. Using a microfluidic system, we created liposomes of various sizes that were taken in by tumor cells. These DHA liposomes showed a better capacity to reduce cell viability and stimulate cell death compared to regular DHA. This research opens new doors in using omega-3 fatty acids in cancer treatments, highlighting a promising approach to combat this challenging disease.
Read More
Most Useful Reviews
9
Improved memory
4 people found this helpful
Very effective! I experienced clarity and improved memory. By the second day, my brain felt much more active, and my speech was noticeably faster. I truly enjoy this product!
Read More
9
Improved focus
3 people found this helpful
Now nailed it with one capsule equalling the potency of three! My husband noticed a significant boost in focus and productivity at work, which is primarily intellectual. We fully endorse this product!
Read More
9
Significant improvements observed
3 people found this helpful
An unexpectedly cool product! I bought it for my parents. After my dad's severe illness, the cognitive function of his brain suffered significantly. After taking this for 1.5 months, we observed improvements! He’s no longer confused and remembers everything. My mum has also become more collected; they are very satisfied.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 20 Researches
8.2
- All Researches
9
We investigated how glutamine metabolism impacts glioblastoma, paving the way for better treatments. By analyzing large datasets, we classified tumor profiles and examined their unique characteristics.
In a promising approach, we combined the glutaminase inhibitor CB839 with dihydroartemisinin (DHA) and found that this combination significantly affected cancer cell behaviors. This new therapy not only reduced glutamine metabolism but also increased cell death and hindered cancer cell movement.
Overall, our findings suggest that targeting glutamine metabolism with this combination could be an exciting strategy in fighting glioblastoma.
In a promising approach, we combined the glutaminase inhibitor CB839 with dihydroartemisinin (DHA) and found that this combination significantly affected cancer cell behaviors. This new therapy not only reduced glutamine metabolism but also increased cell death and hindered cancer cell movement.
Overall, our findings suggest that targeting glutamine metabolism with this combination could be an exciting strategy in fighting glioblastoma.
Read More
9
We investigated how dihydroartemisinin (DHA), an antimalarial compound, impacts malignant gliomas, known for their aggressive nature and limited treatment options. Our study utilized various assays and animal models, revealing that DHA considerably reduced glioma cell growth, even in resistant strains. It prompted cell death through mitochondrial dysfunction and notably lowered the levels of ERRα, a gene responsible for mitochondrial biogenesis. Additionally, combining DHA with temozolomide enhanced its effectiveness. Overall, our findings highlight DHA's potential in targeting glioma progression by influencing cancer cell metabolism.
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9
We explored the impact of a new hybrid molecule made from sulfasalazine (SAS) and dihydroartemisinin (DHA) on glioma cells, which are tough brain tumors. While SAS didn’t show much promise on its own, DHA significantly reduced cell viability in a dose-dependent manner.
The newly synthesized hybrid, AC254, proved to be even more effective than the individual compounds alone. It not only killed more tumor cells but also affected the cell cycle and limited their movement. This study highlights the potential of combining established drugs to create more powerful treatments for brain tumors.
The newly synthesized hybrid, AC254, proved to be even more effective than the individual compounds alone. It not only killed more tumor cells but also affected the cell cycle and limited their movement. This study highlights the potential of combining established drugs to create more powerful treatments for brain tumors.
Read More
9
We explored the potential of docosahexaenoic acid (DHA), an omega-3 fatty acid, in fighting glioblastoma, the most aggressive brain tumor. Our study examined various glioblastoma cell lines, discovering that DHA successfully induced cell death through mechanisms like apoptosis and autophagy. Additionally, findings from animal models suggested that DHA reduced tumor size through similar processes. This indicates that DHA could be a promising candidate for future therapies against glioblastoma, potentially improving treatment options for this challenging cancer type.
Read More
9
We examined the use of microemulsions (MEs) of curcumin combined with docosahexaenoic acid (DHA) for targeting brain tumors. Both intravenous and intranasal methods showed that the DHA microemulsions delivered significantly higher concentrations of curcumin to the brain, with the intranasal approach proving particularly effective. This enhanced delivery is due to DHA's ability to improve transport across the blood-brain barrier. Notably, we observed promising anticancer activity against human glioblastoma cells, suggesting that these formulations could be a valuable addition to brain cancer therapy.
Read More
User Reviews
USERS' SCORE
Good
Based on 30 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved memory
4 people found this helpful
Very effective! I experienced clarity and improved memory. By the second day, my brain felt much more active, and my speech was noticeably faster. I truly enjoy this product!
Read More
9
Improved focus
3 people found this helpful
Now nailed it with one capsule equalling the potency of three! My husband noticed a significant boost in focus and productivity at work, which is primarily intellectual. We fully endorse this product!
Read More
9
Significant improvements observed
3 people found this helpful
An unexpectedly cool product! I bought it for my parents. After my dad's severe illness, the cognitive function of his brain suffered significantly. After taking this for 1.5 months, we observed improvements! He’s no longer confused and remembers everything. My mum has also become more collected; they are very satisfied.
Read More
10
Cognitive clarity
1 people found this helpful
Excellent! NOW Foods DHA-1000 is a superior brain support supplement I have been using. I’m highly satisfied with the improvements in my cognitive function, memory, and mood after taking these capsules for several months. They’re easy to swallow and free from unpleasant odour or taste. The product quality is remarkable, passing stringent checks without artificial additives. I wholeheartedly recommend NOW Foods DHA-1000 for anyone seeking to enhance brain health.
Read More
9
Enhanced brain function
Excellent for maintaining normal brain function. The high docosahexaenoic acid content in this supplement aids brain health significantly. I'm hopeful it alleviates my issues. This Omega is in a beneficial form and high dosage, taken just once a day. It's now my favourite brand, offering great value for money. I’ve been using it regularly and feel a surge of strength and ease with waking up in the morning. Since my son exhibits attention deficit symptoms, it assists in his therapy, especially when paired with other dietary supplements.
Read More
Frequently Asked Questions
9
Improved memory
4 people found this helpful
Very effective! I experienced clarity and improved memory. By the second day, my brain felt much more active, and my speech was noticeably faster. I truly enjoy this product!
9
Significant improvements observed
3 people found this helpful
An unexpectedly cool product! I bought it for my parents. After my dad's severe illness, the cognitive function of his brain suffered significantly. After taking this for 1.5 months, we observed improvements! He’s no longer confused and remembers everything. My mum has also become more collected; they are very satisfied.
6
Boosted energy
1 people found this helpful
Having taken this supplement for months, I've noticed no side effects; rather, my cognitive function and energy levels have improved. It’s potentially useful for anyone aiming to enhance their brain and heart health. I decided to try this supplement based on its high DHA concentration. I take a capsule daily with food—small and easy to swallow. Following a few weeks, I felt positive changes in my concentration and overall energy, and I recommend it to others keen on improving their brain and heart health.
7.5
Improved mental clarity
1 people found this helpful
These softgels provide excellent support for brain health! My experiences with NOW Foods DHA-1000 have led to noticeable improvements in concentration and clarity of thought. Taking one softgel daily is effortless, and the smooth texture makes it even better. I confidently recommend this product to those looking to enhance their brain health.
9
Astonishing results
5 people found this helpful
Excellent! This amazing product enhanced my son's cognition and brain functions, yielding astonishing results. His concentration levels increased gradually, and his communication improved. I also used it to reduce triglycerides and alleviate joint stiffness. I'm thankful for the high manufacturing standards.
7.5
Increased energy noted
1 people found this helpful
I'm loving this product (DHA-1000). I feel more energy and relief from tiredness and heaviness in my head.
7.5
Cognitive improvement
2 people found this helpful
Good omega high in DHA per capsule. I bought it for brain support, and they claimed it improves cognitive abilities. While taking it with lecithin, I noticed a rise in concentration. After experiencing a crowned ARI, my thoughts struggled to settle, and my memory suffered, which initially concerned me about Alzheimer’s. I believe this omega played a significant role in my recovery. Alongside it, I also took magnesium, glycine, coenzyme Q10, and multivitamins, and I can confidently say that everything worked. The only reason for 4 stars is the price. Wishing everyone good health, and thanks to the Iherb team for providing such essential supplements.
7.5
Hope for improvement
1 people found this helpful
I purchased this for my grandfather, who suffers from partial memory loss and impaired cognitive functions due to a brain tumour. He doesn't eat fish, but the docosahexaenoic acid in this supplement may help improve his brain function. I will update the review after the course is complete. Be healthy!
6
Memory enhancement
DHA aids brain memory; I hope this product proves effective in treating my brain tumour.
9
We explored the potential of docosahexaenoic acid (DHA), an omega-3 fatty acid, in fighting glioblastoma, the most aggressive brain tumor. Our study examined various glioblastoma cell lines, discovering that DHA successfully induced cell death through mechanisms like apoptosis and autophagy. Additionally, findings from animal models suggested that DHA reduced tumor size through similar processes. This indicates that DHA could be a promising candidate for future therapies against glioblastoma, potentially improving treatment options for this challenging cancer type.
8
We explored the effectiveness of docosahexaenoic acid (DHA) liposomes for treating glioblastoma, a tough brain tumor to manage. Using a microfluidic system, we created liposomes of various sizes that were taken in by tumor cells. These DHA liposomes showed a better capacity to reduce cell viability and stimulate cell death compared to regular DHA. This research opens new doors in using omega-3 fatty acids in cancer treatments, highlighting a promising approach to combat this challenging disease.
7
We explored how docosahexaenoic acid (DHA) liposomes can help in targeting glioblastoma, a particularly aggressive brain tumor. The liposomes, created using a cutting-edge microfluidic method, were effectively absorbed by macrophages and showed promise in reducing inflammation linked to tumor growth.
While they successfully downregulated several inflammatory genes and cytokines in both macrophages and glioblastoma cells, there was no significant impact on an anti-inflammatory gene. Overall, while DHA liposomes demonstrated some valuable effects, further research is needed to find their full potential in treating glioblastoma.
While they successfully downregulated several inflammatory genes and cytokines in both macrophages and glioblastoma cells, there was no significant impact on an anti-inflammatory gene. Overall, while DHA liposomes demonstrated some valuable effects, further research is needed to find their full potential in treating glioblastoma.
References
- Mendanha D, Casanova MR, Gimondi S, Ferreira H, Neves NM. Microfluidic-Derived Docosahexaenoic Acid Liposomes for Targeting Glioblastoma and Its Inflammatory Microenvironment. ACS Appl Mater Interfaces. 2024;16:40543. 10.1021/acsami.4c01368
- Fu H, Wu S, Shen H, Luo K, Huang Z, et al. Glutamine Metabolism Heterogeneity in Glioblastoma Unveils an Innovative Combination Therapy Strategy. J Mol Neurosci. 2024;74:52. 10.1007/s12031-024-02201-x
- Zhang W, Wang Y, Chen L, Chen H, Qi H, et al. Dihydroartemisinin suppresses glioma growth by repressing ERRα-mediated mitochondrial biogenesis. Mol Cell Biochem. 2024;479:2809. 10.1007/s11010-023-04892-z
- Mendanha D, Gimondi S, Costa BM, Ferreira H, Neves NM. Microfluidic-derived docosahexaenoic acid liposomes for glioblastoma therapy. Nanomedicine. 2023;53:102704. 10.1016/j.nano.2023.102704
- Que Z, Zhou Z, Liu S, Zheng W, Lei B. Dihydroartemisinin inhibits EMT of glioma via gene BASP1 in extrachromosomal DNA. Biochem Biophys Res Commun. 2023;675:130. 10.1016/j.bbrc.2023.07.019
- Liang J, Li L, Tian H, Wang Z, Liu G, et al. Drug Repurposing-Based Brain-Targeting Self-Assembly Nanoplatform Using Enhanced Ferroptosis against Glioblastoma. Small. 2023;19:e2303073. 10.1002/smll.202303073
- Jin R, Xu Y, Jiang P. Inhibitory Effect of Nano-targeted Micelle Administration Combined with in Vitro Radiotherapy on Glioma Based on Nuclear Magnetic Resonance Technology. Cell Mol Biol (Noisy-le-grand). 2022;68:171. 10.14715/cmb/2022.68.7.28
- Gong H, Gao M, Lin Y, Liu J, Hu Z, et al. TUG1/MAZ/FTH1 Axis Attenuates the Antiglioma Effect of Dihydroartemisinin by Inhibiting Ferroptosis. Oxid Med Cell Longev. 2022;2022:7843863. 10.1155/2022/7843863
- Ackermann A, Çapcı A, Buchfelder M, Tsogoeva SB, Savaskan N. Chemical hybridization of sulfasalazine and dihydroartemisinin promotes brain tumor cell death. Sci Rep. 2021;11:20766. 10.1038/s41598-021-99960-z
- Chen M, Cui Y, Hao W, Fan Y, Zhang J, et al. Ligand-modified homologous targeted cancer cell membrane biomimetic nanostructured lipid carriers for glioma therapy. Drug Deliv. 2021;28:2241. 10.1080/10717544.2021.1992038
- Choi WS, Xu X, Goruk S, Wang Y, Patel S, et al. FABP7 Facilitates Uptake of Docosahexaenoic Acid in Glioblastoma Neural Stem-like Cells. Nutrients. 2021;13. 10.3390/nu13082664
- Yi R, Wang H, Deng C, Wang X, Yao L, et al. Dihydroartemisinin initiates ferroptosis in glioblastoma through GPX4 inhibition. Biosci Rep. 2020;40. 10.1042/BSR20193314
- Orchard TS, Gaudier-Diaz MM, Phuwamongkolwiwat-Chu P, Andridge R, Lustberg MB, et al. Low Sucrose, Omega-3 Enriched Diet Has Region-Specific Effects on Neuroinflammation and Synaptic Function Markers in a Mouse Model of Doxorubicin-Based Chemotherapy. Nutrients. 2018;10. 10.3390/nu10122004
- Kim S, Jing K, Shin S, Jeong S, Han SH, et al. ω3-polyunsaturated fatty acids induce cell death through apoptosis and autophagy in glioblastoma cells: In vitro and in vivo. Oncol Rep. 2018;39:239. 10.3892/or.2017.6101
- Shinde RL, Devarajan PV. Docosahexaenoic acid-mediated, targeted and sustained brain delivery of curcumin microemulsion. Drug Deliv. 2017;24:152. 10.1080/10717544.2016.1233593
- Cao L, Duanmu W, Yin Y, Zhou Z, Ge H, et al. Dihydroartemisinin exhibits anti-glioma stem cell activity through inhibiting p-AKT and activating caspase-3. Pharmazie. 2014;69:752.
- Ljungblad L, Bergqvist F, Tümmler C, Madawala S, Olsen TK, et al. Omega-3 fatty acids decrease CRYAB, production of oncogenic prostaglandin E and suppress tumor growth in medulloblastoma. Life Sci. 2022;295:120394. 10.1016/j.lfs.2022.120394
- Xu X, Wang Y, Choi WS, Sun X, Godbout R. Super resolution microscopy reveals DHA-dependent alterations in glioblastoma membrane remodelling and cell migration. Nanoscale. 2021;13:9706. 10.1039/d1nr02128a
- Mena-Hernández J, Jung-Cook H, Llaguno-Munive M, García-López P, Ganem-Rondero A, et al. Preparation and Evaluation of Mebendazole Microemulsion for Intranasal Delivery: an Alternative Approach for Glioblastoma Treatment. AAPS PharmSciTech. 2020;21:264. 10.1208/s12249-020-01805-x
- Tan X, Zou L, Qin J, Xia D, Zhou Y, et al. SQSTM1/p62 is involved in docosahexaenoic acid-induced cellular autophagy in glioblastoma cell lines. In Vitro Cell Dev Biol Anim. 2019;55:703. 10.1007/s11626-019-00387-8
