5/8/2025
Last update
5/8/2025
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.7
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
15
Total Fat
1.5 g
2%**
Fish Oil Concentrate
1.3 g (1,300 mg)
â€
Docosahexaenoic Acid (DHA)
1 g (1,000 mg)
â€
Top Medical Research Studies
8
We assessed the effects of fatty acids, particularly docosahexaenoic acid (DHA), on migraine frequency in a group of 105 participants aged 15 to 50. Our study found a clear relationship: lower DHA intake correlated with a higher frequency of migraine attacks. This was consistent across both men and women. However, no significant link was found between saturated fatty acids and migraine frequency. Our findings suggest that increasing omega-3 fatty acids like DHA could potentially help reduce migraine occurrences, though more research is needed in this area.
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8
We examined whether eating more long-chain omega-3 fatty acids could lead to fewer headaches in the U.S. population. In our investigation involving over 12,000 adults, we found that a higher intake of omega-3s, particularly docosahexaenoic acid (DHA), was linked to a lower occurrence of severe headaches and migraines. The results suggested that as people consumed more DHA, the prevalence of headaches tended to decrease. Notably, this effect was stronger in non-Mexican Hispanics, indicating dietary omega-3s might play a role in headache prevention.
Read More
We explored how dietary changes, particularly increasing omega-3 fats like DHA, could alleviate migraine headaches in adults. In a well-structured trial involving 153 participants, we examined whether targeted dietary modifications could impact headache frequency and severity. Participants followed one of three diets for 16 weeks, with some incorporating higher DHA levels while others maintained usual intakes. The results aim to reveal if these dietary shifts can effectively reduce migraine-related discomfort and enhance quality of life.
Read More
Most Useful Reviews
9
Improved memory
Excellent vitamins for brain activity and memory! We've been using them for three weeks now, and I've noticed a significant improvement in my memory, and the headaches have disappeared.
Read More
7.5
Reduced headache
I'm pleased there is no unpleasant aftertaste with these large capsules. I've noticed a reduction in headaches and anxiety, and I can absorb information more easily.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.7
- All Researches
9.5
We conducted a clinical trial to see how dietary changes targeting omega-3 and omega-6 fatty acids could help people dealing with chronic headaches. Over 12 weeks, we divided participants into two groups: one that increased their omega-3 intake while reducing omega-6 and another that just focused on lowering omega-6.
Our findings were quite promising! Those in the group increasing their omega-3 levels experienced a greater reduction in headache severity and frequency compared to those simply lowering omega-6. Specifically, the high omega-3 group had a significant drop in both daily headache hours and pain impact, while altering levels of important headache-relief mediators in the body.
This suggests that increasing omega-3, particularly docosahexaenoic acid, can be an effective strategy for reducing headache symptoms and improving overall quality of life among chronic headache sufferers. These dietary adjustments could provide a new avenue for managing headaches more effectively.
Our findings were quite promising! Those in the group increasing their omega-3 levels experienced a greater reduction in headache severity and frequency compared to those simply lowering omega-6. Specifically, the high omega-3 group had a significant drop in both daily headache hours and pain impact, while altering levels of important headache-relief mediators in the body.
This suggests that increasing omega-3, particularly docosahexaenoic acid, can be an effective strategy for reducing headache symptoms and improving overall quality of life among chronic headache sufferers. These dietary adjustments could provide a new avenue for managing headaches more effectively.
Read More
9
DHA diet linked to headache relief
We explored the connection between dietary changes and headache relief through a secondary analysis. By focusing on patients who followed a diet low in omega-6 linoleic acid while increasing omega-3 (specifically DHA), we discovered that higher levels of DHA-derived compounds were linked to fewer headaches and better mental and physical health.
Interestingly, while other lipid mediators didn't show significant changes, the rise in DHA-epoxides directly correlated with improved quality of life. Overall, this suggests that dietary omega-3s, like DHA, can play a meaningful role in managing chronic headaches.
Interestingly, while other lipid mediators didn't show significant changes, the rise in DHA-epoxides directly correlated with improved quality of life. Overall, this suggests that dietary omega-3s, like DHA, can play a meaningful role in managing chronic headaches.
Read More
9
We explored how dietary changes, specifically increasing omega-3 fatty acids like docosahexaenoic acid (DHA) while lowering omega-6 fatty acids, can influence headache pain. In a trial involving 55 chronic headache patients, we observed significant benefits from this targeted dietary intervention.
Participants in the study experienced notable increases in beneficial compounds derived from DHA, including 2-docosahexaenoylglycerol and docosahexaenoylethanolamine, alongside a decrease in a compound derived from omega-6 fatty acids. Our findings indicate that these changes in endocannabinoids are linked to reductions in both physical pain and psychological distress related to headaches.
The results suggest that adopting a diet rich in omega-3 fatty acids could be a promising way to manage headaches and related psychological issues effectively. This highlights the potential relevance of diet in addressing chronic pain, opening the door for further exploration into personalized nutrition as a valuable strategy for headache relief.
Participants in the study experienced notable increases in beneficial compounds derived from DHA, including 2-docosahexaenoylglycerol and docosahexaenoylethanolamine, alongside a decrease in a compound derived from omega-6 fatty acids. Our findings indicate that these changes in endocannabinoids are linked to reductions in both physical pain and psychological distress related to headaches.
The results suggest that adopting a diet rich in omega-3 fatty acids could be a promising way to manage headaches and related psychological issues effectively. This highlights the potential relevance of diet in addressing chronic pain, opening the door for further exploration into personalized nutrition as a valuable strategy for headache relief.
Read More
8
We examined whether eating more long-chain omega-3 fatty acids could lead to fewer headaches in the U.S. population. In our investigation involving over 12,000 adults, we found that a higher intake of omega-3s, particularly docosahexaenoic acid (DHA), was linked to a lower occurrence of severe headaches and migraines. The results suggested that as people consumed more DHA, the prevalence of headaches tended to decrease. Notably, this effect was stronger in non-Mexican Hispanics, indicating dietary omega-3s might play a role in headache prevention.
Read More
We explored how dietary changes, particularly increasing omega-3 fats like DHA, could alleviate migraine headaches in adults. In a well-structured trial involving 153 participants, we examined whether targeted dietary modifications could impact headache frequency and severity. Participants followed one of three diets for 16 weeks, with some incorporating higher DHA levels while others maintained usual intakes. The results aim to reveal if these dietary shifts can effectively reduce migraine-related discomfort and enhance quality of life.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved memory
Excellent vitamins for brain activity and memory! We've been using them for three weeks now, and I've noticed a significant improvement in my memory, and the headaches have disappeared.
Read More
7.5
Reduced headache
I'm pleased there is no unpleasant aftertaste with these large capsules. I've noticed a reduction in headaches and anxiety, and I can absorb information more easily.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Shen Q, Yang J, Zamora D, Horowitz M, Faurot KR, et al. Associations between Plasma Lipid Mediators and Chronic Daily Headache Outcomes in Patients Randomized to a Low Linoleic Acid Diet with or without Added Omega-3 Fatty Acids. Metabolites. 2023;13. 10.3390/metabo13060690
- Sanders AE, Weatherspoon ED, Ehrmann BM, Soma PS, Shaikh SR, et al. Circulating Polyunsaturated Fatty Acids and Pain Intensity in Five Chronic Pain Conditions. J Pain. 2023;24:478. 10.1016/j.jpain.2022.10.008
- Faurot KR, Cole WR, MacIntosh BA, Dunlap M, Moore CB, et al. Targeted dietary interventions to reduce pain in persistent post-traumatic headache among service members: Protocol for a randomized, controlled parallel-group trial. Contemp Clin Trials. 2022;119:106851. 10.1016/j.cct.2022.106851
- Ramsden CE, Zamora D, Faurot KR, MacIntosh B, Horowitz M, et al. Dietary alteration of n-3 and n-6 fatty acids for headache reduction in adults with migraine: randomized controlled trial. BMJ. 2021;374:n1448. 10.1136/bmj.n1448
- Khan M, Al Madani A, Habboush S, Abdulla M, Al Basti AK, et al. Multidisciplinary headache clinic-impact of a new model for headache care in Dubai. Clin Neurol Neurosurg. 2021;208:106845. 10.1016/j.clineuro.2021.106845
- Sanders AE, Shaikh SR, Slade GD. Long-chain omega-3 fatty acids and headache in the U.S. population. Prostaglandins Leukot Essent Fatty Acids. 2018;135:47. 10.1016/j.plefa.2018.06.008
- Mann JD, Faurot KR, MacIntosh B, Palsson OS, Suchindran CM, et al. A sixteen-week three-armed, randomized, controlled trial investigating clinical and biochemical effects of targeted alterations in dietary linoleic acid and n-3 EPA+DHA in adults with episodic migraine: Study protocol. Prostaglandins Leukot Essent Fatty Acids. 2018;128:41. 10.1016/j.plefa.2017.11.002
- Sadeghi O, Maghsoudi Z, Khorvash F, Ghiasvand R, Askari G. The relationship between different fatty acids intake and frequency of migraine attacks. Iran J Nurs Midwifery Res. 2015;20:334.
- Domenichiello AF, Jensen JR, Zamora D, Horowitz M, Yuan ZX, et al. Identifying oxidized lipid mediators as prognostic biomarkers of chronic posttraumatic headache. Pain. 2020;161:2775. 10.1097/j.pain.0000000000001983
- Ramsden CE, Zamora D, Makriyannis A, Wood JT, Mann JD, et al. Diet-induced changes in n-3- and n-6-derived endocannabinoids and reductions in headache pain and psychological distress. J Pain. 2015;16:707. 10.1016/j.jpain.2015.04.007
- Ramsden CE, Faurot KR, Zamora D, Suchindran CM, MacIntosh BA, et al. Targeted alteration of dietary n-3 and n-6 fatty acids for the treatment of chronic headaches: a randomized trial. Pain. 2013;154:2441. 10.1016/j.pain.2013.07.028
